Gene: AHCY

191
SAHH|adoHcyase
adenosylhomocysteinase
protein-coding
20q11.22
Ensembl:ENSG00000101444 MIM:180960 Vega:OTTHUMG00000140098 UniprotKB:P23526
NG_012630.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.979e-1 (AD)  2.289e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF4H0.939
CCT70.938
PSMD70.938
XRCC60.937
UBE2D20.933
PA2G40.933
EMC30.93
VCP0.929
AKR1B10.928
RNF340.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.743
OR4F29-0.728
MTRNR2L6-0.366
MTRNR2L9-0.34
MTRNR2L10-0.328
P2RY14-0.288
TTLL10-0.281
C8orf74-0.265
KLRB1-0.263
MTRNR2L3-0.244

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02325Isopropyl AlcoholSmall Molecule67-63-0Approved|InvestigationalTarget
DB03216(1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)AdenineSmall MoleculeExperimentalTarget
DB032733'-Oxo-AdenosineSmall MoleculeExperimentalTarget
DB03769D-EritadenineSmall Molecule23918-98-1ExperimentalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AHCY mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of AHCY protein"21673325
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of AHCY protein"27604104
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AHCY mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AHCY mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AHCY mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AHCY mRNA"25510870
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of AHCY protein26194647
C0182583-deazaadenosine3-deazaadenosine results in decreased activity of AHCY protein9277463
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AHCY mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of AHCY mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of AHCY mRNA19103213
D000082AcetaminophenAcetaminophen affects the expression of AHCY protein16687475
D020106AcrylamideAcrylamide results in increased expression of AHCY mRNA28959563
D012435S-AdenosylhomocysteineAHCY results in increased hydrolysis of S-Adenosylhomocysteine26974671
D012435S-AdenosylhomocysteineAHCY protein results in increased hydrolysis of S-Adenosylhomocysteine23665415
D012435S-Adenosylhomocysteine[AHCY protein results in increased hydrolysis of S-Adenosylhomocysteine] which results in increased chemical synthesis of Homocysteine23665415
D012435S-AdenosylhomocysteineS-Adenosylhomocysteine results in decreased activity of AHCY protein95822
D012435S-AdenosylhomocysteineVitamin U inhibits the reaction [S-Adenosylhomocysteine results in decreased activity of AHCY protein]95822
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of AHCY gene27153756
D006710Homocysteine[Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine18487201
D006710Homocysteine[AHCY protein results in increased hydrolysis of S-Adenosylhomocysteine] which results in increased chemical synthesis of Homocysteine23665415
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AHCY mRNA16483693
D001151ArsenicArsenic results in increased expression of AHCY mRNA18487201
D001151ArsenicArsenic results in increased expression of and results in increased activity of AHCY protein18487201
D001151Arsenic[Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine18487201
C006632arsenic trioxidearsenic trioxide results in increased expression of AHCY mRNA22521957
D001280AtrazineAtrazine results in increased expression of AHCY mRNA25929836
D001554BenzeneBenzene results in increased expression of AHCY mRNA15120971|1512265
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of AHCY mRNA26377693
D001622BetaineBetaine results in decreased expression of AHCY mRNA22945834
D001622BetaineBetaine results in decreased expression of AHCY mRNA26391144
C006780bisphenol Abisphenol A affects the expression of AHCY mRNA21786754
C006780bisphenol Abisphenol A affects the expression of AHCY mRNA21786754
C006780bisphenol Abisphenol A affects the expression of AHCY mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of AHCY protein22649256
D002065BuspironeBuspirone results in increased expression of AHCY mRNA24136188
D002104CadmiumCadmium results in decreased expression of AHCY mRNA24603357
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AHCY protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AHCY mRNA23741332
D002108CeruletideCeruletide results in decreased expression of AHCY protein18024178
C100187chloropicrinchloropicrin results in decreased expression of AHCY mRNA26352163|2847649
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of AHCY mRNA23439872
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] inhibits the reaction [CEBPB protein binds to AHCY promoter]23439872
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AHCY mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AHCY gene20938992
D002994ClofibrateClofibrate results in decreased expression of AHCY protein19952500
D002994ClofibrateClofibrate results in decreased expression of AHCY mRNA17585979
D003300CopperCopper results in decreased expression of AHCY mRNA24603357
D003300CopperCopper results in decreased expression of AHCY mRNA22465980
C030973cupric oxidecupric oxide results in decreased expression of AHCY protein25470785
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AHCY mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AHCY mRNA27392435
D002945CisplatinCisplatin results in increased expression of AHCY mRNA27392435
D002945CisplatinCisplatin results in increased expression of AHCY protein21424131
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AHCY mRNA20360939
D004147DioxinsDioxins affects the expression of AHCY mRNA20463971
D004317DoxorubicinDoxorubicin results in decreased expression of AHCY mRNA18510171
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AHCY protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AHCY mRNA22079256
D005419FlavonoidsFlavonoids results in decreased expression of AHCY mRNA18035473
C470754fluoroneplanocin Afluoroneplanocin A binds to and results in decreased activity of AHCY protein21226494
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of AHCY mRNA23439872
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] inhibits the reaction [CEBPB protein binds to AHCY promoter]23439872
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AHCY mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AHCY gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of AHCY mRNA23649840
C056933fumonisin B1fumonisin B1 results in decreased expression of AHCY mRNA16221962
D005897GlafenineGlafenine results in decreased expression of AHCY mRNA24136188
D017313FenretinideFenretinide results in increased expression of AHCY mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of AHCY mRNA15458575
C492448ICG 001ICG 001 results in decreased expression of AHCY mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AHCY mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of AHCY mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AHCY mRNA27392435
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of AHCY mRNA19187980
C045463leflunomideleflunomide results in increased expression of AHCY mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of AHCY mRNA"24972896
D008148LovastatinLovastatin results in decreased expression of AHCY mRNA20493250
C005095malachite greenmalachite green results in decreased expression of AHCY protein22446826
D008627Mercuric ChlorideMercuric Chloride affects the expression of AHCY protein21458406
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of AHCY mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AHCY gene20938992
D008727MethotrexateMethotrexate affects the expression of AHCY mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AHCY mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of AHCY mRNA27544571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AHCY mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of AHCY mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AHCY mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AHCY mRNA"25554681|2562005
C031096neplanocin Aneplanocin A binds to and results in decreased activity of AHCY protein21226494
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of AHCY mRNA19187980
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of AHCY protein19716841
C025256nonylphenolnonylphenol results in decreased expression of AHCY protein19260726
D010100OxygenOxygen deficiency results in decreased expression of AHCY protein19579223
D010269ParaquatParaquat results in increased expression of AHCY mRNA15458575
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AHCY mRNA"25510870
D010396PenicillaminePenicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]22945834
D010396PenicillaminePenicillamine results in increased activity of AHCY protein22945834
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of AHCY protein19954255
D010416PentachlorophenolPentachlorophenol results in decreased expression of AHCY mRNA24642059
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of AHCY protein26168851
D010634PhenobarbitalPhenobarbital results in decreased expression of AHCY protein19952500
D010634PhenobarbitalPhenobarbital results in decreased expression of AHCY mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in increased expression of AHCY mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of AHCY mRNA16221962|2381119
C006253pirinixic acidpirinixic acid results in increased expression of AHCY protein15226431
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of AHCY mRNA]16221962
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AHCY mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of AHCY mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of AHCY mRNA28903501
C045950propiconazolepropiconazole results in increased metabolism of AHCY protein19714882
C015586propiverinepropiverine binds to AHCY protein29273565
C059514resveratrolresveratrol affects the expression of AHCY protein22234583
D012254RibavirinRibavirin results in decreased activity of AHCY15488656
D012524SarinSarin results in decreased expression of AHCY mRNA19522546
C009277sodium arsenatesodium arsenate results in decreased expression of AHCY mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of AHCY gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AHCY mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AHCY mRNA18465118
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AHCY mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of AHCY mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AHCY protein22595367|2260951
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AHCY protein27319396
D014241TrichloroethyleneTrichloroethylene results in decreased expression of AHCY mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of AHCY mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of AHCY mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of AHCY mRNA17292431
D014640VancomycinVancomycin results in increased expression of AHCY mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AHCY gene25560391
D014814Vitamin UVitamin U inhibits the reaction [S-Adenosylhomocysteine results in decreased activity of AHCY protein]95822
D014814Vitamin UVitamin U results in increased activity of AHCY protein95822
D014859WarfarinWarfarin results in decreased expression of AHCY mRNA20493250
D015032ZincZinc results in increased expression of AHCY mRNA20719420

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004013adenosylhomocysteinase activity-IBA21873635  
GO:0004013adenosylhomocysteinase activity-TAS2596825  
GO:0005515protein binding-IPI25416956  25910212  
GO:0030554adenyl nucleotide binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000096sulfur amino acid metabolic process-TAS-  
GO:0001666response to hypoxia-IEA-  
GO:0002439chronic inflammatory response to antigenic stimulus-IEA-  
GO:0006730one-carbon metabolic process-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0019510S-adenosylhomocysteine catabolic process-IEA-  
GO:0032259methylation-TAS-  
GO:0033353S-adenosylmethionine cycle-IBA21873635  
GO:0042745circadian sleep/wake cycle-IEA-  
GO:0071268homocysteine biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0042470melanosome-IEA-  
GO:0043005neuron projection-IEA-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-5578997Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet