Gene: EDNRA

1909
ET-A|ETA|ETA-R|ETAR|ETRA|MFDA|hET-AR
endothelin receptor type A
protein-coding
4q31.22-q31.23
Ensembl:ENSG00000151617 MIM:131243 Vega:OTTHUMG00000161354 UniprotKB:P25101
NG_013343.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.116e-1 (AD)  9.817e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE5A0.858
TNFAIP80.84
TFPI0.839
VEGFC0.826
EBF10.822
GPX80.822
COL14A10.821
TBX180.815
FN10.812
MECOM0.809

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.479
MYADML2-0.458
KLHL35-0.453
HAS1-0.432
KCNK4-0.43
FBLL1-0.43
GAL3ST3-0.428
ZNF835-0.428
SPEF1-0.426
HIPK4-0.423

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00559BosentanSmall Molecule147536-97-8Approved|InvestigationalTarget
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTarget
DB046742-HYDROXY-3,5-DIIODOBENZOIC ACIDSmall Molecule-ExperimentalTarget
DB04883DarusentanSmall Molecule171714-84-4InvestigationalTarget
DB05290SPP 301Small Molecule-InvestigationalTarget
DB05367Actelion-1Small Molecule-InvestigationalTarget
DB06199AtrasentanSmall Molecule173937-91-2InvestigationalTarget
DB06268SitaxentanSmall Molecule184036-34-8Approved|Investigational|WithdrawnTarget
DB06403AmbrisentanSmall Molecule177036-94-1Approved|InvestigationalTarget
DB06460EnrasentanSmall Molecule167256-08-8InvestigationalTarget
DB06558TezosentanSmall Molecule180384-57-0InvestigationalTarget
DB06677ClazosentanSmall Molecule180384-56-9InvestigationalTarget
DB08932MacitentanSmall Molecule441798-33-0ApprovedTarget
DB12548SparsentanSmall Molecule254740-64-2InvestigationalTarget
ID Drug Name Action PubMed
C0956531,5-dihydroxyisoquinoline"1,5-dihydroxyisoquinoline results in decreased expression of EDNRA mRNA"12824290
C04016819-oxo-11-deoxycorticosterone acetate[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein18516094
C0875511H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-"1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)- binds to and results in decreased activity of EDNRA protein"14687651
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EDNRA mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EDNRA mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of EDNRA mRNA"20406850
C4023063,5-dibromosalicylic acid"3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C4023063,5-dibromosalicylic acid"3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C4023063,5-dibromosalicylic acid"3,5-dibromosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]"11093786
C0208913,5-diiodosalicylic acid"3,5-diiodosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]"11093786
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C4000844-chlorobenzyltetrahydroberberine4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]23270704
C4000844-chlorobenzyltetrahydroberberine4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]23270704
C0857545-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]"16271043
C0857545-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] which results in decreased expression of NOS2 protein"16271043
C0857545-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] which results in increased expression of SOD2 protein"16271043
C0857545-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide"5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein"15477225|1627104
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]"22952915
C4892515-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]"22952915
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C467893A 182086A 182086 binds to and results in decreased activity of EDNRA protein12875994
C095427A 86929A 86929 binds to EDNRA protein8558425
D000082AcetaminophenAcetaminophen results in increased expression of EDNRA mRNA29067470
C056165acetovanilloneacetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]23270704
C056165acetovanilloneacetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]23270704
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EDNRA gene27153756
D000450Aldosterone[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosterone[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000496AlloxanAlloxan results in increased expression of EDNRA mRNA12605241
D000496AlloxanAlloxan results in increased expression of EDNRA protein12605241
C467894ambrisentanambrisentan binds to and results in decreased activity of EDNRA protein16219361
C467894ambrisentanambrisentan results in decreased expression of EDNRA mRNA16364719
C467894ambrisentanambrisentan binds to and results in decreased activity of EDNRA protein16364719
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of EDNRA mRNA18247414
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EDNRA mRNA24449571
D001151ArsenicArsenic affects the expression of EDNRA mRNA19654921
D000069059Atorvastatin CalciumAtorvastatin Calcium promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]23091284
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of EDNRA mRNA23091284
D000069059Atorvastatin CalciumLosartan promotes the reaction [Atorvastatin Calcium results in decreased expression of EDNRA mRNA]23091284
C098644atrasentanatrasentan binds to and results in decreased activity of EDNRA protein12193141|1516528
C098644atrasentanatrasentan binds to and results in decreased activity of EDNRA protein18516094
C098644atrasentanatrasentan binds to and results in decreased activity of EDNRA protein10877991|1199450
C098644atrasentan[atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
C487081belinostatbelinostat results in increased expression of EDNRA mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C044946benazeprilbenazepril inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]15015294
C061004benidipinebenidipine results in decreased expression of EDNRA protein16387788
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDNRA mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDNRA mRNA22228805
D004958EstradiolEstradiol results in increased expression of EDNRA mRNA19943105
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]19943105
C006780bisphenol Abisphenol A results in increased expression of EDNRA mRNA26063408
C006780bisphenol Abisphenol A affects the expression of EDNRA mRNA25181051
C086232bosentanbosentan binds to and results in decreased activity of EDNRA protein15334381
C086232bosentanbosentan binds to and results in decreased activity of EDNRA protein9811577
C086232bosentanbosentan binds to and results in decreased activity of EDNRA protein16219361
C086232bosentan"3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C086232bosentanbosentan binds to and results in decreased activity of EDNRA protein15964565
C086232bosentanbosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]11093786
C086232bosentanbosentan binds to and results in decreased activity of EDNRA protein10796056|1192290
C083116BQ 485[BQ 485 binds to and results in decreased activity of EDNRA protein] which results in decreased expression of BCL2 protein14736733
C083116BQ 485BQ 485 binds to and results in decreased activity of EDNRA protein14736733|1509370
C083116BQ 485[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
C087220BQ 610BQ 610 binds to and results in decreased activity of EDNRA protein15245872|1602361
C405519BSF 302146BSF 302146 binds to and results in decreased activity of EDNRA protein15754391
C405519BSF 302146BSF 302146 binds to and results in decreased activity of EDNRA protein15838271
D002118CalciumCalcium affects the activity of EDNRA protein12628492
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of EDNRA mRNA17484886
D002330CarmustineEDNRA mRNA affects the susceptibility to Carmustine16365179
D000068579CelecoxibCelecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein]25656942
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of EDNRA mRNA"19505368
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of EDNRA protein"19505368
D002791Cholesterol, Dietary"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"19505368
D002791Cholesterol, Dietary"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"19505368
D002791Cholesterol, Dietary"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"19505368
D002791Cholesterol, Dietary"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"19505368
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EDNRA mRNA28472532
C109641clazosentanclazosentan binds to and results in decreased activity of EDNRA protein16219361
D003042CocaineCocaine results in increased expression of EDNRA protein18813882
D003042CocaineCocaine results in increased expression of EDNRA protein17420087
C513821CPU0213"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"19505368
C513821CPU0213"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"19505368
C513821CPU0213CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]18594475|2030764
C513821CPU0213CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]20307649
D003471CuprizoneCuprizone results in increased expression of EDNRA mRNA27523638
D003513CycloheximideCycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
D003513CycloheximideCycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D003513Cycloheximide[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA20561571
D003513Cycloheximide[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA protein20561571
D016572CyclosporineCelecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein]25656942
D016572CyclosporineCyclosporine results in increased expression of EDNRA protein25656942
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein11535565
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDNRA protein18813882
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein15072961
C072247cyclo(Trp-Asp-Pro-Val-Leu)"3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]"11093786
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein16151434|1851609
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] affects the reaction [Doxorubicin results in increased activity of CASP3 protein]14736733
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased expression of BCL2 protein14736733
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine15834289
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine15007106
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]11093786
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein10796056|1236320
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDNRA protein15605384|1568555
D003609DactinomycinDactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
D003609DactinomycinDactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D003609Dactinomycin[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA20561571
D003609Dactinomycin[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein20561571
C107831darusentandarusentan binds to and results in decreased activity of EDNRA protein11181473|1621936
D003630DaunorubicinDaunorubicin results in increased expression of EDNRA protein20888384
D003630Daunorubicintelmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]20888384
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EDNRA mRNA23640034
D013759DronabinolDronabinol results in increased expression of EDNRA mRNA16616335
D003907DexamethasoneDexamethasone results in decreased expression of EDNRA mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EDNRA mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EDNRA mRNA21266533
D002945CisplatinEDNRA protein affects the susceptibility to Cisplatin17032313
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of EDNRA mRNA20920545
C058705diethyl malatediethyl malate affects the expression of EDNRA mRNA24814887
D004121Dimethyl Sulfoxide[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA20561571
D004121Dimethyl Sulfoxide[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA protein20561571
D004121Dimethyl Sulfoxide[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA20561571
D004121Dimethyl Sulfoxide[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein20561571
D004317DoxorubicinDoxorubicin results in decreased expression of EDNRA mRNA28940058
D004317Doxorubicin[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] affects the reaction [Doxorubicin results in increased activity of CASP3 protein]14736733
D004317Doxorubicin[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
D004317Doxorubicin[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]14736733
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]"15015294
C098288enrasentanenrasentan binds to and results in decreased activity of EDNRA protein16219361
D005472FluorouracilEDNRA protein affects the susceptibility to Fluorouracil17032313
C079574FR 139317FR 139317 binds to and results in decreased activity of EDNRA protein21259319
C079574FR 139317FR 139317 binds to and results in decreased activity of EDNRA protein10877991|1102850
D005632FructoseFructose results in increased expression of EDNRA mRNA14568997|9869011
D005632FructoseKLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA]14568997
C070081fulvestrant[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA19943105
C039281furanfuran results in decreased expression of EDNRA mRNA25539665
C039281furanfuran results in increased expression of EDNRA mRNA27387713
D003900Desoxycorticosterone"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]"16271043
D003900Desoxycorticosterone[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDNRA protein22431579
D003900DesoxycorticosteroneEDNRA protein affects the susceptibility to Desoxycorticosterone12600921
C074308IRL 1620EDNRA protein affects the susceptibility to IRL 162018823320
D007545IsoproterenolIsoproterenol results in increased expression of EDNRA mRNA20003209
D007545IsoproterenolCPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]18594475|2030764
D007545IsoproterenolCPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]20307649
D007545IsoproterenolIsoproterenol results in increased expression of EDNRA mRNA18594475|2030764
D007545IsoproterenolIsoproterenol results in increased expression of EDNRA protein20307649
D007545Isoproterenolpimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]18594475
C119319J 104132J 104132 binds to EDNRA protein11483691
C119319J 104132J 104132 binds to EDNRA protein11483691
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EDNRA mRNA24796395
D007657Ketone BodiesKetone Bodies results in decreased expression of EDNRA mRNA16807920
D019808LosartanAtorvastatin Calcium promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]23091284
D019808LosartanLosartan promotes the reaction [Atorvastatin Calcium results in decreased expression of EDNRA mRNA]23091284
D019808LosartanLosartan results in decreased expression of EDNRA mRNA23091284
C113044LU 224332LU 224332 binds to and results in decreased activity of EDNRA protein15754391
C113044LU 224332LU 224332 binds to and results in decreased activity of EDNRA protein15838271
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EDNRA mRNA28001369
C008493methylselenic acidmethylselenic acid results in increased expression of EDNRA mRNA18548127
D015735MifepristoneMifepristone results in decreased expression of EDNRA mRNA25972201
D016686MonocrotalineMonocrotaline results in increased expression of EDNRA mRNA20967148|2202232
D016686MonocrotalineSimvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]22022327
C470655N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,3,3-trimethylbutanamide"N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,3,3-trimethylbutanamide binds to and results in decreased activity of EDNRA protein"16219361
C485107N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide"N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide binds to and results in decreased activity of EDNRA protein"16219361
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EDNRA mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EDNRA mRNA"25620056
D009538NicotineNicotine results in decreased expression of EDNRA mRNA18247414
C007350nitrofennitrofen results in decreased expression of EDNRA mRNA12407540
C007350nitrofennitrofen results in increased expression of EDNRA mRNA10693666|1985177
C007350nitrofennitrofen results in increased expression of EDNRA protein19851775
D009638Norepinephrine[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine15834289
D010100OxygenOxygen deficiency results in increased expression of EDNRA mRNA21926265
D010100OxygenOxygen deficiency results in increased expression of EDNRA protein21926265
D010100OxygenOxygen results in increased expression of EDNRA mRNA25203536
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]21926265
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]21926265
D010100Oxygen4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]23270704
D010100Oxygen4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]23270704
D010100Oxygenacetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]23270704
D010100Oxygenacetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]23270704
D010100OxygenOxygen deficiency results in increased expression of EDNRA mRNA23270704
D010100OxygenOxygen deficiency results in increased expression of EDNRA protein23270704
D010126OzoneOzone results in decreased expression of EDNRA mRNA16081523
D010126OzoneOzone results in increased expression of EDNRA mRNA20980218
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EDNRA mRNA26272509
D010269ParaquatParaquat affects the expression of EDNRA mRNA16854511
D052638Particulate Matter2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
D052638Particulate Matter2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D052638Particulate MatterCycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
D052638Particulate MatterCycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D052638Particulate MatterDactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
D052638Particulate MatterDactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D052638Particulate MatterParticulate Matter results in increased expression of EDNRA mRNA26496744
D052638Particulate MatterParticulate Matter results in increased expression of EDNRA protein20561571|2649674
D052638Particulate Matterpyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
D052638Particulate Matterpyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D052638Particulate MatterU 0126 inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]26496744
C082887PD 145065PD 145065 binds to and results in decreased activity of EDNRA protein17578707
C087850PD 151242PD 151242 binds to and results in decreased activity of EDNRA protein12363203
C106950PD 156252PD 156252 binds to and results in decreased activity of EDNRA protein11751199
C093321PD 156707PD 156707 binds to and results in decreased activity of EDNRA protein11509453
C093321PD 156707PD 156707 binds to EDNRA protein21275367
D010656Phenylephrine[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine15007106
D010656Phenylephrinephosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]15007106
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EDNRA mRNA26272509
C008890phosphoramidonphosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]15007106
C008890phosphoramidonphosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]15007106
D010795Phthalic AcidsPhthalic Acids results in increased expression of EDNRA mRNA21061450
C004479pimagedinepimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]18594475
C006253pirinixic acidpirinixic acid results in decreased expression of EDNRA mRNA16985257
D011189Potassium Chloride[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein18516094
D011192Potassium DichromatePotassium Dichromate results in increased expression of EDNRA mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of EDNRA mRNA21795739
D011441PropylthiouracilPropylthiouracil results in increased expression of EDNRA mRNA24780913
D015237DinoprostDinoprost results in decreased expression of EDNRA mRNA20484870
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of EDNRA mRNA23274088
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of EDNRA mRNA12972712
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]20561571
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]20561571
D011791QuartzQuartz results in decreased expression of EDNRA mRNA27917503
C502851quinocetonequinocetone results in increased expression of EDNRA mRNA27046791
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA19059307
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA19059307
D017382Reactive Oxygen Species"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]"16271043
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]21926265
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]21926265
C057354sarafotoxins s6sarafotoxins s6 binds to and results in increased activity of EDNRA protein15245872
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNA19244175
D012643SeleniumSelenium results in decreased expression of EDNRA mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EDNRA mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of EDNRA mRNA25351596
D019821Simvastatin"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"19505368
D019821Simvastatin"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"19505368
D019821SimvastatinSimvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]22022327
C106276sitaxsentansitaxsentan binds to and results in decreased activity of EDNRA protein16219361
C106276sitaxsentansitaxsentan binds to and results in decreased activity of EDNRA protein12388107|1723451
D012906SmokeSmoke results in increased expression of EDNRA mRNA21095227
C017947sodium arseniteEDNRA protein affects the reaction [sodium arsenite results in decreased expression of PLIN1 protein]23650128
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of EDNRA mRNA25879800
D012965Sodium Chloride[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein18516094
D012965Sodium Chloride[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDNRA protein22431579
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of EDNRA mRNA23274088
D013311Streptozocinbenazepril inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]15015294
D013311Streptozocin"Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]"15015294
D013311StreptozocinStreptozocin results in increased expression of EDNRA mRNA15015294
D010042OuabainOuabain results in increased expression of EDNRA mRNA15477225|1698243
D010042OuabainOuabain results in increased expression of EDNRA protein16982439
D013481SuperoxidesEDNRA protein affects the abundance of Superoxides12600921
D013481Superoxides[atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]12600921
D016559TacrolimusTacrolimus results in increased activity of EDNRA protein15964565
D016559TacrolimusTacrolimus results in increased expression of EDNRA mRNA8587392
C088196TAK 044TAK 044 binds to and results in decreased activity of EDNRA protein11327643
D013629Tamoxifen[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA19943105
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of EDNRA mRNA19059307
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA19059307
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]19943105
D013629TamoxifenTamoxifen results in increased expression of EDNRA mRNA19943105
C424912TBC 3214TBC 3214 binds to and results in decreased activity of EDNRA protein15580650
C084178telmisartantelmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]20888384
C047246temozolomideEDNRA mRNA affects the susceptibility to temozolomide16365179
D013739TestosteroneTestosterone affects the expression of EDNRA mRNA12122504|1461647
C004648testosterone enanthatetestosterone enanthate affects the expression of EDNRA mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of EDNRA mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EDNRA mRNA26290441
C120582tezosentantezosentan binds to and results in decreased activity of EDNRA protein16219361
C120582tezosentantezosentan binds to and results in decreased activity of EDNRA protein16181825|1632700
C009495titanium dioxidetitanium dioxide affects the expression of EDNRA mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EDNRA mRNA28065790
D014028Tobacco Smoke Pollution"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]"22952915
D014028Tobacco Smoke Pollution"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]"22952915
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EDNRA mRNA22952915|2721244
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EDNRA protein22952915|2721244
D014028Tobacco Smoke PollutionU 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]27212444
D014028Tobacco Smoke PollutionU 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]27212444
D014212TretinoinTretinoin results in increased expression of EDNRA mRNA18230668
D014212TretinoinTretinoin results in decreased expression of EDNRA mRNA23724009
D014212TretinoinTretinoin results in increased expression of EDNRA mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of EDNRA gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EDNRA mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of EDNRA mRNA15901671
C113580U 0126U 0126 inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]26496744
C113580U 0126U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]27212444
C113580U 0126U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]27212444
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EDNRA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EDNRA mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of EDNRA mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of EDNRA mRNA24896083
D014635Valproic AcidValproic Acid results in decreased expression of EDNRA mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased expression of EDNRA mRNA20980218
C025643vinclozolinvinclozolin affects the expression of EDNRA mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of EDNRA mRNA20566332
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of EDNRA mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"27188386
C111237vorinostatvorinostat results in increased expression of EDNRA mRNA26272509
C415840ZD 2574ZD 2574 binds to and results in decreased activity of EDNRA protein11046091
C511404ZD4054[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA19943105

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-TAS8702836  
GO:0004962endothelin receptor activity-NAS8611157  9284755  
GO:0005515protein binding-IPI19202075  23597562  
GO ID GO Term Qualifier Evidence PubMed
GO:0001569branching involved in blood vessel morphogenesis-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0006939smooth muscle contraction-NAS9284755  
GO:0007165signal transduction-TAS1326535  
GO:0007186G-protein coupled receptor signaling pathway-NAS8611157  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007190activation of adenylate cyclase activity-TAS8702836  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007202activation of phospholipase C activity-TAS8702836  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS1849646  
GO:0007507heart development-IEA-  
GO:0007585respiratory gaseous exchange-ISS-  
GO:0008217regulation of blood pressure-IEA-  
GO:0008283cell proliferation-NAS9284755  
GO:0010827regulation of glucose transmembrane transport-IEA-  
GO:0014032neural crest cell development-IEA-  
GO:0014824artery smooth muscle contraction-IMP8982507  
GO:0042310vasoconstriction-IMP8982507  
GO:0048484enteric nervous system development-IEA-  
GO:0060322head development-IEA-  
GO:0086100endothelin receptor signaling pathway-IEA-  
GO:1904659glucose transmembrane transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1326535  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25746325Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. (2015 May 15)Li CGene
28761511Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. (2017 Jul-Sep)Theodotou CBAsian J Neurosurg
23336501Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population. (2013 May)Lind LActa Physiol (Oxf)