Gene: S1PR1

1901
CD363|CHEDG1|D1S3362|ECGF1|EDG-1|EDG1|S1P1
sphingosine-1-phosphate receptor 1
protein-coding
1p21.2
Ensembl:ENSG00000170989 MIM:601974 Vega:OTTHUMG00000010835 UniprotKB:P21453
NG_016181.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.438e-1 (AD)  8.427e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SDC20.923
PDLIM50.904
AXL0.903
ARHGEF260.902
FERMT20.899
PON20.898
YAP10.894
ARHGAP310.893
MSI20.892
CYBRD10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADTRP-0.487
NRG1-0.483
CALHM1-0.48
AGMAT-0.474
TYRP1-0.473
CACNA1F-0.47
CNTN6-0.47
ABCC12-0.469
PPEF1-0.465
IL12RB2-0.464

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09105Asfotase AlfaBiotechDrug1174277-80-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5143531-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid1-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid binds to and results in increased activity of S1PR1 protein22765480
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of S1PR1 mRNA"25710175
C5329952-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol"2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol affects the localization of and results in increased ubiquitination of S1PR1 protein"25880547
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of S1PR1 mRNA"12376462
C5131133-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to cobaltous chloride23043544
C5131133-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride23043544
C5131133-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Oxygen deficiency23043544
C5131133-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein23043544
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of S1PR1 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of S1PR1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of S1PR1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of S1PR1 mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of S1PR1 mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of S1PR1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of S1PR1 mRNA16483693
D047310ApigeninApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR1 protein]25557508
D001151ArsenicArsenic affects the expression of S1PR1 protein24675094
D001151ArsenicArsenic results in increased methylation of S1PR1 promoter21291286
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of S1PR1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of S1PR1 mRNA27858113
D001553BenzbromaroneBenzbromarone affects the expression of S1PR1 mRNA19483382
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of S1PR1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of S1PR1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of S1PR1 mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of S1PR1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of S1PR1 mRNA21569818
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of S1PR1 mRNA20404318
C006780bisphenol Abisphenol A results in increased expression of S1PR1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of S1PR1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of S1PR1 mRNA25181051
D001761Bleomycin[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of S1PR1 protein29033951
D004390ChlorpyrifosChlorpyrifos results in increased expression of S1PR1 mRNA18668222
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of S1PR1 mRNA27858113
D002994ClofibrateClofibrate affects the expression of S1PR1 mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of S1PR1 mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of S1PR1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of S1PR1 mRNA19320972
C018021cobaltous chloride[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to cobaltous chloride23043544
C018021cobaltous chloridecobaltous chloride results in decreased expression of S1PR1 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of S1PR1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of S1PR1 mRNA19770486
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of S1PR1 mRNA17189669
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of S1PR1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of S1PR1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of S1PR1 mRNA21151649
D002945CisplatinCisplatin results in increased expression of S1PR1 mRNA22023808
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of S1PR1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of S1PR1 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of S1PR1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of S1PR1 mRNA17602206
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of S1PR1 mRNA"12376462
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of S1PR1 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of S1PR1 mRNA25380136
D004237DiuronDiuron results in decreased expression of S1PR1 mRNA25152437
D004237DiuronDiuron results in increased expression of S1PR1 mRNA21551480
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]18089841
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein]18089841
C118739entinostatentinostat results in increased expression of S1PR1 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of S1PR1 mRNA17606305
D005001EthionineEthionine affects the expression of S1PR1 mRNA19483382
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]24859201
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]24859201
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in decreased expression of S1PR1 protein24859201
D000068876Fingolimod Hydrochloride[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride23043544
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride affects the localization of and results in increased ubiquitination of S1PR1 protein25880547
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride binds to and results in increased activity of S1PR1 protein21478479
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite binds to and results in decreased activity of S1PR1 protein26719367
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite binds to and results in increased activity of S1PR1 protein26719367
D000068876Fingolimod HydrochlorideS1PR1 protein inhibits the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
D000068876Fingolimod HydrochlorideS1PR1 protein modified form inhibits the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]24859201
D005485FlutamideFlutamide results in decreased expression of S1PR1 mRNA24136188|2479361
D004397FonofosFonofos results in increased methylation of S1PR1 promoter22847954
C039281furanfuran results in decreased expression of S1PR1 mRNA26194646
D005665FurosemideFurosemide results in increased expression of S1PR1 mRNA16526316
D005839GentamicinsGentamicins results in increased expression of S1PR1 mRNA22061828
D005947GlucoseGlucose results in decreased expression of S1PR1 mRNA22406263
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of S1PR1 mRNA16206274
D007213IndomethacinIndomethacin results in increased expression of S1PR1 mRNA28201806
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]18089841
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein]18089841
D007545IsoproterenolIsoproterenol results in increased expression of S1PR1 mRNA18089841|2000320
D007545IsoproterenolIsoproterenol results in increased expression of S1PR1 protein18089841
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of S1PR1 mRNA24796395
D007608Kainic AcidKainic Acid results in decreased expression of S1PR1 mRNA17997037
D007854LeadLead affects the expression of S1PR1 mRNA28903495
C008261lead acetatelead acetate results in increased expression of S1PR1 mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of S1PR1 mRNA26582142
D008070LipopolysaccharidesApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR1 protein]25557508
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of S1PR1 protein25557508
C106335macrophage stimulatory lipopeptide 2[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of S1PR1 mRNA18832182
C025340manganese chloridemanganese chloride results in increased expression of S1PR1 mRNA17467022
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of S1PR1 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of S1PR1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of S1PR1 mRNA"25554681|2562005
D009281NaphthalenesNaphthalenes analog binds to and results in increased activity of S1PR1 protein22153936
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of S1PR1 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of S1PR1 mRNA24136188
D009532NickelNickel results in increased expression of S1PR1 mRNA24768652
C029938nickel sulfate[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of S1PR1 mRNA18832182
C029938nickel sulfatenickel sulfate results in decreased expression of S1PR1 mRNA22714537
D009538NicotineNicotine results in decreased expression of S1PR1 mRNA17997037
C012655nimesulidenimesulide results in decreased expression of S1PR1 mRNA24136188
C007350nitrofennitrofen results in increased expression of S1PR1 mRNA26543024
C007350nitrofennitrofen results in increased expression of S1PR1 protein26543024
C570897NSC668394NSC668394 results in increased expression of S1PR1 mRNA27137931
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of S1PR1 mRNA24356939
C025589ochratoxin Aochratoxin A results in decreased expression of S1PR1 mRNA24356939
D009853OmeprazoleOmeprazole affects the expression of S1PR1 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of S1PR1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of S1PR1 mRNA25729387
D010100Oxygen[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Oxygen deficiency23043544
D010278ParathionParathion results in increased methylation of S1PR1 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of S1PR1 mRNA20136073
D010634PhenobarbitalPhenobarbital affects the expression of S1PR1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of S1PR1 mRNA19270015
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of S1PR1 mRNA22484513
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of S1PR1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of S1PR1 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid affects the expression of S1PR1 mRNA19483382
D011372ProgestinsProgestins results in decreased expression of S1PR1 mRNA19609016
D011441PropylthiouracilPropylthiouracil affects the expression of S1PR1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of S1PR1 mRNA24780913
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of S1PR1 mRNA12818353
C009250sevofluranesevoflurane affects the expression of S1PR1 mRNA15967596
C503964SEW2871SEW2871 binds to and results in increased activity of S1PR1 protein20844107
D012822Silicon DioxideSilicon Dioxide results in decreased expression of S1PR1 mRNA19073995
D012834SilverSilver results in decreased expression of S1PR1 mRNA27131904
D019821SimvastatinSimvastatin results in increased expression of S1PR1 mRNA18612546
D020123SirolimusSirolimus results in increased expression of S1PR1 mRNA24356939
C009277sodium arsenatesodium arsenate results in increased expression of S1PR1 mRNA23922661
C009277sodium arsenatesodium arsenate results in increased expression of S1PR1 mRNA21795629
C017947sodium arseniteS1PR1 protein affects the reaction [sodium arsenite results in increased activity of RAC1 protein]19349368
C017947sodium arseniteS1PR1 protein affects the reaction [sodium arsenite results in increased expression of HGF mRNA]19349368
C017947sodium arseniteS1PR1 protein affects the reaction [sodium arsenite results in increased expression of IGF1 mRNA]19349368
C017947sodium arsenitesodium arsenite results in decreased expression of S1PR1 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of S1PR1 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of S1PR1 mRNA27862939
D053260SootSoot results in increased expression of S1PR1 mRNA26551751
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased expression of S1PR1 mRNA24399507
C060506sphingosine 1-phosphateS1PR1 protein results in increased susceptibility to sphingosine 1-phosphate20844107
C060506sphingosine 1-phosphatesphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein20844107
D013629TamoxifenTamoxifen results in decreased expression of S1PR1 mRNA25123088
C012568terbufosterbufos results in increased methylation of S1PR1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S1PR1 mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of S1PR1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S1PR1 mRNA17337447
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S1PR1 mRNA21215274
D013853ThioacetamideThioacetamide affects the expression of S1PR1 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of S1PR1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of S1PR1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of S1PR1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of S1PR1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of S1PR1 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of S1PR1 mRNA15901671
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of S1PR1 mRNA17189669
C012589trichostatin Atrichostatin A results in decreased expression of S1PR1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of S1PR1 mRNA"26743178
C406224valdecoxibvaldecoxib results in decreased expression of S1PR1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of S1PR1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of S1PR1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of S1PR1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of S1PR1 mRNA17963808
D014638VanadatesVanadates results in increased expression of S1PR1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of S1PR1 gene25560391
C111237vorinostatvorinostat inhibits the reaction [S1PR1 protein binds to HDAC1 protein]24859201

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI24851274  
GO:0004930G-protein coupled receptor activity-TAS8626678  
GO:0005515protein binding-IPI16525420  
GO:0038036sphingosine-1-phosphate receptor activity-IDA22344443  
GO:0046625sphingolipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001955blood vessel maturation-ISS-  
GO:0003245cardiac muscle tissue growth involved in heart morphogenesis-ISS-  
GO:0003376sphingosine-1-phosphate signaling pathway-IDA22344443  
GO:0006935chemotaxis-ISS-  
GO:0007155cell adhesion-TAS9488656  10555146  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007420brain development-IEA-  
GO:0016477cell migration-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0019226transmission of nerve impulse-IEA-  
GO:0030032lamellipodium assembly-ISS-  
GO:0030155regulation of cell adhesion-IEA-  
GO:0030182neuron differentiation-IEA-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0030500regulation of bone mineralization-ISS-  
GO:0030595leukocyte chemotaxis-IEA-  
GO:0031532actin cytoskeleton reorganization-ISS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0045124regulation of bone resorption-ISS-  
GO:0045446endothelial cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0050927positive regulation of positive chemotaxis-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IEA-  
GO:0051497negative regulation of stress fiber assembly-IEA-  
GO:0061384heart trabecula morphogenesis-ISS-  
GO:0072678T cell migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005768endosome-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-IDA22344443  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419408Lysosphingolipid and LPA receptorsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One