Gene: CELSR2

1952
ADGRC2|CDHF10|EGFL2|Flamingo1|MEGF3
cadherin EGF LAG seven-pass G-type receptor 2
protein-coding
1p13.3
Ensembl:ENSG00000143126 MIM:604265 Vega:OTTHUMG00000012003 UniprotKB:Q9HCU4
NG_052669.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.630e-1 (AD)  8.491e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PI4KA0.967
MAPT0.963
TLN20.961
MADD0.96
MAST30.958
CNTNAP10.956
BSN0.955
PTPRS0.954
WNK20.954
PGBD50.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.554
RNF135-0.507
C9orf135-0.506
WWTR1-0.506
GNG11-0.505
YES1-0.5
FAM89A-0.498
ZNF114-0.497
OR4F5-0.495
MYL3-0.494

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELSR2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CELSR2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELSR2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELSR2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELSR2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELSR2 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CELSR2 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CELSR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CELSR2 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CELSR2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CELSR2 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of CELSR2 mRNA21635667
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of CELSR2 mRNA21635667
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CELSR2 mRNA]22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CELSR2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of CELSR2 mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of CELSR2 mRNA22687993
C006780bisphenol Abisphenol A results in decreased methylation of CELSR2 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of CELSR2 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CELSR2 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of CELSR2 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of CELSR2 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CELSR2 gene20938992
C031180chrysenechrysene results in increased expression of CELSR2 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of CELSR2 mRNA19376846
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CELSR2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CELSR2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CELSR2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CELSR2 mRNA20106945|2556210
D002945CisplatinCELSR2 protein affects the susceptibility to Cisplatin16217747
D002945Cisplatin[Cisplatin co-treated with RELB mutant form] results in increased expression of CELSR2 mRNA23625948
C000944dicrotophosdicrotophos results in increased expression of CELSR2 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CELSR2 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of CELSR2 mRNA26485663
C013525ENNG[ENNG co-treated with Isoflavones] results in increased expression of CELSR2 protein22248470
D000431EthanolEthanol results in decreased expression of CELSR2 mRNA29018328
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CELSR2 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CELSR2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CELSR2 mRNA23649840
D019833GenisteinGenistein results in increased expression of CELSR2 mRNA20884965
C411652IC 261[IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein]16484285
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of CELSR2 mRNA"21635667
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CELSR2 mRNA25613284
D007529Isoflavones[ENNG co-treated with Isoflavones] results in increased expression of CELSR2 protein22248470
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CELSR2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CELSR2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CELSR2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CELSR2 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalate[IC 261 results in decreased activity of CSNK1A1 protein] inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein]16484285
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the transport of CELSR2 protein16484285
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased phosphorylation of CELSR2 protein16484285
C028007nickel monoxidenickel monoxide results in decreased expression of CELSR2 mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELSR2 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CELSR2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CELSR2 mRNA26272509
D011374ProgesteroneProgesterone results in decreased expression of CELSR2 mRNA23018184
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CELSR2 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CELSR2 mRNA25895662
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CELSR2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CELSR2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CELSR2 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CELSR2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CELSR2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CELSR2 mRNA28065790
D014635Valproic AcidValproic Acid affects the expression of CELSR2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CELSR2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of CELSR2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of CELSR2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of CELSR2 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-NAS10907856  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-NAS10907856  
GO:0016055Wnt signaling pathway-ISS-  
GO:0021999neural plate anterior/posterior regionalization-ISS-  
GO:0022407regulation of cell-cell adhesion-ISS-  
GO:0048813dendrite morphogenesis-ISS-  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0016021integral component of membrane-NAS10907856  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20442857Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (2010 Apr 29)Suchindran SPLoS Genet
22003152Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)Grallert HEur Heart J
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One