Gene: PGAM5

192111
BXLBV68
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
protein-coding
12q24.33
Ensembl:ENSG00000247077 MIM:614939 Vega:OTTHUMG00000168021 UniprotKB:Q96HS1
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.866e-3 (AD)  7.018e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YARS0.948
TIMM220.941
ABCF20.929
ZNRF10.926
MBOAT70.921
PI4K2A0.921
FOXK20.92
GARS0.92
FBXO310.919
NOC2L0.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.575
OR4F29-0.519
IL18RAP-0.451
ASB4-0.446
MBNL3-0.43
VNN2-0.429
PARD3B-0.426
MYOM1-0.425
CXCR2-0.425
SH2D1A-0.422

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PGAM5 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PGAM5 mRNA26690555
C006632arsenic trioxidearsenic trioxide results in decreased expression of PGAM5 protein25419056
D001280AtrazineAtrazine results in increased expression of PGAM5 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PGAM5 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of PGAM5 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PGAM5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PGAM5 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of PGAM5 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PGAM5 mRNA27339419
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PGAM5 mRNA27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGAM5 gene20938992
D016572CyclosporineCyclosporine results in increased expression of PGAM5 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PGAM5 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PGAM5 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of PGAM5 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PGAM5 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PGAM5 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PGAM5 mRNA23649840
D005485FlutamideFlutamide results in increased expression of PGAM5 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGAM5 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PGAM5 mRNA23649840
D019833GenisteinGenistein results in increased expression of PGAM5 mRNA23019147
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGAM5 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PGAM5 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PGAM5 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PGAM5 mRNA29191790
C017557nickel subsulfidenickel subsulfide results in increased expression of PGAM5 mRNA21086188
D010100OxygenOxygen deficiency results in decreased expression of PGAM5 mRNA26516004
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of PGAM5 mRNA21503142
C045362prochlorazprochloraz results in increased expression of PGAM5 mRNA21470553
C031280pyrazolepyrazole results in increased expression of PGAM5 mRNA17945193
D012715Sesame OilSesame Oil results in increased expression of PGAM5 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PGAM5 mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of PGAM5 mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PGAM5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PGAM5 mRNA21354282
D013853ThioacetamideThioacetamide results in increased expression of PGAM5 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of PGAM5 gene28576685
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PGAM5 gene25560391
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of PGAM5 mRNA21503142

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-IDA19590015  
GO:0004722protein serine/threonine phosphatase activity-TAS-  
GO:0005096GTPase activator activity-IMP22265414  
GO:0005515protein binding-IPI19590015  
GO:0016791phosphatase activity-IMP22265414  
GO:0044877protein-containing complex binding-IDA22265414  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IEA-  
GO:0016236macroautophagy-TAS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0070266necroptotic process-IMP22265414  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5205647MitophagyTAS
R-HSA-8934903Receptor Mediated MitophagyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29315717Impact of cigarette-smoking on sperm DNA methylation and its effect on sperm parameters. (2018 Jan 9)Alkhaled YAndrologia