Gene: EDA

1896
ECTD1|ED1|ED1-A1|ED1-A2|EDA-A1|EDA-A2|EDA1|EDA2|HED|HED1|ODT1|STHAGX1|TNLG7C|XHED|XLHED
ectodysplasin A
protein-coding
Xq13.1
Ensembl:ENSG00000158813 MIM:300451 Vega:OTTHUMG00000021764 UniprotKB:Q92838
NG_009809.2
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC4A20.784
FAM114A10.784
SFT2D20.782
CREB3L20.77
BBX0.762
PARP40.757
TCF120.751
LITAF0.751
SPATA130.75
CERS20.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLN7-0.492
PVALB-0.446
HAPLN4-0.445
SCRT2-0.443
ADRA1D-0.443
CDH22-0.439
TCERG1L-0.433
F7-0.433
CHRNA2-0.429
PRTN3-0.428

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDA mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EDA mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EDA gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of EDA mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDA mRNA22316170|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EDA mRNA"26238291
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EDA mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of EDA mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of EDA mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of EDA gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDA mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of EDA mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of EDA mRNA26079696
D003300CopperCopper deficiency results in increased expression of EDA mRNA26033743
C029892cupric chloridecupric chloride results in decreased expression of EDA mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of EDA mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDA mRNA28628672
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EDA mRNA20823114
D019422Dietary SucroseDietary Sucrose results in increased expression of EDA mRNA26033743
C118739entinostatentinostat results in increased expression of EDA mRNA27188386
D005557FormaldehydeFormaldehyde results in increased expression of EDA mRNA27664576
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDA mRNA28628672
C045463leflunomideleflunomide results in increased expression of EDA mRNA28988120
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EDA mRNA20823114
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EDA mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EDA mRNA"25554681
D009532NickelNickel results in decreased expression of EDA mRNA25583101
D011441PropylthiouracilPropylthiouracil results in decreased expression of EDA mRNA24780913
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EDA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EDA mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of EDA gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EDA gene25560391
D014810Vitamin EVitamin E results in decreased expression of EDA mRNA19244175
D015032ZincZinc deficiency results in decreased expression of EDA mRNA18356318
D019287Zinc SulfateZinc Sulfate results in decreased expression of EDA mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IDA11039935  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO:0005515protein binding-IPI11039935  11780064  25416956  25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-IEA-  
GO:0007160cell-matrix adhesion-IEA-  
GO:0010467gene expression-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0042475odontogenesis of dentin-containing tooth-IMP27144394  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043473pigmentation-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA11039935  
GO:0060662salivary gland cavitation-IEA-  
GO:0060789hair follicle placode formation-IEA-  
GO:0061153trachea gland development-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005581collagen trimer-IEA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005811lipid droplet-IDA-  
GO:0005856cytoskeleton-TAS10484778  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0016020membrane-TAS8696334  
GO:0016021integral component of membrane-TAS8696334  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045177apical part of cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9748537Comparison of DNA adduct levels associated with oxidative stress in human pancreas. (1998 Sep 20)Kadlubar FFMutat Res
21506880Molecular changes in the esophageal epithelium after a subchronic exposure to cigarette smoke in the presence of bile-acid reflux. (2011 Apr)Aiyer HSInhal Toxicol
23937155Myofibroblast expression in airways and alveoli is affected by smoking and COPD. (2013 Aug 11)Karvonen HMRespir Res
17147806Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum. (2006 Dec 5)Acquaah-Mensah GKBMC Genomics