Gene: ECE1

1889
ECE
endothelin converting enzyme 1
protein-coding
1p36.12
Ensembl:ENSG00000117298 MIM:600423 Vega:OTTHUMG00000002625 UniprotKB:P42892
NG_013008.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.726e-2 (AD)  8.485e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16416158chr1:21652298ECE14.300e-12Smoking27651444
cg26348226chr1:21617442ECE13.800e-8Smoking27651444
cg17850498chr1:21565755ECE18.900e-8Smoking27651444
cg26348226chr1:21617442ECE11.370e-9Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLN10.891
PTBP10.881
ARAF0.876
STAT30.875
HDAC70.867
SLC39A10.857
PTTG1IP0.855
KHNYN0.85
ASCC20.847
LAMB20.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
OR4F29-0.53
CRH-0.402
SMIM18-0.399
NMU-0.369
HAPLN1-0.369
VWC2-0.354
PRLHR-0.336
LHX6-0.332
PPEF1-0.332

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB071715-(2-hydroxyethyl)nonane-1,9-diolSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of ECE1 mRNA"17690111
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ECE1 mRNA17690111
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ECE1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ECE1 mRNA"18648102
C0101184,4'-dihydroxystilbene"4,4'-dihydroxystilbene results in decreased activity of ECE1 protein"21554123
C0101184,4'-dihydroxystilbene"4,4'-dihydroxystilbene results in decreased expression of ECE1 mRNA"21554123
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA"27188386
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]"26694894
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein]"26694894
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ECE1 mRNA22230336|2906747
D020106AcrylamideAcrylamide results in decreased expression of ECE1 mRNA28959563
D000305Adrenal Cortex HormonesAdrenal Cortex Hormones results in decreased expression of ECE1 mRNA11326888
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ECE1 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ECE1 mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ECE1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ECE1 mRNA16483693
D001104ArbutinArbutin results in increased expression of ECE1 mRNA17103032
D001194AsbestosAsbestos results in increased expression of ECE1 mRNA22398240
C061004benidipinebenidipine results in decreased expression of ECE1 protein16387788
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ECE1 mRNA17905399
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ECE1 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of ECE1 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ECE1 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ECE1 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of ECE1 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ECE1 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ECE1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ECE1 mRNA20127859
D004958EstradiolEstradiol results in increased expression of ECE1 mRNA19943105|2301914
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of ECE1 mRNA]19943105
D004958Estradiol[Estradiol co-treated with Testosterone] results in increased expression of ECE1 mRNA11375906
C006780bisphenol Abisphenol A results in decreased expression of ECE1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of ECE1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ECE1 mRNA17484886
C089987CGS 26303CGS 26303 analog results in decreased activity of ECE1 protein10669576
C089987CGS 26303CGS 26303 results in decreased activity of ECE1 protein10669576
C404931CGS 34043CGS 34043 results in decreased activity of ECE1 protein10669576
C404932CGS 35066CGS 35066 results in decreased activity of ECE1 protein10669576
C404932CGS 35066CGS 35066 results in decreased activity of ECE1 protein16364833
C511403CGS 35601CGS 35601 results in decreased activity of ECE1 protein16364833
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ECE1 mRNA25270620
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ECE120938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ECE1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of ECE1 mRNA25469848
C018021cobaltous chloridecobaltous chloride results in increased expression of ECE1 mRNA25469848
C018021cobaltous chloridecobaltous chloride results in increased expression of ECE1 protein25469848
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ECE1 mRNA]27941970
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of ECE1 mRNA"17690111
C000944dicrotophosdicrotophos results in increased expression of ECE1 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of ECE1 mRNA23041725
D004041Dietary FatsDietary Fats results in increased expression of ECE1 mRNA25016146
D004317DoxorubicinECE1 protein results in increased susceptibility to Doxorubicin20101000
C118739entinostatentinostat results in increased expression of ECE1 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ECE1 mRNA22079256
D005419FlavonoidsFlavonoids results in increased expression of ECE1 mRNA18035473
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ECE1 mRNA17690111
D005485FlutamideFlutamide results in decreased expression of ECE1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ECE120938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ECE1 gene20938992
C070081fulvestrant[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA19943105
D019833GenisteinGenistein results in decreased expression of ECE1 mRNA16399490
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of ECE1 mRNA21782745
D019833GenisteinGenistein results in increased expression of ECE1 mRNA21782745
C004312glycidolglycidol affects the expression of ECE1 mRNA24915197
D007213IndomethacinEDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]16280098
D007213IndomethacinIndomethacin results in increased activity of ECE1 protein16280098
D007213IndomethacinIndomethacin results in increased expression of ECE1 protein11145282
D007213Indomethacinphosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]16280098
D007213Indomethacinphosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein]11145282
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ECE1 mRNA25613284
D008070Lipopolysaccharides"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]"26694894
D008070Lipopolysaccharides"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein]"26694894
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ECE1 mRNA26694894
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ECE1 protein26694894
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of ECE120938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ECE1 gene20938992
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of ECE1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of ECE1 mRNA21782745
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ECE1 mRNA17905399
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ECE1 mRNA"26251327
D008790MetoprololMetoprolol results in decreased expression of ECE1 mRNA9607404
D008898MimosineMimosine results in increased expression of ECE1 mRNA25469848
D008898MimosineMimosine results in increased expression of ECE1 mRNA25469848
D008898MimosineMimosine results in increased expression of ECE1 protein25469848
C029938nickel sulfatenickel sulfate results in increased expression of ECE1 mRNA16780908
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ECE1 mRNA17616710
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to ECE1 intron]25469848
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to ECE1 promoter]25469848
D010100OxygenOxygen deficiency results in increased expression of ECE1 mRNA25469848
D010100OxygenOxygen deficiency results in increased expression of ECE1 mRNA21926265
D010100OxygenOxygen deficiency results in increased expression of ECE1 protein21926265
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of ECE1 mRNA]21926265
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of ECE1 protein]21926265
D010100OxygenOxygen deficiency results in increased expression of ECE1 mRNA25469848
D010126OzoneOzone results in increased expression of ECE1 mRNA16081523|1766297
D052638Particulate MatterParticulate Matter results in decreased expression of ECE1 mRNA23638009
D052638Particulate MatterParticulate Matter results in increased expression of ECE1 mRNA16081523
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ECE1 protein26879310
D010578PetroleumPetroleum affects the expression of ECE1 mRNA25208076
D010634PhenobarbitalPhenobarbital results in decreased expression of ECE1 mRNA25270620
D010634PhenobarbitalPhenobarbital results in decreased expression of ECE1 mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of ECE1 mRNA15007106
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ECE1 mRNA26272509
C008890phosphoramidonEDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]16280098
C008890phosphoramidonphosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]16280098
C008890phosphoramidonphosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein]11145282
C008890phosphoramidonphosphoramidon results in decreased activity of ECE1 protein11145282|1219306
C006253pirinixic acidpirinixic acid results in decreased expression of ECE1 mRNA17426115|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of ECE1 mRNA20707411
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ECE1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ECE1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of ECE1 protein23718831
D011441PropylthiouracilPropylthiouracil results in decreased expression of ECE1 mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of ECE1 mRNA12972712
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of ECE1 protein12972712
D011791QuartzQuartz results in decreased expression of ECE1 mRNA27917503
C059514resveratrolresveratrol results in decreased activity of ECE1 protein21554123
C059514resveratrolresveratrol results in decreased expression of ECE1 mRNA21554123
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of ECE1 mRNA]21926265
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of ECE1 protein]21926265
C093642SB 203580SB 203580 affects the expression of ECE1 mRNA21084678
C009277sodium arsenatesodium arsenate results in decreased expression of ECE1 mRNA21795629
D010042OuabainOuabain results in increased expression of ECE1 protein18247327
D013629Tamoxifen[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA19943105
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of ECE1 mRNA]19943105
D013629TamoxifenTamoxifen results in increased expression of ECE1 mRNA19943105
D013739Testosterone[Estradiol co-treated with Testosterone] results in increased expression of ECE1 mRNA11375906
D013739TestosteroneTestosterone affects the expression of ECE1 mRNA12122504|1461647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ECE1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ECE1 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ECE1 mRNA20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ECE1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ECE1 mRNA18796159|2095900
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ECE1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of ECE1 gene26756918
C483909torcetrapibtorcetrapib results in increased expression of ECE1 mRNA23228038
D014212TretinoinTretinoin results in increased expression of ECE1 mRNA23830798
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of ECE1 mRNA17905399
C012589trichostatin Atrichostatin A affects the expression of ECE1 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of ECE1 mRNA28973697
D017974Uranium CompoundsUranium Compounds results in increased expression of ECE1 mRNA19654044
D014520UrethaneUrethane results in increased expression of ECE1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ECE1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ECE1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of ECE1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ECE1 mRNA23897985
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ECE1 mRNA"25208076
C511404ZD4054[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of ECE1 mRNA19943105
C511404ZD4054ZD4054 results in decreased expression of ECE1 mRNA19943105
C088658zoledronic acidzoledronic acid results in increased expression of ECE1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IDA7805846  18039931  
GO:0004222metalloendopeptidase activity-ISS8062389  
GO:0004222metalloendopeptidase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0008270zinc ion binding-IDA18992253  
GO:0017046peptide hormone binding-IC7864876  
GO:0042803protein homodimerization activity-IPI7805846  
GO ID GO Term Qualifier Evidence PubMed
GO:0001921positive regulation of receptor recycling-IMP18039931  
GO:0003100regulation of systemic arterial blood pressure by endothelin-IC7805846  
GO:0007507heart development-IMP9915973  
GO:0010814substance P catabolic process-IDA18039931  
GO:0010815bradykinin catabolic process-IDA18039931  
GO:0010816calcitonin catabolic process-IDA18039931  
GO:0016485protein processing-IDA7805846  
GO:0016486peptide hormone processing-IDA7864876  
GO:0019229regulation of vasoconstriction-IC7805846  
GO:0034959endothelin maturation-IDA7805846  
GO:0042447hormone catabolic process-IDA7864876  
GO:0042733embryonic digit morphogenesis-IMP9915973  
GO:0043583ear development-IMP9915973  
GO:0060037pharyngeal system development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-HDA17897319  
GO:0005768endosome-IDA18039931  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA9449382  9710124  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IDA7805846  
GO:0031302intrinsic component of endosome membrane-TAS18039931  
GO:0031982vesicle-ISS9449382  
GO:0033093Weibel-Palade body-IDA9710124  
GO:0048471perinuclear region of cytoplasm-IDA9710124  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23336501Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population. (2013 May)Lind LActa Physiol (Oxf)