Gene: EFNA1

1942
B61|ECKLG|EFL1|EPLG1|LERK-1|LERK1|TNFAIP4
ephrin A1
protein-coding
1q22
Ensembl:ENSG00000169242 MIM:191164 Vega:OTTHUMG00000035312 UniprotKB:P20827
NC_000001.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.640e-1 (AD)  2.565e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06639488chr1:155103222EFNA14.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MVP0.898
SYNGR20.878
LMNA0.855
LITAF0.853
SPATA130.853
IFI160.849
RRBP10.848
SERPINB10.847
YBX30.843
HNRNPF0.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VIP-0.516
NEUROD6-0.511
HAPLN1-0.509
KIT-0.507
FBLN7-0.497
DLX1-0.492
IGF1-0.492
MARCH4-0.492
ABCC12-0.485
F7-0.484

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of EFNA1 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of EFNA1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of EFNA1 mRNA"28903501
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of EFNA1 mRNA]"24403227
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EFNA1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EFNA1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EFNA1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EFNA1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of EFNA1 mRNA22634333
D000082AcetaminophenAcetaminophen results in decreased expression of EFNA1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of EFNA1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EFNA1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EFNA1 mRNA]17585979
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFNA1 mRNA22129741
C106812adefovir dipivoxiladefovir dipivoxil results in decreased expression of EFNA1 mRNA25596134
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of EFNA1 mRNA]21233418
D000393Air PollutantsAir Pollutants analog results in decreased expression of EFNA1 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EFNA1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EFNA1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of EFNA1 mRNA20458559
C015001arsenitearsenite results in increased expression of EFNA1 mRNA18191166
C547126AZM551248AZM551248 results in decreased expression of EFNA1 mRNA22323515
C487081belinostatbelinostat results in increased expression of EFNA1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of EFNA1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EFNA1 mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EFNA1 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of EFNA1 mRNA26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EFNA1 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EFNA1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EFNA1 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of EFNA1 mRNA15072547|1522313
C044887beta-methylcholinebeta-methylcholine affects the expression of EFNA1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of EFNA1 mRNA28711546
C006780bisphenol Abisphenol A results in increased expression of EFNA1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EFNA1 gene28505145
C584509C646 compoundC646 compound results in increased expression of EFNA1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EFNA1 mRNA25596134
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA]"20230807
D002220Carbamazepine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in increased expression of EFNA1 mRNA22701549
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of EFNA1 mRNA16644059
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of EFNA1 mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of EFNA1 mRNA26272509
C007036cholanic acidcholanic acid inhibits the reaction [EFNA1 protein binds to and results in increased phosphorylation of and results in increased activity of EPHA2 protein]22529030
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFNA1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EFNA1 mRNA28472532
C031180chrysenechrysene results in increased expression of EFNA1 mRNA26377693
C059262cidofovircidofovir results in decreased expression of EFNA1 mRNA25596134
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of EFNA1 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of EFNA1 mRNA18353800
D004002Clodronic AcidClodronic Acid results in decreased expression of EFNA1 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EFNA1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EFNA1 mRNA]17585979
D002996ClomipheneClomiphene results in increased expression of EFNA1 mRNA26865669
D003042CocaineCocaine affects the expression of EFNA1 mRNA15691709
D019327Copper SulfateCopper Sulfate results in decreased expression of EFNA1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of EFNA1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of EFNA1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of EFNA1 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of EFNA1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of EFNA1 mRNA25562108|2559613
D016572CyclosporineCyclosporine results in increased expression of EFNA1 mRNA27989131
D003561CytarabineCytarabine results in decreased expression of EFNA1 mRNA21198554
C014347decitabinedecitabine affects the expression of EFNA1 mRNA23300844
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in decreased expression of EFNA1 mRNA26271895
D003976DiazinonDiazinon results in increased methylation of EFNA1 gene22964155
D002945CisplatinCisplatin affects the expression of EFNA1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of EFNA1 mRNA25596134
D004041Dietary FatsDietary Fats affects the expression of EFNA1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of EFNA1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of EFNA1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of EFNA1 mRNA]19850644
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of EFNA1 mRNA18691550
D004052DiethylnitrosamineMAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EFNA1 mRNA]18691550
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFNA1 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of EFNA1 mRNA26865669
D002117CalcitriolCalcitriol results in increased expression of EFNA1 mRNA26485663
C118739entinostatentinostat results in increased expression of EFNA1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EFNA1 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of EFNA1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of EFNA1 mRNA21233418
D004970EstroneEstrone results in decreased expression of EFNA1 mRNA26865669
D008656MestranolMestranol results in decreased expression of EFNA1 mRNA26865669
D005419FlavonoidsFlavonoids results in decreased expression of EFNA1 mRNA18035473
D005473Fluoxetine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in increased expression of EFNA1 mRNA22701549
C061365flusilazoleflusilazole affects the expression of EFNA1 mRNA22634333
D005485FlutamideFlutamide results in decreased expression of EFNA1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFNA1 gene20938992
C070081fulvestrantfulvestrant results in increased expression of EFNA1 mRNA15072547|2686566
C039281furanfuran results in decreased expression of EFNA1 mRNA25539665|2619464
D019833GenisteinGenistein results in decreased expression of EFNA1 mRNA26865669
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of EFNA1 mRNA22634610
C010974glyphosateglyphosate results in decreased expression of EFNA1 mRNA28711546
C120099GW 1929GW 1929 results in increased expression of EFNA1 mRNA27435855
C120099GW 1929Mercaptopurine promotes the reaction [GW 1929 results in increased expression of EFNA1 mRNA]27435855
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of EFNA1 mRNA25270620
D017313FenretinideFenretinide results in increased expression of EFNA1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EFNA1 mRNA20044591
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of EFNA1 mRNA15072547
D007069IfosfamideIfosfamide results in decreased expression of EFNA1 mRNA25596134
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFNA1 mRNA22129741
C045463leflunomideleflunomide results in increased expression of EFNA1 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of EFNA1 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of EFNA1 mRNA]16415329
D008095Lithocholic AcidLithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]23489211
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]22529030
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein]21479221
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]21479221
C106335macrophage stimulatory lipopeptide 2[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA1 mRNA18832182
D015122MercaptopurineMercaptopurine promotes the reaction [GW 1929 results in increased expression of EFNA1 mRNA]27435855
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
D008687MetforminMetformin results in decreased expression of EFNA1 mRNA25596134
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFNA1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EFNA1 mRNA23103053
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EFNA1 mRNA16026605
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA]"20230807
D015735MifepristoneMifepristone results in decreased expression of EFNA1 mRNA25972201
D009151Mustard GasMustard Gas results in increased expression of EFNA1 mRNA25102026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of EFNA1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFNA1 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EFNA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EFNA1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFNA1 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of EFNA1 mRNA24136188
C022838nickel chloridenickel chloride results in increased expression of EFNA1 mRNA17312168
C029938nickel sulfate[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA1 mRNA18832182
C029938nickel sulfatenickel sulfate results in increased expression of EFNA1 mRNA18651567
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of EFNA1 mRNA25729387
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of EFNA1 mRNA]"24403227
D010100OxygenOxygen deficiency results in increased expression of EFNA1 mRNA20042640|2440322
D017239PaclitaxelPaclitaxel results in decreased expression of EFNA1 mRNA19682730
D000073878Palm OilPalm Oil results in increased expression of EFNA1 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of EFNA1 mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of EFNA1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of EFNA1 mRNA19429403
D010634PhenobarbitalPhenobarbital results in increased expression of EFNA1 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EFNA1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EFNA1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of EFNA1 mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EFNA1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EFNA1 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of EFNA1 mRNA23012394|2301818
D011374ProgesteroneProgesterone results in increased expression of EFNA1 mRNA18037150
D011794QuercetinQuercetin results in decreased expression of EFNA1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of EFNA1 mRNA26865669
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of EFNA1 mRNA]16415329
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of EFNA1 mRNA19167446
C009250sevofluranesevoflurane affects the expression of EFNA1 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EFNA1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of EFNA1 mRNA23221170
D012906SmokeSmoke results in decreased expression of EFNA1 mRNA21095227
D053260SootSoot results in decreased expression of EFNA1 mRNA26551751
C013698tallowtallow affects the expression of EFNA1 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of EFNA1 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EFNA1 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EFNA1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFNA1 mRNA18172886|2323856
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EFNA1 mRNA23238561
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of EFNA1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of EFNA1 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of EFNA1 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of EFNA1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of EFNA1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EFNA1 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of EFNA1 mRNA19140230
D014415TunicamycinTunicamycin results in increased expression of EFNA1 mRNA22378314
C406224valdecoxibvaldecoxib results in increased expression of EFNA1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EFNA1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EFNA1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of EFNA1 mRNA23179753|2438349
D014638VanadatesVanadates results in decreased expression of EFNA1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EFNA1 gene25560391
D000069470Venlafaxine Hydrochloride[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in increased expression of EFNA1 mRNA22701549
C025643vinclozolinvinclozolin affects the expression of EFNA1 mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EFNA1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of EFNA1 mRNA26272509
D019287Zinc SulfateZinc Sulfate results in increased expression of EFNA1 mRNA16330358
C088658zoledronic acidzoledronic acid results in increased expression of EFNA1 mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS8660976  
GO:0005515protein binding-IPI19525919  19573808  20505120  22244754  
GO:0046875ephrin receptor binding-IBA21873635  
GO:0046875ephrin receptor binding-IPI15777695  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001934positive regulation of protein phosphorylation-IGI24217950  
GO:0003180aortic valve morphogenesis-ISS-  
GO:0003183mitral valve morphogenesis-ISS-  
GO:0003199endocardial cushion to mesenchymal transition involved in heart valve formation-ISS-  
GO:0007267cell-cell signaling-TAS8660976  
GO:0007411axon guidance-IBA21873635  
GO:0010719negative regulation of epithelial to mesenchymal transition-ISS-  
GO:0014028notochord formation-IEA-  
GO:0016477cell migration-IDA10655584  
GO:0033628regulation of cell adhesion mediated by integrin-IDA10655584  
GO:0034446substrate adhesion-dependent cell spreading-IDA10655584  
GO:0043409negative regulation of MAPK cascade-IEA-  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO:0043535regulation of blood vessel endothelial cell migration-IEA-  
GO:0045765regulation of angiogenesis-IEA-  
GO:0048013ephrin receptor signaling pathway-IBA21873635  
GO:0048013ephrin receptor signaling pathway-IDA10655584  
GO:0048013ephrin receptor signaling pathway-IGI24217950  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA10655584  
GO:0050770regulation of axonogenesis-IEA-  
GO:0050821protein stabilization-IGI24217950  
GO:0061002negative regulation of dendritic spine morphogenesis-ISS-  
GO:0061098positive regulation of protein tyrosine kinase activity-IGI24217950  
GO:0070244negative regulation of thymocyte apoptotic process-IEA-  
GO:1902004positive regulation of amyloid-beta formation-IDA24217950  
GO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IGI24217950  
GO:1903051negative regulation of proteolysis involved in cellular protein catabolic process-IGI24217950  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-NAS24217950  
GO:0005886plasma membrane-TAS-  
GO:0046658anchored component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24175772rs12904 polymorphism in the 3'UTR of EFNA1 is associated with colorectal cancer susceptibility in a Chinese population. (2013)Mao YYAsian Pac J Cancer Prev