Gene info: ID 19

Gene: ABCA1

GENE ID: 19

Synonyms: ABC-1|ABC1|CERP|HDLDT1|TGD

Description: ATP binding cassette subfamily A member 1

Gene type: protein-coding

Location: 9q31.1

dbXrefs: Ensembl:ENSG00000165029 MIM:600046 Vega:OTTHUMG00000020417 UniprotKB:O95477

RefSeq: NG_007981.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 33

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.636e-1 (AD) 7.562e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAML2	0.815
USP3	0.809
BNIP2	0.796
FOXO1	0.787
CPNE3	0.781
CMTM6	0.78
ZNF217	0.78
PRKD3	0.779
RREB1	0.779
SFT2D2	0.776

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PIP5KL1	-0.546
PVALB	-0.539
ABCC12	-0.538
ADRA1D	-0.536
PHOSPHO1	-0.532
CALHM1	-0.53
NEUROD6	-0.525
FBLN7	-0.524
LRRC38	-0.519
HAS1	-0.519

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00171	ATP	Small Molecule	56-65-5	Investigational\|Nutraceutical	Target
DB01016	Glyburide	Small Molecule	10238-21-8	Approved	Target
DB01599	Probucol	Small Molecule	23288-49-5	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of ABCA1 mRNA"	26377693
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]"	21908651
C002448	1,2-linoleoylphosphatidylcholine	"1,2-linoleoylphosphatidylcholine results in decreased expression of ABCA1 protein"	19717637
C038237	1-oleoyl-2-acetylglycerol	1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
C038237	1-oleoyl-2-acetylglycerol	1-oleoyl-2-acetylglycerol results in increased phosphorylation of and results in decreased expression of ABCA1 protein	16118212
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ABCA1 mRNA"	20453058
C003585	22-hydroxycholesterol	[22-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein	17478430
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in increased expression of ABCA1 mRNA	15314095\|1538106
C003585	22-hydroxycholesterol	[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA	16184197
C003585	22-hydroxycholesterol	[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein	16184197
C003585	22-hydroxycholesterol	arsenic trioxide inhibits the reaction [[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA]	16184197
C003585	22-hydroxycholesterol	arsenic trioxide inhibits the reaction [[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein]	16184197
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in increased expression of ABCA1 protein	22156476
C003585	22-hydroxycholesterol	[22-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 mRNA	17478430
C003585	22-hydroxycholesterol	[22-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein	17478430
C028358	24,25-epoxycholesterol	"24,25-epoxycholesterol results in increased expression of ABCA1 mRNA"	19426978
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCA1 mRNA]"	23756648
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ABCA1 mRNA"	21346803
C044563	24-hydroxycholesterol	24-hydroxycholesterol results in increased expression of ABCA1 mRNA	15148325
C044563	24-hydroxycholesterol	24-hydroxycholesterol results in increased expression of ABCA1 protein	19126211
C044563	24-hydroxycholesterol	24-hydroxycholesterol affects the localization of ABCA1 protein	16530456
C044563	24-hydroxycholesterol	24-hydroxycholesterol results in increased expression of ABCA1 mRNA	16530456
C007997	25-hydroxycholesterol	[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA	12595494
C007997	25-hydroxycholesterol	[25-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein	16023994
C007997	25-hydroxycholesterol	[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]	12595494
C007997	25-hydroxycholesterol	[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]	12595494
C007997	25-hydroxycholesterol	25-hydroxycholesterol results in increased expression of ABCA1 mRNA	19260826
C007997	25-hydroxycholesterol	[Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNA	17526932
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ABCA1 mRNA"	21346803
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ABCA1 mRNA	15148325\|1884109
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ABCA1 protein	17088262
C076996	27-hydroxycholesterol	[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA	20056921
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ABCA1 protein	22156476
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ABCA1 mRNA	18356535
C076996	27-hydroxycholesterol	Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]	18356535
C076996	27-hydroxycholesterol	Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]	18356535
C076996	27-hydroxycholesterol	Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]	18356535
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ABCA1 mRNA	28167099
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of ABCA1 protein	28167099
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of ABCA1 mRNA]	23041272
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of ABCA1 protein]	23041272
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide results in decreased expression of ABCA1 mRNA	23041272
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide results in decreased expression of ABCA1 protein	23041272
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [Niacin results in increased expression of ABCA1 mRNA]	19797938
D000073738	2-Hydroxypropyl-beta-cyclodextrin	2-Hydroxypropyl-beta-cyclodextrin inhibits the reaction [TO-901317 results in increased expression of ABCA1 protein]	22156476
D000073738	2-Hydroxypropyl-beta-cyclodextrin	2-Hydroxypropyl-beta-cyclodextrin results in decreased expression of ABCA1 mRNA	22156476
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of ABCA1 mRNA"	21703328
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABCA1 mRNA"	21703328
C025160	3-aminobenzamide	3-aminobenzamide promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C025160	3-aminobenzamide	3-aminobenzamide promotes the reaction [alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]]	27026705
C025160	3-aminobenzamide	3-aminobenzamide promotes the reaction [alitretinoin results in increased expression of ABCA1 mRNA]	27026705
C025160	3-aminobenzamide	3-aminobenzamide promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of ABCA1 mRNA"	27567155
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCA1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of ABCA1 mRNA	19191707
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of ABCA1 mRNA	20829426
C071644	5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate	"5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA"	15037193
C071644	5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate	"Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]"	15037193
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCA1 mRNA"	27188386
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]"	17070507
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]"	17070507
C046938	9,11-linoleic acid	"9,11-linoleic acid results in increased expression of ABCA1 mRNA"	15778275
C037112	9-deoxy-delta-9-prostaglandin D2	[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]	12595494
C037112	9-deoxy-delta-9-prostaglandin D2	[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of ABCA1 mRNA	12595494
C037112	9-deoxy-delta-9-prostaglandin D2	[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] inhibits the reaction [IL1B protein results in decreased expression of ABCA1 mRNA]	12595494
D000082	Acetaminophen	Acetaminophen results in decreased expression of ABCA1 mRNA	21420995\|2906747
D000086	Acetazolamide	Acetazolamide results in increased expression of ABCA1 mRNA	19274763
D000242	Cyclic AMP	Cyclic AMP results in increased expression of ABCA1 mRNA	20339114
D000242	Cyclic AMP	Cyclic AMP results in increased expression of ABCA1 protein	20339114
D000242	Cyclic AMP	[HCAR2 protein results in decreased abundance of Cyclic AMP] which results in decreased expression of ABCA1 protein	20655299
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ABCA1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ABCA1 mRNA	22100608
C096920	AGN 193109	AGN 193109 inhibits the reaction [Tretinoin results in increased expression of ABCA1 mRNA]	16505366
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of ABCA1 mRNA	21757418
C103303	alitretinoin	[22-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein	17478430
C103303	alitretinoin	[25-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein	16023994
C103303	alitretinoin	[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA	16184197
C103303	alitretinoin	[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein	16184197
C103303	alitretinoin	arsenic trioxide inhibits the reaction [[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA]	16184197
C103303	alitretinoin	arsenic trioxide inhibits the reaction [[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein]	16184197
C103303	alitretinoin	3-aminobenzamide promotes the reaction [alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]]	27026705
C103303	alitretinoin	3-aminobenzamide promotes the reaction [alitretinoin results in increased expression of ABCA1 mRNA]	27026705
C103303	alitretinoin	alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C103303	alitretinoin	alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 protein]	27026705
C103303	alitretinoin	alitretinoin results in increased expression of ABCA1 mRNA	27026705
C103303	alitretinoin	TO-901317 promotes the reaction [alitretinoin results in increased expression of ABCA1 mRNA]	27026705
C103303	alitretinoin	[22-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 mRNA	17478430
C103303	alitretinoin	[22-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein	17478430
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of ABCA1 mRNA	21298039
D000638	Amiodarone	Amiodarone results in decreased expression of ABCA1 mRNA	29248575
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ABCA1 mRNA	16483693
C530884	anacetrapib	"ABCA1 protein promotes the reaction [anacetrapib results in increased export of Cholesterol, HDL]"	20448206
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ABCA1 mRNA	24449571
D016718	Arachidonic Acid	Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D016718	Arachidonic Acid	Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D016718	Arachidonic Acid	Arachidonic Acid results in increased degradation of ABCA1 protein	16118212
C059427	aranidipine	aranidipine results in increased expression of ABCA1 protein	16306803
C059427	aranidipine	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [aranidipine results in increased expression of ABCA1 protein]	16306803
C519728	archazolid B	archazolid B results in decreased expression of ABCA1 mRNA	25218289
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA]	16184197
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein]	16184197
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ABCA1 mRNA	20339114\|2045855
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ABCA1 protein	20339114
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ABCA1 mRNA	25424538
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ABCA1 mRNA	20339114
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ABCA1 protein	20339114
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ABCA1 mRNA	25932594
D001205	Ascorbic Acid	[bexarotene co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
D001205	Ascorbic Acid	[diazepinylbenzoic acid co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in decreased expression of ABCA1 mRNA	25932594
D001205	Ascorbic Acid	diazepinylbenzoic acid inhibits the reaction [[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
D001205	Ascorbic Acid	diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
D001205	Ascorbic Acid	[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of ABCA1 mRNA	17639512
D001205	Ascorbic Acid	[rosiglitazone co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
D001205	Ascorbic Acid	[TO-901317 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D001205	Ascorbic Acid	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D001205	Ascorbic Acid	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
D001241	Aspirin	Aspirin results in decreased expression of ABCA1 mRNA	15037193
D001241	Aspirin	Aspirin results in increased expression of ABCA1 mRNA	20137092
D001241	Aspirin	Aspirin results in increased expression of ABCA1 protein	20137092
D001241	Aspirin	Aspirin affects the expression of ABCA1 mRNA	21088444
D001241	Aspirin	Aspirin affects the expression of and affects the activity of ABCA1 protein	21088444
D001241	Aspirin	PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]	21088444
D001241	Aspirin	PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]	21088444
C512174	atheronal-A	atheronal-A inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27703007
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of ABCA1 mRNA	16386711
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of ABCA1 protein	16386711
D000069059	Atorvastatin Calcium	[rosiglitazone co-treated with Atorvastatin Calcium] results in increased expression of ABCA1 protein	15183127
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of ABCA1 mRNA	25278499
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in decreased expression of ABCA1 mRNA	26919959
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of ABCA1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ABCA1 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ABCA1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ABCA1 mRNA	21569818
D004958	Estradiol	Estradiol results in decreased expression of ABCA1 mRNA	20106945
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ABCA1 mRNA	25932594
C031463	beta-glycerophosphoric acid	[bexarotene co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
C031463	beta-glycerophosphoric acid	[diazepinylbenzoic acid co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in decreased expression of ABCA1 mRNA	25932594
C031463	beta-glycerophosphoric acid	diazepinylbenzoic acid inhibits the reaction [[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
C031463	beta-glycerophosphoric acid	diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
C031463	beta-glycerophosphoric acid	[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
C031463	beta-glycerophosphoric acid	[rosiglitazone co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
C031463	beta-glycerophosphoric acid	[TO-901317 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
C031463	beta-glycerophosphoric acid	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
C031463	beta-glycerophosphoric acid	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in decreased expression of ABCA1 mRNA	25270620
C095105	bexarotene	[bexarotene co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
C095105	bexarotene	bexarotene results in increased expression of ABCA1	21622945
C095105	bexarotene	bexarotene results in increased expression of ABCA1 mRNA	25932594
C095105	bexarotene	diazepinylbenzoic acid inhibits the reaction [bexarotene results in increased expression of ABCA1 mRNA]	25932594
D001629	Bezafibrate	[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]	12595494
D001629	Bezafibrate	[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA	12595494
D001629	Bezafibrate	Bezafibrate results in increased expression of ABCA1 mRNA	19201410
D001629	Bezafibrate	Bezafibrate results in increased expression of ABCA1 protein	19201410
D001629	Bezafibrate	Bezafibrate results in increased expression of ABCA1 mRNA	19201410
D001629	Bezafibrate	Bezafibrate results in increased expression of ABCA1 protein	19201410
D001629	Bezafibrate	[Bezafibrate binds to and results in increased activity of PPARA protein] inhibits the reaction [IL1B protein results in decreased expression of ABCA1 mRNA]	12595494
C006780	bisphenol A	bisphenol A results in decreased expression of ABCA1 mRNA	25270620\|2750257
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCA1 mRNA]"	23756648
C006780	bisphenol A	bisphenol A results in decreased expression of ABCA1 mRNA	28859904
C006780	bisphenol A	bisphenol A results in increased expression of ABCA1 mRNA	18180321\|2518105
C006780	bisphenol A	bisphenol A results in increased methylation of ABCA1 gene	28505145
C006780	bisphenol A	Cholesterol inhibits the reaction [bisphenol A results in decreased expression of ABCA1 mRNA]	28859904
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of ABCA1 mRNA	23824090\|2435693
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of ABCA1 mRNA	25270620
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ABCA1 protein	17478430
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ABCA1 protein	17478430
D002065	Buspirone	Buspirone results in increased expression of ABCA1 mRNA	24136188
D020001	1-Butanol	1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]	16118212
D020001	1-Butanol	1-Butanol results in increased expression of ABCA1 protein	17478430
D002084	Butylated Hydroxytoluene	[Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein	17070507
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]	17070507
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]	17070507
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA	17070507
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ABCA1 mRNA	15336504
D002104	Cadmium	Cadmium results in decreased expression of ABCA1 mRNA	28315714
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ABCA1 mRNA	24982889
D002211	Capsaicin	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]"	21908651
D002211	Capsaicin	ABCA1 results in increased susceptibility to Capsaicin	21908651
D002211	Capsaicin	APOE affects the reaction [Capsaicin results in increased expression of ABCA1 protein]	21908651
D002211	Capsaicin	Capsaicin results in increased expression of ABCA1 protein	21908651
D002211	Capsaicin	[Capsaicin results in increased expression of ABCA1 protein] which results in decreased uptake of Cholesterol	21908651
D002211	Capsaicin	[Capsaicin results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol	21908651
D002211	Capsaicin	Cyclosporine affects the reaction [Capsaicin results in increased expression of ABCA1 protein]	21908651
D002211	Capsaicin	KT 5720 inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]	21908651
D002211	Capsaicin	TRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]	21908651
D002220	Carbamazepine	Carbamazepine affects the expression of ABCA1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ABCA1 mRNA	25478064
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ABCA1 protein	25478064
D002251	Carbon Tetrachloride	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]	25478064
D002251	Carbon Tetrachloride	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein]	25478064
D048271	Chitosan	[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
D048271	Chitosan	Chitosan inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ABCA1 mRNA	25270620
D002737	Chloroprene	Chloroprene results in increased expression of ABCA1 mRNA	23125180
D002784	Cholesterol	1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]	16118212
D002784	Cholesterol	1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D002784	Cholesterol	ABCA1 protein results in increased export of Cholesterol	15983222\|2065529
D002784	Cholesterol	ABCA1 protein results in increased transport of Cholesterol	16118212
D002784	Cholesterol	APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]	16118212
D002784	Cholesterol	APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol]	15983222
D002784	Cholesterol	Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D002784	Cholesterol	glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	15983222
D002784	Cholesterol	Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	15983222
D002784	Cholesterol	[HCAR2 protein results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol	20655299
D002784	Cholesterol	Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	16118212
D002784	Cholesterol	Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D002784	Cholesterol	mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]	16118212
D002784	Cholesterol	Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D002784	Cholesterol	palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D002784	Cholesterol	PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]	16118212
D002784	Cholesterol	PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]	16118212
D002784	Cholesterol	[resveratrol results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol	20372816
D002784	Cholesterol	triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D002784	Cholesterol	Cholesterol results in increased expression of ABCA1 mRNA	15342687
D002784	Cholesterol	ABCA1 protein affects the export of Cholesterol	14993927
D002784	Cholesterol	ABCA1 protein results in increased export of Cholesterol	20655299\|2202252
D002784	Cholesterol	[Capsaicin results in increased expression of ABCA1 protein] which results in decreased uptake of Cholesterol	21908651
D002784	Cholesterol	[Capsaicin results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol	21908651
D002784	Cholesterol	[Cholesterol co-treated with Dietary Fats] results in increased expression of ABCA1 mRNA	15694933
D002784	Cholesterol	[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCA1 mRNA	18356535
D002784	Cholesterol	[[Niacin binds to and results in increased activity of HCAR2 protein] which results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol	20655299
D002784	Cholesterol	"[[Plant Preparations co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA] which results in increased secretion of Cholesterol"	23900008
D002784	Cholesterol	[Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNA	17526932
D002784	Cholesterol	Cholesterol inhibits the reaction [bisphenol A results in decreased expression of ABCA1 mRNA]	28859904
D002784	Cholesterol	[[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol	17526932
D002784	Cholesterol	ABCA1 protein affects the transport of Cholesterol	15883047
D002784	Cholesterol	ABCA1 protein results in increased secretion of Cholesterol	20372816
D002784	Cholesterol	ABCA1 protein results in increased transport of Cholesterol	16530456
D002784	Cholesterol	[IL1B protein results in decreased expression of ABCA1 mRNA] which results in decreased transport of Cholesterol	12595494
D002784	Cholesterol	[IL1B protein results in decreased expression of ABCA1 mRNA] which results in increased abundance of Cholesterol	12595494
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of ABCA1 mRNA"	19509184
D002791	Cholesterol, Dietary	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA"	19509184
D002791	Cholesterol, Dietary	"[Plant Preparations co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA"	23900008
D002791	Cholesterol, Dietary	"[[Plant Preparations co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA] which results in increased secretion of Cholesterol"	23900008
D002791	Cholesterol, Dietary	"[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCA1 mRNA"	14684380
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of ABCA1 mRNA"	14684380
D008076	Cholesterol, HDL	"ABCA1 gene polymorphism affects the abundance of Cholesterol, HDL"	16030523
D008076	Cholesterol, HDL	"ABCA1 protein promotes the reaction [anacetrapib results in increased export of Cholesterol, HDL]"	20448206
D008076	Cholesterol, HDL	"ABCA1 protein promotes the reaction [Niacin results in increased export of Cholesterol, HDL]"	20448206
D019826	Cholic Acid	Cholic Acid results in increased expression of ABCA1 mRNA	15694933
D019826	Cholic Acid	"[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCA1 mRNA"	14684380
D002857	Chromium	[Chromium co-treated with Niacin] results in decreased expression of ABCA1 mRNA	18602814
D002857	Chromium	Chromium results in increased expression of ABCA1 mRNA	18602814
D002994	Clofibrate	Clofibrate affects the expression of ABCA1 protein	17961437
D002994	Clofibrate	Clofibrate results in increased expression of ABCA1 mRNA	21554872
D002994	Clofibrate	Clofibrate results in increased expression of ABCA1 protein	21554872
D002994	Clofibrate	PPARA protein affects the reaction [Clofibrate results in increased expression of ABCA1 mRNA]	21554872
D002994	Clofibrate	Clofibrate results in increased expression of ABCA1 mRNA	14690017
D002994	Clofibrate	Clofibrate results in increased expression of ABCA1 protein	21554872
D002994	Clofibrate	Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]	14690017
C417427	colestimide	[colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNA	17526932
C417427	colestimide	[colestimide co-treated with Pravastatin] affects the expression of ABCA1 protein	17526932
C417427	colestimide	[[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol	17526932
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of ABCA1 mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ABCA1 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of ABCA1 mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in decreased expression of ABCA1 mRNA	20106945\|2556210
D016572	Cyclosporine	[Sirolimus co-treated with Cyclosporine] results in decreased expression of ABCA1 protein	17016853
D016572	Cyclosporine	Cyclosporine affects the reaction [Capsaicin results in increased expression of ABCA1 protein]	21908651
D016572	Cyclosporine	Cyclosporine results in decreased expression of ABCA1 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of ABCA1 mRNA	21865292
C004742	daidzein	[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA	16963248
D000069439	Dasatinib	Dasatinib results in increased expression of ABCA1 mRNA	20579391
D003634	DDT	DDT results in decreased expression of ABCA1 protein	25720399
D003897	Desmosterol	Desmosterol results in increased expression of ABCA1 mRNA	19260826
D003907	Dexamethasone	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ABCA1 mRNA	25932594
D003907	Dexamethasone	[bexarotene co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
D003907	Dexamethasone	[diazepinylbenzoic acid co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in decreased expression of ABCA1 mRNA	25932594
D003907	Dexamethasone	diazepinylbenzoic acid inhibits the reaction [[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
D003907	Dexamethasone	diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
D003907	Dexamethasone	[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D003907	Dexamethasone	[rosiglitazone co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
D003907	Dexamethasone	[TO-901317 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D003907	Dexamethasone	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D003907	Dexamethasone	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ABCA1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of ABCA1 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of ABCA1 mRNA]	20032058
C438269	diazepinylbenzoic acid	[diazepinylbenzoic acid co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in decreased expression of ABCA1 mRNA	25932594
C438269	diazepinylbenzoic acid	diazepinylbenzoic acid inhibits the reaction [[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
C438269	diazepinylbenzoic acid	diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
C438269	diazepinylbenzoic acid	diazepinylbenzoic acid inhibits the reaction [bexarotene results in increased expression of ABCA1 mRNA]	25932594
C438269	diazepinylbenzoic acid	diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]	25932594
C438269	diazepinylbenzoic acid	diazepinylbenzoic acid results in decreased expression of ABCA1 mRNA	25932594
D003994	Bucladesine	[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNA	20083572
D003994	Bucladesine	[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 protein	23227865
D003994	Bucladesine	[Bucladesine co-treated with LIPE protein] results in increased expression of ABCA1 protein	23362264
D003994	Bucladesine	Oligomycins inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 protein]	23227865
D003994	Bucladesine	STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNA]	20083572
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ABCA1 mRNA	26924002
D004041	Dietary Fats	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA"	19509184
D004041	Dietary Fats	[Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of ABCA1 mRNA	19509184
D004041	Dietary Fats	[APOE affects the susceptibility to Dietary Fats] which affects the expression of ABCA1 protein	21908651
D004041	Dietary Fats	[Cholesterol co-treated with Dietary Fats] results in increased expression of ABCA1 mRNA	15694933
D004041	Dietary Fats	[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCA1 mRNA	18356535
D004041	Dietary Fats	Dietary Fats results in decreased expression of ABCA1 mRNA	18457598
D004041	Dietary Fats	Dietary Fats results in increased expression of ABCA1 mRNA	23756648
D004041	Dietary Fats	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of ABCA1 mRNA	28549616
D004041	Dietary Fats	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of ABCA1 protein	28549616
D004041	Dietary Fats	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCA1 mRNA]"	23756648
D004041	Dietary Fats	[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
D004041	Dietary Fats	Chitosan inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
D004041	Dietary Fats	Dietary Fats results in decreased expression of ABCA1 mRNA	28987369
D004041	Dietary Fats	Fish Oils inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCA1 mRNA]"	23756648
C115058	difenoconazole	difenoconazole results in decreased expression of ABCA1 mRNA	28263823
D002117	Calcitriol	Calcitriol results in increased expression of ABCA1 mRNA	16002434
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of ABCA1 mRNA	24690739
C067311	docetaxel	[docetaxel results in decreased susceptibility to docetaxel] which results in increased expression of ABCA1 mRNA	19944135
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]	18356535
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in increased expression of ABCA1 mRNA	18356535
D004317	Doxorubicin	Doxorubicin results in increased expression of ABCA1 mRNA	15033991
C066425	efonidipine	efonidipine results in increased expression of ABCA1 protein	16306803
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in decreased expression of ABCA1 mRNA	16730733
D015118	Eicosapentaenoic Acid	PPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of ABCA1 mRNA]	18489776
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of ABCA1 mRNA	24165878
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of ABCA1 protein	24165878
D000431	Ethanol	Ethanol results in increased expression of ABCA1 protein	17478430
D000431	Ethanol	Ethanol results in decreased expression of ABCA1 mRNA	26220516
D000431	Ethanol	Ethanol results in decreased expression of ABCA1 protein	26220516
D000431	Ethanol	Ethanol results in increased expression of ABCA1 mRNA	17478430
D000431	Ethanol	Ethanol results in increased expression of ABCA1 protein	17478430
D000431	Ethanol	Ethanol results in increased expression of and affects the localization of ABCA1 protein	17478430
D000069438	Ezetimibe	Ezetimibe results in decreased expression of ABCA1 mRNA	16177187
D005227	Fatty Acids	Fatty Acids results in increased degradation of ABCA1 protein	16118212
D005227	Fatty Acids	triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]	16118212
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated results in decreased expression of ABCA1 mRNA"	18356535
C540355	fenamidone	fenamidone results in increased expression of ABCA1 mRNA	27029645
C540355	fenamidone	sulforafan inhibits the reaction [fenamidone results in increased expression of ABCA1 mRNA]	27029645
C033789	fenarimol	fenarimol results in decreased expression of ABCA1 mRNA	28970091
D011345	Fenofibrate	Fenofibrate results in increased expression of ABCA1 mRNA	19201410
D011345	Fenofibrate	Fenofibrate results in increased expression of ABCA1 protein	19201410
D011345	Fenofibrate	Fenofibrate results in increased expression of ABCA1 mRNA	19201410
D011345	Fenofibrate	Fenofibrate results in increased expression of ABCA1 protein	19201410
D011345	Fenofibrate	Fenofibrate affects the localization of ABCA1 protein	16530456
D000068876	Fingolimod Hydrochloride	[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA	20056921
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride results in increased expression of ABCA1 mRNA	20056921
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride results in increased expression of ABCA1 protein	20056921
D000068876	Fingolimod Hydrochloride	NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]	20056921
D000068876	Fingolimod Hydrochloride	UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]	20056921
D005395	Fish Oils	[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
D005395	Fish Oils	Fish Oils inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]	28987369
C061365	flusilazole	flusilazole results in decreased expression of ABCA1 mRNA	22664269
C061365	flusilazole	flusilazole results in decreased expression of ABCA1 mRNA	22664269\|2826382
C065180	fluvastatin	[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin	19773416
C065180	fluvastatin	[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin	19773416
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of ABCA1 mRNA	24657277
D004397	Fonofos	Fonofos results in increased methylation of ABCA1 promoter	22847954
D005632	Fructose	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA"	19509184
D005632	Fructose	[Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of ABCA1 mRNA	19509184
D005632	Fructose	Fructose results in increased expression of ABCA1 mRNA	19193814
D005632	Fructose	Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA]	19193814
C039281	furan	furan results in increased methylation of ABCA1 gene	22079235
D015248	Gemfibrozil	Gemfibrozil results in increased expression of ABCA1 mRNA	19201410
D015248	Gemfibrozil	Gemfibrozil results in increased expression of ABCA1 protein	19201410
D015248	Gemfibrozil	Gemfibrozil results in increased expression of ABCA1 mRNA	19201410
D015248	Gemfibrozil	Gemfibrozil results in increased expression of ABCA1 protein	19201410
D019833	Genistein	[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA	16963248
D019833	Genistein	Genistein results in increased expression of ABCA1 mRNA	18847459
D005897	Glafenine	Glafenine results in increased expression of ABCA1 mRNA	24136188
D005978	Glutathione	Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]	25204422
D005978	Glutathione	Glutathione results in increased expression of ABCA1 mRNA	25204422
D005978	Glutathione	Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA]	25204422
C086566	glycitein	[Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ABCA1 mRNA	16963248
C010972	glycolaldehyde	glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	15983222
C010972	glycolaldehyde	glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein]	15983222
C010972	glycolaldehyde	glycolaldehyde results in increased degradation of ABCA1 protein	15983222
D006037	Glyoxal	Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	15983222
D006037	Glyoxal	Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]	15983222
D006037	Glyoxal	Glyoxal results in increased degradation of ABCA1 protein	15983222
C504517	GSK 3987	GSK 3987 results in increased expression of ABCA1 mRNA	16107141
C473027	GW 3965	GW 3965 results in increased expression of ABCA1 mRNA	16107141\|1744953
C473027	GW 3965	NR1H3 mutant form inhibits the reaction [GW 3965 results in increased expression of ABCA1 mRNA]	23732298
C473027	GW 3965	GW 3965 results in increased expression of ABCA1 mRNA	15633131
C473027	GW 3965	GW 3965 results in increased expression of ABCA1 mRNA	28315714
C425931	GW 501516	GW 501516 results in increased expression of ABCA1 mRNA	19201410
C425931	GW 501516	GW 501516 results in increased expression of ABCA1 protein	19201410
C425931	GW 501516	GW 501516 results in increased expression of ABCA1 mRNA	19201410
C425931	GW 501516	GW 501516 results in increased expression of ABCA1 protein	19201410
C449302	GW 6471	GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]	21554872
C449302	GW 6471	GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]	21554872
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of ABCA1 mRNA	25270620
D017313	Fenretinide	Fenretinide results in increased expression of ABCA1 mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCA1 mRNA	25613284
C051140	iron(II)-ascorbic acid complex	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]"	17070507
C051140	iron(II)-ascorbic acid complex	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]"	17070507
C051140	iron(II)-ascorbic acid complex	[Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein	17070507
C051140	iron(II)-ascorbic acid complex	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]	17070507
C051140	iron(II)-ascorbic acid complex	Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]	17070507
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of ABCA1 protein]	17070507
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA	17070507
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein	17070507
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ABCA1 mRNA	16054899
D007545	Isoproterenol	Isoproterenol results in increased expression of ABCA1 mRNA	20003209
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ABCA1 mRNA	25307878\|2675264
D007649	Ketamine	Ketamine results in increased expression of ABCA1 mRNA	20080153
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]	14690017
C057416	KT 5720	KT 5720 inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein]	21908651
D064747	Lansoprazole	Lansoprazole results in increased expression of ABCA1 mRNA	20060385
D064747	Lansoprazole	Lansoprazole results in increased expression of ABCA1 protein	20060385
D064747	Lansoprazole	Lansoprazole results in increased expression of ABCA1 protein	20060385
C052901	lemongrass oil	lemongrass oil affects the expression of ABCA1 mRNA	25976427
C095104	LG 100268	diazepinylbenzoic acid inhibits the reaction [[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
C095104	LG 100268	[LG 100268 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
D001556	Lindane	Lindane results in increased expression of ABCA1 mRNA	24356939
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA"	12010990
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA]"	12010990
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]	18192897
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	22240665
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of ABCA1 mRNA	16847310
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ABCA1 mRNA	25613284
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of ABCA1 mRNA	15883047
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of ABCA1 protein	15883047
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of ABCA1 mRNA	20977460
D008095	Lithocholic Acid	NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]	20977460
D008148	Lovastatin	Lovastatin results in increased expression of ABCA1 mRNA	19260826
D008148	Lovastatin	Lovastatin results in decreased expression of ABCA1 mRNA	19260826
C479889	LY 518674	LY 518674 results in increased expression of ABCA1 mRNA	19201410
C479889	LY 518674	LY 518674 results in increased expression of ABCA1 protein	19201410
C479889	LY 518674	LY 518674 results in increased expression of ABCA1 mRNA	19201410
C479889	LY 518674	LY 518674 results in increased expression of ABCA1 protein	19201410
D008315	Malondialdehyde	iron(II)-ascorbic acid complex promotes the reaction [Malondialdehyde results in increased expression of ABCA1 protein]	17070507
C037500	mastoparan	mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]	16118212
C037500	mastoparan	mastoparan results in increased phosphorylation of ABCA1 protein	16118212
D008628	Mercury	Mercury affects the expression of ABCA1 mRNA	23920476
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of ABCA1 mRNA	24657277
D008727	Methotrexate	Methotrexate inhibits the reaction [IFNG protein results in decreased expression of ABCA1 mRNA]	19035488
D008727	Methotrexate	Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA]	19035488
D008727	Methotrexate	Methotrexate results in increased expression of ABCA1 mRNA	19035488\|2123209
D008727	Methotrexate	ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [IFNG protein results in decreased expression of ABCA1 mRNA]]	19035488
D008727	Methotrexate	ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA]]	19035488
D008727	Methotrexate	ZM 241385 inhibits the reaction [Methotrexate results in increased expression of ABCA1 mRNA]	19035488
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of ABCA1 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ABCA1 mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ABCA1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of ABCA1 mRNA	23920476
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ABCA1 mRNA"	20188158
C012258	mevastatin	mevastatin affects the expression of ABCA1 mRNA	17526932
D015735	Mifepristone	Mifepristone results in decreased expression of ABCA1 mRNA	25972201
D008942	Mitoxantrone	ABCA1 protein affects the susceptibility to Mitoxantrone	16217747
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ABCA1 mRNA	26924002
C523799	MRK 003	MRK 003 results in increased expression of ABCA1 mRNA	21169257
C568376	MT19c compound	MT19c compound results in increased expression of ABCA1 mRNA	21781307
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [aranidipine results in increased expression of ABCA1 protein]	16306803
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA]	19035488
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA	19035488
C080955	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA]]	19035488
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ABCA1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ABCA1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ABCA1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ABCA1 mRNA"	25620056
D009525	Niacin	[Chromium co-treated with Niacin] results in decreased expression of ABCA1 mRNA	18602814
D009525	Niacin	Niacin results in increased expression of ABCA1 mRNA	15037193\|1860281
D009525	Niacin	2-chloro-5-nitrobenzanilide inhibits the reaction [Niacin results in increased expression of ABCA1 mRNA]	19797938
D009525	Niacin	"ABCA1 protein promotes the reaction [Niacin results in increased export of Cholesterol, HDL]"	20448206
D009525	Niacin	[Niacin binds to and results in increased activity of HCAR2 protein] which results in decreased expression of ABCA1 protein	20655299
D009525	Niacin	[[Niacin binds to and results in increased activity of HCAR2 protein] which results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol	20655299
D009525	Niacin	Niacin results in increased expression of ABCA1 mRNA	19797938
D009525	Niacin	PPARG protein promotes the reaction [Niacin results in increased expression of ABCA1 mRNA]	19797938
D009525	Niacin	Niacin results in decreased expression of ABCA1 protein	19878707
D009525	Niacin	Niacin results in increased expression of ABCA1 mRNA	20303128
C022838	nickel chloride	nickel chloride results in increased expression of ABCA1 mRNA	17312168
C028007	nickel monoxide	nickel monoxide results in increased expression of ABCA1 mRNA	19167457
D009539	Nicotinic Acids	Nicotinic Acids results in increased expression of ABCA1	16018787
C012655	nimesulide	nimesulide results in decreased expression of ABCA1 mRNA	24136188
C570896	NSC305787	NSC305787 results in increased expression of ABCA1 mRNA	27137931
C464660	obeticholic acid	obeticholic acid results in decreased expression of ABCA1 mRNA	27939613
D019787	Linoleic Acid	1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]	16118212
D019787	Linoleic Acid	Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	16118212
D019787	Linoleic Acid	Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D019787	Linoleic Acid	Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D019787	Linoleic Acid	Linoleic Acid results in increased degradation of ABCA1 protein	16118212
D019787	Linoleic Acid	Linoleic Acid results in increased phosphorylation of ABCA1 protein	16118212
D019787	Linoleic Acid	PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]	16118212
D019787	Linoleic Acid	triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D019787	Linoleic Acid	triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D019787	Linoleic Acid	triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]	16118212
D019787	Linoleic Acid	Linoleic Acid analog results in decreased expression of ABCA1 mRNA	27939595
D019787	Linoleic Acid	Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]	18356535
D019787	Linoleic Acid	Linoleic Acid results in increased expression of ABCA1 mRNA	18356535
D019301	Oleic Acid	Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
D019301	Oleic Acid	Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D019301	Oleic Acid	Oleic Acid results in increased degradation of ABCA1 protein	16118212
D019301	Oleic Acid	Oleic Acid results in increased phosphorylation of ABCA1 protein	16118212
D019301	Oleic Acid	Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]	18356535
D019301	Oleic Acid	Oleic Acid results in increased expression of ABCA1 mRNA	18356535
D009840	Oligomycins	Oligomycins affects the expression of ABCA1 protein	23227865
D009840	Oligomycins	Oligomycins inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 protein]	23227865
D009840	Oligomycins	Oligomycins results in increased expression of ABCA1 mRNA	23227865
D009844	Oligosaccharides	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of ABCA1 mRNA	28549616
D009844	Oligosaccharides	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of ABCA1 protein	28549616
D009853	Omeprazole	Omeprazole results in increased expression of ABCA1 mRNA	20060385
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ABCA1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of ABCA1 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of ABCA1 mRNA	24236059
D010100	Oxygen	Oxygen deficiency results in increased expression of ABCA1 mRNA	26516004
D010100	Oxygen	Oxygen results in increased expression of ABCA1 mRNA	27103661
D010126	Ozone	Ozone inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27703007
D010126	Ozone	Ozone results in decreased expression of ABCA1 mRNA	27703007
D010126	Ozone	Ozone results in decreased expression of ABCA1 protein	27703007
D010126	Ozone	Ozone results in decreased expression of ABCA1 mRNA	16183385
C500026	palbociclib	palbociclib results in increased expression of ABCA1 mRNA	22869556
C008757	palmitoleic acid	palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
C008757	palmitoleic acid	palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
C008757	palmitoleic acid	palmitoleic acid results in increased degradation of ABCA1 protein	16118212
C008757	palmitoleic acid	palmitoleic acid results in increased phosphorylation of ABCA1 protein	16118212
C016030	pantogab	pantogab results in increased expression of ABCA1 mRNA	17379144
C064276	pantoprazole	pantoprazole results in increased expression of ABCA1 mRNA	20060385
D010261	Paraoxon	Paraoxon results in decreased expression of ABCA1 protein	25250848
D010278	Parathion	Parathion results in increased methylation of ABCA1 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in increased expression of ABCA1 mRNA	22178795
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in decreased expression of ABCA1 mRNA	21705711
C584865	perfluorononanoic acid	perfluorononanoic acid results in increased expression of ABCA1 mRNA	29112762
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of ABCA1 mRNA	27153767
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ABCA1 mRNA	21723365
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ABCA1 mRNA	17681415
D010634	Phenobarbital	Phenobarbital affects the expression of ABCA1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of ABCA1 mRNA	25270620
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCA1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ABCA1 mRNA	26272509
D010672	Phenytoin	Phenytoin results in decreased expression of ABCA1 mRNA	15136057
D010743	Phospholipids	ABCA1 protein results in increased transport of Phospholipids	16118212
D010743	Phospholipids	APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]	16118212
D010743	Phospholipids	Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D010743	Phospholipids	Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D010743	Phospholipids	Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D010743	Phospholipids	palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
D010743	Phospholipids	triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
C030614	picolinic acid	picolinic acid results in decreased expression of ABCA1 protein	16870493
C060836	pioglitazone	pioglitazone affects the expression of ABCA1 protein	17961437
C060836	pioglitazone	pioglitazone results in increased expression of ABCA1 mRNA	15381068\|1920141
C060836	pioglitazone	pioglitazone results in increased expression of ABCA1 protein	19201410
C060836	pioglitazone	pioglitazone results in increased expression of ABCA1 mRNA	19201410
C060836	pioglitazone	pioglitazone results in increased expression of ABCA1 protein	19201410
C060836	pioglitazone	pioglitazone affects the localization of ABCA1 protein	16530456
C060836	pioglitazone	pioglitazone results in increased expression of ABCA1 mRNA	16530456
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA	12595494
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA	18489776
C006253	pirinixic acid	pirinixic acid results in increased expression of ABCA1 mRNA	17426115\|1830175
C108475	pitavastatin	GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]	21554872
C108475	pitavastatin	pitavastatin results in increased expression of ABCA1 mRNA	21554872
C108475	pitavastatin	PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]	21554872
C108475	pitavastatin	GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]	21554872
C108475	pitavastatin	pitavastatin results in increased expression of ABCA1 mRNA	21554872
D010938	Plant Oils	Plant Oils results in decreased expression of ABCA1 mRNA	23370395
D028321	Plant Preparations	"[Plant Preparations co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA"	23900008
D028321	Plant Preparations	"[[Plant Preparations co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA] which results in increased secretion of Cholesterol"	23900008
D017035	Pravastatin	Pravastatin results in decreased expression of ABCA1	19461118
D017035	Pravastatin	[colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNA	17526932
D017035	Pravastatin	[colestimide co-treated with Pravastatin] affects the expression of ABCA1 protein	17526932
D017035	Pravastatin	[[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol	17526932
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ABCA1 mRNA	15883047
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ABCA1 protein	15883047
D011341	Probucol	Probucol results in decreased activity of ABCA1 protein	20083572
C045950	propiconazole	propiconazole results in decreased expression of ABCA1 mRNA	28970091
C005556	propionaldehyde	propionaldehyde results in increased expression of ABCA1 mRNA	26079696
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of ABCA1 mRNA	27029645
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of ABCA1 mRNA	17639512
D011794	Quercetin	Quercetin results in decreased expression of ABCA1 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of ABCA1 mRNA	24165878
D011794	Quercetin	Quercetin results in increased expression of ABCA1 protein	24165878
D011794	Quercetin	Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]	25204422
D011794	Quercetin	MAPK14 protein promotes the reaction [Quercetin promotes the reaction [NR1H3 protein binds to ABCA1 promoter]]	22711909
D011794	Quercetin	MAPK14 protein promotes the reaction [Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]]	22711909
D011794	Quercetin	MAPK14 protein promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]	22711909
D011794	Quercetin	MAPK14 protein promotes the reaction [Quercetin results in increased expression of ABCA1 protein]	22711909
D011794	Quercetin	Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA]	25204422
D011794	Quercetin	Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]	22711909
D011794	Quercetin	Quercetin results in increased expression of ABCA1 mRNA	22711909\|2520442
D011794	Quercetin	Quercetin results in increased expression of ABCA1 protein	22711909
D011794	Quercetin	SB 203580 inhibits the reaction [Quercetin results in increased expression of ABCA1 mRNA]	22711909
D011794	Quercetin	SB 203580 inhibits the reaction [Quercetin results in increased expression of ABCA1 protein]	22711909
C502851	quinocetone	quinocetone results in increased expression of ABCA1 mRNA	27046791
C059514	resveratrol	2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of ABCA1 mRNA]	23041272
C059514	resveratrol	2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of ABCA1 protein]	23041272
C059514	resveratrol	ADORA2A protein promotes the reaction [resveratrol results in increased expression of ABCA1 protein]	23041272
C059514	resveratrol	PPARG protein promotes the reaction [resveratrol results in increased expression of ABCA1 mRNA]	23041272
C059514	resveratrol	PPARG protein promotes the reaction [resveratrol results in increased expression of ABCA1 protein]	23041272
C059514	resveratrol	resveratrol results in decreased expression of ABCA1 protein	24165878
C059514	resveratrol	resveratrol results in increased expression of ABCA1 mRNA	16901463\|2304127
C059514	resveratrol	resveratrol results in increased expression of ABCA1 protein	20372816\|2304127
C059514	resveratrol	[resveratrol results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol	20372816
C059514	resveratrol	ZM 241385 inhibits the reaction [resveratrol results in increased expression of ABCA1 protein]	23041272
D015474	Isotretinoin	Isotretinoin results in increased expression of ABCA1 protein	17478430
D012293	Rifampin	Rifampin results in decreased expression of ABCA1 mRNA	15883047
D012293	Rifampin	Rifampin results in decreased expression of ABCA1 protein	15883047
D012293	Rifampin	Rifampin results in increased expression of ABCA1 mRNA	17088262
D012293	Rifampin	Rifampin results in increased expression of ABCA1 protein	17088262
C064758	Ro 31-8220	"Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]"	15037193
C064758	Ro 31-8220	Ro 31-8220 results in decreased expression of ABCA1 mRNA	15037193
C089730	rosiglitazone	ABCA1 protein alternative form affects the susceptibility to rosiglitazone	18215356
C089730	rosiglitazone	[rosiglitazone co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
C089730	rosiglitazone	[rosiglitazone co-treated with Atorvastatin Calcium] results in increased expression of ABCA1 protein	15183127
C089730	rosiglitazone	rosiglitazone results in increased expression of ABCA1 mRNA	16386711
C089730	rosiglitazone	rosiglitazone results in increased expression of ABCA1 protein	15183127\|1638671
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ABCA1 mRNA	16054899
C089730	rosiglitazone	rosiglitazone results in increased expression of ABCA1 mRNA	22240665
C089730	rosiglitazone	rosiglitazone results in increased expression of ABCA1 protein	22240665
D000068718	Rosuvastatin Calcium	Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]	18192897
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA	18192897
D012431	Rutin	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]	25478064
D012431	Rutin	Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein]	25478064
C093642	SB 203580	SB 203580 inhibits the reaction [Quercetin results in increased expression of ABCA1 mRNA]	22711909
C093642	SB 203580	SB 203580 inhibits the reaction [Quercetin results in increased expression of ABCA1 protein]	22711909
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of ABCA1 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ABCA1 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ABCA1 mRNA	19073995
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ABCA1 mRNA	23221170
D012834	Silver	Silver results in decreased expression of ABCA1 mRNA	27131904
D019821	Simvastatin	Simvastatin results in decreased expression of ABCA1	19461118
D019821	Simvastatin	Simvastatin results in decreased expression of ABCA1 mRNA	19383813
D019821	Simvastatin	Simvastatin results in increased expression of ABCA1 mRNA	18270459
D019821	Simvastatin	Simvastatin results in decreased expression of ABCA1 mRNA	22120639
D019821	Simvastatin	Simvastatin results in increased expression of ABCA1 mRNA	16282522\|2124151
D019821	Simvastatin	Simvastatin results in increased expression of ABCA1 protein	21241519
D019821	Simvastatin	Simvastatin results in decreased expression of ABCA1 mRNA	25055962
D020123	Sirolimus	[Sirolimus co-treated with Cyclosporine] results in decreased expression of ABCA1 protein	17016853
D020123	Sirolimus	[Sirolimus co-treated with Tacrolimus] results in increased expression of ABCA1 protein	17016853
D020123	Sirolimus	Sirolimus results in increased expression of ABCA1 mRNA	17016853
D020123	Sirolimus	Sirolimus results in increased expression of ABCA1 mRNA	21865292
C017947	sodium arsenite	sodium arsenite results in decreased expression of ABCA1	25367288
C017947	sodium arsenite	sodium arsenite results in decreased expression of ABCA1 mRNA	21512104
D018038	Sodium Selenite	Sodium Selenite results in increased expression of ABCA1 mRNA	24383545
D012999	Soman	Soman results in increased expression of ABCA1 mRNA	19281266
D053260	Soot	Soot results in decreased expression of ABCA1 mRNA	22461453
C016766	sulforafan	sulforafan inhibits the reaction [fenamidone results in increased expression of ABCA1 mRNA]	27029645
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ABCA1 mRNA	25172293
D016559	Tacrolimus	[Sirolimus co-treated with Tacrolimus] results in increased expression of ABCA1 protein	17016853
D016559	Tacrolimus	Tacrolimus results in increased expression of ABCA1 mRNA	21865292
D013629	Tamoxifen	Tamoxifen results in increased expression of ABCA1 protein	27358406
D013662	Tea	Tea inhibits the reaction [Fructose results in increased expression of ABCA1 mRNA]	19193814
C012568	terbufos	terbufos results in increased methylation of ABCA1 promoter	22847954
D013739	Testosterone	Testosterone results in decreased expression of ABCA1 mRNA	21669218
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of ABCA1 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ABCA1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] promotes the reaction [Dietary Fats results in increased expression of ABCA1 mRNA]"	23756648
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ABCA1 mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ABCA1 mRNA	21215274\|2623252
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ABCA1 mRNA	28973375
D013752	Tetracycline	Tetracycline results in increased expression of ABCA1 mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCA1 mRNA	25613284
C017953	tetramethylpyrazine	tetramethylpyrazine results in increased expression of ABCA1 protein	28034800
D013792	Thalidomide	ABCA1 gene SNP results in increased susceptibility to Thalidomide	21245421
D013853	Thioacetamide	Thioacetamide results in increased expression of ABCA1 mRNA	26222700
C009495	titanium dioxide	titanium dioxide results in decreased expression of ABCA1 mRNA	23557971\|2776080
C423915	TO-901317	3-aminobenzamide promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C423915	TO-901317	atheronal-A inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27703007
C423915	TO-901317	Ozone inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27703007
C423915	TO-901317	PARP1 protein inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C423915	TO-901317	[TO-901317 co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 mRNA	15548517\|1614241
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 protein	17088262
C423915	TO-901317	2-Hydroxypropyl-beta-cyclodextrin inhibits the reaction [TO-901317 results in increased expression of ABCA1 protein]	22156476
C423915	TO-901317	[TO-901317 co-treated with CGA protein co-treated with FSHB protein] results in increased expression of ABCA1 mRNA	20926582
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 mRNA	22156476
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 protein	22156476
C423915	TO-901317	[Fructose co-treated with Dietary Fats co-treated with TO-901317] results in increased expression of ABCA1 mRNA	19509184
C423915	TO-901317	3-aminobenzamide promotes the reaction [alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]]	27026705
C423915	TO-901317	3-aminobenzamide promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C423915	TO-901317	alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C423915	TO-901317	alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 protein]	27026705
C423915	TO-901317	Lipopolysaccharides inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	22240665
C423915	TO-901317	PARP1 protein inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]	27026705
C423915	TO-901317	TO-901317 promotes the reaction [alitretinoin results in increased expression of ABCA1 mRNA]	27026705
C423915	TO-901317	TO-901317 promotes the reaction [PARP1 protein binds to ABCA1 promoter]	27026705
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 mRNA	22240665\|2314656
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 protein	22240665\|2702670
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 mRNA	17526932\|1966551
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 protein	21939782
C423915	TO-901317	TO-901317 affects the localization of ABCA1 protein	16530456
C423915	TO-901317	TO-901317 results in increased expression of ABCA1 mRNA	16530456
D014050	Toluene	Toluene affects the expression of ABCA1 mRNA	18653662
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ABCA1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ABCA1 mRNA	25729387
D014108	Tosylphenylalanyl Chloromethyl Ketone	"Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA]"	12010990
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of ABCA1 mRNA"	17951470
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in decreased expression of ABCA1 mRNA"	26919959
D014212	Tretinoin	Tretinoin results in increased expression of ABCA1 mRNA	23724009
D014212	Tretinoin	AGN 193109 inhibits the reaction [Tretinoin results in increased expression of ABCA1 mRNA]	16505366
D014212	Tretinoin	Tretinoin results in increased expression of ABCA1 mRNA	16505366
C034613	triacsin C	triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]	16118212
C034613	triacsin C	triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]	16118212
C034613	triacsin C	triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]	16118212
C034613	triacsin C	triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein]	16118212
C011559	tributyltin	diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]	25932594
C011559	tributyltin	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA	25932594
C011559	tributyltin	[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein	25932594
C011559	tributyltin	tributyltin results in increased expression of ABCA1 mRNA	23824090\|2435693
C011559	tributyltin	tributyltin results in increased expression of ABCA1 mRNA	27614199
C011559	tributyltin	diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]	25932594
C011559	tributyltin	tributyltin results in increased expression of ABCA1	21622945
C011559	tributyltin	tributyltin results in increased expression of ABCA1 mRNA	25932594
D014241	Trichloroethylene	Trichloroethylene results in decreased methylation of ABCA1 gene	27618143
C012589	trichostatin A	trichostatin A results in decreased expression of ABCA1 mRNA	24935251
C009564	trilinolein	trilinolein results in decreased expression of ABCA1 mRNA	18356535
C101314	trilinolenin	trilinolenin results in decreased expression of ABCA1 mRNA	18356535
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of ABCA1 mRNA	19042947
D014304	Triolein	Triolein results in decreased expression of ABCA1 mRNA	18356535
C057693	troglitazone	troglitazone results in increased expression of ABCA1 mRNA	12759900
C057693	troglitazone	troglitazone affects the localization of ABCA1 protein	16530456
C057693	troglitazone	troglitazone results in decreased expression of ABCA1 mRNA	16530456
C057693	troglitazone	[troglitazone co-treated with TNF protein] results in increased expression of ABCA1 mRNA	12732648
D014502	Uranyl Nitrate	Uranyl Nitrate results in increased expression of ABCA1 mRNA	20362056
C525131	UVI 3003	UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]	20056921
D014635	Valproic Acid	Valproic Acid affects the expression of ABCA1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ABCA1 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of ABCA1 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of ABCA1 mRNA	24489787
D014640	Vancomycin	Vancomycin results in decreased expression of ABCA1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ABCA1 gene	25560391
D014750	Vincristine	[Vincristine results in decreased susceptibility to Vincristine] which results in increased expression of ABCA1 mRNA	19944135
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ABCA1 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of ABCA1 mRNA	27188386
D015032	Zinc	Zinc deficiency results in increased expression of ABCA1 mRNA	22171008
C097270	ZM 241385	ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [IFNG protein results in decreased expression of ABCA1 mRNA]]	19035488
C097270	ZM 241385	ZM 241385 inhibits the reaction [Methotrexate inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA]]	19035488
C097270	ZM 241385	ZM 241385 inhibits the reaction [Methotrexate results in increased expression of ABCA1 mRNA]	19035488
C097270	ZM 241385	ZM 241385 inhibits the reaction [resveratrol results in increased expression of ABCA1 protein]	23041272

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	IPI	23931754
GO:0005515	protein binding	-	IPI	12054535 12084722 15469992 16192269 16443932 23931754 25170080
GO:0005524	ATP binding	-	IDA	11700048
GO:0005543	phospholipid binding	-	IC	16702602
GO:0005548	phospholipid transporter activity	-	IDA	16702602
GO:0008509	anion transmembrane transporter activity	-	ISS	-
GO:0015485	cholesterol binding	-	IC	12084722
GO:0016887	ATPase activity	-	IDA	24097981
GO:0017127	cholesterol transporter activity	-	IDA	12084722
GO:0019905	syntaxin binding	-	IPI	15469992
GO:0031267	small GTPase binding	-	IPI	16443932
GO:0034185	apolipoprotein binding	-	IPI	11162594
GO:0034186	apolipoprotein A-I binding	-	IPI	11162594 16443932
GO:0034188	apolipoprotein A-I receptor activity	-	IDA	16443932
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	-	IBA	21873635
GO:0051117	ATPase binding	-	IPI	23931754
GO:0090554	phosphatidylcholine-translocating ATPase activity	-	IDA	24097981
GO:0090556	phosphatidylserine-translocating ATPase activity	-	IDA	24097981

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006497	protein lipidation	-	IEA	-
GO:0006869	lipid transport	-	IBA	21873635
GO:0006911	phagocytosis, engulfment	-	IEA	-
GO:0007040	lysosome organization	-	IDA	15163665
GO:0007186	G-protein coupled receptor signaling pathway	-	IMP	16443932
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IMP	14701824
GO:0007584	response to nutrient	-	IEA	-
GO:0008203	cholesterol metabolic process	-	IDA	14747463
GO:0010745	negative regulation of macrophage derived foam cell differentiation	-	TAS	18490524
GO:0010875	positive regulation of cholesterol efflux	-	IMP	25084135
GO:0010887	negative regulation of cholesterol storage	-	TAS	18490524
GO:0016197	endosomal transport	-	IDA	14747463
GO:0019216	regulation of lipid metabolic process	-	TAS	-
GO:0032367	intracellular cholesterol transport	-	IMP	10431236
GO:0032489	regulation of Cdc42 protein signal transduction	-	IMP	16443932
GO:0033344	cholesterol efflux	-	IDA	10431236 11162594 23931754
GO:0033344	cholesterol efflux	-	IMP	16443932
GO:0033700	phospholipid efflux	-	IDA	10431236 11162594
GO:0033700	phospholipid efflux	-	IMP	16702602
GO:0034380	high-density lipoprotein particle assembly	-	IMP	10431236 17305370
GO:0034380	high-density lipoprotein particle assembly	-	TAS	-
GO:0034616	response to laminar fluid shear stress	-	IEP	15358760
GO:0038027	apolipoprotein A-I-mediated signaling pathway	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0042632	cholesterol homeostasis	-	IDA	10431236
GO:0042632	cholesterol homeostasis	-	TAS	24097981
GO:0043691	reverse cholesterol transport	-	IMP	10431236
GO:0045332	phospholipid translocation	-	IDA	24097981
GO:0050702	interleukin-1 beta secretion	-	IMP	11855831
GO:0055091	phospholipid homeostasis	-	IMP	16702602
GO:0060155	platelet dense granule organization	-	IMP	15163665
GO:0071222	cellular response to lipopolysaccharide	-	IEA	-
GO:0071300	cellular response to retinoic acid	-	IEA	-
GO:0071397	cellular response to cholesterol	-	IEA	-
GO:0071404	cellular response to low-density lipoprotein particle stimulus	-	IEP	15358760
GO:0090107	regulation of high-density lipoprotein particle assembly	-	TAS	24097981
GO:0098656	anion transmembrane transport	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005886	plasma membrane	-	IDA	23931754
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	10525055
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0030139	endocytic vesicle	-	IDA	14747463
GO:0034364	high-density lipoprotein particle	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635
GO:0045121	membrane raft	-	IDA	15469992
GO:0045335	phagocytic vesicle	-	IDA	15469992
GO:0048471	perinuclear region of cytoplasm	-	IDA	23931754

KEGG ID	KEGG Term
hsa02010	ABC transporters
hsa04975	Fat digestion and absorption

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-1989781	PPARA activates gene expression	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5619084	ABC transporter disorders	TAS
R-HSA-5619115	Disorders of transmembrane transporters	TAS
R-HSA-5682113	Defective ABCA1 causes Tangier disease	TAS
R-HSA-8963896	HDL assembly	TAS
R-HSA-8963898	Plasma lipoprotein assembly	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19405812	Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. (2009 Apr)	Berrougui H	Rejuvenation Res
22247473	Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. (2012 Mar)	Yu Y	Invest Ophthalmol Vis Sci
24796288	Peripheral Blood Mononuclear Cell ABCA1 Transcripts and Protein Expression in Acute Myocardial Infarction. (2015 May)	Shalia K	J Clin Lab Anal
16372134	Quantitative trait loci in ABCA1 modify cerebrospinal fluid amyloid-beta 1-42 and plasma apolipoprotein levels. (2006)	Katzov H	J Hum Genet
18803945	The influence of two variants in the adenosine triphosphate-binding cassette transporter 1 gene on plasma lipids and carotid atherosclerosis. (2008 Oct)	Sandhofer A	Metabolism
22190032	Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women. (2012 Feb)	Romero-Hidalgo S	J Nutr
29758034	Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area. (2018)	Wang X	PLoS One
20595220	A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients. (2011 Feb)	Versmissen J	Eur Heart J
20430392	No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. (2010 Aug)	Marques-Vidal P	Atherosclerosis
21347282	Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (2011 Feb 10)	Lettre G	PLoS Genet
22614118	The transcription levels of ABCA1, ABCG1 and SR-BI are negatively associated with plasma CRP in Chinese populations with various risk factors for atherosclerosis. (2012 Oct)	Li C	Inflammation
24608419	Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. (2014)	Cougnard-Gregoire A	PLoS One
22363809	Monocyte gene expression signature of patients with early onset coronary artery disease. (2012)	Sivapalaratnam S	PLoS One
16080812	[Study on the association of ABCA1 gene common variants with the risk of coronary atherosclerotic heart disease]. (2005 Jul)	Sun P	Zhonghua Xin Xue Guan Bing Za Zhi
23136402	ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden. (2013 Jan)	Bochem AE	Eur Heart J
29531587	Association Study of the ATP - Binding Cassette Transporter A1 (ABCA1) Rs2230806 Genetic Variation with Lipid Profile and Coronary Artery Disease Risk in an Iranian Population. (2018 Feb 15)	Ghaznavi H	Open Access Maced J Med Sci
17268197	ATP-binding cassette transporter A1 gene I823M polymorphism affects plasma high-density lipoprotein cholesterol level and modifies the effect of low high-density lipoprotein cholesterol on the risk of coronary artery disease. (2007)	Tsai CT	Cardiology
24346170	Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)	Meyers KJ	Invest Ophthalmol Vis Sci
28391892	Current smokers with hyperlipidemia lack elevated prebeta1-high-density lipoprotein concentrations. (2017 Jan - Feb)	Nagao Y	J Clin Lipidol
28595104	Pre-beta1 HDL in type 2 diabetes mellitus. (2017 Aug)	Shiu SW	Atherosclerosis
20303467	The role of ATP-binding-cassette-transporter-A1 (ABCA1) gene polymorphism on coronary artery disease risk. (2010 Apr)	Doosti M	Transl Res
25601961	The implication of cigarette smoking and cessation on macrophage cholesterol efflux in coronary artery disease patients. (2015 Mar)	Song W	J Lipid Res
28891316	Associations of the ABCA1 and LPL Gene Polymorphisms With Lipid Levels in a Hyperlipidemic Population. (2018 Jul)	Tao F	Clin Appl Thromb Hemost
21447678	Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)	Yu Y	Invest Ophthalmol Vis Sci
24376512	Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the Japanese population. (2013)	Nakamura A	PLoS One
28889112	Interplay between cigarette smoking and pulmonary reverse lipid transport. (2017 Sep)	Jubinville E	Eur Respir J
27396856	Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E-deficient mice and cells. (2016 Nov)	Ryu HM	J Cell Mol Med
18097620	Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals. (2008 Jan)	Yamada Y	Int J Mol Med
16226177	Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population. (2005 Oct 18)	Frikke-Schmidt R	J Am Coll Cardiol
26095139	Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)	Toselli F	Xenobiotica
20957101	Cigarette smoke affects ABCAl expression via liver X receptor nuclear translocation in human keratinocytes. (2010 Sep 17)	Sticozzi C	Int J Mol Sci
21589926	Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. (2011 May 11)	Turner SD	PLoS One
17368464	Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease. (2007 Nov)	Jensen MK	Atherosclerosis