Gene info: ID 1909

Gene: EDNRA

GENE ID: 1909

Description: endothelin receptor type A

Gene type: protein-coding

Location: 4q31.22-q31.23

dbXrefs: Ensembl:ENSG00000151617 MIM:131243 Vega:OTTHUMG00000161354 UniprotKB:P25101

RefSeq: NG_013343.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.116e-1 (AD) 9.817e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDE5A	0.858
TNFAIP8	0.84
TFPI	0.839
VEGFC	0.826
EBF1	0.822
GPX8	0.822
COL14A1	0.821
TBX18	0.815
FN1	0.812
MECOM	0.809

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASPDH	-0.479
MYADML2	-0.458
KLHL35	-0.453
HAS1	-0.432
KCNK4	-0.43
FBLL1	-0.43
GAL3ST3	-0.428
ZNF835	-0.428
SPEF1	-0.426
HIPK4	-0.423

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00559	Bosentan	Small Molecule	147536-97-8	Approved\|Investigational	Target
DB00945	Acetylsalicylic acid	Small Molecule	50-78-2	Approved	Target
DB04674	2-HYDROXY-3,5-DIIODOBENZOIC ACID	Small Molecule	-	Experimental	Target
DB04883	Darusentan	Small Molecule	171714-84-4	Investigational	Target
DB05290	SPP 301	Small Molecule	-	Investigational	Target
DB05367	Actelion-1	Small Molecule	-	Investigational	Target
DB06199	Atrasentan	Small Molecule	173937-91-2	Investigational	Target
DB06268	Sitaxentan	Small Molecule	184036-34-8	Approved\|Investigational\|Withdrawn	Target
DB06403	Ambrisentan	Small Molecule	177036-94-1	Approved\|Investigational	Target
DB06460	Enrasentan	Small Molecule	167256-08-8	Investigational	Target
DB06558	Tezosentan	Small Molecule	180384-57-0	Investigational	Target
DB06677	Clazosentan	Small Molecule	180384-56-9	Investigational	Target
DB08932	Macitentan	Small Molecule	441798-33-0	Approved	Target
DB12548	Sparsentan	Small Molecule	254740-64-2	Investigational	Target

ID	Drug Name	Action	PubMed
C095653	1,5-dihydroxyisoquinoline	"1,5-dihydroxyisoquinoline results in decreased expression of EDNRA mRNA"	12824290
C040168	19-oxo-11-deoxycorticosterone acetate	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein	18516094
C087551	1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-	"1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)- binds to and results in decreased activity of EDNRA protein"	14687651
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EDNRA mRNA"	27291303
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EDNRA mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of EDNRA mRNA"	20406850
C402306	3,5-dibromosalicylic acid	"3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]"	11093786
C402306	3,5-dibromosalicylic acid	"3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]"	11093786
C402306	3,5-dibromosalicylic acid	"3,5-dibromosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]"	11093786
C020891	3,5-diiodosalicylic acid	"3,5-diiodosalicylic acid inhibits the reaction [EDN1 protein binds to EDNRA protein]"	11093786
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]	23270704
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]	23270704
C085754	5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide	"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]"	16271043
C085754	5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide	"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] which results in decreased expression of NOS2 protein"	16271043
C085754	5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide	"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] which results in increased expression of SOD2 protein"	16271043
C085754	5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide	"5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein"	15477225\|1627104
C489251	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]"	22952915
C489251	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]"	22952915
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C467893	A 182086	A 182086 binds to and results in decreased activity of EDNRA protein	12875994
C095427	A 86929	A 86929 binds to EDNRA protein	8558425
D000082	Acetaminophen	Acetaminophen results in increased expression of EDNRA mRNA	29067470
C056165	acetovanillone	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]	23270704
C056165	acetovanillone	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]	23270704
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of EDNRA gene	27153756
D000450	Aldosterone	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]	18660453
D000450	Aldosterone	[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]	18660453
D000496	Alloxan	Alloxan results in increased expression of EDNRA mRNA	12605241
D000496	Alloxan	Alloxan results in increased expression of EDNRA protein	12605241
C467894	ambrisentan	ambrisentan binds to and results in decreased activity of EDNRA protein	16219361
C467894	ambrisentan	ambrisentan results in decreased expression of EDNRA mRNA	16364719
C467894	ambrisentan	ambrisentan binds to and results in decreased activity of EDNRA protein	16364719
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of EDNRA mRNA	18247414
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of EDNRA mRNA	24449571
D001151	Arsenic	Arsenic affects the expression of EDNRA mRNA	19654921
D000069059	Atorvastatin Calcium	Atorvastatin Calcium promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]	23091284
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of EDNRA mRNA	23091284
D000069059	Atorvastatin Calcium	Losartan promotes the reaction [Atorvastatin Calcium results in decreased expression of EDNRA mRNA]	23091284
C098644	atrasentan	atrasentan binds to and results in decreased activity of EDNRA protein	12193141\|1516528
C098644	atrasentan	atrasentan binds to and results in decreased activity of EDNRA protein	18516094
C098644	atrasentan	atrasentan binds to and results in decreased activity of EDNRA protein	10877991\|1199450
C098644	atrasentan	[atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
C487081	belinostat	belinostat results in increased expression of EDNRA mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]	15015294
C061004	benidipine	benidipine results in decreased expression of EDNRA protein	16387788
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EDNRA mRNA	18247414
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EDNRA mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of EDNRA mRNA	19943105
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]	19943105
C006780	bisphenol A	bisphenol A results in increased expression of EDNRA mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of EDNRA mRNA	25181051
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRA protein	15334381
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRA protein	9811577
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRA protein	16219361
C086232	bosentan	"3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]"	11093786
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRA protein	15964565
C086232	bosentan	bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]	11093786
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRA protein	10796056\|1192290
C083116	BQ 485	[BQ 485 binds to and results in decreased activity of EDNRA protein] which results in decreased expression of BCL2 protein	14736733
C083116	BQ 485	BQ 485 binds to and results in decreased activity of EDNRA protein	14736733\|1509370
C083116	BQ 485	[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
C087220	BQ 610	BQ 610 binds to and results in decreased activity of EDNRA protein	15245872\|1602361
C405519	BSF 302146	BSF 302146 binds to and results in decreased activity of EDNRA protein	15754391
C405519	BSF 302146	BSF 302146 binds to and results in decreased activity of EDNRA protein	15838271
D002118	Calcium	Calcium affects the activity of EDNRA protein	12628492
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of EDNRA mRNA	17484886
D002330	Carmustine	EDNRA mRNA affects the susceptibility to Carmustine	16365179
D000068579	Celecoxib	Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein]	25656942
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of EDNRA mRNA"	19505368
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of EDNRA protein"	19505368
D002791	Cholesterol, Dietary	"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"	19505368
D002791	Cholesterol, Dietary	"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"	19505368
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"	19505368
D002791	Cholesterol, Dietary	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"	19505368
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of EDNRA mRNA	28472532
C109641	clazosentan	clazosentan binds to and results in decreased activity of EDNRA protein	16219361
D003042	Cocaine	Cocaine results in increased expression of EDNRA protein	18813882
D003042	Cocaine	Cocaine results in increased expression of EDNRA protein	17420087
C513821	CPU0213	"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"	19505368
C513821	CPU0213	"CPU0213 inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"	19505368
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]	18594475\|2030764
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]	20307649
D003471	Cuprizone	Cuprizone results in increased expression of EDNRA mRNA	27523638
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D003513	Cycloheximide	[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA	20561571
D003513	Cycloheximide	[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA protein	20561571
D016572	Cyclosporine	Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein]	25656942
D016572	Cyclosporine	Cyclosporine results in increased expression of EDNRA protein	25656942
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein	11535565
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDNRA protein	18813882
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein	15072961
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	"3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]"	11093786
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein	16151434\|1851609
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] affects the reaction [Doxorubicin results in increased activity of CASP3 protein]	14736733
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]	18660453
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased expression of BCL2 protein	14736733
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine	15834289
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine	15007106
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]	11093786
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein	10796056\|1236320
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDNRA protein	15605384\|1568555
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D003609	Dactinomycin	[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA	20561571
D003609	Dactinomycin	[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein	20561571
C107831	darusentan	darusentan binds to and results in decreased activity of EDNRA protein	11181473\|1621936
D003630	Daunorubicin	Daunorubicin results in increased expression of EDNRA protein	20888384
D003630	Daunorubicin	telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]	20888384
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of EDNRA mRNA	23640034
D013759	Dronabinol	Dronabinol results in increased expression of EDNRA mRNA	16616335
D003907	Dexamethasone	Dexamethasone results in decreased expression of EDNRA mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EDNRA mRNA	17361019
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EDNRA mRNA	21266533
D002945	Cisplatin	EDNRA protein affects the susceptibility to Cisplatin	17032313
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of EDNRA mRNA	20920545
C058705	diethyl malate	diethyl malate affects the expression of EDNRA mRNA	24814887
D004121	Dimethyl Sulfoxide	[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA	20561571
D004121	Dimethyl Sulfoxide	[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA protein	20561571
D004121	Dimethyl Sulfoxide	[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA	20561571
D004121	Dimethyl Sulfoxide	[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein	20561571
D004317	Doxorubicin	Doxorubicin results in decreased expression of EDNRA mRNA	28940058
D004317	Doxorubicin	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] affects the reaction [Doxorubicin results in increased activity of CASP3 protein]	14736733
D004317	Doxorubicin	[BQ 485 binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
D004317	Doxorubicin	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in decreased susceptibility to Doxorubicin]	14736733
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]"	15015294
C098288	enrasentan	enrasentan binds to and results in decreased activity of EDNRA protein	16219361
D005472	Fluorouracil	EDNRA protein affects the susceptibility to Fluorouracil	17032313
C079574	FR 139317	FR 139317 binds to and results in decreased activity of EDNRA protein	21259319
C079574	FR 139317	FR 139317 binds to and results in decreased activity of EDNRA protein	10877991\|1102850
D005632	Fructose	Fructose results in increased expression of EDNRA mRNA	14568997\|9869011
D005632	Fructose	KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA]	14568997
C070081	fulvestrant	[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA	19943105
C039281	furan	furan results in decreased expression of EDNRA mRNA	25539665
C039281	furan	furan results in increased expression of EDNRA mRNA	27387713
D003900	Desoxycorticosterone	"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]"	16271043
D003900	Desoxycorticosterone	[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDNRA protein	22431579
D003900	Desoxycorticosterone	EDNRA protein affects the susceptibility to Desoxycorticosterone	12600921
C074308	IRL 1620	EDNRA protein affects the susceptibility to IRL 1620	18823320
D007545	Isoproterenol	Isoproterenol results in increased expression of EDNRA mRNA	20003209
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]	18594475\|2030764
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]	20307649
D007545	Isoproterenol	Isoproterenol results in increased expression of EDNRA mRNA	18594475\|2030764
D007545	Isoproterenol	Isoproterenol results in increased expression of EDNRA protein	20307649
D007545	Isoproterenol	pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]	18594475
C119319	J 104132	J 104132 binds to EDNRA protein	11483691
C119319	J 104132	J 104132 binds to EDNRA protein	11483691
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of EDNRA mRNA	24796395
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of EDNRA mRNA	16807920
D019808	Losartan	Atorvastatin Calcium promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]	23091284
D019808	Losartan	Losartan promotes the reaction [Atorvastatin Calcium results in decreased expression of EDNRA mRNA]	23091284
D019808	Losartan	Losartan results in decreased expression of EDNRA mRNA	23091284
C113044	LU 224332	LU 224332 binds to and results in decreased activity of EDNRA protein	15754391
C113044	LU 224332	LU 224332 binds to and results in decreased activity of EDNRA protein	15838271
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of EDNRA mRNA	28001369
C008493	methylselenic acid	methylselenic acid results in increased expression of EDNRA mRNA	18548127
D015735	Mifepristone	Mifepristone results in decreased expression of EDNRA mRNA	25972201
D016686	Monocrotaline	Monocrotaline results in increased expression of EDNRA mRNA	20967148\|2202232
D016686	Monocrotaline	Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]	22022327
C470655	N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,3,3-trimethylbutanamide	"N-((2'-(((4,5-dimethyl-3-isoxazolyl)amino)sulfonyl)-4-(2-oxazolyl)(1,1'-biphenyl)-2-yl)methyl)-N,3,3-trimethylbutanamide binds to and results in decreased activity of EDNRA protein"	16219361
C485107	N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide	"N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide binds to and results in decreased activity of EDNRA protein"	16219361
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of EDNRA mRNA"	25511174
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of EDNRA mRNA"	25620056
D009538	Nicotine	Nicotine results in decreased expression of EDNRA mRNA	18247414
C007350	nitrofen	nitrofen results in decreased expression of EDNRA mRNA	12407540
C007350	nitrofen	nitrofen results in increased expression of EDNRA mRNA	10693666\|1985177
C007350	nitrofen	nitrofen results in increased expression of EDNRA protein	19851775
D009638	Norepinephrine	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine	15834289
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRA mRNA	21926265
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRA protein	21926265
D010100	Oxygen	Oxygen results in increased expression of EDNRA mRNA	25203536
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]	21926265
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]	21926265
D010100	Oxygen	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]	23270704
D010100	Oxygen	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]	23270704
D010100	Oxygen	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]	23270704
D010100	Oxygen	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]	23270704
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRA mRNA	23270704
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRA protein	23270704
D010126	Ozone	Ozone results in decreased expression of EDNRA mRNA	16081523
D010126	Ozone	Ozone results in increased expression of EDNRA mRNA	20980218
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of EDNRA mRNA	26272509
D010269	Paraquat	Paraquat affects the expression of EDNRA mRNA	16854511
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D052638	Particulate Matter	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
D052638	Particulate Matter	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D052638	Particulate Matter	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
D052638	Particulate Matter	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D052638	Particulate Matter	Particulate Matter results in increased expression of EDNRA mRNA	26496744
D052638	Particulate Matter	Particulate Matter results in increased expression of EDNRA protein	20561571\|2649674
D052638	Particulate Matter	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
D052638	Particulate Matter	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D052638	Particulate Matter	U 0126 inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	26496744
C082887	PD 145065	PD 145065 binds to and results in decreased activity of EDNRA protein	17578707
C087850	PD 151242	PD 151242 binds to and results in decreased activity of EDNRA protein	12363203
C106950	PD 156252	PD 156252 binds to and results in decreased activity of EDNRA protein	11751199
C093321	PD 156707	PD 156707 binds to and results in decreased activity of EDNRA protein	11509453
C093321	PD 156707	PD 156707 binds to EDNRA protein	21275367
D010656	Phenylephrine	[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine	15007106
D010656	Phenylephrine	phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]	15007106
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of EDNRA mRNA	26272509
C008890	phosphoramidon	phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]	15007106
C008890	phosphoramidon	phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]	15007106
D010795	Phthalic Acids	Phthalic Acids results in increased expression of EDNRA mRNA	21061450
C004479	pimagedine	pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]	18594475
C006253	pirinixic acid	pirinixic acid results in decreased expression of EDNRA mRNA	16985257
D011189	Potassium Chloride	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein	18516094
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of EDNRA mRNA	23608068
D011374	Progesterone	Progesterone results in decreased expression of EDNRA mRNA	21795739
D011441	Propylthiouracil	Propylthiouracil results in increased expression of EDNRA mRNA	24780913
D015237	Dinoprost	Dinoprost results in decreased expression of EDNRA mRNA	20484870
C043680	ptaquiloside	[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of EDNRA mRNA	23274088
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of EDNRA mRNA	12972712
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]	20561571
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	20561571
D011791	Quartz	Quartz results in decreased expression of EDNRA mRNA	27917503
C502851	quinocetone	quinocetone results in increased expression of EDNRA mRNA	27046791
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA	19059307
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA	19059307
D017382	Reactive Oxygen Species	"[5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]"	16271043
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]	21926265
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]	21926265
C057354	sarafotoxins s6	sarafotoxins s6 binds to and results in increased activity of EDNRA protein	15245872
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of EDNRA mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of EDNRA mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of EDNRA mRNA	25351596
D019821	Simvastatin	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]"	19505368
D019821	Simvastatin	"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]"	19505368
D019821	Simvastatin	Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]	22022327
C106276	sitaxsentan	sitaxsentan binds to and results in decreased activity of EDNRA protein	16219361
C106276	sitaxsentan	sitaxsentan binds to and results in decreased activity of EDNRA protein	12388107\|1723451
D012906	Smoke	Smoke results in increased expression of EDNRA mRNA	21095227
C017947	sodium arsenite	EDNRA protein affects the reaction [sodium arsenite results in decreased expression of PLIN1 protein]	23650128
C017947	sodium arsenite	sodium arsenite results in decreased expression of and affects the splicing of EDNRA mRNA	25879800
D012965	Sodium Chloride	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA protein	18516094
D012965	Sodium Chloride	[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of EDNRA protein	22431579
D018038	Sodium Selenite	[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of EDNRA mRNA	23274088
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]	15015294
D013311	Streptozocin	"Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of EDNRA mRNA]"	15015294
D013311	Streptozocin	Streptozocin results in increased expression of EDNRA mRNA	15015294
D010042	Ouabain	Ouabain results in increased expression of EDNRA mRNA	15477225\|1698243
D010042	Ouabain	Ouabain results in increased expression of EDNRA protein	16982439
D013481	Superoxides	EDNRA protein affects the abundance of Superoxides	12600921
D013481	Superoxides	[atrasentan binds to and results in decreased activity of EDNRA protein] inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]	12600921
D016559	Tacrolimus	Tacrolimus results in increased activity of EDNRA protein	15964565
D016559	Tacrolimus	Tacrolimus results in increased expression of EDNRA mRNA	8587392
C088196	TAK 044	TAK 044 binds to and results in decreased activity of EDNRA protein	11327643
D013629	Tamoxifen	[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA	19943105
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in increased expression of EDNRA mRNA	19059307
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA	19059307
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]	19943105
D013629	Tamoxifen	Tamoxifen results in increased expression of EDNRA mRNA	19943105
C424912	TBC 3214	TBC 3214 binds to and results in decreased activity of EDNRA protein	15580650
C084178	telmisartan	telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]	20888384
C047246	temozolomide	EDNRA mRNA affects the susceptibility to temozolomide	16365179
D013739	Testosterone	Testosterone affects the expression of EDNRA mRNA	12122504\|1461647
C004648	testosterone enanthate	testosterone enanthate affects the expression of EDNRA mRNA	17440010
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of EDNRA mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EDNRA mRNA	26290441
C120582	tezosentan	tezosentan binds to and results in decreased activity of EDNRA protein	16219361
C120582	tezosentan	tezosentan binds to and results in decreased activity of EDNRA protein	16181825\|1632700
C009495	titanium dioxide	titanium dioxide affects the expression of EDNRA mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of EDNRA mRNA	28065790
D014028	Tobacco Smoke Pollution	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]"	22952915
D014028	Tobacco Smoke Pollution	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]"	22952915
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EDNRA mRNA	22952915\|2721244
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EDNRA protein	22952915\|2721244
D014028	Tobacco Smoke Pollution	U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]	27212444
D014028	Tobacco Smoke Pollution	U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]	27212444
D014212	Tretinoin	Tretinoin results in increased expression of EDNRA mRNA	18230668
D014212	Tretinoin	Tretinoin results in decreased expression of EDNRA mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of EDNRA mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of EDNRA gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of EDNRA mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in decreased expression of EDNRA mRNA	15901671
C113580	U 0126	U 0126 inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]	26496744
C113580	U 0126	U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA mRNA]	27212444
C113580	U 0126	U 0126 inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]	27212444
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of EDNRA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of EDNRA mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of EDNRA mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of EDNRA mRNA	24896083
D014635	Valproic Acid	Valproic Acid results in decreased expression of EDNRA mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of EDNRA mRNA	20980218
C025643	vinclozolin	vinclozolin affects the expression of EDNRA mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of EDNRA mRNA	20566332
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of EDNRA mRNA	19244175
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of EDNRA mRNA	26272509
C415840	ZD 2574	ZD 2574 binds to and results in decreased activity of EDNRA protein	11046091
C511404	ZD4054	[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA	19943105

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004435	phosphatidylinositol phospholipase C activity	-	TAS	8702836
GO:0004962	endothelin receptor activity	-	NAS	8611157 9284755
GO:0005515	protein binding	-	IPI	19202075 23597562

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001569	branching involved in blood vessel morphogenesis	-	IEA	-
GO:0001666	response to hypoxia	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0006939	smooth muscle contraction	-	NAS	9284755
GO:0007165	signal transduction	-	TAS	1326535
GO:0007186	G-protein coupled receptor signaling pathway	-	NAS	8611157
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007190	activation of adenylate cyclase activity	-	TAS	8702836
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007202	activation of phospholipase C activity	-	TAS	8702836
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	TAS	1849646
GO:0007507	heart development	-	IEA	-
GO:0007585	respiratory gaseous exchange	-	ISS	-
GO:0008217	regulation of blood pressure	-	IEA	-
GO:0008283	cell proliferation	-	NAS	9284755
GO:0010827	regulation of glucose transmembrane transport	-	IEA	-
GO:0014032	neural crest cell development	-	IEA	-
GO:0014824	artery smooth muscle contraction	-	IMP	8982507
GO:0042310	vasoconstriction	-	IMP	8982507
GO:0048484	enteric nervous system development	-	IEA	-
GO:0060322	head development	-	IEA	-
GO:0086100	endothelin receptor signaling pathway	-	IEA	-
GO:1904659	glucose transmembrane transport	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	1326535

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04270	Vascular smooth muscle contraction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25746325	Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. (2015 May 15)	Li C	Gene
28761511	Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. (2017 Jul-Sep)	Theodotou CB	Asian J Neurosurg
23336501	Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population. (2013 May)	Lind L	Acta Physiol (Oxf)