Gene: EGR2

1959
AT591|CMT1D|CMT4E|KROX20
early growth response 2
protein-coding
10q21.3
Ensembl:ENSG00000122877 MIM:129010 Vega:OTTHUMG00000018308 UniprotKB:P11161
NG_008936.2
PubMed
1   ANCO-SNPs
OD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.373e-1 (AD)  7.092e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10509177chr10:62908288 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EGR40.838
EGR10.817
ARC0.765
NR4A30.753
FOSB0.709
KLF100.709
NPAS40.707
DUSP40.659
DUSP60.648
EGR30.641

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFTN2-0.43
DOCK5-0.352
NFIA-0.349
KLF15-0.349
SLC14A1-0.346
RHBDL2-0.338
MEGF10-0.336
KIAA1755-0.335
ZCCHC24-0.331
ACSS3-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EGR2 mRNA28329830
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of EGR2 mRNA"25710175
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EGR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EGR2 mRNA"27188386
C0060148-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate"8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate inhibits the reaction [calcium phosphate results in increased expression of EGR2 mRNA]"12784042
C496492abrineabrine results in decreased expression of EGR2 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of EGR2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of EGR2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EGR2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EGR2 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of EGR2 mRNA]19350554
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EGR2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EGR2 mRNA21632981|2164198
D000447AldehydesAldehydes results in increased expression of EGR2 mRNA25014914
D0435825-alpha-Dihydroprogesterone5-alpha-Dihydroprogesterone results in increased expression of EGR2 mRNA17478888
D0435825-alpha-Dihydroprogesterone5-alpha-Dihydroprogesterone results in increased expression of EGR2 protein17478888
D000638AmiodaroneAmiodarone results in increased expression of EGR2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EGR2 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of EGR2 mRNA"22863853
D000936Antigen-Antibody ComplexAntigen-Antibody Complex results in increased expression of EGR2 mRNA25451590
D000936Antigen-Antibody Complexshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR2 mRNA]25451590
D000068180AripiprazoleAripiprazole results in increased expression of EGR2 mRNA17868501
D001151ArsenicArsenic affects the methylation of EGR2 gene25304211
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of EGR2 mRNA]19350554
C006632arsenic trioxidearsenic trioxide results in decreased expression of EGR2 mRNA19128835|1935055
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EGR2 mRNA"18687144
C038422ascladiolascladiol results in increased expression of EGR2 mRNA27913847
D001280AtrazineAtrazine results in decreased expression of EGR2 mRNA25929836
D001285AtropineAtropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]7968354
D001374AzacitidineAzacitidine results in increased expression of EGR2 mRNA20823114
D001379AzathioprineAzathioprine results in increased expression of EGR2 mRNA22623647
C006680baicaleinbaicalein results in decreased expression of EGR2 mRNA24560969
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
C447119bazedoxifenebazedoxifene results in increased expression of EGR2 mRNA19914376
D001554BenzeneBenzene results in increased expression of EGR2 mRNA19162166
D001554BenzeneBenzene results in decreased expression of EGR2 mRNA15120971|1512265
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EGR2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EGR2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EGR2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EGR2 mRNA21839799
C020711beryllium sulfateberyllium sulfate results in increased expression of EGR2 mRNA16314022
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of EGR2 mRNA20404318
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EGR2 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of EGR2 mRNA20660070
D004958EstradiolEstradiol affects the expression of EGR2 mRNA15598610
D004958EstradiolEstradiol results in increased expression of EGR2 mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of EGR2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of EGR2 mRNA25181051
D001761BleomycinBleomycin affects the expression of EGR2 mRNA26345256
D000069286BortezomibBortezomib results in decreased expression of EGR2 mRNA20830808
D000069286BortezomibBortezomib results in decreased expression of EGR2 mRNA20830808
D000069286BortezomibBortezomib results in decreased expression of EGR2 protein20830808
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of EGR2 mRNA20147733|2207961
C018475butyraldehydebutyraldehyde results in increased expression of EGR2 mRNA26079696
D002104CadmiumCadmium results in increased expression of EGR2 mRNA21694771
D000001CalcimycinCalcimycin results in increased expression of EGR2 mRNA25451590
D000001Calcimycinshikonin inhibits the reaction [Calcimycin results in increased expression of EGR2 mRNA]25451590
C020243calcium phosphate"8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate inhibits the reaction [calcium phosphate results in increased expression of EGR2 mRNA]"12784042
C020243calcium phosphatecalcium phosphate results in increased expression of EGR2 mRNA12784042
C020243calcium phosphateU 0126 inhibits the reaction [calcium phosphate results in increased expression of EGR2 mRNA]12784042
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EGR2 mRNA27339419
D002509CephaloridineCephaloridine results in decreased expression of EGR2 mRNA18500788
C026690cerous chloridecerous chloride results in decreased expression of EGR2 mRNA23573234
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EGR2 mRNA"27188386
D002737ChloropreneChloroprene results in decreased expression of EGR2 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of EGR2 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EGR2 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EGR2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of EGR2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EGR2 mRNA]17585979
D003024ClozapineClozapine affects the expression of EGR2 mRNA19401217
D003024ClozapineClozapine results in decreased expression of EGR2 protein17028028
D003042CocaineCocaine results in increased expression of EGR2 mRNA20056891
D003042CocaineCocaine affects the expression of EGR2 mRNA20187946
D003042CocaineCocaine results in increased expression of EGR2 mRNA27899881
D003300CopperCopper results in increased expression of EGR2 mRNA24403277
D003300CopperCopper results in increased expression of EGR224403277
D019327Copper SulfateCopper Sulfate results in increased expression of EGR2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of EGR2 mRNA27523638
D003513CycloheximideCycloheximide results in increased expression of EGR2 mRNA19350554
D003520CyclophosphamideCyclophosphamide results in decreased expression of EGR2 mRNA21041162
D016572CyclosporineCyclosporine results in increased expression of EGR2 mRNA20106945|2163298
D016572CyclosporineCyclosporine inhibits the reaction [Zymosan results in increased expression of EGR2 mRNA]17312158
D016572CyclosporineCyclosporine results in decreased expression of EGR2 mRNA25224403
D016572CyclosporineCyclosporine results in increased expression of EGR2 mRNA21865292
C093628cyproconazolecyproconazole results in decreased expression of EGR2 mRNA22664269
D003703DemecolcineDemecolcine results in increased expression of EGR2 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of EGR2 mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of EGR2 mRNA21041162|2273378
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EGR2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EGR2 mRNA21266533|2174549
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EGR2 mRNA20823114
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of EGR2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EGR2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of EGR2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of EGR2 mRNA22023808
D019422Dietary SucroseDietary Sucrose results in increased expression of EGR2 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of EGR2 mRNA21041162
D0151279,10-Dimethyl-1,2-benzanthracene"[CYP1B1 protein affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene] which affects the expression of EGR2 mRNA"27891153
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of EGR2 mRNA"27840820
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of EGR2 mRNA17374397
D004237DiuronDiuron results in increased expression of EGR2 mRNA25152437
D004317DoxorubicinDoxorubicin affects the expression of EGR2 mRNA15033991
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of EGR2 mRNA23649840
D005054EugenolEugenol results in decreased expression of EGR2 mRNA17374397
C000499ferric oxideferric oxide analog results in increased expression of EGR2 mRNA24525745|2508621
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EGR2 mRNA28329830
C061365flusilazoleflusilazole results in decreased expression of EGR2 mRNA22664269
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EGR2 mRNA20938992
D005557FormaldehydeFormaldehyde inhibits the reaction [H3F3A protein binds to EGR2 promoter]28937961
D005557FormaldehydeFormaldehyde results in increased expression of EGR2 mRNA17938736|2893796
D005557FormaldehydeFormaldehyde results in increased expression of EGR2 mRNA18499655
C039281furanfuran results in increased expression of EGR2 mRNA27387713
C039281furanfuran results in increased methylation of EGR2 gene22079235
C010974glyphosateglyphosate results in decreased expression of EGR2 mRNA20695457
D006220HaloperidolHaloperidol affects the expression of EGR2 mRNA19401217
D006220HaloperidolHaloperidol results in decreased expression of EGR2 protein17028028
D006220HaloperidolHaloperidol results in increased expression of EGR2 mRNA18208916
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EGR2 mRNA20044591
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EGR2 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of EGR2 mRNA22641619
C031895lead chromatelead chromate results in increased expression of EGR2 mRNA23584427
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of EGR2 mRNA25613284
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of EGR2 mRNA24525745
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EGR2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of EGR2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of EGR2 mRNA26378955
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of EGR2 mRNA20823114
D008694MethamphetamineMethamphetamine results in increased expression of EGR2 mRNA15644446|1956491
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EGR2 mRNA20938992
D008731MethoxychlorMethoxychlor results in increased methylation of EGR2 gene19589859
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EGR2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of EGR2 mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate affects the expression of EGR2 mRNA19162170
D009020MorphineMorphine results in increased expression of EGR2 mRNA22454534
D009151Mustard GasMustard Gas results in increased expression of EGR2 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EGR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EGR2 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of EGR2 mRNA18978301
C017096n-butoxyethanoln-butoxyethanol results in increased expression of EGR2 mRNA19812364
D009525NiacinNiacin results in increased expression of EGR2 mRNA20303128
D009538NicotineNicotine results in increased expression of EGR2 mRNA17456735
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of EGR2 mRNA17616710
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of EGR2 mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of EGR2 mRNA17374397
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of EGR2 mRNA]19555225
C010272palytoxinpalytoxin results in increased expression of EGR2 mRNA26436198
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of EGR2 mRNA18593933
C046012pentanalpentanal results in increased expression of EGR2 mRNA26079696
D010634PhenobarbitalPhenobarbital results in decreased expression of EGR2 mRNA19270015
D010705PhosgenePhosgene affects the expression of EGR2 mRNA16300373
D010862PilocarpineAtropine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]7968354
D010862PilocarpinePilocarpine results in increased expression of EGR2 mRNA7968354
D010862PilocarpinePirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]7968354
D010890PirenzepinePirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]7968354
C006253pirinixic acidpirinixic acid results in increased expression of EGR2 mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of EGR2 mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of EGR2 mRNA21334430
D011280PregnanolonePregnanolone results in increased expression of EGR2 mRNA17478888
D011280PregnanolonePregnanolone results in increased expression of EGR2 protein17478888
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EGR2 mRNA22698814
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of EGR2 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of EGR2 mRNA17478888
D011374ProgesteroneProgesterone results in increased expression of EGR2 protein17478888
C005556propionaldehydepropionaldehyde results in increased expression of EGR2 mRNA26079696
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
D011794QuercetinQuercetin results in increased expression of EGR2 mRNA21632981
C012526quercitrinquercitrin results in increased expression of EGR2 mRNA25193878
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of EGR2 mRNA21127053
D018967RisperidoneRisperidone results in decreased expression of EGR2 protein17028028
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of EGR2 mRNA"16678137
C534628SCH 23390SCH 23390 results in decreased expression of EGR2 mRNA19564919
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of EGR2 mRNA17540011
C009250sevofluranesevoflurane affects the expression of EGR2 mRNA15967596
C016101shikoninshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of EGR2 mRNA]25451590
C016101shikoninshikonin inhibits the reaction [Calcimycin results in increased expression of EGR2 mRNA]25451590
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EGR2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EGR2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide affects the expression of EGR2 mRNA19073995
D012822Silicon DioxideSilicon Dioxide results in increased expression of EGR2 mRNA19073995|2322117
D012834SilverSilver results in increased expression of EGR2 mRNA26014281|2655175
D012834SilverSilver results in increased expression of EGR2 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of EGR2 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of EGR2 mRNA27257137
D012999SomanSoman results in increased expression of EGR2 mRNA19281266
D053260SootSoot results in increased expression of EGR2 mRNA22461453|2655175
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EGR2 mRNA21641980
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of EGR2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of EGR2 mRNA26378955
D016559TacrolimusTacrolimus results in increased expression of EGR2 mRNA21865292
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EGR2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of EGR2 5' UTR28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of EGR2 exon28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of EGR2 gene28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the methylation of EGR2 promoter28011154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EGR2 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EGR2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EGR2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EGR2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EGR2 mRNA16962184
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of EGR2 mRNA20830808
C009495titanium dioxidetitanium dioxide analog results in increased expression of EGR2 mRNA25111187
C009495titanium dioxidetitanium dioxide results in increased expression of EGR2 mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of EGR2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EGR2 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of EGR2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of EGR2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of EGR2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of EGR2 mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of EGR2 mRNA20488242|2266426
C032910triadimefontriadimefon results in decreased expression of EGR2 mRNA22664269
D014230TriazolesTriazoles results in decreased expression of EGR2 mRNA17343997
C011559tributyltintributyltin results in increased expression of EGR2 mRNA28011154
C012589trichostatin Atrichostatin A affects the expression of EGR2 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of EGR2 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of EGR2 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EGR2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EGR2 mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [calcium phosphate results in increased expression of EGR2 mRNA]12784042
D017974Uranium CompoundsUranium Compounds results in increased expression of EGR2 mRNA19654044
D014520UrethaneUrethane results in increased expression of EGR2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of EGR2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EGR2 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased expression of EGR2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of EGR2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of EGR2 mRNA15799026
C025643vinclozolinvinclozolin affects the expression of EGR2 mRNA19015723
C121611VIVIT peptideVIVIT peptide inhibits the reaction [Zymosan results in increased expression of EGR2 mRNA]17312158
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of EGR2 mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of EGR2 mRNA20977926
D015054ZymosanCLEC7A protein affects the reaction [Zymosan results in increased expression of EGR2 mRNA]17312158
D015054ZymosanCyclosporine inhibits the reaction [Zymosan results in increased expression of EGR2 mRNA]17312158
D015054ZymosanVIVIT peptide inhibits the reaction [Zymosan results in increased expression of EGR2 mRNA]17312158
D015054ZymosanZymosan results in increased expression of EGR2 mRNA17312158

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12687019  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA12687019  
GO:0001102RNA polymerase II activating transcription factor binding-ISS-  
GO:0003682chromatin binding-ISS-  
GO:0003700DNA-binding transcription factor activity-IDA14532282  
GO:0005515protein binding-IPI14532282  
GO:0016740transferase activity-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI19651900  
GO:0044212transcription regulatory region DNA binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0071837HMG box domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0006611protein export from nucleus-ISS-  
GO:0007420brain development-TAS9537424  
GO:0007422peripheral nervous system development-TAS9537424  
GO:0007611learning or memory-IEA-  
GO:0007622rhythmic behavior-IEA-  
GO:0008045motor neuron axon guidance-IEA-  
GO:0014037Schwann cell differentiation-IEA-  
GO:0016925protein sumoylation-IEA-  
GO:0021612facial nerve structural organization-IEA-  
GO:0021660rhombomere 3 formation-IEA-  
GO:0021666rhombomere 5 formation-IEA-  
GO:0030278regulation of ossification-IEA-  
GO:0032868response to insulin-IEA-  
GO:0035284brain segmentation-IEA-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0042552myelination-IEA-  
GO:0045444fat cell differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12687019  
GO:0048168regulation of neuronal synaptic plasticity-IEA-  
GO:0071310cellular response to organic substance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC14532282  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28956832Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)Sharafeldin NInt J Environ Res Public Health
25025380Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats. (2014)Pravetoni MPLoS One