Gene: ECHS1

1892
ECHS1D|SCEH
enoyl-CoA hydratase, short chain 1
protein-coding
10q26.3
Ensembl:ENSG00000127884 MIM:602292 Vega:OTTHUMG00000019320 UniprotKB:P30084
NG_042077.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.089e-1 (AD)  1.214e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26182964chr10:135186011ECHS1Gene body6.108e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TUFM0.956
TXN20.955
PARK70.945
UQCR100.942
GNPTG0.938
AK10.935
COPE0.934
NAP1L40.934
COPS60.932
NDUFB40.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.872
OR4F29-0.844
KRT73-0.3
GADL1-0.293
PZP-0.292
DPPA4-0.288
FER1L6-0.286
C2orf83-0.282
KCNJ15-0.271
LY9-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ECHS1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ECHS1 protein"25670856
D000082AcetaminophenAcetaminophen results in decreased expression of ECHS1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ECHS1 mRNA17562736
C047011acryloyl-coenzyme AECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A25125611
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ECHS1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ECHS1 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ECHS1 mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of ECHS1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ECHS1 mRNA16483693
D001151ArsenicArsenic affects the methylation of ECHS1 gene25304211
D001151ArsenicArsenic results in decreased expression of ECHS1 protein25110733
C006632arsenic trioxidearsenic trioxide results in increased expression of ECHS1 protein19364129|2541905
D001280AtrazineAtrazine results in decreased expression of ECHS1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of ECHS1 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of ECHS1 mRNA19483382
C006780bisphenol Abisphenol A results in increased expression of ECHS1 mRNA25181051
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein26930160
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of ECHS1 mRNA17553608
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ECHS1 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ECHS1 protein24394546
C584509C646 compoundC646 compound results in increased expression of ECHS1 mRNA26191083
D002104CadmiumCadmium results in increased oxidation of ECHS1 protein24496640
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ECHS1 mRNA23741332
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ECHS1 mRNA20360939
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ECHS1 mRNA24763279
D002994ClofibrateClofibrate results in increased expression of ECHS1 protein19952500
D002994ClofibrateClofibrate results in increased expression of ECHS1 mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of ECHS1 mRNA17585979
D002994ClofibrateClofibrate affects the expression of ECHS1 mRNA19483382
D002994ClofibrateClofibrate results in increased expression of ECHS1 protein16470657
D003300CopperCopper results in decreased expression of ECHS1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of ECHS1 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of ECHS1 protein25470785
D016572CyclosporineCyclosporine results in decreased expression of ECHS1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of ECHS1 mRNA23830897
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ECHS1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of ECHS1 protein22023808
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA18313992
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of ECHS1 mRNA"23626681
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ECHS1 mRNA20360939
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ECHS1 mRNA27638505
D004317DoxorubicinECHS1 affects the susceptibility to Doxorubicin15492826
D004317DoxorubicinDoxorubicin results in decreased expression of ECHS1 mRNA26873546
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of ECHS1 protein"18422750
C071192entacaponeentacapone binds to ECHS1 protein19783845
D004837Epinephrine[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein19464573
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ECHS1 mRNA16872691
D005001EthionineEthionine affects the expression of ECHS1 mRNA19483382
D005459FluoridesFluorides results in increased expression of ECHS1 protein19497429
D005472FluorouracilFluorouracil results in increased expression of ECHS1 mRNA15152939
D005485FlutamideFlutamide results in decreased expression of ECHS1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of ECHS1 mRNA21525395|2648540
D005485FlutamideFlutamide results in increased expression of ECHS1 protein21525395
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of ECHS1 protein26930160
C056933fumonisin B1fumonisin B1 results in decreased expression of ECHS1 mRNA16221962
C039281furanfuran binds to ECHS1 protein22240984
C039281furanfuran results in increased activity of ECHS1 protein27402187
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ECHS1 mRNA24763279
C410337K 7174K 7174 results in decreased expression of ECHS1 mRNA24086573
D007649KetamineKetamine results in increased expression of ECHS1 protein18504422
D007854LeadLead results in decreased expression of ECHS1 mRNA19921347
C052901lemongrass oillemongrass oil affects the expression of ECHS1 mRNA25976427
D008627Mercuric ChlorideMercuric Chloride affects the expression of ECHS1 mRNA20353558
C035909methacrylyl-coenzyme AECHS1 gene mutant form results in increased abundance of methacrylyl-coenzyme A25125611
D008727MethotrexateMethotrexate results in increased expression of ECHS1 mRNA17400583
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ECHS1 mRNA27544571
C063855microcystin RRmicrocystin RR results in decreased expression of ECHS1 protein19111056
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ECHS1 protein"21135415
D009534NiclosamideNiclosamide results in decreased expression of ECHS1 mRNA22576131
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ECHS1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ECHS1 protein19716841
D009853OmeprazoleOmeprazole affects the expression of ECHS1 mRNA19483382
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ECHS1 mRNA23427857
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of ECHS1 mRNA"23626681
D010634PhenobarbitalPhenobarbital results in increased expression of ECHS1 mRNA19270015
D010695PhlorhizinPhlorhizin results in decreased expression of ECHS1 mRNA22538082
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ECHS1 mRNA15728792
C006253pirinixic acidpirinixic acid affects the expression of ECHS1 mRNA19483382
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ECHS1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of ECHS1 mRNA20726854
D011441PropylthiouracilPropylthiouracil affects the expression of ECHS1 mRNA19483382
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of ECHS1 protein19264907
C089730rosiglitazonerosiglitazone affects the expression of ECHS1 mRNA22013433
C080703SK&F 83959SK&F 83959 results in decreased expression of ECHS1 protein25852303
D012999SomanSoman results in decreased expression of ECHS1 mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of ECHS1 protein21136691
D010042OuabainOuabain affects the expression of ECHS1 protein17268060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ECHS1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ECHS1 mRNA17949056
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ECHS1 mRNA21215274
D013853ThioacetamideThioacetamide affects the expression of ECHS1 mRNA19483382
D013893ThiramThiram results in increased expression of ECHS1 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of ECHS1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ECHS1 protein22595367|2260951
C066340tolcaponetolcapone binds to ECHS1 protein19783845
C011559tributyltintributyltin results in decreased expression of ECHS1 mRNA29191790
C012589trichostatin Atrichostatin A results in increased expression of ECHS1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ECHS1 mRNA"26179874
D014315TriterpenesTriterpenes results in decreased expression of ECHS1 protein18422750
D014635Valproic AcidValproic Acid results in increased expression of ECHS1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of ECHS1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of ECHS1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ECHS1 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of ECHS1 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of ECHS1 mRNA22570695
D019820Xanthine[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein19464573
D019820Xanthine[Xanthine co-treated with XDH protein] results in decreased expression of ECHS1 protein19464573
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004300enoyl-CoA hydratase activity-IBA21873635  
GO:0004300enoyl-CoA hydratase activity-IDA26251176  
GO:0004300enoyl-CoA hydratase activity-TAS-  
GO:0005515protein binding-IPI14557246  23416296  24510904  24947832  
GO ID GO Term Qualifier Evidence PubMed
GO:0006635fatty acid beta-oxidation-IBA21873635  
GO:0006635fatty acid beta-oxidation-IDA26251176  
GO:0006635fatty acid beta-oxidation-IEA-  
GO:0006635fatty acid beta-oxidation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-TAS16130169  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00062Fatty acid elongation
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa00310Lysine degradation
hsa00380Tryptophan metabolism
hsa00410beta-Alanine metabolism
hsa00640Propanoate metabolism
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-77286mitochondrial fatty acid beta-oxidation of saturated fatty acidsTAS
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationTAS
R-HSA-77310Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoATAS
R-HSA-77346Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoATAS
R-HSA-77348Beta oxidation of octanoyl-CoA to hexanoyl-CoATAS
R-HSA-77350Beta oxidation of hexanoyl-CoA to butanoyl-CoATAS
R-HSA-77352Beta oxidation of butanoyl-CoA to acetyl-CoATAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24658151Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. (2014)Wang YPLoS One
25803269Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)Filis PJ Clin Endocrinol Metab