Gene: DYRK1A

1859
DYRK|DYRK1|HP86|MNB|MNBH|MRD7
dual specificity tyrosine phosphorylation regulated kinase 1A
protein-coding
21q22.13
Ensembl:ENSG00000157540 MIM:600855 Vega:OTTHUMG00000086657 UniprotKB:Q13627
NG_009366.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.063e-1 (AD)  2.477e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2835725chr21:37418854 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05089897chr21:38886664DYRK1A1.650e-10Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLTC0.962
CAND10.96
NCKAP10.96
ATP2A20.959
UBE2K0.959
SPIN10.955
MARCH60.954
ATP6V1C10.954
MAPK10.954
RALGAPB0.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.571
CSAG1-0.414
MYL3-0.375
TFPI2-0.366
KLRB1-0.358
MTRNR2L10-0.354
SH2D1A-0.345
CXCR2-0.339
MTRNR2L6-0.338

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB07608N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DYRK1A mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DYRK1A mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DYRK1A mRNA"18648102
C0342145-iodotubercidin5-iodotubercidin results in decreased activity of DYRK1A protein26953159
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) inhibits the reaction [DYRK1A protein results in increased phosphorylation of CCND1 protein]"24806449
C578491((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one)"((5Z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4-one) results in decreased activity of DYRK1A protein"21615147
C4718436-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased activity of DYRK1A protein12534346
D000082AcetaminophenAcetaminophen affects the expression of DYRK1A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DYRK1A gene27153756
C482289Ageladine AAgeladine A analog binds to and results in decreased activity of DYRK1A protein21413800
C482289Ageladine AAgeladine A results in decreased activity of DYRK1A protein21413800
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DYRK1A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DYRK1A mRNA24449571
C006632arsenic trioxideDYRK1A protein results in increased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in decreased expression of DYRK1A mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DYRK1A gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DYRK1A mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DYRK1A mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of DYRK1A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DYRK1A gene28505145
C059041calyculin Acalyculin A results in increased expression of DYRK1A mRNA25270620
C054133casticincasticin results in decreased expression of DYRK1A mRNA28444820
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DYRK1A mRNA20938992
D002994ClofibrateClofibrate affects the expression of DYRK1A mRNA16081524
D019327Copper SulfateCopper Sulfate results in increased expression of DYRK1A mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DYRK1A mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DYRK1A mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of DYRK1A mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DYRK1A protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in decreased activity of DYRK1A protein12534346
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DYRK1A mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of DYRK1A mRNA20655997
D006247HarmineHarmine binds to DYRK1A protein25751815
D006247HarmineHarmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]21573099
D006247HarmineHarmine results in decreased activity of DYRK1A protein21573099
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DYRK1A mRNA20044591
C051890irinotecanirinotecan metabolite results in decreased expression of DYRK1A mRNA15956246
C051890irinotecanirinotecan results in decreased expression of DYRK1A mRNA15956246
C544151jinfukangjinfukang results in decreased expression of DYRK1A mRNA27392435
C045463leflunomideleflunomide results in increased expression of DYRK1A mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DYRK1A mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DYRK1A mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DYRK1A mRNA26924002
D005996NitroglycerinNitroglycerin results in decreased expression of DYRK1A mRNA12102619
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DYRK1A mRNA25729387
D010269ParaquatParaquat results in increased expression of DYRK1A mRNA21371552
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of DYRK1A mRNA28973697
C432165pyrazolanthronepyrazolanthrone results in decreased activity of DYRK1A protein12534346
C059514resveratrolresveratrol results in decreased expression of DYRK1A mRNA12569576
C104586roscovitineroscovitine results in decreased activity of DYRK1A protein12534346
D012834SilverSilver results in increased expression of DYRK1A mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of DYRK1A mRNA21795629
C416927SU 6656SU 6656 results in decreased activity of DYRK1A protein12534346
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DYRK1A mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DYRK1A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DYRK1A mRNA19465110
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of DYRK1A mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DYRK1A mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DYRK1A mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of DYRK1A mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of DYRK1A mRNA28973697
D014520UrethaneUrethane results in increased expression of DYRK1A mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DYRK1A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DYRK1A mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DYRK1A gene25560391
D014800VitalliumVitallium analog results in decreased expression of DYRK1A mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS-  
GO:0004674protein serine/threonine kinase activity-IGI17906291  25556849  
GO:0004674protein serine/threonine kinase activity-ISS20736167  
GO:0004674protein serine/threonine kinase activity-NAS28386764  
GO:0004712protein serine/threonine/tyrosine kinase activity-IEA-  
GO:0004713protein tyrosine kinase activity-ISS-  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IDA9748265  
GO:0005515protein binding-IPI14500717  14593110  15324660  15369779  17353931  20736167  
20940704  23602568  27173435  27705803  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO:0043621protein self-association-ISS-  
GO:0048156tau protein binding-ISS17906291  20736167  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IEA-  
GO:0006468protein phosphorylation-ISS-  
GO:0006468protein phosphorylation-TAS24327345  28377597  
GO:0007399nervous system development-TAS8769099  
GO:0007623circadian rhythm-ISS-  
GO:0016032viral process-IEA-  
GO:0018105peptidyl-serine phosphorylation-IGI25556849  
GO:0018105peptidyl-serine phosphorylation-ISS-  
GO:0018107peptidyl-threonine phosphorylation-ISS20736167  25556849  
GO:0018108peptidyl-tyrosine phosphorylation-IDA9748265  
GO:0018108peptidyl-tyrosine phosphorylation-ISS-  
GO:0031115negative regulation of microtubule polymerization-ISS17906291  
GO:0033120positive regulation of RNA splicing-IDA28377597  
GO:0034205amyloid-beta formation-IMP25556849  
GO:0036289peptidyl-serine autophosphorylation-TAS24327345  
GO:0038083peptidyl-tyrosine autophosphorylation-IDA24327345  
GO:0038083peptidyl-tyrosine autophosphorylation-TAS24327345  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-ISS20736167  
GO:0046777protein autophosphorylation-ISS-  
GO:0048025negative regulation of mRNA splicing, via spliceosome-IEA-  
GO:0090312positive regulation of protein deacetylation-ISS20736167  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA23415227  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0005737cytoplasm-TAS24327345  
GO:0005856cytoskeletoncolocalizes_withIDA24327345  
GO:0016607nuclear speck-ISS-  
GO:0016607nuclear speck-TAS28377597  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:1990904ribonucleoprotein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1538133G0 and Early G1TAS
R-HSA-1640170Cell CycleTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal