Gene: EDN1

1906
ARCND3|ET1|HDLCQ7|PPET1|QME
endothelin 1
protein-coding
6p24.1
Ensembl:ENSG00000078401 MIM:131240 Vega:OTTHUMG00000014266 UniprotKB:P05305
NG_016196.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.261e-1 (AD)  6.291e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROBO40.706
ENG0.684
BMP60.675
VWF0.665
CDH50.653
GGT50.653
CFLAR0.646
CMTM80.646
CTGF0.645
EVA1C0.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.44
PRLHR-0.383
PTHLH-0.381
CRH-0.379
KCNG1-0.377
VIP-0.373
DLX1-0.365
NEK2-0.365
ADRA2C-0.364
GLRA3-0.363

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05407TBC-3711Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]"15685554
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]"17391658
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of EDN1 mRNA"19162173
C0389831,3-dimethylthiourea"1,3-dimethylthiourea results in decreased expression of EDN1 mRNA"11603923
C0389831,3-dimethylthiourea"1,3-dimethylthiourea results in decreased expression of EDN1 protein"11603923
C0389831,3-dimethylthiourea"1,3-dimethylthiourea results in increased expression of EDN1 protein"9357851
C0502321,3-ditolylguanidine"1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]"9714087
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of EDN1 protein"9920814
C0956531,5-dihydroxyisoquinoline"1,5-dihydroxyisoquinoline results in decreased expression of EDN1 mRNA"12824290
C0956531,5-dihydroxyisoquinoline"1,5-dihydroxyisoquinoline results in decreased expression of EDN1 protein"12824290
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]"15245872
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]"14759557
C02036517-alpha-hydroxy-progesterone caproate17-alpha-hydroxy-progesterone caproate affects the expression of EDN1 mRNA19733289
C04016819-oxo-11-deoxycorticosterone acetate[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA18823320
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EDN1 mRNA28329830
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of EDN1 mRNA25827057
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EDN1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EDN1 mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased secretion of EDN1 protein]16373398
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of GATA4 protein]11583584
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]11583584
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]11583584
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased expression of HOMER1 mRNA alternative form]16786172
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]12169099
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]12169099
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased susceptibility to EDN1 protein]20561571
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased susceptibility to EDN1 protein18656273
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]"12411397
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]"12411397
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]12411397
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EDN1 mRNA"15215175
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]15245872
C4887182'-O-methyl-8-(4-chlorophenylthio)cAMP2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]22796455
C4887182'-O-methyl-8-(4-chlorophenylthio)cAMP2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]22796455
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EDN1 mRNA"23196670
C4023063,5-dibromosalicylic acid"3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C4023063,5-dibromosalicylic acid"3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C4023063,5-dibromosalicylic acid"3,5-dibromosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]"11093786
C0208913,5-diiodosalicylic acid"3,5-diiodosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]"11093786
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of EDN1 mRNA22841810
C0473683-methylquercetin3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]18436224
C0473683-methylquercetin3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]18436224
C4466024-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline"4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]"20177073
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EDN1 protein"26116029
C0101184,4'-dihydroxystilbene"4,4'-dihydroxystilbene results in decreased expression of EDN1 mRNA"21554123
C0101184,4'-dihydroxystilbene"4,4'-dihydroxystilbene results in decreased secretion of EDN1 protein"21554123
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C4000844-chlorobenzyltetrahydroberberine4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]16225752
C4000844-chlorobenzyltetrahydroberberine4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]16225752
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA19191707
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]"26694894
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]"26694894
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]"26694894
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C0801227-nitroindazole7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]15245872
C0162768-bromocyclic GMP8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]16023617
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of EDN1 mRNA"26238291
C120508A 192621A 192621 inhibits the reaction [EDN1 protein results in decreased secretion of TNF protein]11994508
D000082AcetaminophenAcetaminophen affects the expression of EDN1 mRNA17562736
D000082AcetaminophenAcetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]21811393
D000082AcetaminophenAcetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]21811393
C056165acetovanilloneacetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]17391658
C056165acetovanilloneacetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]20977430
C056165acetovanilloneacetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]22431579
C056165acetovanilloneacetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
D000109Acetylcholineacetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]20977430
D000109AcetylcholineCatechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]20977430
D000109AcetylcholineEDN1 protein results in decreased susceptibility to Acetylcholine20977430
D000109AcetylcholinePolyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]20977430
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]14623829
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]14623829
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]21765237
D000111AcetylcysteineAcetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]16261333
D000111AcetylcysteineAcetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]16261333
D000111AcetylcysteineAcetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]16261333
D000117AcetylglucosamineEDN1 protein results in increased abundance of Acetylglucosamine19948983
D000171AcroleinAcrolein results in increased expression of EDN1 protein22928487
D000171Acroleincesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein]22928487
D000171AcroleinRotenone inhibits the reaction [Acrolein results in increased expression of EDN1 protein]22928487
D000305Adrenal Cortex HormonesAdrenal Cortex Hormones results in decreased expression of EDN1 mRNA11326888
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EDN1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EDN1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EDN1 mRNA21632981|2164198
D000450AldosteroneAldosterone results in increased expression of EDN1 protein18660453
D000450Aldosterone[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
C467894ambrisentanambrisentan results in decreased expression of EDN1 mRNA16364719
C467894ambrisentanambrisentan results in decreased expression of EDN1 protein16364719
D006710HomocysteineHomocysteine affects the expression of EDN1 protein16757814
D006710HomocysteineZeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein]16757814
D017311AmlodipineAmlodipine affects the expression of EDN1 protein11369837
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EDN1 mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of EDN1 mRNA21632981
C030419andrographolideandrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]27297870
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors results in decreased secretion of EDN1 protein19079593
D018943AnthracyclinesAnthracyclines results in decreased expression of EDN1 protein12193102
D016718Arachidonic AcidArachidonic Acid promotes the reaction [EDN1 protein inhibits the reaction [LHB protein results in increased chemical synthesis of Progesterone]]18809207
D016718Arachidonic Acid[EDN1 protein co-treated with Arachidonic Acid] results in decreased abundance of 6-Ketoprostaglandin F1 alpha18809207
D016718Arachidonic Acid[EDN1 protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprost18809207
C006632arsenic trioxidearsenic trioxide results in increased expression of EDN1 mRNA26705709
C015001arsenitearsenite affects the expression of EDN1 mRNA15738583
D001194AsbestosAsbestos results in decreased expression of EDN1 mRNA22398240
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EDN1 mRNA"25351596
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in increased expression of EDN1 mRNA16443354
D001262AtenololEDN1 gene polymorphism affects the susceptibility to Atenolol15188945
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of EDN1 mRNA alternative form9637705
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of EDN1 protein9637705
D000069059Atorvastatin CalciumMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in decreased expression of EDN1 mRNA alternative form]9637705
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of EDN1 protein16360360
C098644atrasentanatrasentan inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]22431579
C098644atrasentan[atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
D001285AtropineEDN1 protein results in decreased activity of [Atropine co-treated with Histamine]12906840
C547126AZM551248AZM551248 results in decreased expression of EDN1 mRNA22323515
C487081belinostatbelinostat results in increased expression of EDN1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C044946benazeprilbenazepril results in decreased expression of EDN1 mRNA16191423
C044946benazeprilbenazepril results in decreased expression of EDN1 protein16191423
C044946benazeprilbenazepril results in increased activity of EDN1 protein7528292
C044946benazepril[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein11136700
C044946benazeprilbenazepril inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]15015294
C061004benidipinebenidipine results in decreased expression of EDN1 protein16387788
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of EDN1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of EDN1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDN1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EDN1 mRNA16269432|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to EDN1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDN1 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of EDN1 mRNA"20382639|2623829
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EDN1 mRNA18457675
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA24657404
D004958EstradiolDydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein]12385860
D004958EstradiolEstradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]19943105
D004958EstradiolEstradiol results in decreased expression of EDN1 mRNA19167446|2010694
D004958EstradiolEstradiol results in decreased expression of EDN1 protein12385860
D004958EstradiolEstradiol results in increased expression of EDN1 mRNA19153601|1994310
D004958EstradiolEstradiol results in increased secretion of EDN1 protein21795739
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of EDN1 mRNA]21795739
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased secretion of EDN1 protein]21795739
D004958EstradiolEstradiol results in increased expression of EDN1 mRNA19484750
D001629BezafibrateBezafibrate results in decreased expression of EDN1 protein11330878
D001629BezafibrateBezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]12967931
D001629BezafibrateBezafibrate inhibits the reaction [EDN1 protein results in increased activity of RELA protein]18660453
D001629BezafibrateBezafibrate inhibits the reaction [EDN1 protein results in increased expression of IL18 mRNA]18660453
D001663BilirubinBilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]27297870
D001663BilirubinBilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]27297870
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]15245872
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]12169099
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]12169099
C070515bisindolylmaleimide Ibisindolylmaleimide I results in decreased expression of EDN1 mRNA16080914
C070515bisindolylmaleimide Ibisindolylmaleimide I results in decreased expression of EDN1 protein16080914
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of EDN1 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of EDN1 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of EDN1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased secretion of EDN1 protein27745655
C006780bisphenol Abisphenol A results in increased expression of EDN1 mRNA25181051
D001761BleomycinBleomycin results in increased expression of EDN1 mRNA26093215
D001761BleomycinPhytochemicals inhibits the reaction [Bleomycin results in increased expression of EDN1 mRNA]26093215
C086232bosentanbosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]22483689
C086232bosentanbosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]22796455
C086232bosentanbosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]22796455
C086232bosentanbosentan results in decreased activity of EDN1 protein22796455
C086232bosentanEDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]20392896
C086232bosentan"3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C086232bosentanbosentan binds to and results in decreased activity of EDN1 protein10474778
C086232bosentanbosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]11093786
C086232bosentanbosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]20967148
C086232bosentanbosentan results in decreased activity of EDN1 protein10961375
C086232bosentanbosentan results in decreased expression of EDN1 protein16431896
C086232bosentanbosentan results in decreased activity of EDN1 protein15063187
C083116BQ 485BQ 485 inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]16391241
C083116BQ 485[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
C087220BQ 610BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]14759557
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PTK2 protein]12875994
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]12875994
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]12875994
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]12875994
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]12875994
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]12906840
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]12875994
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]12875994
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]12875994
C086539BQ 788BQ 788 results in decreased activity of EDN1 protein12906840
C086539BQ 788[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased expression of BCL2 protein]20369390
C086539BQ 788[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]20369390
C086539BQ 788BQ 788 results in increased activity of EDN1 protein16612843
C086539BQ 788BQ 788 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]15245872
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in decreased expression of AQP4 mRNA]21259319
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in decreased expression of AQP9 mRNA]21259319
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]12184995
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]16380457
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]14759557
C086539BQ 788"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]"26694894
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of EDN1 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of EDN1 mRNA12414654
D002104CadmiumCadmium results in increased expression of EDN1 mRNA21120746
D002104CadmiumCadmium promotes the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]9439784
D002104CadmiumCadmium results in decreased activity of EDN1 protein8553374
D002104CadmiumCadmium results in increased secretion of EDN1 protein10993771
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EDN1 mRNA18560533
D019256Cadmium ChlorideTNF affects the reaction [Cadmium Chloride results in increased expression of EDN1 mRNA]18560533
C040048caffeic acid[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA16806235
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]21926265
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]21926265
D002110CaffeineCaffeine results in increased activity of EDN1 protein1860718
D000001Calcimycin[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides20977430
D000001CalcimycinNOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]20977430
D000001CalcimycinPolyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]20977430
D002118CalciumEDN1 protein results in increased abundance of Calcium15537863
D002118CalciumEDN1 protein results in increased uptake of Calcium11572466
D002118CalciumEDN1 protein affects the transport of Calcium9138053
D002118CalciumEDN1 protein results in increased transport of and results in increased abundance of Calcium27226631
D002118CalciumPropofol inhibits the reaction [EDN1 protein affects the transport of Calcium]9138053
D002118CalciumEDN1 protein affects the localization of and affects the abundance of Calcium11425647
D002118CalciumEDN1 protein results in increased uptake of Calcium11425647
D002118Calciumcarvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]14711191
D002118CalciumEDN1 protein affects the abundance of and affects the localization of Calcium12821678
D002118CalciumEDN1 protein affects the localization of Calcium12628492
D002118CalciumEDN1 protein results in increased abundance of Calcium1443220
D002118CalciumEDN1 protein results in increased import of and results in increased abundance of Calcium14711191
D002118CalciumGlucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium]12821678
D002118CalciumHeparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]1443220
D002118CalciumCalcium affects the activity of EDN1 protein9352311
D002118CalciumEDN1 protein promotes the reaction [Capsaicin results in increased abundance of Calcium]19429182
D002118CalciumEDN1 protein results in increased abundance of Calcium9430702
D002121Calcium Channel BlockersCalcium Channel Blockers results in decreased susceptibility to EDN1 protein alternative form9605596
C058819calphostin Ccalphostin C results in decreased activity of EDN1 protein15464066
C077793candesartan cilexetilcandesartan cilexetil inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]9853001
D002211CapsaicinCapsaicin results in decreased activity of EDN1 protein7507780
D002211CapsaicinEDN1 protein promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]19429182
D002211CapsaicinEDN1 protein results in decreased activity of Capsaicin9932722
D002211CapsaicinFR 139317 inhibits the reaction [EDN1 protein results in decreased activity of Capsaicin]9932722
D002211CapsaicinEDN1 protein promotes the reaction [Capsaicin results in increased abundance of Calcium]19429182
D002244CarbonCarbon analog results in decreased activity of EDN1 protein20214918
D002248Carbon MonoxideCarbon Monoxide results in increased expression of EDN1 mRNA20197249
D002248Carbon MonoxideCarbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]12969895
D002248Carbon MonoxideCarbon Monoxide results in increased expression of EDN1 mRNA11781074
D002248Carbon MonoxideCarbon Monoxide results in increased expression of EDN1 protein11781074
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EDN1 mRNA17484886|2582705
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EDN1 protein25445725
D002251Carbon TetrachlorideLipids inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]25445725
D002251Carbon TetrachlorideCarbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]18205269
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of EDN1 protein25858767
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EDN1 mRNA17595544
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EDN1 protein12575897|1263251
D002251Carbon TetrachlorideEDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]18205269
D002251Carbon TetrachlorideIL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]12632514
C093373cariporidecariporide inhibits the reaction [EDN1 protein results in increased uptake of Sodium]15681704
C093373cariporidecariporide affects the expression of EDN1 mRNA14749038
C043211carvedilolcarvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]16428915
C043211carvedilolcarvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]16428915
C043211carvedilolcarvedilol results in decreased expression of EDN1 mRNA9500873
C043211carvedilolcarvedilol results in decreased expression of EDN1 protein9500873
C043211carvedilolcarvedilol results in decreased secretion of EDN1 protein11078433
C043211carvedilolcarvedilol results in decreased susceptibility to EDN1 protein18435936
C043211carvedilolcarvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]14711191
C043211carvedilolcarvedilol results in decreased expression of EDN1 mRNA18971572
C043211carvedilolcarvedilol results in decreased expression of EDN1 protein18840580
C043211carvedilolGlyburide inhibits the reaction [carvedilol results in decreased expression of EDN1 protein]18840580
D002392CatechinCatechin inhibits the reaction [APOE gene mutant form results in increased expression of EDN1 protein]20093625
D002392Catechin[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA16806235
D002392CatechinCatechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]20977430
D002392CatechinCatechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]20977430
D002392CatechinCatechin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]20977430
D002392CatechinCatechin inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]20977430
D002392CatechinCatechin inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]20977430
D002395CatecholaminesEDN1 protein results in increased chemical synthesis of and results in increased abundance of Catecholamines11911850
C469298CEP-11004CEP-11004 inhibits the reaction [EDN1 protein results in increased activity of GATA4 protein]20067472
C469298CEP-11004CEP-11004 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]20067472
C469298CEP-11004CEP-11004 inhibits the reaction [EDN1 protein results in increased secretion of NPPA protein]20067472
C469298CEP-11004CEP-11004 inhibits the reaction [EDN1 protein results in increased secretion of NPPB protein]20067472
C469298CEP-11004CEP-11004 results in decreased susceptibility to EDN1 protein20067472
C028019cesium chloridecesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein]22928487
C087223CGP 48369CGP 48369 results in increased activity of EDN1 protein7528292
C511403CGS 35601CGS 35601 affects the expression of EDN1 protein16364833
C016299chelerythrinechelerythrine inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]18436224
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of EDN1 mRNA16357303
C001598chetominchetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]21926265
C001598chetominchetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]21926265
D002713ChlorineChlorine results in increased expression of EDN1 protein16625121
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form"15486036
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of EDN1 protein"15486036
D002791Cholesterol, Dietary"Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]]"15486036
D002791Cholesterol, Dietary"Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]]"15486036
D002791Cholesterol, Dietary"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]"15486036
D002791Cholesterol, Dietary"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]"15486036
D002794CholineCholine results in increased expression of EDN1 protein27567547
D002794Cholineursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein]27567547
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EDN1 mRNA28472532
C427471chromium mesoporphyrinchromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]23089228
C427471chromium mesoporphyrinchromium mesoporphyrin promotes the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]23089228
C427471chromium mesoporphyrinchromium mesoporphyrin results in increased expression of EDN1 protein12969895
C427471chromium mesoporphyrinOxygen deficiency promotes the reaction [chromium mesoporphyrin results in increased expression of EDN1 protein]12969895
C043561chrysinchrysin results in increased expression of EDN1 mRNA18457675
C043867cicaprostcicaprost results in decreased expression of EDN1 protein12391278
D002994ClofibrateClofibrate inhibits the reaction [Desoxycorticosterone results in increased expression of EDN1 protein]16054168
D002994ClofibrateClofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]17105827
D002994ClofibrateClofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]17105827
D002994ClofibrateClofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]17105827
D002994ClofibrateClofibrate results in decreased expression of EDN1 protein17105827
D002994ClofibrateNitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]17105827
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAP2K1 protein]11158304
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAP2K2 protein]11158304
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]11158304
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]11158304
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B inhibits the reaction [EDN1 protein results in increased phosphorylation of RAF1 protein]11158304
D003033Coal TarCoal Tar results in increased expression of EDN1 mRNA27858113
C018021cobaltous chlorideandrographolide inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]27297870
C018021cobaltous chlorideBilirubin inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]27297870
C018021cobaltous chlorideBilirubin inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]27297870
C018021cobaltous chloridecobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]10939628
C018021cobaltous chloridecobaltous chloride results in decreased expression of EDN1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of EDN1 mRNA10939628|2546984
C018021cobaltous chloridecobaltous chloride results in increased expression of EDN1 protein25469848
C018021cobaltous chloridecobaltous chloride results in increased secretion of EDN1 protein27297870
C018021cobaltous chlorideGenistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
C018021cobaltous chlorideGenistein inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]10939628
C018021cobaltous chlorideSB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]27297870
C018021cobaltous chloridetricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]27297870
C018021cobaltous chloridetricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]27297870
C018021cobaltous chloridecobaltous chloride results in decreased expression of EDN1 mRNA15948191
C018021cobaltous chloridecobaltous chloride results in increased expression of EDN1 mRNA11078357|1107837
C018021cobaltous chloridecobaltous chloride results in increased expression of EDN1 protein25469848
D003042CocaineCocaine results in increased expression of EDN1 protein11948058|1881388
D003042CocaineCocaine results in increased secretion of EDN1 protein17578707
D003042CocaineCocaine results in increased expression of EDN1 protein17420087
D003042Cocaine"1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]"9714087
D003042CocaineCocaine results in increased expression of EDN1 protein9714087
D003042CocaineHaloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]9714087
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]23640862
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]23640862
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]23640862
D005576ColforsinColforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA]25194819
D005576ColforsinColforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA]25194819
D003287Contrast MediaContrast Media results in increased expression of EDN17967349
D003300CopperCopper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein]20302851
D019327Copper SulfateCopper Sulfate results in increased expression of EDN1 mRNA19549813
D003345CorticosteroneEDN1 results in increased secretion of Corticosterone1659878
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of EDN1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of EDN1 mRNA19167446
D003513Cycloheximide[Cycloheximide co-treated with EDN1 protein] results in increased expression of ADRB2 mRNA22483689
D003520CyclophosphamideCyclophosphamide results in increased expression of EDN1 protein17562616|1854819
D016572CyclosporineCyclosporine results in decreased expression of EDN1 mRNA27989131
D016572CyclosporineCyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]11435416
D016572CyclosporineCyclosporine results in increased secretion of EDN1 protein16391421
D016572CyclosporineCyclosporine results in increased expression of EDN17967349
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PTK2 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased expression of BCL2 protein]20369390
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]20369390
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]12906840
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin]21656314
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]24557580
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDN1 protein12906840
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) results in increased secretion of EDN1 protein24557580
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA]19150882
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]12839867
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]12839867
C072247cyclo(Trp-Asp-Pro-Val-Leu)"cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA]"25230003
C072247cyclo(Trp-Asp-Pro-Val-Leu)EDN1 protein affects the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [AGT protein results in increased expression of COL1A1 protein]]17391658
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) affects the activity of EDN1 protein16612843
C072247cyclo(Trp-Asp-Pro-Val-Leu)"3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein]16651399
C072247cyclo(Trp-Asp-Pro-Val-Leu)"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]"26694894
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]11093786
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein]11911850
C072247cyclo(Trp-Asp-Pro-Val-Leu)"cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]"11911850
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]15685554
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]11911850
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]9439784
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDN1 protein9352311
C089595cylindrospermopsincylindrospermopsin results in increased expression of EDN1 mRNA24921660
C077420Cys(11)-Cys(15)-endothelin-1 (11-21)Cys(11)-Cys(15)-endothelin-1 (11-21) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]15685554
D003561CytarabineEDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Cytarabine]24184161
D003561CytarabineEDN1 mutant form affects the reaction [VEGFC protein results in decreased susceptibility to Cytarabine]24184161
D003609DactinomycinDactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]22483689
D003620DantroleneDantrolene results in decreased activity of EDN1 protein12628492
D003622DapsoneDapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]21765237
D003630DaunorubicinDaunorubicin results in increased expression of EDN1 protein20888384
D003630Daunorubicintelmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]20888384
D003676DeferoxamineDeferoxamine results in increased expression of EDN1 protein9357851
D003687Dehydroepiandrosterone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased secretion of EDN1 protein]16373398
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased secretion of EDN1 protein16373398
D015230Prostaglandin D2EDN1 results in increased secretion of Prostaglandin D27507780
D015230Prostaglandin D2EDN1 results in increased secretion of Prostaglandin D2 metabolite7507780
D064791Desoxycorticosterone Acetatechromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]23089228
D064791Desoxycorticosterone Acetatechromium mesoporphyrin promotes the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]23089228
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of EDN1 protein"7721389
D064791Desoxycorticosterone AcetateDesoxycorticosterone Acetate results in increased expression of EDN1 protein23089228
D064791Desoxycorticosterone Acetateheme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]23089228
D003907DexamethasoneDexamethasone results in decreased expression of EDN1 mRNA12206003
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA16054899
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 mRNA]12407540
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 protein]12407540
D003907DexamethasoneDexamethasone results in increased expression of EDN1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EDN1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EDN1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of EDN1 mRNA21674241
D002945Cisplatincyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin]21656314
D002945CisplatinEDN1 results in decreased susceptibility to Cisplatin21656314
D002945CisplatinCisplatin results in decreased expression of EDN1 mRNA22023808
D004008DiclofenacDiclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium]15083534
D019259Lamivudinecoenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]23640862
D019259LamivudineLamivudine results in increased secretion of EDN1 protein23640862
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased susceptibility to EDN1 protein23872130
D004040Dietary Carbohydratesresveratrol inhibits the reaction [Dietary Carbohydrates results in decreased susceptibility to EDN1 protein]23872130
D004041Dietary FatsDietary Fats results in increased expression of EDN1 mRNA25016146
D004041Dietary Fats[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of EDN1 mRNA19891982
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of EDN1 mRNA20920545
D004052DiethylnitrosamineCopper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein]20302851
D004052Diethylnitrosamine[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein20302851
D002117CalcitriolCalcitriol results in decreased expression of EDN1 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of EDN1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of EDN1 mRNA23876855
D004147DioxinsDioxins affects the expression of EDN1 mRNA20463971
C007517diphenyleneiodonium"diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
C007517diphenyleneiodonium"diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]17391658
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein]16391241
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]16391241
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
C031291diphenyliodoniumdiphenyliodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]16261333
C031291diphenyliodoniumdiphenyliodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]16261333
C031291diphenyliodoniumdiphenyliodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]16261333
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
D004317DoxorubicinDoxorubicin results in increased activity of EDN1 protein7665224
D004317DoxorubicinDoxorubicin results in increased expression of EDN1 protein17974986|7969316
D004317Doxorubicintyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
D004317DoxorubicinDoxorubicin results in increased expression of EDN1 mRNA17974986|1832177
D004317DoxorubicinDoxorubicin results in increased expression of EDN1 protein17974986|1832177
D004317DoxorubicinTLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 mRNA]18321777
D004317DoxorubicinTLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 protein]18321777
D004317Doxorubicintyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
D004317DoxorubicinDoxorubicin results in increased expression of EDN1 mRNA16766856|1797498
D004317DoxorubicinDoxorubicin results in increased expression of EDN1 protein11589785
D004317DoxorubicinEDN1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]14736733
D004317Doxorubicintyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
D004317Doxorubicin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
D004317Doxorubicin[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
D004317Doxorubicin[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
D004317DoxorubicinEDN1 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]14736733
D004317DoxorubicinEDN1 protein inhibits the reaction [Doxorubicin results in increased expression of SOD2 protein]14736733
D004317DoxorubicinEDN1 protein results in decreased susceptibility to Doxorubicin14736733
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of EDN1"16981460
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]"15015294
D004394DydrogesteroneDydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein]12385860
D004656EnalaprilEnalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]9175058
D015773EnalaprilatEnalaprilat results in decreased secretion of EDN1 protein19079593
C118739entinostatentinostat results in increased expression of EDN1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]20021702
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of EDN1 mRNA20021702
D000431EthanolEthanol results in increased expression of EDN1 mRNA12193144
D000431Ethanolcyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein]16651399
D000431EthanolEthanol affects the activity of EDN1 protein16651399
D000431EthanolEthanol results in increased expression of EDN1 protein25289771
D000431Ethanolnymphayol inhibits the reaction [Ethanol results in increased expression of EDN1 protein]25289771
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EDN1 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EDN1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EDN1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EDN1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EDN1 mRNA20170705|2686566
D005047EtoposideEDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]24184161
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum results in decreased expression of EDN1 mRNA"11009568
D005277FenfluramineFenfluramine results in increased activity of EDN1 protein9918753
D011345FenofibrateEDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]22198280
D011345FenofibrateFenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]22198280
D011345FenofibrateFenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]22198280
D011345FenofibrateFenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]22198280
D011345FenofibratePPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]22198280
D011345FenofibratePPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]]22198280
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EDN1 mRNA28329830
D005472FluorouracilFluorouracil results in increased expression of EDN1 mRNA19098008
D005472FluorouracilFluorouracil results in increased expression of EDN1 protein1606078
D005557FormaldehydeFormaldehyde results in decreased expression of EDN1 mRNA27664576
D005557FormaldehydeFormaldehyde results in increased expression of EDN1 mRNA17938736
D002955LeucovorinLeucovorin results in increased expression of EDN1 mRNA16925845
D002955LeucovorinLeucovorin results in increased expression of EDN1 protein16925845
C079574FR 139317FR 139317 inhibits the reaction [EDN1 protein results in decreased activity of Capsaicin]9932722
C079574FR 139317FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]9175058
D005632FructoseFructose results in increased expression of EDN1 mRNA11172478|1456899
D005632FructoseFructose results in increased expression of EDN1 protein modified form25108154
D005632FructoseFructose results in increased susceptibility to EDN1 protein9869011
D005632FructoseKLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]14568997
D005632FructoseMetformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]25108154
D005632Fructoseresveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]25108154
C070081fulvestrant[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA19943105
C039281furanfuran results in increased expression of EDN1 mRNA27387713
C001277geldanamycingeldanamycin results in increased expression of EDN1 mRNA26705709
C056507gemcitabinegemcitabine results in decreased expression of EDN1 protein20531411
D019833GenisteinGenistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
D019833GenisteinGenistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
D019833GenisteinGenistein inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]10939628
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]10939628
D019833GenisteinGenistein results in decreased expression of EDN1 mRNA26865667
D019833GenisteinGenistein results in increased methylation of EDN1 gene28505145
D005839GentamicinsGentamicins results in increased expression of EDN1 protein10607017|8160791
C031049geranylgeranylacetonegeranylgeranylacetone results in decreased expression of EDN1 protein16324314
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]11009568
D005947Glucosecarvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]16428915
D005947Glucosecarvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]16428915
D005947Glucose"CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
D005947GlucoseCEBPA protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]24376792
D005947GlucoseCEBPA protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D005947GlucoseCEBPB protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]24376792
D005947GlucoseCEBPB protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D005947GlucoseCEBPD protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]24376792
D005947GlucoseCEBPD protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D005947Glucose"diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
D005947GlucoseGlucose promotes the reaction [CEBPA protein binds to EDN1 promoter]24376792
D005947GlucoseGlucose promotes the reaction [CEBPB protein binds to EDN1 promoter]24376792
D005947GlucoseGlucose promotes the reaction [CEBPD protein binds to EDN1 promoter]24376792
D005947Glucose"Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]"20691780
D005947GlucoseGlucose results in increased expression of EDN1 mRNA16428915|2096027
D005947GlucoseGlucose results in increased expression of EDN1 protein16428915|2437679
D005947Glucosepyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]20960276
D005947GlucoseSB 203580 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D005947GlucoseU 0126 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D005947GlucoseGlucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium]12821678
D005947GlucoseGlucose results in increased expression of EDN1 protein26891083
D005947GlucoseHIF1A protein affects the reaction [Glucose results in increased expression of EDN1 protein]26891083
D005947GlucoseMIR217 mRNA affects the reaction [Glucose results in increased expression of EDN1 protein]26891083
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]26891083
D005947GlucoseSIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]]26891083
D005905GlyburideGlyburide inhibits the reaction [carvedilol results in decreased expression of EDN1 protein]18840580
C004312glycidolglycidol results in decreased expression of EDN1 mRNA24915197
C024033glycoursodeoxycholic acidglycoursodeoxycholic acid results in decreased expression of EDN1 protein15556138
C465546green tea extract AR25green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]17235729
C465546green tea extract AR25green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 protein]17235729
D006152Cyclic GMPEDN1 protein results in increased abundance of Cyclic GMP12972712
D006152Cyclic GMPPuromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]12972712
C412815GW 4064GW 4064 results in decreased expression of EDN1 mRNA16357303
D006220HaloperidolHaloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]9714087
C048849heme arginatechromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]23089228
C048849heme arginateheme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]23089228
D006493HeparinHeparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]8408661
D006493HeparinHeparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]7509996|8408661
D006493HeparinHeparin results in decreased expression of EDN1 mRNA7509996|8408661
D006493HeparinHeparin results in decreased secretion of EDN1 protein7509996|8408661
D006493HeparinHeparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]1443220
D006493Heparin"Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"1443220
D006632HistamineEDN1 protein results in decreased activity of [Atropine co-treated with Histamine]12906840
D017313FenretinideFenretinide results in increased expression of EDN1 mRNA28973697
D012701SerotoninSerotonin results in increased activity of EDN1 protein9918753
D006830HydralazineHydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]16326922
D006830HydralazineHydralazine inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]15302986
D006830HydralazineHydralazine inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]15302986
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of EDN1 protein19262391
D006852HydrochlorothiazideHydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]16326922
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]14623829
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]14623829
D006861Hydrogen Peroxideepigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]20021702
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EDN1 mRNA20044591|2341063
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of EDN1 mRNA11755377|1241465
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of EDN1 protein11755377
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of EDN1 protein14623829|2002170
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]20021702
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]11755377
D006861Hydrogen PeroxideQuercetin inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]20021702
D006861Hydrogen Peroxideresveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]11755377|1462382
D006861Hydrogen Peroxideresveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]11755377
D006861Hydrogen Peroxideresveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]14623829|2002170
D006861Hydrogen PeroxideCAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of EDN1 protein]9357851
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of EDN1 protein9357851
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of 6-Ketoprostaglandin F1 alpha"16325014
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of Dinoprostone"16325014
D003900DesoxycorticosteroneClofibrate inhibits the reaction [Desoxycorticosterone results in increased expression of EDN1 protein]16054168
D003900DesoxycorticosteroneDesoxycorticosterone results in increased expression of EDN112600921
D003900DesoxycorticosteroneDesoxycorticosterone results in increased expression of EDN1 protein16054168
D003900Desoxycorticosterone"Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA]"8934362
D003900Desoxycorticosterone"[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA"8934362
D003900Desoxycorticosterone"[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 protein"1860718
D003900Desoxycorticosterone[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDN122431579
D003900DesoxycorticosteroneDesoxycorticosterone results in increased expression of EDN115834289
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of EDN1 mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of EDN1 mRNA19153601
C492448ICG 001ICG 001 results in increased expression of EDN1 mRNA26191083
C026777ICI 118551ICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]22796455
D007213IndomethacinIndomethacin inhibits the reaction [EDN1 protein results in increased secretion of 6-Ketoprostaglandin F1 alpha]12056553
D007213IndomethacinBQ 788 inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]12906840
D007213Indomethacincyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]12906840
D007213IndomethacinEDN1 protein results in decreased activity of Indomethacin12906840
D007213IndomethacinIndomethacin results in decreased secretion of EDN1 protein16133044
D007213IndomethacinIndomethacin results in increased expression of EDN1 mRNA16984733
D007213IndomethacinIndomethacin affects the activity of EDN1 protein16612843|1755287
D007213IndomethacinEDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]16280098
D007213IndomethacinEDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]16280098
D007213IndomethacinEDN1 protein promotes the reaction [Indomethacin results in increased expression of LEP protein]16280098
D007213IndomethacinIndomethacin results in increased expression of EDN1 protein10423059|1114528
D007213Indomethacinphosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]11145282|1628009
D007213IndomethacinSucralfate inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]10423059
D007213IndomethacinIndomethacin results in decreased activity of EDN1 protein7507780
D007295Inositol PhosphatesEDN1 protein results in increased chemical synthesis of Inositol Phosphates11572466
C044834iodixanoliodixanol results in increased expression of EDN1 protein21354280
C038192iopromideiopromide results in increased expression of EDN1 protein21354280
C081309irbesartanEDN1 gene polymorphism affects the susceptibility to irbesartan15188945
D007501IronCopper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein]20302851
D007501Iron[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein20302851
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA16054899
D007545IsoproterenolCyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]11435416
D007545IsoproterenolIsoproterenol results in increased activity of EDN1 promoter11435416
D007545IsoproterenolIsoproterenol results in increased expression of EDN1 protein9861301
D007545IsoproterenolNifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]11435416
D007545IsoproterenolIsoproterenol results in increased secretion of EDN1 protein10993771
D007548Isosorbide Dinitrate[Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA15719745
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EDN1 mRNA24796395
D0151216-Ketoprostaglandin F1 alpha[EDN1 protein co-treated with Arachidonic Acid] results in decreased abundance of 6-Ketoprostaglandin F1 alpha18809207
D0151216-Ketoprostaglandin F1 alphaEDN1 protein results in decreased abundance of 6-Ketoprostaglandin F1 alpha18809207
D0151216-Ketoprostaglandin F1 alphaEDN1 results in increased secretion of 6-Ketoprostaglandin F1 alpha7507780
D0151216-Ketoprostaglandin F1 alphaEDN1 protein results in increased secretion of 6-Ketoprostaglandin F1 alpha12056553
D0151216-Ketoprostaglandin F1 alphaIndomethacin inhibits the reaction [EDN1 protein results in increased secretion of 6-Ketoprostaglandin F1 alpha]12056553
D0151216-Ketoprostaglandin F1 alpha"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of 6-Ketoprostaglandin F1 alpha"16325014
C063302KN 62KN 62 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]15245872
C073601KT 5823KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]12184995
C073601KT 5823KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]16389725
C073601KT 5823KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]16389725
C029891lead chloridelead chloride results in increased secretion of EDN1 protein15915659
C045463leflunomideleflunomide results in increased expression of EDN1 mRNA19751817
C533894LG 100815LG 100815 results in increased expression of EDN1 mRNA16951191
C010210lignoceric acidlignoceric acid results in increased expression of EDN1 protein16895544
C018584linaloollinalool results in increased expression of EDN1 mRNA19922762
D008055LipidsLipids inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein]25445725
C433788lipopolysaccharide, E. coli O26-B6"cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA]"25230003
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA"25230003
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of EDN1 mRNA21355878
D008070Lipopolysaccharides"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]"26694894
D008070Lipopolysaccharides"5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]"26694894
D008070Lipopolysaccharides"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]"26694894
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein26694894
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of EDN1 mRNA26694894
D017706LisinoprilLisinopril results in decreased secretion of EDN1 protein19079593
D019808LosartanLosartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]17666345
D019808LosartanLosartan results in decreased expression of EDN1 protein11369837
D019808LosartanLosartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]12901495
D019808LosartanLosartan results in decreased expression of EDN1 mRNA16191423|1897157
D019808LosartanLosartan results in decreased expression of EDN1 protein16191423
D017997Leukotriene C4Leukotriene C4 results in increased expression of EDN1 mRNA11372388
D017997Leukotriene C4Leukotriene C4 results in increased expression of EDN1 protein11372388
D017997Leukotriene C4zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]11372388
D017997Leukotriene C4zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]11372388
D008558MelphalanMelphalan results in increased expression of EDN1 protein18548196
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of EDN1 mRNA20353558
D008627Mercuric Chloridecandesartan cilexetil inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]9853001
D008627Mercuric ChlorideMercuric Chloride results in increased expression of EDN1 mRNA9853001
D008627Mercuric ChlorideMercuric Chloride results in increased expression of EDN1 protein9788586|9853001
D008627Mercuric Chloridepimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]9853001
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]26497364
D008687MetforminMetformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]25108154
D008727MethotrexateMethotrexate results in increased expression of EDN1 mRNA21678067
D008731MethoxychlorMethoxychlor results in increased methylation of EDN1 gene23303685
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [EDN1 protein affects the localization of CD38 protein]23940720
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EDN1 mRNA28001369
D008775MethylprednisoloneMethylprednisolone results in decreased expression of EDN1 protein14688695
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]7756592
D008790MetoprololMetoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]11435416
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in decreased expression of EDN1 mRNA alternative form]9637705
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]11009568
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA alternative form]9637705
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]18390205
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]18390205
D008798Mevalonic Acid"Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]]"15486036
D008798Mevalonic Acid"Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]]"15486036
D020748Mibefradil"Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA]"8934362
D008898MimosineMimosine results in increased expression of EDN1 mRNA25469848
D008898MimosineMimosine results in increased expression of EDN1 protein25469848
D008898MimosineMimosine results in increased expression of EDN1 mRNA25469848
D008898MimosineMimosine results in increased expression of EDN1 protein25469848
C070571ML 7ML 7 results in decreased activity of EDN1 protein15939040
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of EDN1 mRNA16809437
D016686Monocrotaline4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]16225752
D016686Monocrotaline4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]16225752
D016686Monocrotalinebosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]20967148
D016686MonocrotalineMonocrotaline results in increased expression of EDN1 mRNA16225752|2202232
D016686MonocrotalineMonocrotaline results in increased expression of EDN1 protein16225752|2096714
D016686MonocrotalineSimvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]22022327
D009151Mustard GasMustard Gas results in increased expression of EDN1 mRNA25102026
D015544Inositol 1,4,5-Trisphosphate"CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
D015544Inositol 1,4,5-Trisphosphate"diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
D015544Inositol 1,4,5-Trisphosphate"diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
D015544Inositol 1,4,5-Trisphosphate"EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate"20691780
D015544Inositol 1,4,5-Trisphosphate"Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]"20691780
D015544Inositol 1,4,5-Trisphosphate"Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]"20691780
D015544Inositol 1,4,5-Trisphosphate"cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]"11911850
D015544Inositol 1,4,5-Trisphosphate"EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate"1443220
D015544Inositol 1,4,5-Trisphosphate"EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate"11911850
D015544Inositol 1,4,5-Trisphosphate"Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]"1443220
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]15245872
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]14759557
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide affects the reaction [PTPN11 protein affects the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]]16261333
C071595N(6)-benzyl-cyclic adenosine 5'-monophosphateN(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]22796455
C071595N(6)-benzyl-cyclic adenosine 5'-monophosphateN(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]22796455
C024376NAADPEDN1 protein results in increased metabolism of NAADP23940720
C024376NAADPNOX1 mutant form inhibits the reaction [EDN1 protein results in increased metabolism of NAADP]23940720
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EDN1 mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of EDN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EDN1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of EDN1 mRNA18978301
C017096n-butoxyethanoln-butoxyethanol results in increased expression of EDN1 mRNA19812364
D000068577NebivololNebivolol results in decreased expression of EDN1 mRNA11078433
D000068577NebivololNebivolol results in decreased secretion of EDN1 protein11078433
D000068577NebivololNebivolol results in decreased susceptibility to EDN1 protein18435936
D009532NickelNickel results in decreased expression of EDN1 mRNA25583101
D009532NickelNickel affects the activity of EDN1 protein9352311
C029938nickel sulfatenickel sulfate results in increased expression of EDN1 mRNA22714537
D009538NicotineNicotine affects the expression of EDN119637760
D009543NifedipineNifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]11435416
D009543NifedipineNifedipine results in decreased activity of EDN1 protein12628492
D009543NifedipineNifedipine results in increased activity of EDN1 protein7528292
C012655nimesulidenimesulide results in increased activity of EDN1 protein16612843
C012655nimesulidenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]21811393
C012655nimesulidenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]21811393
C012655nimesulidenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]21811393
D015737NisoldipineNisoldipine results in decreased expression of EDN1 protein8742913
D009569Nitric OxideEDN1 protein results in increased chemical synthesis of Nitric Oxide11187978
D009569Nitric OxideNitric Oxide results in decreased expression of EDN1 protein15838368
D009569Nitric OxideNitric Oxide results in increased expression of EDN1 protein20929026
D009569Nitric OxideNitric Oxide results in increased expression of EDN1 mRNA20197249
D009569Nitric OxideNitric Oxide affects the activity of EDN1 protein17552879
D009569Nitric Oxide[Nitric Oxide co-treated with EDN1 protein] results in increased abundance of Peroxynitrous Acid11509453
D009569Nitric OxideBQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]16380457
D009569Nitric OxideEDN1 protein results in increased abundance of Nitric Oxide16380457
D009569Nitric Oxide[EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide16380457
D009569Nitric Oxide[EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide16380457
D009569Nitric OxideHydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]16326922
D009569Nitric OxideHydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]16326922
D009569Nitric OxideNitric Oxide deficiency results in decreased activity of EDN1 protein16810074
D009569Nitric OxideNitric Oxide deficiency results in increased expression of EDN1 mRNA16326922
D009569Nitric OxideNitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]16389725
D009569Nitric OxideNitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]16389725
D009569Nitric OxideNitric Oxide results in increased secretion of EDN1 protein15640287
D009569Nitric OxideS-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]16380457
D009569Nitric OxideEDN1 protein results in increased abundance of Nitric Oxide12672649
D009569Nitric OxideNitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]17105827
D009569Nitric OxideEDN1 protein promotes the reaction [EDNRB protein results in increased chemical synthesis of Nitric Oxide]10976779
D009569Nitric OxideNitric Oxide results in decreased expression of EDN1 protein7828305
D009569Nitric OxideNitric Oxide results in increased expression of EDN1 protein11509453
D020030Nitric Oxide DonorsNitric Oxide Donors inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]16389725
D020030Nitric Oxide DonorsNitric Oxide Donors inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]16389725
D020030Nitric Oxide DonorsNitric Oxide Donors results in increased secretion of EDN1 protein15640287
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 mRNA]12407540
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 protein]12407540
C007350nitrofennitrofen results in decreased expression of EDN1 mRNA12407540
C007350nitrofennitrofen results in decreased expression of EDN1 protein12407540
C007350nitrofennitrofen results in increased expression of EDN1 mRNA10693666|1575656
C007350nitrofennitrofen results in increased expression of EDN1 protein10693666
D005996NitroglycerinNitroglycerin results in decreased expression of EDN1 mRNA12206003
D005996NitroglycerinNitroglycerin results in increased expression of EDN1 protein7539147
D005996NitroglycerinLosartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]12901495
D005996NitroglycerinNitroglycerin results in decreased expression of EDN1 mRNA11751199
D005996NitroglycerinNitroglycerin results in decreased expression of EDN1 protein11751199
D005996NitroglycerinNitroglycerin results in increased expression of EDN1 protein12901495
D009599NitroprussideNitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]16023617
D009599NitroprussideNitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]16389725
D009599NitroprussideNitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]16389725
D009599NitroprussideNitroprusside results in decreased secretion of EDN1 protein10993771
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein15640287
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased secretion of EDN1 protein10993771
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of EDN1 mRNA17616710
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]"14759557
D009638NorepinephrineBQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]14759557
D009638NorepinephrineBQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]12184995
D009638NorepinephrineBQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]14759557
D009638Norepinephrine[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine16023617
D009638NorepinephrineEDN1 protein results in decreased secretion of Norepinephrine12184995
D009638NorepinephrineEDN1 protein results in increased secretion of Norepinephrine14759557
D009638NorepinephrineKT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]12184995
D009638NorepinephrineMetoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]11435416
D009638NorepinephrineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]14759557
D009638NorepinephrineNorepinephrine results in increased activity of EDN1 promoter11435416
D009638NorepinephrineNorepinephrine results in increased expression of EDN1 mRNA11435416
D009638NorepinephrinePicrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]12184995
C570897NSC668394NSC668394 results in increased expression of EDN1 mRNA27137931
C558013NSC 689534NSC 689534 results in increased expression of EDN1 mRNA20971185
C482205nutlin 3nutlin 3 results in increased expression of EDN1 mRNA19098008
C482205nutlin 3nutlin 3 results in increased expression of EDN1 protein19098008
C010722nylestriolnylestriol results in decreased expression of EDN1 protein12536650|1293440
C000594859nymphayolnymphayol inhibits the reaction [Ethanol results in increased expression of EDN1 protein]25289771
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of EDN1 mRNA"16951191
D019787Linoleic AcidLinoleic Acid results in decreased expression of EDN1 mRNA16895544
D019787Linoleic AcidLinoleic Acid results in decreased expression of EDN1 protein16895544
D019301Oleic AcidOleic Acid results in decreased expression of EDN1 mRNA16895544
D019301Oleic AcidOleic Acid results in decreased expression of EDN1 protein16895544
C437965olmesartanolmesartan inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]15302986
C437965olmesartanolmesartan inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]15302986
D000068557Olmesartan MedoxomilOlmesartan Medoxomil results in decreased expression of EDN1 mRNA16336959
C549647olodaterol2'-O-methyl-8-(4-chlorophenylthio)cAMP inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]22796455
C549647olodaterolEDN1 protein promotes the reaction [olodaterol results in increased expression of ADRB2 mRNA]22483689
C549647olodaterolICI 118551 inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]22796455
C549647olodaterolN(6)-benzyl-cyclic adenosine 5'-monophosphate inhibits the reaction [olodaterol results in decreased expression of EDN1 mRNA]22796455
C549647olodaterololodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]22796455
C549647olodaterololodaterol inhibits the reaction [TGFB1 protein results in increased expression of EDN1 mRNA]22796455
C549647olodaterololodaterol promotes the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]22483689
C549647olodaterololodaterol results in decreased expression of EDN1 mRNA22796455
D009963Orotic AcidOrotic Acid results in increased expression of EDN1 protein25601987
D010095Oxotremorinebosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]22796455
D010095Oxotremorineolodaterol inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]22796455
D010095Oxotremorine[Oxotremorine co-treated with TGFB1 protein] results in increased expression of EDN1 mRNA22796455
D010095OxotremorineOxotremorine results in increased activity of EDN1 protein22796455
D010095OxotremorineOxotremorine results in increased expression of EDN1 mRNA22796455
D010095OxotremorineTiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]22796455
D010100Oxygencaffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]21926265
D010100Oxygencaffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]21926265
D010100Oxygenchetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]21926265
D010100Oxygenchetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]21926265
D010100Oxygencyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]24557580
D010100OxygenEPO protein inhibits the reaction [Oxygen deficiency results in increased secretion of EDN1 protein]24557580
D010100OxygenGenistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]10939628
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]10939628
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]10939628
D010100OxygenOxygen deficiency results in increased expression of EDN1 mRNA10939628|1450806
D010100OxygenOxygen deficiency results in increased expression of EDN1 protein18001528|2236355
D010100OxygenOxygen deficiency results in increased secretion of EDN1 protein21926265|2455758
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]22363556
D010100OxygenMMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]16980344
D010100OxygenOxygen deficiency results in increased expression of EDN1 mRNA10939628|2192626
D010100OxygenOxygen deficiency results in increased expression of EDN1 protein21926265
D010100OxygenOxygen results in increased expression of EDN1 mRNA25203536
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]21926265
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]21926265
D010100OxygenMMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency]16980344
D010100OxygenOxygen deficiency promotes the reaction [chromium mesoporphyrin results in increased expression of EDN1 protein]12969895
D010100OxygenOxygen deficiency results in increased expression of EDN1 mRNA25469848
D010100OxygenOxygen deficiency results in increased expression of EDN1 protein25469848
D010126OzoneOzone results in increased expression of EDN1 mRNA27206323
D010126OzoneOzone results in increased expression of EDN1 mRNA16081523|1671689
D010126OzoneOzone results in increased expression of EDN1 protein16081523|1674103
D010126Ozone[Particulate Matter co-treated with Ozone] results in increased expression of EDN1 mRNA16081523
D019308Palmitic AcidPalmitic Acid results in increased expression of EDN1 mRNA16895544
D019308Palmitic AcidPalmitic Acid results in increased expression of EDN1 protein16895544
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EDN1 mRNA26272509
D010269ParaquatAcetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]21765237
D010269ParaquatDapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]21765237
D010269ParaquatParaquat results in increased expression of EDN1 mRNA21765237
D010269Paraquatgreen tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]17235729
D010269Paraquatgreen tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 protein]17235729
D010269ParaquatParaquat results in increased expression of EDN1 mRNA17235729
D010269ParaquatParaquat results in increased expression of EDN1 protein17235729
C084656paricalcitolparicalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]21565836
C084656paricalcitolparicalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form]21565836
D052638Particulate MatterParticulate Matter results in decreased expression of EDN1 mRNA24769257
D052638Particulate MatterParticulate Matter results in increased expression of EDN1 protein23451061
D052638Particulate Matter2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased susceptibility to EDN1 protein]20561571
D052638Particulate Matter[Particulate Matter co-treated with Ozone] results in increased expression of EDN1 mRNA16081523
D052638Particulate MatterParticulate Matter results in decreased expression of EDN1 mRNA12396869
D052638Particulate MatterParticulate Matter results in increased expression of EDN1 mRNA16081523|1674103
D052638Particulate MatterParticulate Matter results in increased expression of EDN1 protein12396869|1608152
D052638Particulate MatterParticulate Matter results in increased susceptibility to EDN1 protein19535675|2056157
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA18593933
C073402PD 123319PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]15007106
C076213PD 142893PD 142893 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]12234805
C093321PD 156707PD 156707 inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]11509453
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of EDN1 mRNA23602845
D030421Peroxynitrous Acid[Nitric Oxide co-treated with EDN1 protein] results in increased abundance of Peroxynitrous Acid11509453
D015232DinoprostoneEDN1 results in increased secretion of Dinoprostone7507780
D015232DinoprostoneEDN1 protein results in increased secretion of Dinoprostone16384872
D015232DinoprostoneAcetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]21811393
D015232Dinoprostone[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone21811393
D015232Dinoprostonenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]21811393
D015232Dinoprostone"[15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid co-treated with EDN1 protein] results in decreased chemical synthesis of Dinoprostone"16325014
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of EDN1 mRNA26678675
D010634PhenobarbitalPhenobarbital results in decreased expression of EDN1 mRNA19084549
D010656PhenylephrineEP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]12724418
D010656PhenylephrineEDN1 protein results in increased susceptibility to Phenylephrine20977430
D010656PhenylephrinePhenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]10788492
D010656PhenylephrinePhenylephrine results in increased expression of EDN1 mRNA10788492
D010656PhenylephrinePhenylephrine results in increased expression of EDN1 protein15220332
D010656PhenylephrinePolyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]20977430
D010656PhenylephrinePrazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]15007106
D010656PhenylephrineY 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]11739382
D010656PhenylephrineZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]15220332
D010656PhenylephrineEDN1 protein results in increased susceptibility to Phenylephrine19948983
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
D010705PhosgenePhosgene results in increased expression of EDN1 protein18645720
D010716PhosphatidylinositolsCadmium promotes the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]9439784
D010716Phosphatidylinositolscyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols]9439784
D010716PhosphatidylinositolsEDN1 protein results in increased metabolism of Phosphatidylinositols9439784
C030090phosphoramide mustardphosphoramide mustard results in increased expression of EDN1 mRNA27888070
C008890phosphoramidonEDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]16280098
C008890phosphoramidonEDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]16280098
C008890phosphoramidonphosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]11145282|1628009
C008890phosphoramidonphosphoramidon results in decreased expression of EDN1 protein16391412
D064209PhytochemicalsPhytochemicals inhibits the reaction [Bleomycin results in increased expression of EDN1 mRNA]26093215
D010852PicrotoxinPicrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]12184995
C121565pifithrinpifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]19098008
C121565pifithrinpifithrin results in decreased expression of EDN1 mRNA19098008
C004479pimagedinepimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]9853001
C060836pioglitazonepioglitazone inhibits the reaction [EDN1 protein results in increased activity of RELA protein]18660453
C060836pioglitazonepioglitazone inhibits the reaction [EDN1 protein results in increased expression of IL18 mRNA]18660453
C060836pioglitazonepioglitazone results in decreased secretion of EDN1 protein9920814
D010936Plant ExtractsPlant Extracts results in decreased expression of EDN1 mRNA16680075
D010936Plant ExtractsPlant Extracts results in increased expression of EDN1 mRNA20707411
D010938Plant OilsPlant Oils results in increased expression of EDN1 mRNA23370395
D028321Plant Preparations[Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA15719745
D028321Plant PreparationsPlant Preparations results in decreased susceptibility to EDN1 protein23872130
D028321Plant Preparationsresveratrol inhibits the reaction [Plant Preparations results in decreased susceptibility to EDN1 protein]23872130
D010972Platelet Activating FactorCarbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]18205269
D010972Platelet Activating FactorEDN1 protein results in increased abundance of Platelet Activating Factor18205269
D010972Platelet Activating FactorEDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]18205269
D010972Platelet Activating FactorEDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]18205269
D059808PolyphenolsPolyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]20977430
D059808PolyphenolsPolyphenols inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]20977430
D059808PolyphenolsPolyphenols inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]20977430
D059808PolyphenolsPolyphenols inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]20977430
D059808PolyphenolsPolyphenols inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]20977430
D059808PolyphenolsPolyphenols inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]20977430
D059808PolyphenolsPolyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]20977430
D011137PolystyrenesPolystyrenes analog results in decreased expression of EDN1 mRNA25102311
D011137PolystyrenesPolystyrenes results in decreased expression of EDN1 mRNA25102311
D011188PotassiumDiclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium]15083534
D011188PotassiumEDN1 protein results in decreased transport of Potassium15083534
D011188PotassiumPotassium results in increased secretion of EDN1 protein10993771
D011189Potassium Chloride[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA18823320
D011189Potassium ChlorideAcetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]21811393
D011189Potassium ChlorideAcetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]21811393
D011189Potassium Chloride[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA21811393
D011189Potassium Chloride[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone21811393
D011189Potassium Chloride[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein21811393
D011189Potassium Chloridenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]21811393
D011189Potassium Chloridenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]21811393
D011189Potassium Chloridenimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of TAC1 protein]21811393
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EDN1 mRNA22714537
D017035PravastatinPravastatin results in decreased expression of EDN1 protein12105140
D017035PravastatinPravastatin results in decreased expression of EDN1 mRNA19812503
D017035PravastatinPravastatin results in decreased expression of EDN1 protein19812503
D011224PrazosinPrazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]12513686
D011224PrazosinPrazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]15007106
D011374ProgesteroneArachidonic Acid promotes the reaction [EDN1 protein inhibits the reaction [LHB protein results in increased chemical synthesis of Progesterone]]18809207
D011374ProgesteroneEDN1 protein inhibits the reaction [LHB protein results in increased abundance of Progesterone]15537863
D011374ProgesteroneEDN1 protein inhibits the reaction [LHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]18809207
D011374ProgesteroneEDN1 protein results in decreased abundance of Progesterone15537863|1638892
D011374ProgesteroneProgesterone results in decreased expression of EDN1 mRNA23012394
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of EDN1 mRNA]21795739
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased secretion of EDN1 protein]21795739
D011374ProgesteroneProgesterone results in increased expression of EDN1 mRNA22238285
D011374ProgesteroneProgesterone results in decreased expression of EDN1 mRNA20726854
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [EDN1 protein results in increased activity of RELA protein]18660453
D015742PropofolPropofol inhibits the reaction [EDN1 protein affects the transport of Calcium]9138053
D015742PropofolPropofol results in decreased expression of EDN1 protein17470888
D015237DinoprostDinoprost results in increased expression of EDN1 mRNA20484870
D015237Dinoprost[EDN1 protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprost18809207
D015237DinoprostEDN1 protein results in increased abundance of Dinoprost18809207
D015237DinoprostEDN1 results in increased secretion of Dinoprost7507780
D011692Puromycin AminonucleosideEnalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]9175058
D011692Puromycin AminonucleosideFR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]9175058
D011692Puromycin AminonucleosideMethylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]7756592
D011692Puromycin AminonucleosidePuromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP]12972712
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of EDN1 mRNA12972712|7756592
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
D011791QuartzQuartz results in decreased expression of EDN1 mRNA27917503
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]20021702
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]11755377
D011794QuercetinQuercetin inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]20021702
D011794QuercetinQuercetin results in decreased expression of EDN1 mRNA18234130|2002170
D011794QuercetinQuercetin results in decreased secretion of EDN1 protein20021702
D011794QuercetinQuercetin results in increased expression of EDN1 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [APOE gene mutant form results in increased expression of EDN1 protein]20093625
D011794QuercetinQuercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]18436224
D011794QuercetinQuercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]18436224
C041125quinaprilquinapril results in decreased expression of EDN112149661
C041125quinaprilquinapril results in decreased expression of EDN1 protein12425201
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of EDN1 protein11603923
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased phosphorylation of and results in increased activity of EDN1 protein11603923
D017382Reactive Oxygen Speciesacetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]22431579
D017382Reactive Oxygen Speciesatrasentan inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]22431579
D017382Reactive Oxygen SpeciesBQ 485 inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]16391241
D017382Reactive Oxygen SpeciesEDN1 protein results in increased abundance of Reactive Oxygen Species16391241|2243157
D017382Reactive Oxygen SpeciesEDN1 protein results in increased chemical synthesis of Reactive Oxygen Species16271043
C087120RES 701-1RES 701-1 inhibits the reaction [EDN1 protein results in decreased secretion of NPY protein]12234805
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of EDN1 mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]20960276
C059514resveratrolresveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]11755377|1462382
C059514resveratrolresveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]11755377
C059514resveratrolresveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]14623829|2002170
C059514resveratrolresveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]25493383
C059514resveratrolresveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]25493383
C059514resveratrolresveratrol results in decreased expression of EDN1 mRNA14623829|1823413
C059514resveratrolresveratrol results in decreased secretion of EDN1 protein14623829|2002170
C059514resveratrol[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA16806235
C059514resveratrolresveratrol results in decreased expression of EDN1 mRNA22935447
C059514resveratrolresveratrol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]15878161
C059514resveratrolresveratrol inhibits the reaction [Fructose results in increased expression of EDN1 protein]25108154
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]26891083
C059514resveratrolresveratrol results in decreased expression of EDN116535856
C059514resveratrolSIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]]26891083
C059514resveratrolresveratrol inhibits the reaction [Dietary Carbohydrates results in decreased susceptibility to EDN1 protein]23872130
C059514resveratrolresveratrol inhibits the reaction [Plant Preparations results in decreased susceptibility to EDN1 protein]23872130
C059514resveratrolresveratrol results in decreased activity of EDN1 protein21554123
C059514resveratrolresveratrol results in decreased susceptibility to EDN1 protein18656273
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA21127053
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]12169099
C085989Ro 32-0432Ro 32-0432 inhibits the reaction [EDN1 protein results in increased activity of TH protein]11911850
C085989Ro 32-0432Ro 32-0432 inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]11911850
D020889RolipramRolipram results in increased activity of EDN1 protein15464066
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA16054899
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]21926265
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]21926265
D012402RotenoneRotenone inhibits the reaction [Acrolein results in increased expression of EDN1 protein]22928487
D012402RotenoneRotenone results in increased expression of and results in increased secretion of EDN1 protein11707688
D012402RotenoneRotenone results in increased expression of EDN1 mRNA11078378|1170768
C093642SB 203580SB 203580 inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]27297870
C093642SB 203580SB 203580 inhibits the reaction [EDN1 protein results in increased expression of CXCL8 mRNA]18457675
C093642SB 203580SB 203580 inhibits the reaction [EDN1 protein results in increased expression of EDN1 mRNA]18457675|1845767
C093642SB 203580SB 203580 inhibits the reaction [EDN1 protein results in increased expression of IL6 mRNA]18457675
C093642SB 203580SB 203580 inhibits the reaction [EDN1 protein results in increased expression of PTGS2 mRNA]18457675
C093642SB 203580SB 203580 inhibits the reaction [EDN1 protein results in increased expression of VCAM1 mRNA]18457675
C093642SB 203580SB 203580 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
C093642SB 203580SB 203580 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]14741741
C078903seocalcitolseocalcitol results in decreased expression of EDN1 mRNA12040012
C009250sevofluranesevoflurane affects the expression of EDN1 mRNA15967596
D000068677Sildenafil CitrateSildenafil Citrate inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA]18818482
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EDN1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of EDN1 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of EDN1 mRNA19073995
D012834SilverSilver results in increased expression of EDN1 mRNA26014281
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]11009568
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]11009568
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA alternative form]9637705
D019821SimvastatinSimvastatin inhibits the reaction [RHOA results in increased expression of EDN1 mRNA]11009568
D019821SimvastatinSimvastatin results in decreased expression of EDN1 mRNA11009568|1637590
D019821SimvastatinSimvastatin results in decreased expression of EDN1 mRNA alternative form9637705
D019821SimvastatinSimvastatin results in decreased expression of EDN1 protein9637705
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]18390205
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]18390205
D019821SimvastatinSimvastatin results in decreased expression of EDN1 mRNA18390205
D019821SimvastatinSimvastatin results in decreased expression of EDN1 protein18390205
D019821SimvastatinSimvastatin results in decreased secretion of EDN1 protein16375908
D019821SimvastatinSimvastatin results in increased expression of and results in increased secretion of EDN1 protein20369390
D019821Simvastatin"Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]]"15486036
D019821Simvastatin"Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]]"15486036
D019821Simvastatin"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 mRNA alternative form]"15486036
D019821Simvastatin"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDN1 protein]"15486036
D019821SimvastatinSimvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]20644009
D019821SimvastatinSimvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]22022327
D019821SimvastatinSimvastatin results in decreased expression of EDN1 mRNA19099753|2184407
D020123SirolimusSirolimus inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]12411397
D020123SirolimusSirolimus inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]12411397
C086717S-methylthiocitrullineS-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]16380457
C118258SN50 peptideSN50 peptide inhibits the reaction [EDN1 protein results in increased activity of RELA protein]18660453
D012964Sodiumcariporide inhibits the reaction [EDN1 protein results in increased uptake of Sodium]15681704
D012964SodiumEDN1 protein results in increased uptake of Sodium15681704
D012964SodiumEDN1 protein affects the export of Sodium16340664
D012964SodiumEDN1 protein affects the susceptibility to Sodium16340664
C017947sodium arseniteRELA protein affects the reaction [sodium arsenite results in increased expression of EDN1 mRNA]28470405
C017947sodium arsenitesodium arsenite inhibits the reaction [EDN1 protein results in increased expression of EDNRB]28470405
C017947sodium arsenitesodium arsenite inhibits the reaction [EDN1 protein results in increased expression of MITF]28470405
C017947sodium arsenitesodium arsenite results in increased expression of EDN1 mRNA28470405
C017947sodium arsenitesodium arsenite results in increased expression of EDN1 protein28470405
D012965Sodium Chloride[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA18823320
D012965Sodium Chloride[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDN122431579
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of EDN1 protein"7721389
D017673Sodium Chloride, Dietary"Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA]"8934362
D017673Sodium Chloride, Dietary"[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA"8934362
D017673Sodium Chloride, Dietary"[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 protein"1860718
D053260SootSoot affects the expression of EDN1 mRNA26551751
D019311StaurosporineStaurosporine results in decreased activity of EDN1 protein15464066
C031183stearic acidstearic acid results in increased expression of EDN1 mRNA16895544
C031183stearic acidstearic acid results in increased expression of EDN1 protein16895544
D013311Streptozocin"diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]"20691780
D013311Streptozocin"Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]"20691780
D013311StreptozocinBezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]12967931
D013311StreptozocinStreptozocin results in increased expression of EDN1 mRNA12458661|1296793
D013311Streptozocinbenazepril inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]15015294
D013311Streptozocin"Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]"15015294
D013311StreptozocinStreptozocin results in increased expression of EDN1 mRNA15015294
D010042OuabainOuabain results in decreased expression of EDN1 mRNA28795476
D010042OuabainOuabain results in increased expression of EDN1 mRNA15477225
D013392SucralfateSucralfate inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]10423059
D013458Sulfur DioxideSulfur Dioxide results in increased expression of EDN1 mRNA20083630
D013458Sulfur DioxideSulfur Dioxide results in increased expression of EDN1 protein20083630
D013481SuperoxidesEDN1 protein results in increased abundance of Superoxides23940720
D013481SuperoxidesNOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]23940720
D013481SuperoxidesEDN1 protein results in increased abundance of Superoxides11509453
D013481SuperoxidesPD 156707 inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]11509453
D013481SuperoxidesCatechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]20977430
D013481Superoxides[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides20977430
D013481SuperoxidesEDN1 protein results in increased abundance of Superoxides20977430
D013481SuperoxidesNOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]20977430
D013481SuperoxidesPolyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]20977430
D013481Superoxidesacetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
D013481Superoxides[atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
D013481Superoxidesdiphenyleneiodonium inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
D013481SuperoxidesEDN1 protein results in increased abundance of Superoxides12600921|1530298
D013481SuperoxidesHydralazine inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]15302986
D013481Superoxidesolmesartan inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]15302986
D016559TacrolimusTacrolimus results in increased expression of EDN1 mRNA9517403|9931093
D016559TacrolimusTacrolimus results in increased expression of EDN1 protein9931093
C061133tamibarotenetamibarotene results in increased expression of EDN1 mRNA15498508
D013629TamoxifenEstradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]19943105
D013629Tamoxifen[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA19943105
D013629TamoxifenTamoxifen results in increased expression of EDN1 mRNA19943105
D013629Tamoxifen[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA19943105
D013629TamoxifenTamoxifen affects the expression of EDN1 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of EDN1 protein15556138
C424912TBC 3214TBC 3214 results in decreased expression of EDN1 mRNA15580650
C424912TBC 3214TBC 3214 results in decreased expression of EDN1 protein15580650
C084178telmisartantelmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein]20888384
C001803tempoltempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]17391658
C001803tempoltempol results in decreased expression of EDN1 mRNA28039404
C001803tempoltempol results in decreased expression of EDN1 protein28039404
D000068698Tenofovircoenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]23640862
D000068698TenofovirTenofovir results in increased secretion of EDN1 protein23640862
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of EDN1 mRNA21592394
D013739TestosteroneTestosterone affects the expression of EDN1 mRNA12122504|1461647
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of EDN1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EDN1 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EDN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EDN1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA17942748|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EDN1 mRNA16120747|1797511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EDN1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA21724226
D013755Tetradecanoylphorbol AcetateClofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]17105827
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of EDN1 protein17105827
D007978LevamisoleLevamisole results in decreased expression of EDN1 mRNA11139434
D013806TheophyllineTheophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA]10374451
D013853ThioacetamideThioacetamide results in increased expression of EDN1 mRNA23411599
D017392Thiobarbituric Acid Reactive SubstancesEDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances15302986
D017392Thiobarbituric Acid Reactive SubstancesHydralazine inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]15302986
D017392Thiobarbituric Acid Reactive Substancesolmesartan inhibits the reaction [EDN1 protein results in increased abundance of Thiobarbituric Acid Reactive Substances]15302986
D013928Thromboxane A2EDN1 protein results in increased secretion of Thromboxane A212056553
D013929Thromboxane B2EDN1 results in increased secretion of Thromboxane B27507780
D013936ThymidineEDN1 protein results in increased uptake of Thymidine10100047
D000069447Tiotropium BromideTiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]22796455
C009495titanium dioxidetitanium dioxide results in increased expression of EDN1 mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EDN1 mRNA27404394|2786577
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EDN119637760
C483909torcetrapibtorcetrapib affects the expression of and affects the activity of EDN1 protein21920972
D014212TretinoinTretinoin results in increased expression of EDN1 mRNA18230668
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in increased expression of EDN1 mRNA16443354
D014212TretinoinTretinoin results in increased expression of EDN1 mRNA15498508
D014212TretinoinTretinoin results in decreased expression of EDN1 protein17551590
D014212TretinoinTretinoin results in decreased expression of EDN1 protein16619265
C032910triadimefontriadimefon results in decreased expression of EDN1 mRNA26705709
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]27297870
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer inhibits the reaction [cobaltous chloride results in increased secretion of EDN1 protein]27297870
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDN1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of EDN1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of EDN1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EDN1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EDN1 mRNA"26179874
C057693troglitazonetroglitazone inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]17666345
C057693troglitazonetroglitazone inhibits the reaction [INS results in increased secretion of EDN1 protein]9920814
C057693troglitazonetroglitazone results in decreased expression of EDN1 mRNA9920814
C057693troglitazonetroglitazone results in decreased secretion of EDN1 protein9920814
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]17974986
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]16261333
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]16261333
C113580U 0126U 0126 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]24376792
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]12411397
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased expression of HOMER1 mRNA alternative form]16786172
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased expression of JUN mRNA]12169099
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of CREB1 protein]14741741
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]12411397
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of GSK3A protein]17993264
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of GSK3B protein]17993264
D014520UrethaneUrethane results in decreased expression of EDN1 mRNA28818685
D014527Uric Acidresveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]25493383
D014527Uric Acidresveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]25493383
D014527Uric AcidUric Acid results in increased expression of EDN1 mRNA25493383
D014527Uric AcidUric Acid results in increased expression of EDN1 protein25493383
C027278urovisionurovision results in increased expression of EDN1 protein9413771
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of EDN1 mRNA15556138
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of EDN1 protein15556138
C005466ursolic acidursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein]27567547
D014635Valproic AcidValproic Acid affects the expression of EDN1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EDN1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of EDN1 mRNA17292431
D000068756Valsartan[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein11136700
C034028vanadyl sulfatevanadyl sulfate results in increased expression of EDN1 mRNA16330358
D001335Vehicle Emissions[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA19150882
D001335Vehicle Emissionscyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA]19150882
D001335Vehicle Emissions[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in increased expression of EDN1 mRNA19891982
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of EDN1 mRNA21920430
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EDN1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of EDN1 mRNA17065432|2019724
D001335Vehicle EmissionsVehicle Emissions results in increased expression of EDN1 mRNA20980218|2389798
D001335Vehicle EmissionsVehicle Emissions results in increased metabolism of EDN1 protein23897985
D001335Vehicle EmissionsVehicle Emissions results in increased susceptibility to EDN1 protein19535675
C025643vinclozolinvinclozolin results in increased methylation of EDN1 promoter22570695
D024483Vitamin K 3Vitamin K 3 affects the expression of EDN1 mRNA20044591|2341063
D024483Vitamin K 3Vitamin K 3 results in increased expression of EDN1 mRNA12414654
D014867WaterEDN1 protein affects the export of Water16340664
C009687wortmanninwortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]12839867
C108830Y 27632Y 27632 results in decreased activity of EDN1 protein15939040
C108830Y 27632Y 27632 results in decreased activity of EDN1 protein12605241
C108830Y 27632Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]11739382
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]11372388
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]11372388
C062735zafirlukastzafirlukast results in decreased expression of EDN1 protein12781059
C415840ZD 2574ZD 2574 results in increased expression of EDN1 protein11046091
C511404ZD4054Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]19943105
C511404ZD4054[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA19943105
C511404ZD4054[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA19943105
C511404ZD4054ZD4054 results in decreased expression of EDN1 mRNA19943105
D015029ZeranolZeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein]16757814
D015215Zidovudinecoenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]23640862
D015215ZidovudineZidovudine results in increased secretion of EDN1 protein23640862
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of EDN1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IDA19767294  
GO:0005179hormone activity-IDA2649896  10770212  
GO:0005515protein binding-IPI23597562  
GO:0031707endothelin A receptor binding-IDA10770212  
GO:0031708endothelin B receptor binding-IDA10770212  
GO:0031708endothelin B receptor binding-IPI1713452  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA19767294  
GO:0001516prostaglandin biosynthetic process-IDA9492062  
GO:0001569branching involved in blood vessel morphogenesis-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0001821histamine secretion-IEA-  
GO:0003100regulation of systemic arterial blood pressure by endothelin-IDA2649896  
GO:0006885regulation of pH-IEA-  
GO:0007166cell surface receptor signaling pathway-IDA1713452  
GO:0007186G-protein coupled receptor signaling pathway-IDA17078114  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA1917960  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007267cell-cell signaling-IDA12379507  
GO:0007507heart development-IEA-  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0007589body fluid secretion-IEA-  
GO:0008284positive regulation of cell proliferation-IDA1917960  17078114  
GO:0009953dorsal/ventral pattern formation-IEA-  
GO:0010193response to ozone-IEA-  
GO:0010259multicellular organism aging-IEA-  
GO:0010460positive regulation of heart rate-IDA2649896  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010595positive regulation of endothelial cell migration-TAS8999856  
GO:0010613positive regulation of cardiac muscle hypertrophy-IDA12847114  
GO:0010827regulation of glucose transmembrane transport-IEA-  
GO:0010870positive regulation of receptor biosynthetic process-IDA17178876  
GO:0014032neural crest cell development-IEA-  
GO:0014065phosphatidylinositol 3-kinase signaling-IDA17078114  
GO:0014823response to activity-IEA-  
GO:0014824artery smooth muscle contraction-IDA8982507  
GO:0014824artery smooth muscle contraction-TAS1725334  
GO:0014826vein smooth muscle contraction-IDA9422810  
GO:0019229regulation of vasoconstriction-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0019722calcium-mediated signaling-IDA1917960  10770212  
GO:0030072peptide hormone secretion-IDA10770212  
GO:0030185nitric oxide transport-IDA16820593  
GO:0030195negative regulation of blood coagulation-TAS16820593  
GO:0030335positive regulation of cell migration-IDA9696419  
GO:0030593neutrophil chemotaxisNOTIDA9696419  
GO:0031583phospholipase D-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0032269negative regulation of cellular protein metabolic process-IDA19767294  
GO:0032308positive regulation of prostaglandin secretion-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0034392negative regulation of smooth muscle cell apoptotic process-IEA-  
GO:0034696response to prostaglandin F-IEA-  
GO:0035094response to nicotine-IEA-  
GO:0035690cellular response to drug-IEA-  
GO:0035810positive regulation of urine volume-IEA-  
GO:0035815positive regulation of renal sodium excretion-IEA-  
GO:0035994response to muscle stretch-IEA-  
GO:0042045epithelial fluid transport-IEA-  
GO:0042310vasoconstriction-IDA2649896  11410113  
GO:0042313protein kinase C deactivation-IDA16820593  
GO:0042474middle ear morphogenesis-IEA-  
GO:0042482positive regulation of odontogenesis-IEA-  
GO:0042554superoxide anion generation-IEA-  
GO:0043179rhythmic excitation-IEA-  
GO:0043200response to amino acid-IEA-  
GO:0043406positive regulation of MAP kinase activity-IDA10770212  12847114  
GO:0043507positive regulation of JUN kinase activity-IDA12847114  
GO:0044321response to leptin-IEA-  
GO:0045321leukocyte activation-TAS16820593  
GO:0045429positive regulation of nitric oxide biosynthetic process-TAS8999856  
GO:0045793positive regulation of cell size-IDA12847114  
GO:0045840positive regulation of mitotic nuclear division-IDA10770212  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24117217  
GO:0045987positive regulation of smooth muscle contraction-IEA-  
GO:0046887positive regulation of hormone secretion-IDA10770212  
GO:0046888negative regulation of hormone secretion-IEA-  
GO:0048016inositol phosphate-mediated signaling-IDA1917960  
GO:0048661positive regulation of smooth muscle cell proliferation-IDA10393673  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA24117217  
GO:0051216cartilage development-IEA-  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IEA-  
GO:0051771negative regulation of nitric-oxide synthase biosynthetic process-IDA16820593  
GO:0051899membrane depolarization-IEA-  
GO:0051930regulation of sensory perception of pain-IEA-  
GO:0060137maternal process involved in parturition-IEA-  
GO:0060298positive regulation of sarcomere organization-IMP12847114  
GO:0060585positive regulation of prostaglandin-endoperoxide synthase activity-IMP9492062  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-IDA24117217  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-IGI24117217  
GO:0070101positive regulation of chemokine-mediated signaling pathway-IC17178876  
GO:0071277cellular response to calcium ion-IEA-  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IEA-  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO:0071389cellular response to mineralocorticoid stimulus-IEA-  
GO:0071398cellular response to fatty acid-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0071548response to dexamethasone-IEA-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEA-  
GO:0090023positive regulation of neutrophil chemotaxis-IEA-  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO:1902074response to salt-IEA-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA10770212  15691296  16820593  
GO:0005737cytoplasm-IDA12379507  
GO:0030133transport vesicle-TAS-  
GO:0033093Weibel-Palade body-IEA-  
GO:0045178basal part of cell-IEA-  
GO:0048237rough endoplasmic reticulum lumen-IEA-  
KEGG ID KEGG Term
hsa04916Melanogenesis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24035903The -974C>A (rs3087459) gene polymorphism in the endothelin gene (EDN1) is associated with risk of developing acute coronary syndrome in Mexican patients. (2014 Jun 1)Vargas-Alarcon GGene
19672034Lack of association between endothelin-1 gene variants and myocardial infarction. (2009 Aug)Palacin MJ Atheroscler Thromb
23336501Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population. (2013 May)Lind LActa Physiol (Oxf)
19730395Maternal EDN1 G5665T polymorphism influences circulating endothelin-1 levels and plays a role in determination of preeclampsia phenotype. (2009 Oct)Aggarwal PKJ Hypertens