Gene info: ID 189

Gene: AGXT

GENE ID: 189

Synonyms: AGT|AGT1|AGXT1|PH1|SPAT|SPT|TLH6

Description: alanine--glyoxylate and serine--pyruvate aminotransferase

Gene type: protein-coding

Location: 2q37.3

dbXrefs: Ensembl:ENSG00000172482 MIM:604285 Vega:OTTHUMG00000133354 UniprotKB:P21549

RefSeq: NG_008005.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.728e-1 (AD) 5.939e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FGA	0.727
FGB	0.721
APCS	0.694
APOC3	0.684
FGG	0.682
HP	0.635
CRP	0.608
APOH	0.597
ORM2	0.588
ALB	0.586

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GOLGA8N	-0.26
HYPK	-0.208
OR2AG2	-0.207
ZNF454	-0.204
RGPD4	-0.204
RFPL4B	-0.203
PAX3	-0.198
NBPF11	-0.194
TSSK4	-0.193
ZNF157	-0.191

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00133	Serine	Small Molecule	56-45-1	Approved\|Nutraceutical	Target
DB00145	Glycine	Small Molecule	56-40-6	Approved\|Nutraceutical	Target
DB00160	L-Alanine	Small Molecule	56-41-7	Approved\|Nutraceutical	Target
DB02079	Aminooxyacetic acid	Small Molecule	645-88-5	Experimental	Target
DB04083	N'-Pyridoxyl-Lysine-5'-Monophosphate	Small Molecule		Experimental	Target
DB08060	4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of AGXT mRNA"	19162173
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in increased expression of AGXT mRNA	25088246
D000082	Acetaminophen	Acetaminophen results in decreased expression of AGXT mRNA	25704631\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of AGXT mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of AGXT mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AGXT mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of AGXT protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of AGXT mRNA	21641981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of AGXT mRNA	19770486
D000499	Allylamine	Allylamine affects the expression of AGXT mRNA	15910882
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of AGXT mRNA	16483693
C547126	AZM551248	AZM551248 results in increased expression of AGXT mRNA	22323515
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AGXT mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of AGXT mRNA	20106945\|2163298
D004958	Estradiol	Estradiol results in decreased expression of AGXT mRNA	20106945
C095105	bexarotene	bexarotene results in increased expression of AGXT mRNA	16648578
C006780	bisphenol A	bisphenol A results in increased methylation of AGXT gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of AGXT mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of AGXT mRNA	18804290
D012721	Carbaryl	Carbaryl results in decreased activity of AGXT protein	2119399
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of AGXT mRNA	27339419
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of AGXT mRNA	18804290
D002994	Clofibrate	Clofibrate results in decreased expression of AGXT protein	19952500
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of AGXT mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of AGXT mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AGXT mRNA]	17585979
D002995	Clofibric Acid	Clofibric Acid affects the expression of AGXT mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of AGXT mRNA	21139344
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of AGXT mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of AGXT mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in decreased expression of AGXT mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of AGXT mRNA	23830897
D003976	Diazinon	Diazinon results in increased methylation of AGXT gene	22964155
D004041	Dietary Fats	Dietary Fats results in decreased expression of AGXT mRNA	15238619\|2260994
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AGXT mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AGXT mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AGXT mRNA]	17942915
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AGXT mRNA	18164116
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AGXT mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of AGXT mRNA	19041683
D004147	Dioxins	Dioxins affects the expression of AGXT mRNA	20463971
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of AGXT mRNA	24690739
D004317	Doxorubicin	Doxorubicin results in increased expression of AGXT mRNA	26873546
C082360	fipronil	fipronil results in decreased expression of AGXT mRNA	23962444
D005419	Flavonoids	Flavonoids results in decreased expression of AGXT mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of AGXT mRNA	24793618
C056933	fumonisin B1	fumonisin B1 results in decreased expression of AGXT mRNA	16221962
C039281	furan	furan results in decreased expression of AGXT mRNA	25539665
C039281	furan	furan results in increased methylation of AGXT gene	22079235
C010178	heliotrine	heliotrine results in decreased expression of AGXT mRNA	26100227
D017313	Fenretinide	Fenretinide results in increased expression of AGXT mRNA	16671099
D001556	Lindane	Lindane results in increased expression of AGXT mRNA	18804290
D015122	Mercaptopurine	Mercaptopurine results in increased expression of AGXT mRNA	23358152
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of AGXT mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of AGXT mRNA	23103053
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of AGXT mRNA	16966085
C500085	muraglitazar	muraglitazar results in increased expression of AGXT mRNA	21515302
D009532	Nickel	Nickel results in increased expression of AGXT mRNA	24084258
C012655	nimesulide	nimesulide results in decreased expression of AGXT mRNA	24136188
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of AGXT mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of AGXT protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of AGXT mRNA	18804290
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of AGXT mRNA	17097637
D010634	Phenobarbital	Phenobarbital results in decreased expression of AGXT protein	19952500
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AGXT mRNA	24535843
D010634	Phenobarbital	Phenobarbital results in decreased expression of AGXT mRNA	19162173
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AGXT mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AGXT mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of AGXT mRNA	16221962
C006253	pirinixic acid	pirinixic acid results in increased expression of AGXT mRNA	17164430\|1916217
D059808	Polyphenols	Polyphenols results in decreased expression of AGXT mRNA	16293270
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of AGXT mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of AGXT mRNA	19162173
C045950	propiconazole	propiconazole results in decreased expression of AGXT mRNA	21278054
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of AGXT mRNA	26100227
D011794	Quercetin	Quercetin affects the expression of AGXT mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of AGXT mRNA	16455785
C089730	rosiglitazone	rosiglitazone results in increased expression of AGXT mRNA	21515302
C009237	senecionine	senecionine results in decreased expression of AGXT mRNA	26100227
C009238	senkirkine	senkirkine results in decreased expression of AGXT mRNA	26100227
C501413	tesaglitazar	tesaglitazar results in increased expression of AGXT mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AGXT mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of AGXT mRNA	27562557
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AGXT mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of AGXT mRNA	16054898\|2095900
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AGXT mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in decreased expression of AGXT mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of AGXT mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of AGXT protein	22609517
C052342	topiramate	topiramate results in increased expression of AGXT mRNA	16979414
D014241	Trichloroethylene	Trichloroethylene results in increased expression of AGXT mRNA	19254012
D014520	Urethane	Urethane results in decreased expression of AGXT mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of AGXT mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of AGXT mRNA	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of AGXT gene	25560391
D015032	Zinc	Zinc deficiency results in decreased expression of AGXT mRNA	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004760	serine-pyruvate transaminase activity	-	IBA	21873635
GO:0005102	signaling receptor binding	-	IPI	20178365
GO:0005515	protein binding	-	IPI	15911627 22529745
GO:0008453	alanine-glyoxylate transaminase activity	-	IBA	21873635
GO:0008453	alanine-glyoxylate transaminase activity	-	IDA	16971151 17696873 18492492 22198249
GO:0008453	alanine-glyoxylate transaminase activity	-	TAS	2363689
GO:0008483	transaminase activity	-	IDA	18492492 20133649
GO:0016597	amino acid binding	-	IDA	18492492
GO:0030170	pyridoxal phosphate binding	-	IDA	17696873 20133649
GO:0030170	pyridoxal phosphate binding	-	IMP	15802217
GO:0042802	identical protein binding	-	IPI	22529745
GO:0042803	protein homodimerization activity	-	IDA	12899834 16971151 20133649
GO:0043621	protein self-association	-	IDA	16971151

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006625	protein targeting to peroxisome	-	TAS	-
GO:0007219	Notch signaling pathway	-	IEA	-
GO:0009436	glyoxylate catabolic process	-	IDA	22198249
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	-	IBA	21873635
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	-	IDA	22198249
GO:0019448	L-cysteine catabolic process	-	IDA	18492492
GO:0034641	cellular nitrogen compound metabolic process	-	TAS	-
GO:0042853	L-alanine catabolic process	-	IDA	17696873 18492492 22198249
GO:0042866	pyruvate biosynthetic process	-	IEA	-
GO:0046487	glyoxylate metabolic process	-	IMP	3709805
GO:0046724	oxalic acid secretion	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051591	response to cAMP	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005759	mitochondrial matrix	-	IEA	-
GO:0005777	peroxisome	-	IBA	21873635
GO:0005777	peroxisome	-	IDA	1703535 3709805 7813517 9053548
GO:0005782	peroxisomal matrix	-	IDA	3418107 22198249
GO:0005782	peroxisomal matrix	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00260	Glycine, serine and threonine metabolism
hsa01100	Metabolic pathways
hsa04146	Peroxisome

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-389661	Glyoxylate metabolism and glycine degradation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-9033241	Peroxisomal protein import	TAS
R-HSA-9033241	Peroxisomal protein import	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal