Gene: TOR1A

1861
DQ2|DYT1
torsin family 1 member A
protein-coding
9q34.11
Ensembl:ENSG00000136827 MIM:605204 Vega:OTTHUMG00000020794 UniprotKB:O14656
NG_008049.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.076e-1 (AD)  4.981e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIAPIN10.955
COPS30.954
RTCA0.954
NDFIP10.953
UBE2N0.953
GARS0.952
CLTC0.952
UBQLN10.951
VDAC10.951
CHMP70.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.61
OR4F29-0.557
MTRNR2L6-0.409
CSAG1-0.406
MTRNR2L9-0.4
MTRNR2L10-0.383
RAI14-0.363
MAGEA12-0.358
HEY2-0.356
CXCR2-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of TOR1A mRNA"20702594
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of TOR1A mRNA"20638727
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TOR1A mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of TOR1A protein26194647
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TOR1A mRNA]"19467301
D020106AcrylamideAcrylamide results in increased expression of TOR1A mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TOR1A mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TOR1A mRNA16483693
D001280AtrazineAtrazine results in decreased expression of TOR1A mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TOR1A mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TOR1A mRNA19770486
D003078ColchicineColchicine results in decreased expression of TOR1A mRNA24211769
D019327Copper SulfateCopper Sulfate results in decreased expression of TOR1A mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TOR1A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TOR1A mRNA24211769
D002945CisplatinCisplatin results in increased expression of TOR1A mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TOR1A mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of TOR1A mRNA19467301
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of TOR1A mRNA27638505
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of TOR1A mRNA28939011
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TOR1A mRNA24211769
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TOR1A mRNA23649840
D005047EtoposideEtoposide results in decreased expression of TOR1A mRNA24211769
D018120FinasterideFinasteride results in increased expression of TOR1A mRNA24136188
D006220HaloperidolTOR1A gene mutant form affects the susceptibility to Haloperidol20227500
D006918HydroxyureaHydroxyurea results in decreased expression of TOR1A mRNA24211769
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TOR1A mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TOR1A mRNA27392435
D008727MethotrexateMethotrexate affects the expression of TOR1A mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TOR1A mRNA24211769
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TOR1A mRNA23649840
D016685MitomycinMitomycin results in decreased expression of TOR1A mRNA24211769
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TOR1A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TOR1A mRNA"25620056
C051752nefazodonenefazodone results in increased expression of TOR1A mRNA24136188
D009532NickelNickel results in decreased expression of TOR1A mRNA23195993
D009532NickelNickel results in increased expression of TOR1A mRNA24768652|2558310
C012655nimesulidenimesulide results in increased expression of TOR1A mRNA24136188
C025256nonylphenolnonylphenol results in decreased expression of TOR1A protein19260726
D016627OxidopamineOxidopamine results in decreased expression of TOR1A protein16325337
D019319Okadaic AcidOkadaic Acid results in increased expression of TOR1A mRNA28939011
C006253pirinixic acidpirinixic acid results in increased expression of TOR1A mRNA17426115|1830175
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of TOR1A mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of TOR1A mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TOR1A mRNA22698814
D012402RotenoneRotenone results in decreased expression of TOR1A mRNA19013527
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of TOR1A mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of TOR1A mRNA16014739
D013467SulindacSulindac results in decreased expression of TOR1A mRNA24136188
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of TOR1A mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOR1A mRNA20702594|2157046
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TOR1A mRNA25613284
D014635Valproic AcidValproic Acid affects the expression of TOR1A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TOR1A mRNA28001369|2915479
D014635Valproic AcidValproic Acid affects the expression of TOR1A mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of TOR1A mRNA23034163
D000225AdenineAdenine results in decreased expression of TOR1A mRNA24211769
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of TOR1A mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15147511  15505207  18167355  18827015  21102408  23569223  
25416956  25910212  
GO:0005524ATP binding-IEA-  
GO:0008092cytoskeletal protein binding-IPI16361107  18827015  
GO:0016887ATPase activity-IDA23569223  
GO:0019894kinesin binding-IPI14970196  
GO:0051082unfolded protein binding-IEA-  
GO:0051787misfolded protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000338protein deneddylation-IMP21102408  
GO:0006979response to oxidative stress-IEA-  
GO:0006996organelle organization-ISS-  
GO:0006998nuclear envelope organization-ISS-  
GO:0007155cell adhesion-IMP16361107  
GO:0031175neuron projection development-IMP16361107  
GO:0034504protein localization to nucleus-IMP18827015  
GO:0034504protein localization to nucleus-ISS-  
GO:0044319wound healing, spreading of cells-ISS-  
GO:0045104intermediate filament cytoskeleton organization-IMP16361107  
GO:0048489synaptic vesicle transport-IMP18167355  
GO:0051085chaperone cofactor-dependent protein refolding-IEA-  
GO:0051260protein homooligomerization-IDA20015956  
GO:0051584regulation of dopamine uptake involved in synaptic transmission-IDA15505207  
GO:0061077chaperone-mediated protein folding-IDA20169475  
GO:0071712ER-associated misfolded protein catabolic process-ISS-  
GO:0071763nuclear membrane organization-ISS-  
GO:0072321chaperone-mediated protein transport-IDA15505207  
GO:1900244positive regulation of synaptic vesicle endocytosis-IMP21102408  
GO:2000008regulation of protein localization to cell surface-IMP15505207  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-ISS-  
GO:0005783endoplasmic reticulum-IDA12671990  
GO:0005788endoplasmic reticulum lumen-IDA17037984  20015956  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0008021synaptic vesicle-IDA21102408  
GO:0016020membrane-IDA23569223  
GO:0030054cell junction-IEA-  
GO:0030141secretory granule-ISS-  
GO:0030426growth cone-ISS-  
GO:0030659cytoplasmic vesicle membrane-ISS-  
GO:0031965nuclear membrane-IDA-  
GO:0042406extrinsic component of endoplasmic reticulum membrane-IDA17037984  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23365103SGCE mutations cause psychiatric disorders: clinical and genetic characterization. (2013 Jan)Peall KJBrain