Gene: AGO4

192670
EIF2C4
argonaute 4, RISC catalytic component
protein-coding
1p34.3
Ensembl:ENSG00000134698 MIM:607356 Vega:OTTHUMG00000004243 UniprotKB:Q9HCK5
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.419e-1 (AD)  4.611e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NKTR0.902
PKD20.889
TAF10.879
ANKHD10.875
RECK0.874
TTC170.871
RBM250.87
PAN30.868
WDR110.862
FNBP40.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.522
OR4F29-0.515
LCN1-0.235
MUC12-0.234
GHRH-0.221
OXT-0.213
HCRT-0.213
NPW-0.208
AVP-0.198
NANOGNB-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AGO4 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AGO4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AGO4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AGO4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AGO4 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of AGO4 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of AGO4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AGO4 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of AGO4 mRNA21757418
D001280AtrazineAtrazine results in decreased expression of AGO4 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of AGO4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGO4 mRNA26001963
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of AGO4 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AGO4 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGO4 mRNA22228805
C018475butyraldehydebutyraldehyde results in decreased expression of AGO4 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of AGO4 mRNA24752500
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AGO4 mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AGO4 mRNA28472532
D003300CopperCopper results in decreased expression of AGO4 mRNA24403277
D003471CuprizoneCuprizone results in decreased expression of AGO4 mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AGO4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of AGO4 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of AGO4 mRNA24752500
C118739entinostatentinostat results in decreased expression of AGO4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of AGO4 mRNA20227414
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of AGO4 mRNA23649840
D004397FonofosFonofos results in decreased methylation of AGO4 promoter22847954
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AGO4 mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AGO4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AGO4 mRNA27392435
D008727MethotrexateMethotrexate affects the expression of AGO4 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AGO4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AGO4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AGO4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AGO4 mRNA"25554681|2562005
D010278ParathionParathion results in decreased methylation of AGO4 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of AGO4 mRNA"25510870
C046012pentanalpentanal results in decreased expression of AGO4 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of AGO4 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of AGO4 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of AGO4 mRNA20813756
D010936Plant ExtractsPlant Extracts results in increased expression of AGO4 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AGO4 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of AGO4 mRNA24780913
D012834SilverSilver results in increased expression of AGO4 mRNA26014281
D053260SootSoot results in decreased expression of AGO4 mRNA26551751
C012568terbufosterbufos results in decreased methylation of AGO4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGO4 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AGO4 mRNA25613284
D014212TretinoinTretinoin results in increased expression of AGO4 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of AGO4 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AGO4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AGO4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AGO4 mRNA23179753|2493525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003725double-stranded RNA binding-IDA19966796  
GO:0003727single-stranded RNA binding-IDA19966796  
GO:0005515protein binding-IPI15766526  19167051  19324964  19383768  
GO:0035198miRNA binding-IDA15260970  
GO ID GO Term Qualifier Evidence PubMed
GO:0006402mRNA catabolic process-IDA18771919  
GO:0007130synaptonemal complex assembly-IEA-  
GO:0007140male meiotic nuclear division-IEA-  
GO:0007223Wnt signaling pathway, calcium modulating pathway-TAS-  
GO:0008584male gonad development-IEA-  
GO:0010501RNA secondary structure unwinding-IDA19966796  
GO:0010501RNA secondary structure unwinding-IMP22795694  
GO:0010586miRNA metabolic process-IEA-  
GO:0022604regulation of cell morphogenesis-IEA-  
GO:0031054pre-miRNA processing-IDA19966796  
GO:0035194posttranscriptional gene silencing by RNA-TAS-  
GO:0035196production of miRNAs involved in gene silencing by miRNA-IMP22795694  
GO:0035278miRNA mediated inhibition of translation-IDA18771919  
GO:0035279mRNA cleavage involved in gene silencing by miRNANOTIDA15260970  
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA-IDA19966796  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0090625mRNA cleavage involved in gene silencing by siRNANOTIDA15260970  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA15260970  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016442RISC complex-IDA15260970  19966796  
GO:0016604nuclear body-IDA-  
GO:0035068micro-ribonucleoprotein complex-IEA-  
GO:0070578RISC-loading complex-IDA19966796  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086398Ca2+ pathwayTAS
R-HSA-426486Small interfering RNA (siRNA) biogenesisTAS
R-HSA-426496Post-transcriptional silencing by small RNAsTAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8943723Regulation of PTEN mRNA translationTAS
R-HSA-8948700Competing endogenous RNAs (ceRNAs) regulate PTEN translationTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23398123Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. (2013 May)Kitagawa NCancer Sci