Gene: EEF1A2

1917
EEF1AL|EF-1-alpha-2|EF1A|EIEE33|HS1|MRD38|STN|STNL
eukaryotic translation elongation factor 1 alpha 2
protein-coding
20q13.33
Ensembl:ENSG00000101210 MIM:602959 Vega:OTTHUMG00000033076 UniprotKB:Q05639
NG_034083.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.432e-1 (AD)  6.146e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKAR1B0.975
PLD30.972
SCAMP50.972
RAB3A0.97
GSK3A0.969
DMTN0.963
SLC22A170.962
BASP10.961
TMEM59L0.961
DNM10.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.667
OR4F29-0.617
TFPI2-0.469
REST-0.452
KCNJ15-0.443
RAI14-0.431
IL18RAP-0.429
CXCR2-0.42
WWTR1-0.413
FZD10-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of EEF1A2 protein19738051
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of EEF1A2 protein]19738051
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF1A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF1A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF1A2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EEF1A2 mRNA19770486
D000447AldehydesAldehydes results in increased expression of EEF1A2 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EEF1A2 mRNA16483693
C006632arsenic trioxideEEF1A2 protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite results in increased expression of EEF1A2 mRNA23974009
D001280AtrazineAtrazine results in decreased expression of EEF1A2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of EEF1A2 mRNA18522720
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EEF1A2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EEF1A2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EEF1A2 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of EEF1A2 mRNA20106945
C006780bisphenol Abisphenol A results in increased methylation of EEF1A2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of EEF1A2 mRNA25181051|2717856
C006780bisphenol A[Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein26930160
C026105butylidenephthalidebutylidenephthalide results in decreased expression of EEF1A2 protein23770345
C018475butyraldehydebutyraldehyde results in increased expression of EEF1A2 mRNA26079696
D002104CadmiumCadmium results in increased expression of EEF1A2 mRNA24376830
C459604candoxincandoxin results in decreased expression of EEF1A2 mRNA16309724
C018021cobaltous chloridecobaltous chloride results in increased expression of EEF1A2 mRNA19376846
D003042CocaineCocaine affects the expression of EEF1A2 mRNA20187946
D016572CyclosporineCyclosporine results in decreased expression of EEF1A2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of EEF1A2 mRNA20106945
C014347decitabinedecitabine affects the expression of EEF1A2 mRNA23300844
C014347decitabinedecitabine results in increased expression of EEF1A2 mRNA16367923
D003907DexamethasoneDexamethasone results in increased expression of EEF1A2 mRNA16144937
D002945CisplatinCisplatin affects the expression of EEF1A2 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of EEF1A2 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of EEF1A2 mRNA26924002
C118739entinostatentinostat results in increased expression of EEF1A2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF1A2 mRNA"27188386
C540355fenamidonefenamidone results in decreased expression of EEF1A2 mRNA27029645
D005632Fructose[Fructose co-treated with bisphenol A] results in decreased expression of EEF1A2 protein26930160
C069837fullerene C60fullerene C60 affects the expression of EEF1A2 mRNA19167457
D006108GraphiteGraphite results in increased expression of EEF1A2 mRNA27440207
D017313FenretinideFenretinide results in decreased expression of EEF1A2 mRNA16467112
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of EEF1A2 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EEF1A2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EEF1A2 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EEF1A2 protein26558463
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EEF1A2 mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of EEF1A2 mRNA15674844
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of EEF1A2 mRNA16467112
C028007nickel monoxidenickel monoxide results in decreased expression of EEF1A2 mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of EEF1A2 protein19716841
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EEF1A2 mRNA27935865
C025589ochratoxin Aochratoxin A results in increased expression of EEF1A2 mRNA23358140
D010269ParaquatParaquat results in decreased expression of EEF1A2 mRNA21371552
C046012pentanalpentanal results in increased expression of EEF1A2 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of EEF1A2 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EEF1A2 mRNA22237054
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of EEF1A2 mRNA17616710
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of EEF1A2 mRNA27935865
D028321Plant PreparationsPlant Preparations results in increased expression of EEF1A2 protein28284660
D011192Potassium DichromatePotassium Dichromate results in increased expression of EEF1A2 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of EEF1A2 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of EEF1A2 protein19207037
C059514resveratrolresveratrol results in decreased expression of EEF1A2 protein19738051
C059514resveratrolresveratrol inhibits the reaction [INS protein results in increased expression of EEF1A2 protein]19738051
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of EEF1A2 mRNA19244175
D012643SeleniumSelenium results in increased expression of EEF1A2 mRNA19244175
D012838SilymarinSilymarin results in decreased expression of EEF1A2 mRNA22386810
C009277sodium arsenatesodium arsenate results in increased expression of EEF1A2 mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of EEF1A2 mRNA12727804
D012969Sodium FluorideSodium Fluoride results in increased expression of EEF1A2 protein27548804
D053260SootSoot results in increased expression of EEF1A2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EEF1A2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EEF1A2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EEF1A2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EEF1A2 mRNA15667827
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of EEF1A2 protein20109541
D013849ThimerosalThimerosal results in decreased expression of EEF1A2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EEF1A2 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of EEF1A2 mRNA15770638|2372400
D014212TretinoinTretinoin results in decreased expression of EEF1A2 protein15770638
D014241TrichloroethyleneTrichloroethylene results in increased expression of EEF1A2 protein22771849
C012589trichostatin Atrichostatin A results in increased expression of EEF1A2 mRNA15901671
D014415TunicamycinTunicamycin results in increased expression of EEF1A2 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF1A2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EEF1A2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EEF1A2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of EEF1A2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of EEF1A2 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EEF1A2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EEF1A2 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of EEF1A2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of EEF1A2 mRNA19244175
C016837zinc chloridezinc chloride results in decreased expression of EEF1A2 mRNA19683351
D015034Zinc OxideZinc Oxide analog results in decreased expression of EEF1A2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of EEF1A2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003746translation elongation factor activity-IBA21873635  
GO:0003924GTPase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0005525GTP binding-IEA-  
GO:0008135translation factor activity, RNA binding-NAS8812466  
GO:0019901protein kinase binding-IPI17088255  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-IBA21873635  
GO:0006414translational elongation-IBA21873635  
GO:0006414translational elongation-IEA-  
GO:0010035response to inorganic substance-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0090218positive regulation of lipid kinase activity-IDA17088255  
GO:1904714regulation of chaperone-mediated autophagy-NAS20797626  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleusNOTIDA12426392  
GO:0005737cytoplasm-IDA12426392  
GO:0005853eukaryotic translation elongation factor 1 complex-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0098574cytoplasmic side of lysosomal membrane-NAS20797626  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17409975Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (2006 Nov)Lam DCJ Thorac Oncol