Gene info: ID 1946

Gene: EFNA5

GENE ID: 1946

Description: ephrin A5

Gene type: protein-coding

Location: 5q21.3

dbXrefs: Ensembl:ENSG00000184349 MIM:601535 Vega:OTTHUMG00000128741 UniprotKB:P52803

RefSeq: NC_000005.10

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.654e-1 (AD) 6.644e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6881619	chr5:107573359 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07019857	chr5:106822849	EFNA5		1.200e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GLS2	0.926
NOS1AP	0.925
SRRM4	0.92
AMER3	0.918
AP3B2	0.917
MICAL2	0.916
SRGAP3	0.916
CHGA	0.911
KCNB1	0.911
IPCEF1	0.907

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TFPI2	-0.594
RAI14	-0.567
WWTR1	-0.537
YES1	-0.533
REST	-0.531
ARHGEF5	-0.51
KLRB1	-0.505
FZD10	-0.504
HEY2	-0.503
KLRF1	-0.499

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of EFNA5 mRNA	17562736
D020106	Acrylamide	Acrylamide affects the expression of EFNA5 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of EFNA5 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of EFNA5 mRNA	21298039
D001151	Arsenic	Arsenic affects the methylation of EFNA5 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of EFNA5 mRNA	25929836
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of EFNA5 mRNA"	20382639
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EFNA5 mRNA"	20018196
D004958	Estradiol	Estradiol results in decreased expression of EFNA5 mRNA	21185374
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of EFNA5 mRNA	27685785
C006780	bisphenol A	bisphenol A results in increased expression of EFNA5 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of EFNA5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of EFNA5 gene	28505145
C018475	butyraldehyde	butyraldehyde results in decreased expression of EFNA5 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EFNA5 mRNA	12160620
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of EFNA5 mRNA	27363782
D002220	Carbamazepine	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in increased expression of EFNA5 mRNA	22701549
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of EFNA5 mRNA	12734012
C084597	chlorcyclizine	chlorcyclizine results in increased expression of EFNA5 mRNA	21058326
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFNA5 gene	20938992
D003042	Cocaine	Cocaine results in increased expression of EFNA5 mRNA	15691709
D003471	Cuprizone	Cuprizone results in increased expression of EFNA5 mRNA	26577399
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of EFNA5 mRNA	23914054
C014347	decitabine	decitabine results in decreased methylation of EFNA5 gene	27923600
D004041	Dietary Fats	Dietary Fats results in increased expression of EFNA5 mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of EFNA5 mRNA]	19030233
D002117	Calcitriol	Calcitriol results in increased expression of EFNA5 mRNA	26485663
C118739	entinostat	entinostat results in decreased expression of EFNA5 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EFNA5 mRNA	22079256
D005473	Fluoxetine	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in increased expression of EFNA5 mRNA	22701549
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFNA5 gene	20938992
D005665	Furosemide	Furosemide results in increased expression of EFNA5 mRNA	16526316
D017313	Fenretinide	Fenretinide results in decreased expression of EFNA5 mRNA	28973697
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of EFNA5 mRNA	21396975
C561695	(+)-JQ1 compound	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of EFNA5 mRNA	25119042
D048628	Ketolides	Ketolides analog results in decreased expression of EFNA5 mRNA	24967691
D008558	Melphalan	Melphalan results in decreased expression of EFNA5 mRNA	22363485
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFNA5 gene	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of EFNA5 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of EFNA5 mRNA	27188386
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of EFNA5 mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in decreased expression of EFNA5 mRNA	22714537
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of EFNA5 mRNA	26272509
C506614	PD 0325901	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of EFNA5 mRNA	25119042
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of EFNA5 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of EFNA5 mRNA	18301758\|2381119
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EFNA5 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of EFNA5 mRNA	22079256
D011374	Progesterone	Progesterone results in decreased expression of EFNA5 mRNA	23012394
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of EFNA5 mRNA]	19030233
D012834	Silver	Silver results in decreased expression of EFNA5 mRNA	27131904
D013853	Thioacetamide	Thioacetamide results in decreased expression of EFNA5 mRNA	23411599
D014212	Tretinoin	Tretinoin results in decreased expression of EFNA5 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of EFNA5 mRNA	22723015\|2493525
C057693	troglitazone	troglitazone results in decreased expression of EFNA5 mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFNA5 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of EFNA5 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of EFNA5 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of EFNA5 gene	25560391
D000069470	Venlafaxine Hydrochloride	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in increased expression of EFNA5 mRNA	22701549
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of EFNA5 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005168	neurotrophin TRKA receptor binding	-	NAS	19036963
GO:0005169	neurotrophin TRKB receptor binding	-	NAS	19036963
GO:0005170	neurotrophin TRKC receptor binding	-	NAS	19036963
GO:0005515	protein binding	-	IPI	19836338 20228801 20505120 23812375
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	-	NAS	19036963
GO:0045499	chemorepellent activity	-	IEA	-
GO:0046875	ephrin receptor binding	-	IBA	21873635
GO:0046875	ephrin receptor binding	-	IPI	11870224 15777695

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	NAS	19036963
GO:0006915	apoptotic process	NOT	IDA	11870224
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	-	IEA	-
GO:0007399	nervous system development	-	TAS	9245480
GO:0007411	axon guidance	-	IBA	21873635
GO:0022407	regulation of cell-cell adhesion	-	IBA	21873635
GO:0022407	regulation of cell-cell adhesion	-	IDA	11870224
GO:0022604	regulation of cell morphogenesis	-	IDA	23242526
GO:0031290	retinal ganglion cell axon guidance	-	IEA	-
GO:0032956	regulation of actin cytoskeleton organization	-	IBA	21873635
GO:0032956	regulation of actin cytoskeleton organization	-	IDA	11870224
GO:0043087	regulation of GTPase activity	-	IDA	11870224
GO:0043087	regulation of GTPase activity	-	ISS	-
GO:0048013	ephrin receptor signaling pathway	-	IBA	21873635
GO:0048013	ephrin receptor signaling pathway	-	IDA	11870224
GO:0048013	ephrin receptor signaling pathway	-	TAS	-
GO:0048668	collateral sprouting	-	IEA	-
GO:0048672	positive regulation of collateral sprouting	-	IEA	-
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	ISS	-
GO:0050919	negative chemotaxis	-	IEA	-
GO:0051893	regulation of focal adhesion assembly	-	IDA	11870224
GO:0051965	positive regulation of synapse assembly	-	IEA	-
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	-	ISS	-
GO:0070507	regulation of microtubule cytoskeleton organization	-	IDA	11870224
GO:0071372	cellular response to follicle-stimulating hormone stimulus	-	IEA	-
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	-	IDA	23242526
GO:1904322	cellular response to forskolin	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005604	basement membrane	-	IEA	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005901	caveola	-	IEA	-
GO:0005912	adherens junction	-	IEA	-
GO:0031362	anchored component of external side of plasma membrane	-	IDA	11870224

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-2682334	EPH-Ephrin signaling	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-3928663	EPHA-mediated growth cone collapse	TAS
R-HSA-3928663	EPHA-mediated growth cone collapse	IEA
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	TAS
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22072270	Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. (2012 Apr)	Wang KS	J Neural Transm (Vienna)