Gene: DVL3

1857
DRS3
dishevelled segment polarity protein 3
protein-coding
3q27.1
Ensembl:ENSG00000161202 MIM:601368 Vega:OTTHUMG00000156841 UniprotKB:Q92997
NG_046860.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.402e-1 (AD)  4.766e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ILF30.932
CSNK1E0.924
KHSRP0.919
PHF10.919
TMEM2590.916
TRIM280.909
MTA10.905
HGS0.905
CDK90.904
SF10.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.83
OR4F29-0.79
OR6C74-0.176
IAPP-0.174
MTRNR2L9-0.173
HMHB1-0.172
CARD17-0.17
SH2D1A-0.162
MTRNR2L6-0.16
OR4F16-0.158

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DVL3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DVL3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DVL3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DVL3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DVL3 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of DVL3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DVL3 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DVL3 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of DVL3 mRNA18585445
D001151ArsenicArsenic affects the methylation of DVL3 gene25304211
D001280AtrazineAtrazine results in increased expression of DVL3 mRNA25929836
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of DVL3 mRNA18585445
D001280AtrazineAtrazine results in increased expression of DVL3 mRNA18585445
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of DVL3 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DVL3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DVL3 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of DVL3 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DVL3 mRNA27858113
C044887beta-methylcholinebeta-methylcholine affects the expression of DVL3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of DVL3 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of DVL3 mRNA27858113
C031180chrysenechrysene results in decreased expression of DVL3 mRNA26377693
D003024ClozapineClozapine results in increased expression of DVL3 protein16144542
D003024ClozapineDRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]16144542
D003033Coal TarCoal Tar results in decreased expression of DVL3 mRNA27858113
D003300CopperCopper deficiency results in increased expression of DVL3 mRNA26033743
C014347decitabinedecitabine results in increased expression of DVL3 mRNA27915011
D003976DiazinonDiazinon affects the expression of DVL3 mRNA19130878
C000944dicrotophosdicrotophos results in increased expression of DVL3 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of DVL3 mRNA21658437
D004221DisulfiramDisulfiram results in decreased expression of DVL3 mRNA20530235
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DVL3 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DVL3 mRNA27776689
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in increased methylation of DVL3 mRNA22959928
D006220HaloperidolDRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]16144542
D006220HaloperidolHaloperidol results in increased expression of DVL3 protein16144542
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of DVL3 mRNA"26377693
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DVL3 mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of DVL3 mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DVL3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DVL3 mRNA"25554681
D009534NiclosamideNiclosamide results in increased expression of DVL3 mRNA22576131
C030110oxaliplatinoxaliplatin results in increased expression of DVL3 mRNA17762391
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DVL3 mRNA"25510870
D010795Phthalic AcidsPhthalic Acids results in increased expression of DVL3 mRNA22112501
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DVL3 mRNA19710929
D018967RisperidoneDRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]16144542
D018967RisperidoneRisperidone results in increased expression of DVL3 protein16144542
C010327salinomycinsalinomycin results in decreased expression of DVL3 mRNA19682730
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in increased methylation of DVL3 mRNA22959928
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DVL3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of DVL3 protein modified form21602191
D013893ThiramThiram results in decreased expression of DVL3 mRNA20530235
D014635Valproic AcidValproic Acid affects the expression of DVL3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DVL3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DVL3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI20227366  
GO:0005102signaling receptor binding-IPI17030191  
GO:0005109frizzled binding-IBA21873635  
GO:0005109frizzled binding-IPI19388021  
GO:0005109frizzled binding-TAS25424568  
GO:0005515protein binding-IPI10330181  10644691  11113207  12805222  15677333  16189514  
17030191  19465938  19625296  20412773  20439735  21880741  
22863007  23109420  25416956  25557784  25910212  26359454  
27107014  
GO:0008013beta-catenin binding-IDA10644691  21880741  
GO:0046982protein heterodimerization activity-IDA19137009  
GO:0048365Rac GTPase binding-IPI23109420  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IMP20137080  
GO:0016055Wnt signaling pathway-IDA10644691  
GO:0035556intracellular signal transduction-IEA-  
GO:0035567non-canonical Wnt signaling pathway-IMP19137009  
GO:0035567non-canonical Wnt signaling pathway-TAS25424568  
GO:0038031non-canonical Wnt signaling pathway via JNK cascade-ISS-  
GO:0042493response to drug-IEA-  
GO:0043507positive regulation of JUN kinase activity-IMP19137009  
GO:0043547positive regulation of GTPase activity-IDA23109420  
GO:0045893positive regulation of transcription, DNA-templated-IDA10644691  12805222  17593335  
GO:0050821protein stabilization-IGI26359454  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA17593335  
GO:0060070canonical Wnt signaling pathway-IGI18093802  
GO:0060070canonical Wnt signaling pathway-IMP20137080  
GO:0060070canonical Wnt signaling pathway-TAS25424568  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-IDA12805222  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS-  
GO:0090179planar cell polarity pathway involved in neural tube closure-IBA21873635  
GO:0150012positive regulation of neuron projection arborization-ISS-  
GO:1903827regulation of cellular protein localization-IDA19625296  
GO:1904886beta-catenin destruction complex disassembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA21880741  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA23109420  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201688WNT mediated activation of DVLTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-4086400PCP/CE pathwayIEA
R-HSA-4641258Degradation of DVLTAS
R-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneTAS
R-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneIEA
R-HSA-5368598Negative regulation of TCF-dependent signaling by DVL-interacting proteinsIEA
R-HSA-5663220RHO GTPases Activate ForminsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20658532Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. (2011 May 15)Huang YInt J Cancer