Gene: S1PR3

1903
EDG-3|EDG3|LPB3|S1P3
sphingosine-1-phosphate receptor 3
protein-coding
9q22.1
Ensembl:ENSG00000213694 MIM:601965 Vega:OTTHUMG00000020173 UniprotKB:Q99500
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.765e-1 (AD)  7.136e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL1R10.882
COL4A10.877
OSMR0.862
ANXA20.861
CD930.847
CLIC10.839
MYOF0.838
CASP40.837
LTBR0.836
DRAM10.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.535
BCL11A-0.525
TMEM179-0.524
MYADML2-0.519
SMIM18-0.518
SLC7A4-0.517
NEUROD6-0.516
SPEF1-0.51
DLK2-0.508
LRTM2-0.506

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of S1PR3 mRNA19933214
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of S1PR3 mRNA"20702594
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of S1PR3 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of S1PR3 mRNA25458485
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of S1PR3 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of S1PR3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of S1PR3 mRNA24449571
D047310ApigeninApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR3 protein]25557508
C487081belinostatbelinostat results in decreased expression of S1PR3 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of S1PR3 mRNA20106945
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of S1PR3 mRNA20404318
D004958EstradiolEstradiol results in decreased expression of S1PR3 mRNA19167446|2871154
C006780bisphenol Abisphenol A affects the expression of S1PR3 mRNA21786754|2355768
C006780bisphenol Abisphenol A results in increased expression of S1PR3 mRNA19371625
C006780bisphenol Abisphenol A results in decreased expression of S1PR3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of S1PR3 gene28505145
D001761BleomycinBleomycin results in increased expression of S1PR3 mRNA29033951
D001761BleomycinS1PR5 protein affects the reaction [Bleomycin results in increased expression of S1PR3 mRNA]29033951
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of S1PR3 mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of S1PR3 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of S1PR3 mRNA17341687
D002737ChloropreneChloroprene results in decreased expression of S1PR3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of S1PR3 gene20938992
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of S1PR3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of S1PR3 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of S1PR3 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of S1PR3 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of S1PR3 mRNA20106945|2798913
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA27424125
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of S1PR3 mRNA17189669
D003907DexamethasoneDexamethasone results in increased expression of S1PR3 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of S1PR3 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of S1PR3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of S1PR3 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of S1PR3 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of S1PR3 mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of S1PR3 mRNA19371625
C118739entinostatentinostat results in decreased expression of S1PR3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
D015025ZearalenoneZearalenone results in increased expression of S1PR3 mRNA19371625
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]25980589
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride metabolite binds to and results in increased activity of S1PR3 protein26719367
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of S1PR3 gene20938992
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA27424125
D019833GenisteinGenistein results in increased expression of S1PR3 mRNA19371625
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA27424125
D005947GlucoseGlucose results in decreased expression of S1PR3 mRNA22406263
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA27424125
D008070LipopolysaccharidesApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR3 protein]25557508
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of S1PR3 protein25557508
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of S1PR3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of S1PR3 mRNA28001369
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of S1PR3 mRNA24399507
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of S1PR3 mRNA24810058
C568376MT19c compoundMT19c compound results in decreased expression of S1PR3 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of S1PR3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of S1PR3 mRNA"25554681
D009532NickelNickel results in increased expression of S1PR3 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of S1PR3 mRNA22714537
C007350nitrofennitrofen results in decreased expression of S1PR3 mRNA26543024
C007350nitrofennitrofen results in decreased expression of S1PR3 protein26543024
C016340o,p'-DDT"o,p'-DDT results in increased expression of S1PR3 mRNA"19371625
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of S1PR3 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of S1PR3 mRNA26516004
D000073878Palm OilPalm Oil results in increased expression of S1PR3 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of S1PR3 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of S1PR3 mRNA23091169
D064209PhytochemicalsPhytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]25980589
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of S1PR3 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of S1PR3 mRNA17950772
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of S1PR3 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of S1PR3 mRNA23608068
C513428pyrachlostrobinpyrachlostrobin results in increased expression of S1PR3 mRNA27029645
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of S1PR3 mRNA19167446
C059514resveratrolresveratrol results in increased expression of S1PR3 mRNA19371625
D012822Silicon DioxideSilicon Dioxide results in increased expression of S1PR3 mRNA23221170
D019821SimvastatinSimvastatin results in decreased expression of S1PR3 mRNA18981156
D019821SimvastatinSimvastatin results in increased expression of S1PR3 mRNA18612546
D012906SmokeSmoke results in increased expression of S1PR3 mRNA21095227
D012999SomanSoman results in increased expression of S1PR3 mRNA19281266
C060506sphingosine 1-phosphateFingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]25980589
C060506sphingosine 1-phosphatePhytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]25980589
C060506sphingosine 1-phosphateS1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]18612546
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased expression of S1PR3 protein25980589
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of S1PR3 mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of S1PR3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S1PR3 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S1PR3 mRNA21889950
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of S1PR3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of S1PR3 mRNA21934132
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of S1PR3 mRNA17189669
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of S1PR3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of S1PR3 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of S1PR3 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of S1PR3 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of S1PR3 mRNA28973697
D014520UrethaneUrethane results in increased expression of S1PR3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of S1PR3 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased expression of S1PR3 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of S1PR3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of S1PR3 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of S1PR3 mRNA24896083
C034028vanadyl sulfatevanadyl sulfate results in increased expression of S1PR3 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of S1PR3 gene25560391
C070417Win 55212-2Win 55212-2 results in increased expression of S1PR3 mRNA12237329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS10555146  
GO:0005178integrin binding-IPI24851274  
GO:0005515protein binding-IPI24851274  
GO:0008289lipid binding-TAS9409733  
GO:0038036sphingosine-1-phosphate receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001816cytokine production-IEA-  
GO:0003376sphingosine-1-phosphate signaling pathway-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS9409733  
GO:0007219Notch signaling pathway-IEA-  
GO:0008284positive regulation of cell proliferation-TAS10617617  
GO:0009653anatomical structure morphogenesis-TAS10555146  
GO:0032651regulation of interleukin-1 beta production-IEA-  
GO:1903141negative regulation of establishment of endothelial barrier-IMP24851274  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA24851274  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9409733  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419408Lysosphingolipid and LPA receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One