Gene: E2F2

1870
E2F-2
E2F transcription factor 2
protein-coding
1p36.12
Ensembl:ENSG00000007968 MIM:600426 Vega:OTTHUMG00000003223 UniprotKB:Q14209
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.870e-2 (AD)  9.732e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC12A0.758
SPTA10.704
RETN0.697
KCNJ150.687
LILRB20.679
SLC4A10.677
LILRA50.67
IL18RAP0.67
CEACAM30.667
KLRD10.656

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.424
CORT-0.423
SPEF1-0.423
SVOP-0.419
TM7SF2-0.415
MAGIX-0.414
LRRC73-0.412
SLC7A4-0.412
THY1-0.407
ROBO2-0.404

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of E2F2 mRNA"23826121
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of E2F2 mRNA"21354444|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F2 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of E2F2 mRNA"26988655
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of E2F2 protein"26988655
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of E2F2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F2 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of E2F2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of E2F2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of E2F2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of E2F2 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of E2F2 mRNA19191707
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of E2F2 mRNA26988655
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of E2F2 protein26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of E2F2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of E2F2 mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in increased expression of E2F2 mRNA26988655
C5805996-OH-BDE-476-OH-BDE-47 results in increased expression of E2F2 protein26988655
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of E2F2 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of E2F2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of E2F2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of E2F2 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of E2F2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of E2F2 mRNA24449571
D001151ArsenicArsenic results in decreased expression of E2F2 mRNA19945496
C006632arsenic trioxidearsenic trioxide results in increased expression of E2F2 mRNA17530438
D001280AtrazineAtrazine results in decreased expression of E2F2 mRNA22378314
C105832auraptenaurapten affects the expression of E2F2 mRNA23320178
C487081belinostatbelinostat results in decreased expression of E2F2 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of E2F2 mRNA20064835|2180250
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of E2F2 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of E2F2 mRNA25210133
C006780bisphenol Abisphenol A affects the methylation of E2F2 promoter27334623
C584509C646 compoundC646 compound results in increased expression of E2F2 mRNA26921506
D019256Cadmium ChlorideCadmium Chloride results in increased expression of E2F2 mRNA24982889
D002220CarbamazepineCarbamazepine affects the expression of E2F2 mRNA24752500
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of E2F2 mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of E2F2 mRNA18353800
C045645cilostazolcilostazol results in decreased expression of E2F2 protein15723965
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of E2F2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of E2F2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of E2F2 mRNA19167446
C014347decitabinedecitabine results in increased expression of E2F2 mRNA27915011
D003907DexamethasoneDexamethasone results in decreased expression of E2F2 mRNA22733784
C100805DIBA-1DIBA-1 results in decreased expression of E2F2 mRNA14702633
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of E2F2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of E2F2 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of E2F2 mRNA24752500
D002117CalcitriolCalcitriol results in decreased expression of E2F2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of E2F2 mRNA21592394
D005054EugenolEugenol results in decreased expression of E2F2 mRNA15574415
D005054EugenolEugenol results in decreased expression of E2F2 protein15574415
D005472FluorouracilFluorouracil results in decreased expression of E2F211300326
D019833GenisteinGenistein results in decreased expression of E2F2 mRNA18847459
D006247HarmineHarmine results in increased expression of E2F2 mRNA25751815
D006247HarmineHarmine results in increased expression of E2F2 protein25751815
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of E2F2 mRNA20044591
D004441EcdysteroneEcdysterone results in decreased expression of E2F2 mRNA15776001
C492448ICG 001ICG 001 results in increased expression of E2F2 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to E2F2 promoter]27081696
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of E2F2 mRNA24796395|2530787
D007854LeadLead affects the expression of E2F2 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of E2F2 mRNA28988120
D008012LidocaineLidocaine affects the expression of E2F2 mRNA18931217
C002385linsidominelinsidomine results in decreased activity of E2F2 protein12600834
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of E2F2 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of E2F2 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of E2F2 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of E2F2 mRNA19945496
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of E2F2 mRNA"25554681|2562005
D009538NicotineNicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]16862215
D009585Nitrogen DioxideNitrogen Dioxide results in decreased activity of E2F2 protein12600834
D010100OxygenOxygen deficiency results in decreased expression of E2F2 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of E2F2 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of E2F2 mRNA]22629407
C500026palbociclibE2F2 protein inhibits the reaction [palbociclib results in decreased expression of CCNA2 protein]20100483
C500026palbociclibE2F2 protein inhibits the reaction [palbociclib results in decreased expression of RNR2 protein]20100483
C500026palbociclibE2F2 protein inhibits the reaction [palbociclib results in decreased phosphorylation of RB1 protein]20473330
C500026palbociclibpalbociclib results in decreased expression of E2F2 mRNA22869556
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of E2F2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of E2F2 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of E2F2 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of E2F2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of E2F2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of E2F2 mRNA26272509
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of E2F2 mRNA24583197
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of E2F2 mRNA28903501
D011794QuercetinQuercetin results in decreased expression of E2F2 mRNA14715546|2372791
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of E2F2 mRNA16497877
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of E2F2 mRNA19167446
D019438RitonavirRitonavir results in decreased expression of E2F2 mRNA19386116
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of E2F2 mRNA23806026
D012835Silver NitrateSilver Nitrate analog results in increased expression of E2F2 mRNA22831968
C017947sodium arsenitesodium arsenite results in increased expression of E2F2 mRNA28595984
C016104sodium bichromatesodium bichromate results in increased expression of E2F2 mRNA22155349
D012969Sodium FluorideSodium Fluoride results in increased expression of E2F2 mRNA27862939
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of E2F2 mRNA21641980
D013629TamoxifenTamoxifen results in increased expression of E2F2 mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of E2F2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of E2F2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of E2F2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of E2F2 mRNA21802500
D013749TetrachlorodibenzodioxinE2F2 protein results in decreased susceptibility to Tetrachlorodibenzodioxin20573986
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of E2F2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of E2F2 mRNA19770486
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of E2F2 mRNA28973375
D019284ThapsigarginThapsigargin results in decreased expression of E2F2 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of E2F2 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of E2F2 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in decreased expression of E2F2 mRNA28973375
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of E2F2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of E2F2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of E2F2 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of E2F2 mRNA22378314
C000602704UF010 compoundUF010 compound results in decreased activity of E2F2 protein25699604
D014520UrethaneUrethane results in decreased expression of E2F2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of E2F2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of E2F2 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of E2F2 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of E2F2 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingcontributes_toIDA7739537  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000987proximal promoter sequence-specific DNA binding-IDA15735762  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA bindingcontributes_toIDA7739537  
GO:0003677DNA binding-TAS8246995  
GO:0003700DNA-binding transcription factor activity-NAS8246995  
GO:0005515protein binding-IPI16360038  17380128  
GO:0008134transcription factor binding-IPI16360038  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006367transcription initiation from RNA polymerase II promoter-TAS8246996  
GO:0007049cell cycle-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA7739537  
GO:0051726regulation of cell cycle-IEA-  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IEA-  
GO:1903671negative regulation of sprouting angiogenesis-IGI27731397  
GO:1990086lens fiber cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0090575RNA polymerase II transcription factor complex-IDA7739537  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-68689CDC6 association with the ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27609456Effect of human papillomavirus seropositivity and E2F2 promoter variants on risk of squamous cell carcinomas of oropharynx and oral cavity. (2016 Sep 8)Li YCarcinogenesis