Gene: AGO3

192669
EIF2C3
argonaute 3, RISC catalytic component
protein-coding
1p34.3
Ensembl:ENSG00000126070 MIM:607355 Vega:OTTHUMG00000184172 UniprotKB:Q9H9G7
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.029e-1 (AD)  4.365e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRCH30.925
UBN20.906
ZFC3H10.901
INO80D0.895
SMC60.889
PCF110.889
ZC3H11A0.889
ZNF8410.885
LCOR0.884
VPS13C0.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.437
OR4F29-0.402
TNNT1-0.284
HES5-0.262
KLRC2-0.262
PLA2G5-0.244
S100A1-0.24
OR4F16-0.236
BTBD17-0.222
GSDMC-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of AGO3 mRNA"28903501
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA19191707
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AGO3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AGO3 mRNA19770486
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of AGO3 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGO3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGO3 mRNA"20018196
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of AGO3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AGO3 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of AGO3 mRNA24752500
D016572CyclosporineCyclosporine results in increased expression of AGO3 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of AGO3 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AGO3 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of AGO3 mRNA24752500
C024565ethylene dichlorideethylene dichloride results in decreased expression of AGO3 mRNA28189721
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGO3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AGO3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AGO3 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AGO3 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AGO3 mRNA27392435
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA22563483
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AGO3 mRNA23649840
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA22563483
D010269ParaquatParaquat results in increased expression of AGO3 mRNA22563483
D052638Particulate MatterParticulate Matter results in decreased methylation of AGO3 gene28495853
C410127PCB 180PCB 180 results in decreased expression of AGO3 mRNA23829299
D010634PhenobarbitalPhenobarbital affects the expression of AGO3 mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AGO3 protein23718831
C428725pyridabenpyridaben results in increased expression of AGO3 mRNA22563483
D012834SilverSilver affects the expression of AGO3 mRNA27131904
D012834SilverSilver results in increased expression of AGO3 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of AGO3 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of AGO3 mRNA27862939
C004648testosterone enanthatetestosterone enanthate affects the expression of AGO3 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGO3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AGO3 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGO3 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGO3 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of AGO3 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AGO3 mRNA"26179874
D014520UrethaneUrethane results in increased expression of AGO3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of AGO3 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AGO3 gene28495853
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AGO3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IDA19966796  
GO:0003727single-stranded RNA binding-IDA19966796  
GO:0004521endoribonuclease activity-IMP29040713  
GO:0005515protein binding-IPI19167051  19324964  19383768  22915799  23064648  28330616  
GO:0035198miRNA binding-IDA15260970  
GO:0090624endoribonuclease activity, cleaving miRNA-paired mRNA-IMP29040713  
GO ID GO Term Qualifier Evidence PubMed
GO:0006402mRNA catabolic process-IDA18771919  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0010501RNA secondary structure unwinding-IDA19966796  
GO:0010501RNA secondary structure unwinding-IMP22795694  
GO:0010628positive regulation of gene expression-IEA-  
GO:0031054pre-miRNA processing-IDA19966796  
GO:0035194posttranscriptional gene silencing by RNA-TAS-  
GO:0035196production of miRNAs involved in gene silencing by miRNA-IMP22795694  
GO:0035278miRNA mediated inhibition of translation-IDA18771919  
GO:0035279mRNA cleavage involved in gene silencing by miRNANOTIDA15260970  
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA-IDA19966796  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0072091regulation of stem cell proliferation-IMP23064648  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO:0090625mRNA cleavage involved in gene silencing by siRNANOTIDA15260970  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-IEA-  
GO:0000932P-body-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA15260970  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016442RISC complex-IDA15260970  19966796  
GO:0035068micro-ribonucleoprotein complex-IEA-  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA-  
GO:0070578RISC-loading complex-IDA19966796  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-426486Small interfering RNA (siRNA) biogenesisTAS
R-HSA-426496Post-transcriptional silencing by small RNAsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8943723Regulation of PTEN mRNA translationTAS
R-HSA-8948700Competing endogenous RNAs (ceRNAs) regulate PTEN translationTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23398123Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. (2013 May)Kitagawa NCancer Sci