Gene info: ID 1869

Gene: E2F1

GENE ID: 1869

Synonyms: E2F-1|RBAP1|RBBP3|RBP3

Description: E2F transcription factor 1

Gene type: protein-coding

Location: 20q11.22

dbXrefs: Ensembl:ENSG00000101412 MIM:189971 Vega:OTTHUMG00000032265 UniprotKB:Q01094

RefSeq: NG_046988.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.040e-1 (AD) 4.609e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg19593285	chr20:32267661	E2F1		2.100e-13	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DOHH	0.823
EML2	0.815
FCHO1	0.813
KCNJ9	0.813
ROGDI	0.799
TRUB2	0.797
SRCIN1	0.795
RAB11FIP4	0.793
MYH7B	0.792
SH3GL3	0.785

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CCDC36	-0.49
GJB2	-0.474
LYN	-0.473
RREB1	-0.456
MTRNR2L10	-0.454
ANKRD22	-0.453
RDH10	-0.453
SIX1	-0.452
LPP	-0.451
BAIAP2L1	-0.451

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C015699	1,2-benzisothiazoline-3-one	"1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]"	14702633
C015699	1,2-benzisothiazoline-3-one	"1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 protein]"	14702633
C044985	1',2'-dihydrorotenone	"1',2'-dihydrorotenone results in decreased expression of E2F1 protein"	24615755
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of E2F1 mRNA"	23626729
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to FOXM1 promoter]"	26171734
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to MYC promoter]"	26171734
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of E2F1 mRNA"	22698814\|2368455
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of E2F1 protein"	12807759\|1538217
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to FOXM1 promoter]]"	26171734
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to MYC promoter]]"	26171734
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of E2F1 mRNA]"	22698814
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of E2F1 mRNA"	26988655
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of E2F1 protein"	26988655
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of E2F1 protein]	14971663
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of E2F1 mRNA	17872378
C497101	2-hydroxy-9-cis-octadecenoic acid	2-hydroxy-9-cis-octadecenoic acid results in decreased expression of E2F1 mRNA	16027227
C497101	2-hydroxy-9-cis-octadecenoic acid	2-hydroxy-9-cis-octadecenoic acid results in decreased expression of E2F1 protein	16027227
C025160	3-aminobenzamide	3-aminobenzamide promotes the reaction [RB1 protein binds to E2F1 protein]	15670817
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of E2F1 mRNA	12419474
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of E2F1 mRNA	15982314
C510786	5-nitroso-8-quinolinol	5-nitroso-8-quinolinol results in decreased expression of E2F1 protein	16497787
C510786	5-nitroso-8-quinolinol	Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of E2F1 protein]	16497787
C580598	5-OH-BDE-47	5-OH-BDE-47 results in increased expression of E2F1 mRNA	26988655
C580599	6-OH-BDE-47	6-OH-BDE-47 results in decreased expression of E2F1 protein	26988655
C580599	6-OH-BDE-47	6-OH-BDE-47 results in increased expression of E2F1 mRNA	26988655
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of E2F1 protein"	19936915
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]	22403396
D000082	Acetaminophen	Acetaminophen results in increased expression of E2F1 mRNA	22230336\|2570463
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of E2F1 protein]	16497787
C058956	acteoside	[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]	17634406
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of E2F1 mRNA	15120964
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of E2F1 mRNA	23630614
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of E2F1 mRNA	15647840
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of E2F1 protein	15647840
C077990	alvocidib	alvocidib results in decreased expression of E2F1 mRNA	21239698
C077990	alvocidib	alvocidib results in increased expression of E2F1 protein	12533675
C077990	alvocidib	E2F1 results in increased susceptibility to alvocidib	12533675
C077990	alvocidib	E2F1 results in increased susceptibility to alvocidib	12533675
D000643	Ammonium Chloride	Ammonium Chloride results in increased expression of E2F1 protein	16483693
D000655	Amodiaquine	Amodiaquine affects the expression of E2F1 mRNA	24113242
D000655	Amodiaquine	Amodiaquine affects the expression of E2F1 protein	24113242
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of E2F1 mRNA"	22863853
D000732	Androstanols	"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to FOXM1 promoter]]"	26171734
D000732	Androstanols	"Androstanols inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [E2F1 protein binds to MYC promoter]]"	26171734
C483690	apo-14'-carotenoic acid	apo-14'-carotenoic acid results in decreased expression of E2F1 protein	12042460
D001151	Arsenic	Arsenic results in decreased expression of E2F1 mRNA	19945496
D001151	Arsenic	Arsenic results in increased expression of E2F1 protein	23174854
D001151	Arsenic	E2F1 protein affects the reaction [Arsenic results in increased expression of AURKA protein]	23174854
C006632	arsenic trioxide	arsenic trioxide affects the methylation of E2F1 promoter	26046465
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of E2F1 protein	24691991\|2517435
C006632	arsenic trioxide	arsenic trioxide results in increased expression of E2F1 mRNA	20016248
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of E2F1 protein"	20855422
C010302	aspidin BB	aspidin BB results in increased expression of E2F1 protein	23628508
D001241	Aspirin	Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter]	17848598
D001241	Aspirin	Aspirin results in decreased expression of E2F1 mRNA	20457246
D001241	Aspirin	[troglitazone co-treated with Aspirin] results in decreased expression of E2F1 protein	19908241
D001280	Atrazine	Atrazine results in decreased expression of E2F1 mRNA	22378314
C105832	aurapten	aurapten affects the expression of E2F1 mRNA	23320178
D001374	Azacitidine	E2F1 protein affects the reaction [Azacitidine results in decreased activity of TERT protein]	19451745
D001374	Azacitidine	E2F1 protein affects the reaction [Azacitidine results in decreased expression of TERT mRNA]	19451745
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of E2F1 mRNA	23117580
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the activity of E2F1 protein	20624995
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of E2F1 mRNA	20064835\|2180250
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of E2F1 protein	21802500
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of E2F1 protein	16406622
D001564	Benzo(a)pyrene	CCND1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]	16406622
D001564	Benzo(a)pyrene	CDK4 protein promotes the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]	16406622
D001564	Benzo(a)pyrene	Tretinoin inhibits the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]	16406622
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of E2F1 mRNA"	19150397
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dronabinol results in decreased expression of E2F1 protein]	17934890
D004958	Estradiol	"1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]"	14702633
D004958	Estradiol	"1,2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased expression of E2F1 protein]"	14702633
D004958	Estradiol	DIBA-1 inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]	14702633
D004958	Estradiol	DIBA-1 inhibits the reaction [Estradiol results in increased expression of E2F1 protein]	14702633
D004958	Estradiol	Estradiol results in increased activity of E2F1 protein	27592001
D004958	Estradiol	Estradiol results in increased expression of E2F1 mRNA	14702633\|1787237
D004958	Estradiol	Estradiol results in increased expression of E2F1 protein	14702633
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in increased expression of E2F1 mRNA]	25210133
D004958	Estradiol	Estradiol affects the expression of E2F1 mRNA	15598610
D004958	Estradiol	Estradiol results in increased expression of E2F1 mRNA	23684557\|2521013
D004958	Estradiol	Estradiol results in increased expression of E2F1 protein	23684557
C006780	bisphenol A	bisphenol A results in increased expression of E2F1 protein	21277958\|2593341
C006780	bisphenol A	bisphenol A results in decreased expression of E2F1 mRNA	25181051
D000069286	Bortezomib	[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased activity of E2F1 protein	25522274
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of E2F1 mRNA	12419474
C584509	C646 compound	C646 compound results in decreased expression of E2F1 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of E2F1 mRNA	20839231
C028031	cadmium acetate	cadmium acetate affects the localization of E2F1 protein	20839231
C028031	cadmium acetate	cadmium acetate promotes the reaction [RB1 protein modified form binds to E2F1 protein]	20839231
C028031	cadmium acetate	cadmium acetate results in decreased activity of E2F1 protein	20839231
C028031	cadmium acetate	cadmium acetate results in decreased expression of E2F1 mRNA	18155341\|2083923
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of E2F1 mRNA	27510461
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter]	25046863
D002110	Caffeine	Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]	22403396
D002166	Camptothecin	7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]	22403396
D002166	Camptothecin	Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]	22403396
D002166	Camptothecin	Camptothecin results in increased expression of E2F1 mRNA	22403396
D002166	Camptothecin	E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
D002211	Capsaicin	Capsaicin results in increased expression of E2F1 mRNA	19502594
D002220	Carbamazepine	Carbamazepine affects the expression of E2F1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of E2F1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of E2F1 protein	19887370
C038590	cardanol	cardanol results in increased expression of E2F1 mRNA	26694491
D002330	Carmustine	Carmustine results in increased expression of E2F1 protein	18632648
C099555	CD 437	CD 437 results in increased expression of E2F1 protein	10766194
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of E2F1 mRNA	15924885
D002794	Choline	Choline results in increased expression of E2F1 mRNA	16014740
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of E2F1 gene	20938992
D002794	Choline	Choline results in increased expression of E2F1 mRNA	16014740
C045645	cilostazol	cilostazol results in decreased expression of E2F1 protein	15723965
D002953	Citrinin	Citrinin results in increased expression of E2F1 mRNA	23856526
D003035	Cobalt	[Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of E2F1 mRNA	22198552
D003078	Colchicine	Colchicine results in decreased expression of E2F1 mRNA	24211769
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of E2F1 mRNA	20971185
D003300	Copper	Copper deficiency results in increased expression of E2F1 mRNA	17418555
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of E2F1 mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of E2F1 mRNA	19167446
D003474	Curcumin	Curcumin results in decreased expression of E2F1 mRNA	18299980
D003634	DDT	DDT results in increased expression of E2F1 mRNA	23684557
D003634	DDT	DDT results in increased expression of E2F1 protein	23684557
D003634	DDT	fulvestrant inhibits the reaction [DDT results in increased expression of E2F1 mRNA]	23684557
C014347	decitabine	decitabine results in increased expression of E2F1 mRNA	27915011
D013759	Dronabinol	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Dronabinol results in decreased expression of E2F1 protein]	17934890
D013759	Dronabinol	Dronabinol results in decreased expression of E2F1 mRNA	17934890
D013759	Dronabinol	Dronabinol results in decreased expression of E2F1 protein	17934890
C576677	demycarosyl-3D-digitoxosylmithramycin SK	demycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of E2F1 mRNA	24907531
C100805	DIBA-1	DIBA-1 inhibits the reaction [Estradiol results in increased expression of E2F1 mRNA]	14702633
C100805	DIBA-1	DIBA-1 inhibits the reaction [Estradiol results in increased expression of E2F1 protein]	14702633
C100805	DIBA-1	DIBA-1 results in decreased expression of E2F1 mRNA	14702633
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of E2F1 mRNA"	16269432
D002945	Cisplatin	Cisplatin results in decreased expression of E2F1 mRNA	24211769
D002945	Cisplatin	Cisplatin results in increased acetylation of E2F1 protein	21157427
D002945	Cisplatin	Cisplatin results in increased expression of E2F1 mRNA	21603599
D004008	Diclofenac	Diclofenac affects the expression of E2F1 mRNA	24752500
D004026	Dieldrin	Dieldrin affects the expression of E2F1 mRNA	22546817
D004026	Dieldrin	Dieldrin results in increased expression of E2F1 mRNA	23153324
C020283	diethanolamine	diethanolamine results in increased expression of E2F1 mRNA	16014740
C020283	diethanolamine	diethanolamine results in increased expression of E2F1 mRNA	16014740
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of E2F1 mRNA	20101389
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of E2F1 mRNA	17854601
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of E2F1 protein	17854601\|1988737
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of E2F1 mRNA]	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of E2F1 protein]	17854601\|1988737
D002117	Calcitriol	Calcitriol promotes the reaction [Testosterone results in decreased expression of E2F1 mRNA]	21592394
D002117	Calcitriol	Calcitriol results in decreased expression of E2F1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of E2F1 mRNA	21592394
D002117	Calcitriol	Testosterone promotes the reaction [Calcitriol results in decreased expression of E2F1 mRNA]	21592394
C547156	dimethylthioarsinic acid	dimethylthioarsinic acid results in decreased expression of E2F1 mRNA	19945496
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of E2F1 mRNA	22302311
D004317	Doxorubicin	Doxorubicin affects the expression of E2F1 protein	25124555
D004317	Doxorubicin	Doxorubicin inhibits the reaction [[RBBP8 protein binds to BRCA1 protein binds to E2F1 protein] which results in increased expression of ATM mRNA]	22832221
D004317	Doxorubicin	Doxorubicin promotes the reaction [E2F1 protein binds to CCNE1 promoter]	25124555
D004317	Doxorubicin	Doxorubicin promotes the reaction [E2F1 protein binds to TP73 promoter]	25124555
D004317	Doxorubicin	Doxorubicin promotes the reaction [E2F1 protein results in decreased expression of ATM mRNA]	22832221
D004317	Doxorubicin	Doxorubicin results in decreased expression of E2F1 mRNA	24816189
D004317	Doxorubicin	Doxorubicin results in decreased expression of E2F1 protein	24816189
D004317	Doxorubicin	Doxorubicin results in increased expression of E2F1 protein	22751436
D004317	Doxorubicin	E2F1 protein affects the susceptibility to Doxorubicin	25124555
D004317	Doxorubicin	E2F1 protein promotes the reaction [Doxorubicin results in increased expression of CCNE1 protein]	25124555
D004317	Doxorubicin	E2F1 protein promotes the reaction [Doxorubicin results in increased expression of TP73 protein]	25124555
D004317	Doxorubicin	palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]	22751436
D004317	Doxorubicin	RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]	22751436
D004317	Doxorubicin	SETD7 protein promotes the reaction [Doxorubicin affects the expression of E2F1 protein]	25124555
D004317	Doxorubicin	SETD7 protein promotes the reaction [Doxorubicin promotes the reaction [E2F1 protein binds to CCNE1 promoter]]	25124555
D004317	Doxorubicin	SETD7 protein promotes the reaction [Doxorubicin promotes the reaction [E2F1 protein binds to TP73 promoter]]	25124555
C509867	E804 bisindole	E804 bisindole results in decreased expression of E2F1 mRNA	23107598
C509867	E804 bisindole	Lipopolysaccharides promotes the reaction [E804 bisindole results in decreased expression of E2F1 mRNA]	23107598
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of E2F1 mRNA	14976129\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of E2F1 mRNA	17942748
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in decreased expression of E2F1 mRNA	22711419
D005047	Etoposide	E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]	19491197
D005047	Etoposide	Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter]	19491197
D005054	Eugenol	Eugenol results in decreased expression of E2F1 mRNA	15574415
D005054	Eugenol	Eugenol results in decreased expression of E2F1 protein	15574415
D005054	Eugenol	Eugenol results in decreased activity of E2F1 protein	15574415
C063007	exoenzyme C3, Clostridium botulinum	"exoenzyme C3, Clostridium botulinum results in decreased expression of E2F1 mRNA"	27351882
C093323	farnesylthiosalicylic acid	farnesylthiosalicylic acid results in decreased expression of E2F1 protein	16780807
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in decreased expression of E2F1 protein	15158336
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of E2F1 mRNA	19167416\|2221319
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of E2F1 gene	20938992
C070081	fulvestrant	fulvestrant results in decreased expression of E2F1 mRNA	20215421
C070081	fulvestrant	fulvestrant inhibits the reaction [DDT results in increased expression of E2F1 mRNA]	23684557
C039281	furan	furan results in increased expression of E2F1 mRNA	20562052\|2207923
C419708	gefitinib	gefitinib results in decreased expression of E2F1 mRNA	17094457
C419708	gefitinib	gefitinib results in decreased expression of E2F1 protein	17094457\|1834714
C479979	GW0742	[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of E2F1 protein	22473992
D006247	Harmine	Harmine results in increased expression of E2F1 mRNA	25751815
D006247	Harmine	Harmine results in increased expression of E2F1 protein	25751815
D006493	Heparin	Heparin analog results in decreased expression of E2F1 protein	20201787
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde affects the expression of E2F1 mRNA	22302311
D017313	Fenretinide	Fenretinide results in decreased expression of E2F1 mRNA	28973697
C403899	HS 1030	HS 1030 promotes the reaction [RB1 protein binds to E2F1 protein]	15202011
C403900	HS 1183	HS 1183 promotes the reaction [RB1 protein binds to E2F1 protein]	15202011
C503536	HS-1199	HS-1199 promotes the reaction [RB1 protein binds to E2F1 protein]	15202011
C479128	HS 1200	HS 1200 promotes the reaction [RB1 protein binds to E2F1 protein]	15202011
D006918	Hydroxyurea	Hydroxyurea results in decreased expression of E2F1 mRNA	24211769
C027185	indirubin	indirubin results in decreased expression of E2F1 mRNA	15056799
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of E2F1 mRNA	25613284
D007501	Iron	[Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of E2F1 mRNA	22198552
C544151	jinfukang	jinfukang results in increased expression of E2F1 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of E2F1 mRNA	27169980
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased activity of E2F1 protein	24796395
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of E2F1 mRNA	25961927
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of E2F1 protein	25174395
C017461	lead nitrate	E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]	24639330
C017461	lead nitrate	E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]	24639330
C017461	lead nitrate	lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]	24639330
C038753	leptomycin B	leptomycin B results in decreased expression of E2F1 mRNA	20803015
D008012	Lidocaine	Lidocaine affects the expression of E2F1 mRNA	18931217
D008070	Lipopolysaccharides	E2F1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	21131441
D008070	Lipopolysaccharides	E2F1 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]	21131441
D008070	Lipopolysaccharides	E2F1 protein results in increased susceptibility to Lipopolysaccharides	21131441
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [E804 bisindole results in decreased expression of E2F1 mRNA]	23107598
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in increased expression of E2F1 mRNA	25532727
D008344	Maneb	[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]	23963992
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]	23963992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of E2F1 gene	20938992
D008727	Methotrexate	Methotrexate inhibits the reaction [RB1 protein binds to E2F1 protein]	22484375
D008727	Methotrexate	Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter]	22484375
D008727	Methotrexate	Methotrexate promotes the reaction [E2F1 protein binds to KAT2B protein]	22484375
D008727	Methotrexate	Methotrexate results in decreased methylation of and results in increased acetylation of E2F1 protein	22484375
D008727	Methotrexate	Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter]	22484375
D008727	Methotrexate	Methotrexate promotes the reaction [E2F1 protein binds to DHFR promoter]	22484375
C008493	methylselenic acid	methylselenic acid affects the expression of E2F1 mRNA	14617803
C008493	methylselenic acid	methylselenic acid promotes the reaction [E2F1 protein binds to RB1 protein]	17847021
C008493	methylselenic acid	methylselenic acid results in decreased expression of E2F1 mRNA	11830524
C008493	methylselenic acid	methylselenic acid results in decreased expression of E2F1 protein	17847021
D015735	Mifepristone	Mifepristone results in decreased expression of E2F1 protein	17545545
D016685	Mitomycin	Mitomycin results in decreased expression of E2F1 mRNA	24211769
C060893	MK-886	MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]	20061081
D016686	Monocrotaline	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA	21224054
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of E2F1 mRNA	19945496
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of E2F1 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA	16357179
D009151	Mustard Gas	Mustard Gas results in increased expression of E2F1 mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of E2F1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of E2F1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of E2F1 mRNA"	25620056
D009532	Nickel	[Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of E2F1 mRNA	22198552
D009532	Nickel	[Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of E2F1 mRNA	22198552
C022838	nickel chloride	HIF1A affects the reaction [nickel chloride results in increased expression of E2F1 mRNA]	12729255
C022838	nickel chloride	nickel chloride results in increased expression of E2F1 mRNA	12729255
C022838	nickel chloride	nickel chloride affects the expression of E2F1 mRNA	22546817
D009538	Nicotine	MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]	20061081
D009538	Nicotine	Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]	16601104
D009538	Nicotine	Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]	16862215
D009538	Nicotine	Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]	16862215
D009538	Nicotine	Nicotine results in increased expression of E2F1 protein	20061081
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of E2F1 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in increased acetylation of E2F1 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of E2F1 promoter] which results in increased expression of E2F1 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of E2F1 mRNA	29098329
D019301	Oleic Acid	Oleic Acid results in decreased expression of E2F1 protein	16027227
D009840	Oligomycins	Oligomycins promotes the reaction [RB1 protein binds to E2F1 protein]	15925326
D010100	Oxygen	Oxygen deficiency results in decreased expression of E2F1 mRNA	26516004
D017239	Paclitaxel	E2F1 protein results in increased susceptibility to Paclitaxel	16849574
C500026	palbociclib	palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]	22751436
C500026	palbociclib	RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of E2F1 protein]]	22751436
C500026	palbociclib	E2F1 protein affects the susceptibility to palbociclib	23898052
D010269	Paraquat	[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]	23963992
C074968	pentaacetyl geniposide	pentaacetyl geniposide results in decreased phosphorylation of E2F1 protein	15975050
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of E2F1 protein	19442831
C011272	perfosfamide	perfosfamide results in increased expression of E2F1 mRNA	19429390
D010634	Phenobarbital	Phenobarbital affects the expression of E2F1 mRNA	23091169
D010672	Phenytoin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA	21224054
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of E2F1 mRNA	26708502
D009764	o-Phthalaldehyde	o-Phthalaldehyde affects the expression of E2F1 mRNA	22302311
D010882	Piperonyl Butoxide	[Diethylnitrosamine co-treated with Piperonyl Butoxide] results in increased expression of E2F1 mRNA	20101389
C006253	pirinixic acid	pirinixic acid results in increased expression of E2F1 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in decreased expression of E2F1 protein	15327971
D011285	Pregnenolone Carbonitrile	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of E2F1 mRNA"	23626729
D011374	Progesterone	Progesterone results in decreased expression of E2F1 mRNA	16966611
D011441	Propylthiouracil	Propylthiouracil results in increased expression of E2F1 mRNA	24780913
C573121	ProstaCaid	ProstaCaid results in decreased expression of E2F1 mRNA	21468543
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of E2F1 mRNA"	21152443
D011794	Quercetin	Quercetin results in increased expression of E2F1 mRNA	21632981\|2751452
C037219	quinoline	quinoline analog affects the expression of E2F1 protein	15450938
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased activity of E2F1 protein]	19011540
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of E2F1 mRNA	19167446
D012293	Rifampin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA	21224054
D019438	Ritonavir	Ritonavir results in decreased expression of E2F1 mRNA	19386116
D019438	Ritonavir	Ritonavir results in decreased expression of E2F1 protein	19386116
D012643	Selenium	Selenium results in increased expression of E2F1 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of E2F1 mRNA	23806026
D012835	Silver Nitrate	Silver Nitrate analog results in increased expression of E2F1 mRNA	22831968
D019821	Simvastatin	Simvastatin results in decreased expression of E2F1 mRNA	17428261
D020123	Sirolimus	[TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 mRNA	12417722
D020123	Sirolimus	[TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 protein	12417722
D020123	Sirolimus	[TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 protein	12417722
D020123	Sirolimus	[TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 protein	12417722
C009277	sodium arsenate	sodium arsenate results in decreased expression of E2F1 mRNA	24349563
C017947	sodium arsenite	sodium arsenite results in increased expression of E2F1 mRNA	28595984
C017947	sodium arsenite	sodium arsenite inhibits the reaction [E2F1 protein binds to DLGAP5 promoter]	17998272
C017947	sodium arsenite	sodium arsenite inhibits the reaction [E2F1 protein binds to MELK promoter]	17998272
C017947	sodium arsenite	sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of E2F1 protein]	28003426
C017947	sodium arsenite	sodium arsenite results in increased expression of E2F1 protein	10764629
D013467	Sulindac	Sulindac results in decreased expression of E2F1 protein	16488075
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of E2F1 mRNA"	26680231
D013629	Tamoxifen	Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]	20215421
D013629	Tamoxifen	Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]	20215421\|2021542
D013629	Tamoxifen	Tamoxifen results in decreased expression of E2F1 mRNA	15590111
D013629	Tamoxifen	Tamoxifen results in increased expression of E2F1 mRNA	20215421
D013629	Tamoxifen	Tamoxifen results in increased expression of E2F1 protein	20215421
D013629	Tamoxifen	Tamoxifen results in decreased expression of E2F1 protein	17343880
D013629	Tamoxifen	[Tamoxifen results in increased expression of MIR17 mRNA] which results in decreased expression of E2F1 protein	17343880
D013629	Tamoxifen	[Tamoxifen results in increased expression of MIR92A1 mRNA] which results in decreased expression of E2F1 protein	17343880
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [E2F1 protein results in increased expression of BAX protein]	14514686
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]	14514686
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]	14514686
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of E2F1 protein	15255934
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in increased expression of E2F1 mRNA	15255934
D013739	Testosterone	Calcitriol promotes the reaction [Testosterone results in decreased expression of E2F1 mRNA]	21592394
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of E2F1 mRNA	21592394
D013739	Testosterone	Testosterone promotes the reaction [Calcitriol results in decreased expression of E2F1 mRNA]	21592394
D013739	Testosterone	Testosterone results in decreased expression of E2F1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of E2F1 mRNA	15056799\|2180250
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of E2F1 protein	21802500
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of E2F1 mRNA	21570461\|2405805
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of E2F1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of E2F1 mRNA	15667827
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of E2F1 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of E2F1 mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in increased expression of E2F1 mRNA	16297948
D024505	Tocopherols	Tocopherols results in increased expression of E2F1 protein	15883045
D014118	Toxins, Biological	"Toxins, Biological affects the expression of E2F1 mRNA"	19682533
C099150	trabectedin	trabectedin results in increased expression of E2F1 mRNA	15961672
C099150	trabectedin	trabectedin results in increased expression of E2F1 mRNA	15961672
D014212	Tretinoin	Tretinoin inhibits the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]	16406622
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of E2F1 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of E2F1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in decreased expression of E2F1 protein	12042460
D014212	Tretinoin	Tretinoin results in increased expression of E2F1 mRNA	17218384
C015559	trimellitic anhydride	trimellitic anhydride affects the expression of E2F1 mRNA	22302311
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of E2F1 mRNA	19042947
C001899	triptolide	triptolide results in increased expression of E2F1 mRNA	23639586
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of E2F1 mRNA"	26179874
C057693	troglitazone	[troglitazone co-treated with Aspirin] results in decreased expression of E2F1 protein	19908241
C057693	troglitazone	troglitazone results in decreased expression of E2F1 mRNA	19140230\|1963173
D014414	Tungsten	[Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of E2F1 mRNA	22198552
D014414	Tungsten	[Nickel co-treated with Iron co-treated with Tungsten] results in decreased expression of E2F1 mRNA	22198552
D014415	Tunicamycin	Tunicamycin results in decreased expression of E2F1 mRNA	22378314
C000602704	UF010 compound	UF010 compound results in decreased activity of E2F1 protein	25699604
D014520	Urethane	Urethane results in decreased expression of E2F1 mRNA	28818685
D014520	Urethane	Urethane results in increased expression of E2F1 mRNA	12117781
D014580	Ursodeoxycholic Acid	NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]	15222754
D014580	Ursodeoxycholic Acid	NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]	15222754
D014580	Ursodeoxycholic Acid	NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]	15222754
D014580	Ursodeoxycholic Acid	NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]	15222754
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of BAX protein]	14514686
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]	14514686
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]	14514686
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]	15222754
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of E2F1 protein	15222754
D014635	Valproic Acid	Valproic Acid affects the expression of E2F1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of E2F1 mRNA	20585447
D014635	Valproic Acid	Valproic Acid results in increased methylation of E2F1 gene	29154799
D014638	Vanadates	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of E2F1 protein]	14971663
D014638	Vanadates	Vanadates results in increased expression of E2F1 protein	14971663
D014638	Vanadates	wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein]	14971663
C551177	vemurafenib	[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of E2F1 mRNA	27169980
D014747	Vinblastine	E2F1 protein results in increased susceptibility to Vinblastine	16849574
C017963	vinyl carbamate	vinyl carbamate results in decreased expression of E2F1 mRNA	17849452
D000225	Adenine	Adenine results in decreased expression of E2F1 mRNA	24211769
D024483	Vitamin K 3	Vitamin K 3 affects the expression of E2F1 mRNA	20044591
C009687	wortmannin	wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein]	14971663
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of E2F1 mRNA	16357179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IMP	20040599
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0000987	proximal promoter sequence-specific DNA binding	-	IDA	15735762
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IC	-
GO:0003677	DNA binding	-	IDA	15073182 15731768
GO:0003677	DNA binding	-	IMP	11418595
GO:0003700	DNA-binding transcription factor activity	-	IDA	15731768
GO:0003700	DNA-binding transcription factor activity	-	TAS	11418595
GO:0005515	protein binding	-	IPI	8657141 9418871 9468139 9468140 11418595 11486038 11713253 14576432 14627987 16061792 16249186 16360038 16374512 16892051 17006541 17380128 17690688 17704056 18660752 18794899 19188449 19249677 20040599 20133863 20195357 20224733 20622854 20729920 20871633 21653699 22327218 22810586 23397142 23472054 23629655 27705803
GO:0008134	transcription factor binding	-	IPI	16360038 20176812
GO:0019901	protein kinase binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IDA	23332764
GO:0043565	sequence-specific DNA binding	-	ISS	-
GO:0046983	protein dimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000077	DNA damage checkpoint	-	IMP	12717439
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	-
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	20224733
GO:0006351	transcription, DNA-templated	-	ISS	-
GO:0006355	regulation of transcription, DNA-templated	-	IDA	12717439
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	-
GO:0007283	spermatogenesis	-	IEA	-
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	IMP	12717439
GO:0010628	positive regulation of gene expression	-	IDA	15766563
GO:0030900	forebrain development	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IDA	15565177
GO:0043276	anoikis	-	IEA	-
GO:0043392	negative regulation of DNA binding	-	IDA	20176812
GO:0045599	negative regulation of fat cell differentiation	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	20176812
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	20224733
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	21454377 22476863
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	15565177 20224733
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	20040599 20224733
GO:0048146	positive regulation of fibroblast proliferation	-	IMP	20224733
GO:0048255	mRNA stabilization	-	IDA	15766563
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	-
GO:0070345	negative regulation of fat cell proliferation	-	ISS	-
GO:0071398	cellular response to fatty acid	-	IEA	-
GO:0071456	cellular response to hypoxia	-	IEA	-
GO:0071466	cellular response to xenobiotic stimulus	-	IEA	-
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	-	IMP	20224733
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	-	IEA	-
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	-
GO:1990086	lens fiber cell apoptotic process	-	IEA	-
GO:1990090	cellular response to nerve growth factor stimulus	-	IEA	-
GO:2000045	regulation of G1/S transition of mitotic cell cycle	-	IMP	20224733

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IDA	21454377
GO:0005634	nucleus	-	IDA	12717439 20040599
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005739	mitochondrion	-	IEA	-
GO:0005813	centrosome	-	IDA	-
GO:0032991	protein-containing complex	-	IDA	23629655
GO:0035189	Rb-E2F complex	-	IDA	20224733

KEGG ID	KEGG Term
hsa04110	Cell cycle
hsa05200	Pathways in cancer
hsa05212	Pancreatic cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109606	Intrinsic Pathway for Apoptosis	TAS
R-HSA-111448	Activation of NOXA and translocation to mitochondria	TAS
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	IEA
R-HSA-113510	E2F mediated regulation of DNA replication	IEA
R-HSA-114452	Activation of BH3-only proteins	TAS
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	IEA
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	TAS
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	IEA
R-HSA-139915	Activation of PUMA and translocation to mitochondria	TAS
R-HSA-1538133	G0 and Early G1	IEA
R-HSA-1538133	G0 and Early G1	TAS
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-157118	Signaling by NOTCH	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-1912408	Pre-NOTCH Transcription and Translation	IEA
R-HSA-1912408	Pre-NOTCH Transcription and Translation	TAS
R-HSA-1912422	Pre-NOTCH Expression and Processing	IEA
R-HSA-1912422	Pre-NOTCH Expression and Processing	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2559580	Oxidative Stress Induced Senescence	TAS
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2559585	Oncogene Induced Senescence	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453279	Mitotic G1-G1/S phases	IEA
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-539107	Activation of E2F1 target genes at G1/S	TAS
R-HSA-539107	Activation of E2F1 target genes at G1/S	IEA
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	TAS
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	TAS
R-HSA-68689	CDC6 association with the ORC:origin complex	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68911	G2 Phase	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69205	G1/S-Specific Transcription	TAS
R-HSA-69205	G1/S-Specific Transcription	IEA
R-HSA-69206	G1/S Transition	TAS
R-HSA-69206	G1/S Transition	IEA
R-HSA-69231	Cyclin D associated events in G1	TAS
R-HSA-69236	G1 Phase	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69278	Cell Cycle, Mitotic	IEA
R-HSA-69306	DNA Replication	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953750	Transcriptional Regulation by E2F6	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22240023	Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity. (2012 Feb 3)	Alamanda V	Biochem Biophys Res Commun
27228072	Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. (2016)	Schaal C	PLoS One
18448277	Benzo(a)pyrene-caused increased G1-S transition requires the activation of c-Jun through p53-dependent PI-3K/Akt/ERK pathway in human embryo lung fibroblasts. (2008 May 30)	Jiao S	Toxicol Lett
25631445	Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)	-	Nature
22537161	Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. (2012 Apr 26)	Kunigal S	Mol Cancer
18155341	Gene expression profiling in human lung fibroblast following cadmium exposure. (2008 Mar)	Li GY	Food Chem Toxicol
26305796	Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq. (2015)	Min JW	PLoS One
16601104	Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. (2006 Apr 18)	Dasgupta P	Proc Natl Acad Sci U S A
25600647	beta-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. (2015 Mar 15)	Pillai S	Cancer Res
16255782	CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. (2005 Oct 29)	Mullins DN	BMC Cancer
28464886	A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. (2017 May 2)	Yeo J	BMC Cancer