Gene: LPAR1

1902
EDG2|GPR26|Gpcr26|LPA1|Mrec1.3|VZG1|edg-2|rec.1.3|vzg-1
lysophosphatidic acid receptor 1
protein-coding
9q31.3
Ensembl:ENSG00000198121 MIM:602282 Vega:OTTHUMG00000020486 UniprotKB:Q92633
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.064e-2 (AD)  2.306e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14426371chr9:113714986LPAR1Gene body1.817e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCAS10.97
PAIP2B0.948
MBP0.945
MOBP0.937
HIPK20.929
TP53INP20.928
KIF1C0.926
MAP4K40.915
FGF10.903
MCM70.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.548
PCDH8-0.545
FFAR4-0.508
IGSF3-0.503
FBLN7-0.5
CDH22-0.499
HCN4-0.499
KCNK3-0.498
PIP5K1B-0.495
SDK1-0.495

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LPAR1 mRNA"19114083
C4778983-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid binds to and results in decreased activity of LPAR1 protein25822713
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LPAR1 mRNA"23196670
C0354193,4-dihydroxybenzohydroxamic acid"3,4-dihydroxybenzohydroxamic acid promotes the reaction [Lipopolysaccharides results in increased expression of LPAR1 mRNA]"25843059
C0354193,4-dihydroxybenzohydroxamic acid"3,4-dihydroxybenzohydroxamic acid results in increased expression of LPAR1 mRNA"25843059
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
D000171AcroleinAcrolein results in decreased expression of LPAR1 mRNA18515264
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LPAR1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of LPAR1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of LPAR1 mRNA22378314
C487081belinostatbelinostat results in decreased expression of LPAR1 mRNA27188386
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPAR1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of LPAR1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LPAR1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of LPAR1 mRNA"20382639
D004958EstradiolEstradiol affects the expression of LPAR1 mRNA23557687
D004958EstradiolEstradiol affects the expression of LPAR1 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of LPAR1 mRNA20404318
D004958EstradiolEstradiol affects the expression of LPAR1 mRNA15598610
D004958EstradiolEstradiol results in increased expression of LPAR1 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of LPAR1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of LPAR1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of LPAR1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of LPAR1 mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of LPAR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of LPAR1 mRNA12075121|1590192
C006780bisphenol Abisphenol A results in increased methylation of LPAR1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of LPAR1 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LPAR1 mRNA17484886
D002737ChloropreneChloroprene results in increased expression of LPAR1 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of LPAR1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of LPAR1 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LPAR1 mRNA28472532
D003042CocaineCocaine results in decreased expression of LPAR1 mRNA15009677
D003345CorticosteroneCorticosterone results in increased expression of LPAR1 mRNA15755911
D003471CuprizoneCuprizone results in decreased expression of LPAR1 mRNA26577399|2752363
D003474CurcuminCurcumin results in decreased expression of LPAR1 mRNA17999991
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of LPAR1 mRNA17330099
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LPAR1 mRNA21266533|2489317
D002945CisplatinCisplatin results in decreased expression of LPAR1 mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of LPAR1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPAR1 mRNA18164116
D002117CalcitriolCalcitriol results in decreased expression of LPAR1 mRNA26485663
D004317DoxorubicinLPAR1 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LPAR1 mRNA12075121|1590192
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LPAR1 mRNA23649840
D005419FlavonoidsFlavonoids results in increased expression of LPAR1 mRNA18035473
D005492Folic AcidFolic Acid results in increased expression of LPAR1 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA20938992
D004397FonofosFonofos results in increased methylation of LPAR1 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of LPAR1 mRNA19167457
C039281furanfuran results in increased expression of LPAR1 mRNA27387713
D019833GenisteinGenistein results in increased expression of LPAR1 mRNA12075121
D017313FenretinideFenretinide results in increased expression of LPAR1 mRNA28973697
C029424hydrazinehydrazine results in decreased expression of LPAR1 mRNA15282401
D007501IronIron deficiency results in decreased expression of LPAR1 mRNA19821111
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of LPAR1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LPAR1 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LPAR1 mRNA26644586
D007854LeadLead affects the expression of LPAR1 mRNA28903495
D007854LeadLead results in decreased expression of LPAR1 mRNA19921347
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of LPAR1 mRNA"23090859
D008070Lipopolysaccharides"3,4-dihydroxybenzohydroxamic acid promotes the reaction [Lipopolysaccharides results in increased expression of LPAR1 mRNA]"25843059
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]21821728
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LPAR1 mRNA21821728|2584305
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LPAR1 protein21821728
D008070LipopolysaccharidesLPAR1 affects the susceptibility to Lipopolysaccharides21821728
D008070LipopolysaccharidesLPAR1 mRNA affects the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]21821728
D008070Lipopolysaccharidesmethyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]]21821728
C032881lysophosphatidic acidLPAR1 protein affects the reaction [lysophosphatidic acid results in increased stability of and affects the localization of NFE2L2 protein]25398768
C032881lysophosphatidic acidLPAR1 protein results in increased susceptibility to lysophosphatidic acid16809448
C032881lysophosphatidic acidlysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein]16224106
C032881lysophosphatidic acidlysophosphatidic acid results in decreased expression of [CXCR1 protein binds to LPAR1 protein]16224106
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LPAR1 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LPAR1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LPAR1 mRNA20938992
D008727MethotrexateLPAR1 protein affects the susceptibility to Methotrexate16217747
D008731MethoxychlorMethoxychlor results in increased methylation of LPAR1 gene23303685
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]]21821728
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of LPAR1 mRNA"26251327
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of LPAR1 protein24625837
C523799MRK 003MRK 003 results in decreased expression of LPAR1 mRNA21169257
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in decreased expression of LPAR1 mRNA21487212
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LPAR1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of LPAR1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of LPAR1 mRNA18042831
D010278ParathionParathion results in increased methylation of LPAR1 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of LPAR1 mRNA20136073
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LPAR1 mRNA26272509
D011374ProgesteroneProgesterone results in increased expression of LPAR1 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of LPAR1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LPAR1 mRNA27029645
D012643SeleniumSelenium results in increased expression of LPAR1 mRNA19244175
D012834SilverSilver results in decreased expression of LPAR1 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of LPAR1 mRNA27862939
C075117squalestatin 1squalestatin 1 results in increased expression of LPAR1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of LPAR1 mRNA27225895
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of LPAR1 mRNA21641980
C012568terbufosterbufos results in increased methylation of LPAR1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LPAR1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LPAR1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LPAR1 mRNA18691609
C402769tipifarnibtipifarnib results in increased expression of LPAR1 mRNA16403772
C009495titanium dioxidetitanium dioxide affects the expression of LPAR1 mRNA17656681
C009495titanium dioxidetitanium dioxide results in increased expression of LPAR1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LPAR1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LPAR1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of LPAR1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of LPAR1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of LPAR1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LPAR1 mRNA26272509
C022884undecaneundecane results in increased expression of LPAR1 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LPAR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LPAR1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of LPAR1 mRNA19101580
D014635Valproic AcidValproic Acid results in increased expression of LPAR1 mRNA19136453|2489608
D014635Valproic AcidValproic Acid results in increased expression of LPAR1 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LPAR1 gene25560391
D014747VinblastineLPAR1 protein affects the susceptibility to Vinblastine16217747
D014810Vitamin EVitamin E results in increased expression of LPAR1 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of LPAR1 mRNA17330099

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IEA-  
GO:0004930G-protein coupled receptor activity-TAS8922387  
GO:0005515protein binding-IPI19306925  
GO:0030165PDZ domain binding-IEA-  
GO:0035727lysophosphatidic acid binding-IDA9070858  
GO:0070915lysophosphatidic acid receptor activity-IDA19306925  
GO:0070915lysophosphatidic acid receptor activity-IMP9070858  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-ISS-  
GO:0007202activation of phospholipase C activity-IDA19306925  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS9804623  
GO:0008360regulation of cell shape-ISS-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0014003oligodendrocyte development-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0021554optic nerve development-IEA-  
GO:0022038corpus callosum development-IEA-  
GO:0032060bleb assembly-IEA-  
GO:0035025positive regulation of Rho protein signal transduction-ISS-  
GO:0042552myelination-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0043410positive regulation of MAPK cascade-ISS-  
GO:0043951negative regulation of cAMP-mediated signaling-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IMP19733258  
GO:0051496positive regulation of stress fiber assembly-ISS-  
GO:0060326cell chemotaxis-IMP19733258  
GO:0060999positive regulation of dendritic spine development-IEA-  
GO:0071453cellular response to oxygen levels-IEA-  
GO:0071673positive regulation of smooth muscle cell chemotaxis-IEA-  
GO:1904566cellular response to 1-oleoyl-sn-glycerol 3-phosphate-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IDA19306925  
GO:0005886plasma membrane-IDA19306925  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0009986cell surface-IDA19306925  
GO:0030139endocytic vesiclecolocalizes_withIDA19306925  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043198dendritic shaft-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419408Lysosphingolipid and LPA receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21546496Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children. (2011 Sep)Guerrero JAHaematologica