Gene info: ID 1910

Gene: EDNRB

GENE ID: 1910

Description: endothelin receptor type B

Gene type: protein-coding

Location: 13q22.3

dbXrefs: Ensembl:ENSG00000136160 MIM:131244 Vega:OTTHUMG00000017111 UniprotKB:P24530

RefSeq: NG_011630.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.089e-1 (AD) 3.996e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07495027	chr13:78492216	EDNRB	Gene body	9.944e-5	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC4A4	0.914
ELOVL2	0.902
PREX2	0.891
GPC5	0.89
SDC2	0.887
GJA1	0.883
ARHGEF26	0.874
HEPH	0.873
BMPR1B	0.873
SLC1A3	0.873

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CACNA1F	-0.433
FAM160A1	-0.392
THEM5	-0.391
DRGX	-0.384
TRABD2A	-0.379
CCDC68	-0.378
OSBPL10	-0.374
ARHGEF28	-0.374
DUSP27	-0.372
NRG1	-0.372

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00559	Bosentan	Small Molecule	147536-97-8	Approved\|Investigational	Target
DB06138	IRL-1620	Small Molecule	142569-99-1	Investigational	Target
DB06268	Sitaxentan	Small Molecule	184036-34-8	Approved\|Investigational\|Withdrawn	Target
DB06403	Ambrisentan	Small Molecule	177036-94-1	Approved\|Investigational	Target
DB06460	Enrasentan	Small Molecule	167256-08-8	Investigational	Target
DB06558	Tezosentan	Small Molecule	180384-57-0	Investigational	Target
DB08932	Macitentan	Small Molecule	441798-33-0	Approved	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of EDNRB mRNA"	26377693
C020888	1,2-dielaidoylphosphatidylethanolamine	"1,2-dielaidoylphosphatidylethanolamine results in decreased expression of EDNRB mRNA alternative form"	14668052
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of EDNRB mRNA"	19162173
C095653	1,5-dihydroxyisoquinoline	"1,5-dihydroxyisoquinoline results in decreased expression of EDNRB mRNA"	12824290
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]"	15245872
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]"	15245872
C040168	19-oxo-11-deoxycorticosterone acetate	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA	18823320
C040168	19-oxo-11-deoxycorticosterone acetate	atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA]	18823320
C087551	1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-	"1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)- binds to and results in decreased activity of EDNRB protein"	14687651
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of EDNRB mRNA	25088246
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25772258
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C080122	7-nitroindazole	7-nitroindazole inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C080122	7-nitroindazole	7-nitroindazole inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C016276	8-bromocyclic GMP	8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]	16023617
C016276	8-bromocyclic GMP	8-bromocyclic GMP inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]	16023617
C467893	A 182086	A 182086 binds to and results in decreased activity of EDNRB protein	12875994
C120508	A 192621	A 192621 binds to and results in decreased activity of EDNRB protein	19040731
C120508	A 192621	A 192621 binds to and results in decreased activity of EDNRB protein	10877991\|1199450
C095427	A 86929	A 86929 binds to EDNRB protein	8558425
D000082	Acetaminophen	Acetaminophen results in decreased expression of EDNRB mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of EDNRB mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of EDNRB mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of EDNRB mRNA	28959563
D000496	Alloxan	Alloxan results in increased expression of EDNRB mRNA	12605241
D000496	Alloxan	Alloxan results in increased expression of EDNRB protein	12605241
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EDNRB mRNA	16483693
D000666	Amphotericin B	Amphotericin B results in increased expression of EDNRB mRNA	20849824
D000804	Angiotensin II	Angiotensin II results in increased expression of EDNRB protein	15007106
D001151	Arsenic	Arsenic results in decreased expression of EDNRB mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of EDNRB mRNA	26705709
C006632	arsenic trioxide	arsenic trioxide results in increased expression of EDNRB mRNA alternative form	19128835
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of EDNRB mRNA	15305145
D001241	Aspirin	Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB]	12126971
C098644	atrasentan	atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA]	18823320
C547126	AZM551248	AZM551248 results in decreased expression of EDNRB mRNA	22323515
C487081	belinostat	belinostat results in increased expression of EDNRB mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C061004	benidipine	benidipine results in decreased expression of EDNRB protein	16387788
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EDNRB mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EDNRB mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of EDNRB mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EDNRB mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of EDNRB mRNA	22228805\|2261060
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EDNRB mRNA	19770486\|2196490
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of EDNRB mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of EDNRB mRNA	20660070
C095105	bexarotene	bexarotene results in increased expression of EDNRB mRNA	16648578
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C006780	bisphenol A	bisphenol A results in increased methylation of EDNRB promoter	27271280
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDNRB mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of EDNRB mRNA	25181051
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRB protein	15334381
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRB protein	16219361
C086232	bosentan	bosentan binds to and results in decreased activity of EDNRB protein	10796056\|1192290
C086539	BQ 788	BQ 788 binds to and results in decreased activity of EDNRB protein	19040731
C086539	BQ 788	BQ 788 binds to and results in decreased activity of EDNRB protein	16151434\|2125931
C086539	BQ 788	BQ 788 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C086539	BQ 788	BQ 788 inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C086539	BQ 788	BQ 788 results in decreased expression of EDNRB protein	24462674
C086539	BQ 788	Celecoxib inhibits the reaction [BQ 788 results in decreased expression of EDNRB protein]	24462674
C086539	BQ 788	Celecoxib results in decreased susceptibility to [BQ 788 binds to and results in decreased activity of EDNRB protein]	24462674
C086539	BQ 788	BQ 788 binds to and results in decreased activity of EDNRB protein	11028503\|1236320
C086539	BQ 788	BQ 788 results in decreased activity of EDNRB protein	15605384
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of EDNRB mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of EDNRB mRNA	16644059
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased activity of EDNRB protein	12873816
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of EDNRB mRNA	12873816\|1623916
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of EDNRB protein	12708965
D002251	Carbon Tetrachloride	EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]	18205269
D000068579	Celecoxib	Celecoxib inhibits the reaction [BQ 788 results in decreased expression of EDNRB protein]	24462674
D000068579	Celecoxib	Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of EDNRB protein]	24462674
D000068579	Celecoxib	Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25656942
D000068579	Celecoxib	Celecoxib results in decreased susceptibility to [BQ 788 binds to and results in decreased activity of EDNRB protein]	24462674
D002699	Chlorambucil	Chlorambucil results in increased mutagenesis of EDNRB gene	10517996
D002737	Chloroprene	Chloroprene results in increased expression of EDNRB mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of EDNRB mRNA	20691718
D002793	Cholic Acids	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of EDNRB mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EDNRB mRNA	20938992
D002857	Chromium	LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of EDNRB mRNA]	16940432
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EDNRB mRNA	27858113
C418118	CI 1044	CI 1044 results in increased expression of EDNRB mRNA	17569694
D003042	Cocaine	Cocaine affects the expression of EDNRB mRNA	20187946
D003078	Colchicine	Colchicine results in increased expression of EDNRB mRNA	20624997
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRB mRNA]	18594475
D003471	Cuprizone	Cuprizone results in increased expression of EDNRB mRNA	26577399\|2752363
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of EDNRB mRNA	20849824
D016572	Cyclosporine	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
D016572	Cyclosporine	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25772258
D016572	Cyclosporine	Celecoxib inhibits the reaction [Cyclosporine results in decreased expression of EDNRB protein]	24462674
D016572	Cyclosporine	Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25656942
D016572	Cyclosporine	Cyclosporine results in decreased expression of EDNRB protein	24462674\|2565694
D016572	Cyclosporine	Cyclosporine results in increased expression of EDNRB mRNA	25772258
D016572	Cyclosporine	Cyclosporine results in increased expression of EDNRB protein	25772258
D016572	Cyclosporine	Dactinomycin inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
D016572	Cyclosporine	SB 203580 inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
D016572	Cyclosporine	SB 203580 inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25772258
D016572	Cyclosporine	U 0126 inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
D016572	Cyclosporine	U 0126 inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25772258
C077420	Cys(11)-Cys(15)-endothelin-1 (11-21)	Cys(11)-Cys(15)-endothelin-1 (11-21) results in decreased activity of EDNRB protein	15685554
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D003609	Dactinomycin	Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]	22207076
D003630	Daunorubicin	Daunorubicin results in increased expression of EDNRB protein	20888384
D003630	Daunorubicin	telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein]	20888384
D003907	Dexamethasone	Dexamethasone results in increased expression of EDNRB mRNA	21356098
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDNRB mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of EDNRB mRNA	28628672
D003907	Dexamethasone	Dexamethasone promotes the reaction [nitrofen results in increased expression of EDNRB mRNA]	10693666
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EDNRB mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin results in increased expression of EDNRB mRNA	20849824
D004041	Dietary Fats	Dietary Fats results in decreased expression of EDNRB mRNA	18042831\|2501614
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of EDNRB mRNA	20920545
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of EDNRB mRNA	19638242
D002117	Calcitriol	Calcitriol results in increased expression of EDNRB mRNA	12230499
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EDNRB mRNA"	19480007
D004121	Dimethyl Sulfoxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D004121	Dimethyl Sulfoxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
D004121	Dimethyl Sulfoxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]]	20561571
D004121	Dimethyl Sulfoxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]]	20561571
D004121	Dimethyl Sulfoxide	Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D004121	Dimethyl Sulfoxide	Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
D004121	Dimethyl Sulfoxide	Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D004121	Dimethyl Sulfoxide	Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of EDNRB mRNA	20561571
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of EDNRB protein	20561571
D004121	Dimethyl Sulfoxide	pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D004121	Dimethyl Sulfoxide	pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
D004121	Dimethyl Sulfoxide	wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
D004121	Dimethyl Sulfoxide	wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
C098288	enrasentan	enrasentan binds to and results in decreased activity of EDNRB protein	16219361
C118739	entinostat	entinostat results in increased expression of EDNRB mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EDNRB mRNA	22079256
D000431	Ethanol	Ethanol results in decreased expression of EDNRB protein	16651399
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of EDNRB mRNA	27344345
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of EDNRB gene	17174358\|9475716
D005047	Etoposide	Etoposide results in decreased expression of EDNRB mRNA	25270620
D005280	Fenoterol	Fenoterol results in increased expression of EDNRB mRNA	16340002
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EDNRB mRNA	20938992
D005620	Freund's Adjuvant	Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of EDNRB mRNA]	12810352
C419708	gefitinib	gefitinib inhibits the reaction [TGFA protein results in decreased expression of EDNRB mRNA]	18424623
D005839	Gentamicins	Gentamicins results in increased expression of EDNRB mRNA	20849824
D005839	Gentamicins	Gentamicins results in increased expression of EDNRB protein	15200423
D005839	Gentamicins	[Gentamicins results in increased expression of EDNRB protein] which results in increased abundance of Nitrites	15200423
C010176	halofuginone	halofuginone results in increased expression of EDNRB mRNA	17180598
D017313	Fenretinide	Fenretinide results in increased expression of EDNRB mRNA	28973697
D007213	Indomethacin	Indomethacin inhibits the reaction [IL1B results in increased activity of EDNRB]	12126971
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDNRB mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of EDNRB mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EDNRB mRNA	25613284
C074308	IRL 1620	IRL 1620 binds to and results in increased activity of EDNRB protein	16151434
C074308	IRL 1620	IRL 1620 binds to and results in increased activity of EDNRB protein	10961375
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EDNRB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of EDNRB mRNA	28628672
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRB mRNA]	18594475
D007545	Isoproterenol	Isoproterenol results in increased expression of EDNRB mRNA	18594475
C119319	J 104132	J 104132 binds to EDNRB protein	11483691
C119319	J 104132	J 104132 binds to EDNRB protein	11483691
C063302	KN 62	KN 62 inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C063302	KN 62	KN 62 inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C008261	lead acetate	lead acetate results in increased expression of EDNRB mRNA	22839698
C031895	lead chromate	lead chromate results in increased expression of EDNRB mRNA	23584427
C113044	LU 224332	LU 224332 binds to and results in decreased activity of EDNRB protein	15754391
C113044	LU 224332	LU 224332 binds to and results in decreased activity of EDNRB protein	15838271
C042720	mercuric bromide	mercuric bromide results in increased expression of EDNRB mRNA	26272509
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EDNRB mRNA	20938992
D008727	Methotrexate	Methotrexate affects the expression of EDNRB mRNA	18502557
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EDNRB mRNA"	26251327
D008770	Methylnitrosourea	Methylnitrosourea results in increased mutagenesis of EDNRB gene	17174358
D008775	Methylprednisolone	Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA]	7756592
C008493	methylselenic acid	methylselenic acid results in increased expression of EDNRB mRNA	18548127
D015735	Mifepristone	Mifepristone results in increased expression of EDNRB mRNA	17584828
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]	15245872
C492919	N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide	"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Smoke results in increased expression of EDNRB protein]"	18718921
C492919	N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide	"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]"	22207076
C492919	N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide	"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [TNF protein results in increased expression of EDNRB protein]"	22207076
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of EDNRB mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of EDNRB mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of EDNRB mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of EDNRB mRNA	19812364
D009525	Niacin	LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of EDNRB mRNA]	16940432
D009538	Nicotine	Nicotine results in increased activity of EDNRB protein	21316381
C012655	nimesulide	nimesulide inhibits the reaction [IL1B results in increased activity of EDNRB]	12126971
D009569	Nitric Oxide	[EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide	16380457
D009569	Nitric Oxide	EDN1 protein promotes the reaction [EDNRB protein results in increased chemical synthesis of Nitric Oxide]	10976779
D009569	Nitric Oxide	EDNRB protein affects the secretion of Nitric Oxide	11067800
D009569	Nitric Oxide	EDNRB protein results in increased chemical synthesis of Nitric Oxide	10976779
D009573	Nitrites	[Gentamicins results in increased expression of EDNRB protein] which results in increased abundance of Nitrites	15200423
C007350	nitrofen	Dexamethasone promotes the reaction [nitrofen results in increased expression of EDNRB mRNA]	10693666
C007350	nitrofen	nitrofen results in increased expression of EDNRB mRNA	10693666\|1985177
C007350	nitrofen	nitrofen results in increased expression of EDNRB protein	19851775
D009599	Nitroprusside	Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]	16023617
D009599	Nitroprusside	Nitroprusside inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein]	16023617
C025256	nonylphenol	nonylphenol results in increased expression of EDNRB mRNA	15620428
D009638	Norepinephrine	[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine	16023617
D009638	Norepinephrine	[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine	16023617
C484027	oligofectamine	oligofectamine results in increased expression of EDNRB mRNA	14668052
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRB mRNA	24236059
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRB mRNA	21926265
D010100	Oxygen	Oxygen deficiency results in increased expression of EDNRB protein	21926265
D010100	Oxygen	Oxygen results in increased expression of EDNRB mRNA	25203536
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRB mRNA]	21926265
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRB protein]	21926265
D010126	Ozone	[Ozone co-treated with Vehicle Emissions] results in increased expression of EDNRB mRNA	20980218
D010126	Ozone	Ozone results in increased expression of EDNRB mRNA	16081523\|2098021
D000073878	Palm Oil	Palm Oil results in decreased expression of EDNRB mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of EDNRB mRNA	26272509
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] affects the expression of EDNRB mRNA	17715259
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]]	20561571
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]]	20561571
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
D052638	Particulate Matter	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	Cycloheximide inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
D052638	Particulate Matter	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
D052638	Particulate Matter	Particulate Matter results in increased expression of EDNRB mRNA	16081523\|2056157
D052638	Particulate Matter	Particulate Matter results in increased expression of EDNRB protein	20561571\|2649674
D052638	Particulate Matter	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571\|2649674
D052638	Particulate Matter	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571\|2649674
D052638	Particulate Matter	Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
D052638	Particulate Matter	U 0126 inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	26496744
D052638	Particulate Matter	wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D052638	Particulate Matter	wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
C082887	PD 145065	PD 145065 binds to and results in decreased activity of EDNRB protein	17578707
C106950	PD 156252	PD 156252 binds to and results in decreased activity of EDNRB protein	11751199
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of EDNRB mRNA	23602845
D010634	Phenobarbital	Phenobarbital affects the expression of EDNRB mRNA	23091169
D010656	Phenylephrine	Phenylephrine results in increased expression of EDNRB protein	15007106
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of EDNRB mRNA	26272509
C008890	phosphoramidon	phosphoramidon results in increased expression of EDNRB protein	15007106
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] affects the expression of EDNRB mRNA	17715259
D010852	Picrotoxin	Picrotoxin results in decreased expression of EDNRB mRNA	15170462
C121565	pifithrin	pifithrin results in decreased expression of EDNRB mRNA	19098008
D010972	Platelet Activating Factor	EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]	18205269
D010972	Platelet Activating Factor	EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]	18205269
D011189	Potassium Chloride	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA	18823320
D011189	Potassium Chloride	atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA]	18823320
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EDNRB mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of EDNRB mRNA	22079256
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of EDNRB mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of EDNRB mRNA	21540246
D011374	Progesterone	Progesterone results in increased expression of EDNRB mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of EDNRB mRNA	24780913
D015237	Dinoprost	Dinoprost results in increased expression of EDNRB mRNA	20484870
D011464	Epoprostenol	EDNRB protein affects the secretion of Epoprostenol	11067800
D011692	Puromycin Aminonucleoside	Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA]	7756592
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of EDNRB mRNA	7756592
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571\|2649674
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D011794	Quercetin	Quercetin results in increased expression of EDNRB mRNA	21356098
D011794	Quercetin	Quercetin results in increased expression of EDNRB mRNA	15309432
D011794	Quercetin	Quercetin affects the expression of EDNRB mRNA	18178720
C116926	rofecoxib	rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]	12126971
C089730	rosiglitazone	rosiglitazone results in increased expression of EDNRB mRNA	20516393
C089730	rosiglitazone	rosiglitazone results in increased expression of EDNRB protein	20516393
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRB mRNA]	21926265
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRB protein]	21926265
C089730	rosiglitazone	rosiglitazone promotes the reaction [[PPARG protein binds to EDNRB promoter] which results in increased expression of EDNRB mRNA]	20516393\|2051639
C089730	rosiglitazone	rosiglitazone results in increased expression of EDNRB mRNA	20516393
C089730	rosiglitazone	rosiglitazone results in increased expression of EDNRB protein	20516393
C089730	rosiglitazone	rosiglitazone results in increased expression of EDNRB mRNA	21172411
C057354	sarafotoxins s6	sarafotoxins s6 binds to and results in increased activity of EDNRB protein	15072961
C057354	sarafotoxins s6	sarafotoxins s6 binds to and results in increased activity of EDNRB protein	12056553\|1236320
C093642	SB 203580	SB 203580 inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
C093642	SB 203580	SB 203580 inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25772258
C093642	SB 203580	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
C093642	SB 203580	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571\|2649674
C093642	SB 203580	SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]	18718921
C093642	SB 203580	SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
C406525	SB 239063	SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]	18718921
C406525	SB 239063	SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
D012906	Smoke	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
D012906	Smoke	Cycloheximide inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D012906	Smoke	Dactinomycin inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D012906	Smoke	"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Smoke results in increased expression of EDNRB protein]"	18718921
D012906	Smoke	pyrazolanthrone inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D012906	Smoke	SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]	18718921
D012906	Smoke	SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
D012906	Smoke	SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]	18718921
D012906	Smoke	SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
D012906	Smoke	Smoke analog results in increased expression of EDNRB protein	20716444
D012906	Smoke	Smoke results in increased expression of EDNRB mRNA	18718921
D012906	Smoke	Smoke results in increased expression of EDNRB protein	18718921
D012906	Smoke	U 0126 inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
D012906	Smoke	U 0126 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]	18718921
D012906	Smoke	U 0126 inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
D012906	Smoke	wedelolactone inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
C017947	sodium arsenite	sodium arsenite inhibits the reaction [EDN1 protein results in increased expression of EDNRB]	28470405
C017947	sodium arsenite	sodium arsenite results in increased expression of EDNRB mRNA	20371982
D012965	Sodium Chloride	[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA	18823320
D012965	Sodium Chloride	atrasentan inhibits the reaction [[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in decreased expression of EDNRB mRNA]	18823320
D053260	Soot	Soot affects the expression of EDNRB mRNA	26551751
D019311	Staurosporine	Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
D019311	Staurosporine	Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
C088196	TAK 044	TAK 044 binds to and results in decreased activity of EDNRB protein	11327643
C084178	telmisartan	telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein]	20888384
D013739	Testosterone	Testosterone affects the expression of EDNRB mRNA	12122504\|1461647
C004648	testosterone enanthate	testosterone enanthate affects the expression of EDNRB mRNA	17440010
D013749	Tetrachlorodibenzodioxin	AHR gene SNP affects the reaction [Tetrachlorodibenzodioxin results in increased expression of EDNRB mRNA]	25445724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EDNRB mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EDNRB mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EDNRB mRNA	25445724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EDNRB mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EDNRB mRNA	25613284
C120582	tezosentan	tezosentan binds to and results in decreased activity of EDNRB protein	16219361
C120582	tezosentan	tezosentan binds to and results in decreased activity of EDNRB protein	16181825\|1632700
D013849	Thimerosal	Thimerosal results in decreased expression of EDNRB mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in decreased expression of EDNRB mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EDNRB mRNA	22363418
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of EDNRB mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EDNRB mRNA	22952915
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EDNRB protein	22952915
C082097	tocotrienol, delta	"tocotrienol, delta results in increased expression of EDNRB mRNA"	21356098
D014118	Toxins, Biological	"Toxins, Biological affects the expression of EDNRB mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of EDNRB mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of EDNRB mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in decreased expression of EDNRB mRNA	28973697
C113580	U 0126	U 0126 inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]	25772258
C113580	U 0126	U 0126 inhibits the reaction [Cyclosporine results in increased expression of EDNRB protein]	25772258
C113580	U 0126	U 0126 inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	26496744
C113580	U 0126	U 0126 inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]	20716444
C113580	U 0126	U 0126 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]	18718921
C113580	U 0126	U 0126 inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
C419664	udenafil	udenafil results in decreased expression of EDNRB	21366883
D014520	Urethane	Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of EDNRB mRNA]	12810352
D014520	Urethane	IFNG protein inhibits the reaction [Urethane results in decreased expression of EDNRB mRNA]	12810352
D014520	Urethane	Urethane results in decreased expression of EDNRB mRNA	12810352
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of EDNRB mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of EDNRB mRNA	19101580\|2317975
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of EDNRB gene	25560391
D001335	Vehicle Emissions	[Ozone co-treated with Vehicle Emissions] results in increased expression of EDNRB mRNA	20980218
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in increased expression of EDNRB mRNA	25423262
D014747	Vinblastine	Vinblastine results in increased expression of EDNRB mRNA	20624997
D014750	Vincristine	Vincristine results in increased expression of EDNRB mRNA	20624997
D014800	Vitallium	Vitallium analog results in increased expression of EDNRB mRNA	23825117
D012256	Riboflavin	Riboflavin results in increased expression of EDNRB mRNA	21356098
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRB mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of EDNRB mRNA	26272509
C051122	wedelolactone	wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]	20561571
C051122	wedelolactone	wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]	20561571
C051122	wedelolactone	wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]	20561571
C051122	wedelolactone	wedelolactone inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]	20561571
C051122	wedelolactone	wedelolactone inhibits the reaction [Smoke results in increased expression of EDNRB protein]	18718921
C051122	wedelolactone	wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]	22207076
C051122	wedelolactone	wedelolactone inhibits the reaction [TNF protein results in increased expression of EDNRB protein]	22207076
C415840	ZD 2574	ZD 2574 binds to and results in decreased activity of EDNRB protein	11046091
D015032	Zinc	Zinc results in decreased expression of EDNRB mRNA	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of EDNRB mRNA	17074742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004962	endothelin receptor activity	-	IDA	1713452
GO:0004962	endothelin receptor activity	-	IMP	19767294 28236341
GO:0005515	protein binding	-	IPI	23597562
GO:0017046	peptide hormone binding	-	IPI	1713452
GO:0031702	type 1 angiotensin receptor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	19767294
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001755	neural crest cell migration	-	IEA	-
GO:0001934	positive regulation of protein phosphorylation	-	IEA	-
GO:0006885	regulation of pH	-	IEA	-
GO:0007166	cell surface receptor signaling pathway	-	TAS	8810293
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007194	negative regulation of adenylate cyclase activity	-	TAS	9556633
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0007399	nervous system development	-	TAS	8001158
GO:0007422	peripheral nervous system development	-	IEA	-
GO:0007497	posterior midgut development	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0008217	regulation of blood pressure	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0014043	negative regulation of neuron maturation	-	ISS	-
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0014826	vein smooth muscle contraction	-	IMP	8982507
GO:0019233	sensory perception of pain	-	IEA	-
GO:0019722	calcium-mediated signaling	-	IMP	28236341
GO:0019934	cGMP-mediated signaling	-	IEA	-
GO:0030318	melanocyte differentiation	-	IEA	-
GO:0031620	regulation of fever generation	-	IEA	-
GO:0032269	negative regulation of cellular protein metabolic process	-	IMP	19767294
GO:0035645	enteric smooth muscle cell differentiation	-	ISS	-
GO:0035810	positive regulation of urine volume	-	IEA	-
GO:0035815	positive regulation of renal sodium excretion	-	IEA	-
GO:0042045	epithelial fluid transport	-	IEA	-
GO:0042310	vasoconstriction	-	IMP	8982507
GO:0042311	vasodilation	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0048246	macrophage chemotaxis	-	IMP	12207323
GO:0048265	response to pain	-	IEA	-
GO:0048484	enteric nervous system development	-	ISS	-
GO:0050678	regulation of epithelial cell proliferation	-	IEA	-
GO:0051930	regulation of sensory perception of pain	-	IEA	-
GO:0060406	positive regulation of penile erection	-	IEA	-
GO:0071222	cellular response to lipopolysaccharide	-	IEA	-
GO:0086100	endothelin receptor signaling pathway	-	IDA	1713452
GO:0086100	endothelin receptor signaling pathway	-	IMP	19767294 28236341
GO:1990839	response to endothelin	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	28236341
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	8810293
GO:0031965	nuclear membrane	-	IEA	-
GO:0045121	membrane raft	-	IEA	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04916	Melanogenesis

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21380558	Methylation analysis of cancer-related genes in non-neoplastic cells from patients with oral squamous cell carcinoma. (2011 Nov)	de Freitas Cordeiro-Silva M	Mol Biol Rep
18676844	RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. (2008 Aug 1)	Wolff EM	Cancer Res
21445666	Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. (2011 Sep)	Wang KS	J Neural Transm (Vienna)
20970515	Similar gene expression profiles in smokers and patients with moderate COPD. (2011 Feb)	Llinas L	Pulm Pharmacol Ther
27459457	Epidemiological Assessments of Skin Outcomes in the Nurses' Health Studies. (2016 Sep)	Li WQ	Am J Public Health
23336501	Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population. (2013 May)	Lind L	Acta Physiol (Oxf)