Gene: EEF2

1938
EEF-2|EF-2|EF2|SCA26
eukaryotic translation elongation factor 2
protein-coding
19p13.3
Ensembl:ENSG00000167658 MIM:130610 Vega:OTTHUMG00000181790 UniprotKB:P13639
NG_042274.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.246e-1 (AD)  5.958e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNB10.935
SLC25A60.935
ST6GALNAC60.932
AES0.932
DVL10.925
BAP10.922
CTNND20.92
SLC25A230.918
NELFB0.917
PPP1R9B0.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.898
OR4F29-0.885
KCNJ15-0.141
ODAM-0.14
IL18RAP-0.137
TFPI2-0.135
VNN3-0.135
OR6C74-0.135
NANOGNB-0.133
XCL2-0.126

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02059Adenosine-5-DiphosphoriboseSmall Molecule-ExperimentalTarget
DB03223DiphthamideSmall Molecule75645-22-6ExperimentalTarget
DB04315Guanosine-5'-DiphosphateSmall Molecule146-91-8ExperimentalTarget
DB08348N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of EEF2 mRNA"19162173
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in increased phosphorylation of EEF2 protein"25940091
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of EEF2 protein"21673325
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of EEF2 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of EEF2 protein"24680724
C0247092,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to EEF2 protein"16533022
C0194992-nitrofluorene2-nitrofluorene results in increased expression of EEF2 mRNA15890375
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of EEF2 mRNA12958071
C5307733,5-diethoxycarbonyl-1,4-dihydrocollidine"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EEF2 mRNA"20512997
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of EEF2 protein16469450
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of EEF2 mRNA15890375
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]"17510559
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid results in increased expression of EEF2 protein"17510559
D000079AcetaldehydeAcetaldehyde results in decreased expression of EEF2 protein16469450
D000082AcetaminophenAcetaminophen affects the expression of EEF2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EEF2 mRNA17585979
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which affects the expression of EEF2 protein25499718
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EEF2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EEF2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EEF2 mRNA15890375
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of EEF2 protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of EEF2 protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EEF2 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of EEF2 mRNA12558987
C023650anilineaniline results in increased nitrosation of EEF2 protein21708182
C006632arsenic trioxidearsenic trioxide results in decreased expression of EEF2 protein19364129
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of EEF2 mRNA15654877
D001280AtrazineAtrazine results in increased expression of EEF2 mRNA18522720
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of EEF2 mRNA16532367
D001554BenzeneBenzene affects the expression of EEF2 mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EEF2 protein25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of EEF2 protein]25628927
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EEF2 mRNA20440473
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of EEF2 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EEF2 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EEF2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of EEF2 protein24909818
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of EEF2 promoter23359474
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of EEF2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of EEF2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EEF2 mRNA28628672
C013418bromfenacoumbromfenacoum results in increased expression of EEF2 protein28903499
C515564bromovaninbromovanin results in increased expression of EEF2 protein21419150
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of EEF2 mRNA18804290
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of EEF2 protein16469450
C026105butylidenephthalidebutylidenephthalide results in increased expression of EEF2 protein23770345
D002104CadmiumCadmium results in increased expression of EEF2 mRNA20447699
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA]"20230807
D002118Calcium[Calcium co-treated with Calcitriol] affects the expression of EEF2 mRNA15913539
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of EEF2 protein]20359164
C099555CD 437CD 437 results in decreased expression of EEF2 mRNA12958071
D002509CephaloridineCephaloridine results in increased expression of EEF2 mRNA18172885
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of EEF2 mRNA18636392
C100187chloropicrinchloropicrin results in decreased expression of EEF2 mRNA26352163
C023600chromic oxidechromic oxide results in decreased expression of EEF2 mRNA15003702
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of EEF2 mRNA15003702
D002922CiguatoxinsCiguatoxins affects the expression of EEF2 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EEF2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of EEF2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EEF2 mRNA]17585979
D003300CopperCopper affects the expression of EEF2 mRNA23825565
C107393Coptidis rhizoma extractCoptidis rhizoma extract results in increased phosphorylation of and results in decreased activity of EEF2 protein24363282
C007164cumene hydroperoxide"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]"17510559
C007164cumene hydroperoxidecumene hydroperoxide results in decreased expression of EEF219447174
C007164cumene hydroperoxidecumene hydroperoxide results in decreased expression of EEF2 protein16469450|1751055
C007164cumene hydroperoxideVitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]17510559
D003520CyclophosphamideCyclophosphamide results in decreased expression of EEF2 mRNA18246545
D016572CyclosporineCyclosporine results in decreased expression of EEF2 mRNA21163907
D016572CyclosporineCyclosporine results in increased expression of EEF2 mRNA20106945
D003561CytarabineCytarabine results in decreased expression of EEF2 mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EEF2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EEF2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EEF2 mRNA28628672
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of EEF2 promoter23359474
D002945CisplatinEEF2 protein modified form results in decreased susceptibility to Cisplatin21554491
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of EEF2 protein]20359164
D004041Dietary FatsDietary Fats results in decreased expression of EEF2 protein20359164
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of EEF2 promoter23359474
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of EEF2 mRNA15890375
D002117Calcitriol[Calcium co-treated with Calcitriol] affects the expression of EEF2 mRNA15913539
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of EEF2 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of EEF2 mRNA"21785161
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of EEF2 mRNA15890375
C024629dimethyl phthalatedimethyl phthalate affects the expression of EEF2 mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of EEF2 mRNA22169935
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of EEF2 mRNA15654877
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of EEF2 mRNA16532367
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EEF2 protein23301498
D000431EthanolEthanol results in decreased expression of EEF2 mRNA28069986
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EEF2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EEF2 mRNA17942748
D005411Flame RetardantsFlame Retardants results in increased expression of EEF2 protein18550172
D005473FluoxetineFluoxetine results in increased phosphorylation of EEF2 protein16817885
D019833GenisteinGenistein results in decreased expression of EEF2 mRNA16705744
D005839GentamicinsGentamicins results in decreased expression of EEF2 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of EEF2 protein22061828
D005947GlucoseGlucose results in decreased phosphorylation of EEF2 protein19765649
D005947Glucoseresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of EEF2 protein]19765649
C010974glyphosateglyphosate results in increased expression of EEF2 mRNA16532367
D006046GoldGold analog results in decreased expression of EEF2 protein24780912
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of EEF2 protein24680724
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EEF2 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of EEF2 protein23178681
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of EEF2 mRNA"18077114
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of EEF2 protein12071973
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of EEF2 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of EEF2 protein23178681
C001654hyperforinhyperforin affects the expression of EEF2 protein15095150
C492448ICG 001ICG 001 results in decreased expression of EEF2 mRNA26191083
C020758indium trichlorideindium trichloride results in decreased expression of EEF2 protein19539025
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EEF2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EEF2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EEF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EEF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of EEF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EEF2 mRNA28628672
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of EEF2 mRNA15654877
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of EEF2 mRNA16532367
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of EEF2 protein10768784
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EEF2 mRNA23430699
D008148LovastatinLovastatin results in decreased expression of EEF2 mRNA20493250
D008315MalondialdehydeMalondialdehyde results in decreased expression of EEF2 protein16469450
D008701MethapyrileneMethapyrilene results in increased expression of EEF2 mRNA15890375
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of EEF2 mRNA16966085
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EEF2 mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA]"20230807
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to EEF2 protein]17220478
D015741MetriboloneMetribolone results in increased expression of EEF2 protein17152098
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of EEF2 protein"21135415
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of EEF2 protein19438287
C031721naphthalenenaphthalene results in decreased expression of EEF2 protein19438287
C022838nickel chloridenickel chloride results in increased expression of EEF2 mRNA12729255
C028007nickel monoxidenickel monoxide results in increased expression of EEF2 mRNA19167457
C017557nickel subsulfidenickel subsulfide affects the expression of EEF2 mRNA12729255
D009538NicotineNicotine results in increased expression of EEF2 protein modified form21554491
D009538Nicotine[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein21554491
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of EEF2 protein19716841
C025589ochratoxin Aochratoxin A results in increased expression of EEF2 protein26861962
C018620oleoresinsoleoresins results in decreased expression of EEF2 mRNA20008804
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of EEF2 mRNA"23246600
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of EEF2 mRNA18636392
D017239PaclitaxelPaclitaxel results in decreased expression of EEF2 mRNA15000894
D052638Particulate MatterParticulate Matter results in increased expression of EEF2 protein17922515
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of EEF2 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of EEF2 protein19954255
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of EEF2 protein22609092
D010578PetroleumPetroleum affects the expression of EEF2 mRNA25208076
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of EEF2 mRNA17616710
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of EEF2 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of EEF2 mRNA15890375
D011441PropylthiouracilPropylthiouracil results in decreased expression of EEF2 mRNA18077114
C100573prostaglandin A1prostaglandin A1 analog results in increased metabolism of EEF2 protein19800325
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased phosphorylation of EEF2 protein25330770
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased phosphorylation of EEF2 protein25330770
C010313pseudocumenepseudocumene results in decreased expression of EEF2 protein17337753
D011748PyrogallolPyrogallol results in decreased expression of EEF2 mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in decreased expression of EEF2 mRNA]20362636
C037219quinolinequinoline analog results in decreased expression of EEF2 protein18645022
C059514resveratrolresveratrol results in decreased expression of EEF2 protein22349766
C059514resveratrolresveratrol results in increased phosphorylation of EEF2 protein22349766
C059514resveratrolresveratrol inhibits the reaction [Glucose results in decreased phosphorylation of EEF2 protein]19765649
C059514resveratrolresveratrol results in decreased expression of EEF2 mRNA25394677
C059514resveratrolresveratrol results in increased phosphorylation of and results in decreased activity of EEF2 protein25394677
C059514resveratrolresveratrol results in increased phosphorylation of EEF2 protein18562309
C085746rottlerinrottlerin results in decreased phosphorylation of EEF2 protein12720544
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of EEF2 protein25895662
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in decreased expression of EEF2 mRNA]20362636
D020123SirolimusSirolimus results in increased phosphorylation of EEF2 protein25940091
C017947sodium arsenitesodium arsenite results in decreased expression of EEF2 protein20050688
D012969Sodium FluorideSodium Fluoride results in increased phosphorylation of EEF2 protein24954634
D012969Sodium FluorideSodium Fluoride results in increased expression of EEF2 mRNA27862939
D012969Sodium FluorideSodium Fluoride results in increased expression of EEF2 protein27548804
D018038Sodium SeleniteSodium Selenite results in increased expression of EEF2 mRNA18175754
D053260SootSoot results in decreased expression of EEF2 protein modified form24464499
D013012SorbitolSorbitol results in decreased phosphorylation of EEF2 protein12071973
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of EEF2 mRNA"26680231
D013605T-2 ToxinT-2 Toxin affects the expression of EEF2 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EEF2 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EEF2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EEF2 protein16548065
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of EEF2 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of EEF2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased metabolism of EEF2 protein23396223
D014241TrichloroethyleneTrichloroethylene results in increased expression of EEF2 mRNA28973375
D014241TrichloroethyleneTrichloroethylene results in decreased expression of EEF2 mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EEF2 mRNA19042947
D014520UrethaneUrethane results in increased expression of EEF2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of EEF2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of EEF2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of EEF2 protein17922515
C025643vinclozolinvinclozolin results in decreased expression of EEF2 mRNA23034163
D014810Vitamin EVitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]17510559
D014810Vitamin EVitamin E analog results in increased expression of EEF2 protein17510559
D014859WarfarinWarfarin results in decreased expression of EEF2 mRNA20493250
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of EEF2 mRNA"25208076
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of EEF2 mRNA"23246600
C016837zinc chloridezinc chloride results in increased expression of EEF2 mRNA19683351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003746translation elongation factor activity-IEA-  
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI19417104  23823123  25064856  25231979  
GO:0005525GTP binding-IEA-  
GO:00080975S rRNA binding-IEA-  
GO:0019901protein kinase binding-IPI23823123  
GO:0043022ribosome binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0002931response to ischemia-IEA-  
GO:0003009skeletal muscle contraction-IEA-  
GO:0006414translational elongation-IBA21873635  
GO:0006414translational elongation-TAS-  
GO:0007568aging-IEA-  
GO:0014009glial cell proliferation-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0034976response to endoplasmic reticulum stress-IEA-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0042542response to hydrogen peroxide-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045471response to ethanol-IEA-  
GO:0045727positive regulation of translation-IMP23184662  
GO:0051593response to folic acid-IEA-  
GO:1990416cellular response to brain-derived neurotrophic factor stimulus-IEA-  
GO:2000767positive regulation of cytoplasmic translation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IDA25064856  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016235aggresome-IDA-  
GO:0034774secretory granule lumen-TAS-  
GO:0042788polysomal ribosome-IEA-  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
GO:1904813ficolin-1-rich granule lumen-TAS-  
GO:1990904ribonucleoprotein complex-IDA18809582  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-156842Eukaryotic Translation ElongationTAS
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-156902Peptide chain elongationTAS
R-HSA-156902Peptide chain elongationIEA
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationIEA
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5336415Uptake and function of diphtheria toxinTAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5358493Synthesis of diphthamide-EEF2TAS
R-HSA-5358493Synthesis of diphthamide-EEF2IEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-597592Post-translational protein modificationIEA
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA
R-HSA-8876725Protein methylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29431650Protein Translation in the Nucleus Accumbens Is Dysregulated during Cocaine Withdrawal and Required for Expression of Incubation of Cocaine Craving. (2018 Mar 14)Werner CTJ Neurosci