Gene: EIF2S1

1965
EIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2A
eukaryotic translation initiation factor 2 subunit alpha
protein-coding
14q23.3
Ensembl:ENSG00000134001 MIM:603907 Vega:OTTHUMG00000029800 UniprotKB:P05198
NC_000014.9
PubMed
CD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.617e-3 (AD)  1.663e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YME1L10.957
ARCN10.951
KPNA40.95
MRPL30.947
RAN0.946
RAB140.946
TAX1BP10.945
CAPRIN10.944
RSL1D10.944
CSNK2A10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.699
OR4F29-0.652
VNN3-0.256
CSAG1-0.244
MTRNR2L10-0.243
ANPEP-0.243
MTRNR2L6-0.242
MTRNR2L9-0.232
TNFRSF13B-0.222
P2RY14-0.219

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Palmitates results in increased phosphorylation of EIF2S1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2S1 protein]23576437
C5616191-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]23576437
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of EIF2S1 protein]25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]]"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]"25639565
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of EIF2S1 protein"25950987
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased phosphorylation of EIF2S1 protein"21703327
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased phosphorylation of EIF2S1 protein"27853103
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased expression of EIF2S1 protein modified form"25160872
C0047622,4-dichlorophenol"Enzyme Inhibitors promotes the reaction [2,4-dichlorophenol results in increased expression of EIF2S1 protein modified form]"25160872
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EIF2S1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EIF2S1 mRNA"21346803
C4388683,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide"3,4,5-trihydroxy-2--methoxy-8,8-dimethyl-N-(hexahydro-2-oxo-6-(cyclohexylcarbonyl)oxy-2H-azepin-3-yl)non-6-enamide affects the metabolism of EIF2S1 protein"14534293
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EIF2S1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2S1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased phosphorylation of EIF2S1 protein"19561079
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"EIF2S1 protein modified form affects the susceptibility to (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"19561079
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of EIF2S1 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein24291486
C0275764-hydroxy-2-nonenalAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]24291486
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Atorvastatin Calcium results in increased phosphorylation of EIF2S1 protein]20876807
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]28063906
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2S1 protein]27638049
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of EIF2S1 protein modified form]26804720
C0757734-phenylbutyric acid4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]28063906
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]27484784
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of EIF2S1 protein modified form27484784
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of EIF2S1 protein"22898769
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2S1 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased phosphorylation of EIF2S1 protein"27709270
C1118556-formylindolo(3,2-b)carbazole"Acetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased phosphorylation of EIF2S1 protein]"27709270
C4996938-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2S1 protein]26338418
D000082AcetaminophenAcetaminophen results in increased phosphorylation of EIF2S1 protein19931551
C099158acetyl-aspartyl-glutamyl-valyl-aspartalacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein]18973755
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of EIF2S1 protein]27634458
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]15788408
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of EIF2S1 protein]"27816613
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased phosphorylation of EIF2S1 protein]"27709270
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of EIF2S1 protein]21911445
D000111AcetylcysteineAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]24291486
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of EIF2S1 protein]16324875
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]27484784
D000171AcroleinAcrolein results in increased phosphorylation of EIF2S1 protein18951912
D020106AcrylamideAcetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of EIF2S1 protein]27634458
D020106AcrylamideAcrylamide results in increased phosphorylation of EIF2S1 protein27634458
D020106AcrylamideAcrylamide results in increased expression of EIF2S1 mRNA15749267
C016601afimoxifeneafimoxifene results in decreased expression of EIF2S1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EIF2S1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EIF2S1 mRNA22100608
C031143AICA ribonucleotideAICA ribonucleotide results in decreased phosphorylation of EIF2S1 protein22898769
C518327aloe emodinaloe emodin results in increased phosphorylation of EIF2S1 protein22210228
D000596Amino AcidsEIF2S1 protein mutant form inhibits the reaction [Amino Acids deficiency results in increased expression of DDIT3 protein]16330322
D006710HomocysteineHomocysteine results in increased phosphorylation of EIF2S1 protein22964297
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EIF2S1 mRNA16483693
D000841AnisomycinAnisomycin results in increased phosphorylation of EIF2S1 protein10477262
C000228aristolochic acid Iaristolochic acid I results in increased phosphorylation of EIF2S1 protein22445861
C006632arsenic trioxidearsenic trioxide results in increased expression of EIF2S1 protein modified form22922937
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of EIF2S1 protein25258189
C006632arsenic trioxidesulforafan promotes the reaction [arsenic trioxide results in increased expression of EIF2S1 protein modified form]22922937
C006632arsenic trioxide"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2S1 protein]"27638049
C006632arsenic trioxide4-phenylbutyric acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2S1 protein]27638049
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of EIF2S1 protein27638049
C015001arsenitearsenite results in increased phosphorylation of EIF2S1 protein17553788|2431537
C015001arsenite[arsenite results in increased phosphorylation of EIF2S1 protein] which results in decreased expression of MCL1 protein17553788
C015001arsenitearsenite results in increased phosphorylation of EIF2S1 protein24315374
C015001arseniteEIF2S1 protein mutant form inhibits the reaction [arsenite results in decreased expression of TIMM17A protein]24315374
C015001arseniteEIF2S1 protein mutant form inhibits the reaction [arsenite results in decreased expression of TIMM23 protein]24315374
C015001arseniteEIF2S1 protein mutant form results in decreased susceptibility to arsenite24315374
C015001arsenitearsenite results in increased phosphorylation of EIF2S1 protein10477262
C015001arsenitearsenite results in increased phosphorylation of EIF2S1 protein9545260
D000069059Atorvastatin Calcium4-phenylbutyric acid inhibits the reaction [Atorvastatin Calcium results in increased phosphorylation of EIF2S1 protein]20876807
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased phosphorylation of EIF2S1 protein20876807
D000069059Atorvastatin CalciumEIF2AK3 mutant form inhibits the reaction [Atorvastatin Calcium results in increased phosphorylation of EIF2S1 protein]20876807
C017037aurinaurin results in increased phosphorylation of EIF2S1 protein25477506
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of EIF2S1 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of EIF2S1 protein modified form22321511
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein21090173
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of EIF2S1 protein23684743
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA24657404
D004958EstradiolEstradiol promotes the reaction [EIF2S1 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in increased expression of EIF2S1 mRNA16514628
D004958EstradiolEstradiol affects the expression of EIF2S1 mRNA15598610
D001663BilirubinBilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein20196124
C109992bis(isopropyl methyl)phosphonatebis(isopropyl methyl)phosphonate results in increased phosphorylation of EIF2S1 protein27665771
C006780bisphenol Abisphenol A affects the expression of EIF2S1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of EIF2S1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of EIF2S1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of EIF2S1 mRNA21601586
C032688boric acidboric acid results in increased phosphorylation of EIF2S1 protein25425213|2758702
D000069286BortezomibBortezomib inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]16357177
D000069286BortezomibBortezomib results in increased phosphorylation of EIF2S1 protein16357177|2002296
D000069286BortezomibEIF2AK3 mutant form inhibits the reaction [Bortezomib results in increased phosphorylation of EIF2S1 protein]20022965
D000069286BortezomibBortezomib results in increased phosphorylation of EIF2S1 protein21090173
D016642BupropionBupropion results in increased phosphorylation of EIF2S1 protein21354251
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of EIF2S1 protein20600546|2180909
D019256Cadmium Chloridesalubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]21809093
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EIF2S1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EIF2S1 protein modified form21908765
D019256Cadmium ChloridePhenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of EIF2S1 protein modified form]21908765
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EIF2S1 mRNA21297351
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of EIF2S1 protein20600546
D002211CapsaicinCapsaicin results in increased phosphorylation of EIF2S1 protein19139269
D002220CarbamazepineCarbamazepine affects the expression of EIF2S1 mRNA24752500
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of EIF2S1 protein]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased phosphorylation of EIF2S1 protein25827057
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of EIF2S1 mRNA18636392
D004390ChlorpyrifosChlorpyrifos results in increased phosphorylation of EIF2S1 protein27993609
D002784CholesterolEIF2S1 protein modified form results in decreased abundance of Cholesterol16330322
C512471chromium (D-Phenylalanine)3chromium (D-Phenylalanine)3 results in decreased expression of EIF2S1 protein modified form18388893
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of EIF2S1 mRNA28472532
D003042CocaineCocaine results in increased phosphorylation of EIF2S118593214
D003375CoumestrolCoumestrol results in increased expression of EIF2S1 mRNA19167446
D003513CycloheximideCycloheximide results in increased expression of EIF2S1 mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of EIF2S1 mRNA19684285
D003513CycloheximideCycloheximide results in increased phosphorylation of EIF2S1 protein24315374
D016572CyclosporineCyclosporine results in increased phosphorylation of EIF2S1 protein22155090
D003620DantroleneDantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]23743301
D003620DantroleneDantrolene results in decreased phosphorylation of EIF2S1 protein15921666
C017180decamethrin[salubrinal results in decreased activity of EIF2S1 protein] which results in decreased susceptibility to decamethrin21555338
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased phosphorylation of EIF2S1 protein"24532803
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"EIF2AK3 protein promotes the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased phosphorylation of EIF2S1 protein]"24532803
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"NDRG1 protein inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased phosphorylation of EIF2S1 protein]"24532803
D003993Dibutyl Phthalate4-phenylbutyric acid inhibits the reaction [Dibutyl Phthalate results in increased expression of EIF2S1 protein modified form]26804720
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EIF2S1 protein modified form26804720
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EIF2S1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EIF2S1 mRNA21266533
D002945Cisplatin8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2S1 protein]26338418
D002945CisplatinCisplatin results in increased phosphorylation of EIF2S1 protein26338418
D004008DiclofenacDiclofenac affects the expression of EIF2S1 mRNA24752500
D004008Diclofenac[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein27313093
D004041Dietary Fats1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2S1 protein]23576437
D004041Dietary FatsDietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2S1 protein]23576437
D004041Dietary FatsDietary Fats results in increased phosphorylation of EIF2S1 protein23576437
D004041Dietary Fats[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased phosphorylation of EIF2S1 protein22509299
C012906dihydrocapsaicindihydrocapsaicin results in increased phosphorylation of EIF2S1 protein19139269
D002117CalcitriolCalcitriol results in decreased expression of EIF2S1 mRNA16847355
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2S1 protein]"27638049
D004147DioxinsDioxins affects the expression of EIF2S1 mRNA20463971
C042986ebselenebselen results in increased phosphorylation of EIF2S1 protein27282967
D004791Enzyme Inhibitors"Enzyme Inhibitors promotes the reaction [2,4-dichlorophenol results in increased expression of EIF2S1 protein modified form]"25160872
D004791Enzyme InhibitorsEnzyme Inhibitors results in increased expression of EIF2S1 protein modified form25160872
C078846epoxomicin"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]]"25639565
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of EIF2S1 protein modified form24768708
D000431EthanolEthanol results in increased expression of EIF2S1 protein modified form24224909
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in increased expression of EIF2S1 protein modified form]24224909
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EIF2S1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EIF2S1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF2S1 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of EIF2S1 mRNA28189721
D005419FlavonoidsFlavonoids results in decreased expression of EIF2S1 mRNA18035473
D005485FlutamideFlutamide results in increased expression of EIF2S1 mRNA24136188
D005632FructoseFructose results in increased phosphorylation of EIF2S1 protein22698815
D005632FructosePhenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein]22698815
C070081fulvestrantfulvestrant results in decreased expression of EIF2S1 mRNA16514628
C056933fumonisin B1fumonisin B1 results in increased phosphorylation of EIF2S1 protein25925693
D005688Galactosamine4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]28844859
D005688Galactosamine4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]28844859
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of and results in decreased phosphorylation of EIF2S1 protein28844859
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA28844859
D005839GentamicinsGentamicins results in increased expression of EIF2S1 mRNA22061828
D005897GlafenineGlafenine results in increased expression of EIF2S1 mRNA24136188
D005944GlucosamineGlucosamine results in increased phosphorylation of EIF2S1 protein19383982
D005944GlucosamineEIF2AK3 gene mutant form inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein]16324875
D005944GlucosamineGlucosamine results in increased phosphorylation of EIF2S1 protein16324875
D005947Glucoseacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein]18973755
D005947GlucoseGlucose results in increased phosphorylation of EIF2S1 protein18973755
C010974glyphosateglyphosate results in decreased expression of EIF2S1 mRNA26302742
D006143GuanabenzGuanabenz promotes the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]24892553
D017313FenretinideEIF2AK3 mutant form inhibits the reaction [Fenretinide results in increased phosphorylation of EIF2S1 protein]20022965
D017313FenretinideFenretinide results in increased phosphorylation of EIF2S1 protein20022965
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of EIF2S1 protein]16324875
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of EIF2S1 protein16324875
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EIF2S1 mRNA25613284
D007654KetoconazoleEIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]16330322
D007654KetoconazoleEIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]16330322
D007654KetoconazoleEIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]16330322
C008261lead acetatelead acetate results in increased phosphorylation of EIF2S1 protein25088297
C008261lead acetateProanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2S1 protein]25088297
C029891lead chloridelead chloride results in increased phosphorylation of EIF2S1 protein25410796
C045463leflunomideleflunomide results in increased phosphorylation of EIF2S1 protein28988120
C002385linsidominelinsidomine results in increased phosphorylation of EIF2S1 protein21703327
D008070Lipopolysaccharides4-phenylbutyric acid affects the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased phosphorylation of EIF2S1 protein]28844859
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA]28844859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of and results in decreased phosphorylation of EIF2S1 protein28844859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of EIF2S1 mRNA28844859
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EIF2S1 mRNA21641980
C025340manganese chloridemanganese chloride results in increased phosphorylation of EIF2S1 protein23764342
C025340manganese chloridemanganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein]23948121
D008550MelatoninMelatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]28070110
D008627Mercuric ChlorideMercuric Chloride affects the expression of EIF2S1 mRNA20353558
D008694MethamphetamineMelatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein]28070110
D008694MethamphetamineMethamphetamine results in increased phosphorylation of EIF2S1 protein28070110
D008701MethapyrileneMethapyrilene results in increased expression of EIF2S1 mRNA17450226
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased phosphorylation of EIF2S1 protein24810058
C012258mevastatinEIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]16330322
C012258mevastatinEIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]16330322
C012258mevastatinEIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]16330322
C012258mevastatinEIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]16330322
D008911MinocyclineMinocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]17406652
D008911MinocyclineMinocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]17406652
D008911MinocyclineMinocycline results in increased phosphorylation of EIF2S1 protein22245251
D008942MitoxantroneEIF2S1 protein affects the susceptibility to Mitoxantrone16217747
D009270NaloxoneNaloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein]26377394
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EIF2S1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EIF2S1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of EIF2S1 mRNA24136188
D009534NiclosamideNiclosamide results in increased phosphorylation of EIF2S1 protein26917416
D009538NicotineNicotine results in increased phosphorylation of EIF2S1 protein26803847
C012655nimesulidenimesulide results in increased expression of EIF2S1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of EIF2S1 mRNA17616710
D019319Okadaic AcidOkadaic Acid results in increased phosphorylation of EIF2S1 protein26732598
C484027oligofectamineoligofectamine results in increased expression of EIF2S1 mRNA14668052
D010098OxycodoneNaloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein]26377394
D010098OxycodoneOxycodone results in increased phosphorylation of EIF2S1 protein26377394
D010098OxycodoneOxycodone results in increased phosphorylation of EIF2S1 protein26377394
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of EIF2S1 mRNA18636392
D010168Palmitates1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Palmitates results in increased phosphorylation of EIF2S1 protein]23576437
D010168PalmitatesPalmitates results in increased phosphorylation of EIF2S1 protein22898769|2357643
D010168PalmitatesPalmitates results in increased expression of EIF2S1 protein modified form21209018
D010168PalmitatesTO-901317 inhibits the reaction [Palmitates results in increased expression of EIF2S1 protein modified form]21209018
D010269ParaquatEIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]28986289
D010269ParaquatEIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]28986289
D010269ParaquatParaquat results in increased expression of EIF2S1 protein modified form28986289
D010269Paraquatsalubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]28986289
D010269ParaquatParaquat results in increased phosphorylation of EIF2S1 protein27442881
D010269ParaquatParaquat results in increased phosphorylation of EIF2S1 protein22245251
D010396PenicillaminePenicillamine results in increased phosphorylation of EIF2S1 protein22843330
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EIF2S1 mRNA19162173
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased phosphorylation of EIF2S1 protein27579538
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased phosphorylation of EIF2S1 protein27579538
D010654PhenylbutyratesPhenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of EIF2S1 protein modified form]21908765
D010654PhenylbutyratesPhenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2S1 protein]22698815
D010862PilocarpinePilocarpine promotes the reaction [EIF2AK2 protein modified form results in increased phosphorylation of EIF2S1 protein]16492139
D010862PilocarpinePilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]16492139
D010862PilocarpinePilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of ACTB protein]16492139
D010862PilocarpinePilocarpine promotes the reaction [EIF2S1 protein modified form results in decreased expression of RPL32 protein]16492139
D010862PilocarpinePilocarpine results in increased phosphorylation of EIF2S1 protein15003282
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EIF2S1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of EIF2S1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of EIF2S1 mRNA19162173
D010894PiroxicamPiroxicam results in decreased expression of EIF2S1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of EIF2S1 mRNA23557933
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2S1 protein]25088297
D011718Pyrazinamide4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]28063906
D011718PyrazinamidePyrazinamide results in increased phosphorylation of EIF2S1 protein28063906
D011718Pyrazinamide4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2S1 protein]28063906
D011718PyrazinamidePyrazinamide results in increased phosphorylation of EIF2S1 protein28063906
D011794QuercetinQuercetin results in increased expression of EIF2S1 mRNA21632981
D011794QuercetinQuercetin results in increased expression of EIF2S1 protein modified form19017364
D011794QuercetinQuercetin results in increased phosphorylation of EIF2S1 protein25611565
D011794Quercetinsalubrinal promotes the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]25611565
D011794Quercetintauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]25611565
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of EIF2S1 mRNA16514628
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in increased expression of EIF2S1 protein modified form]24224909
C059514resveratrolresveratrol results in increased phosphorylation of EIF2S1 protein17914584|2289876
D012293RifampinRifampin results in increased phosphorylation of EIF2S1 protein24638036
D012402RotenoneRotenone results in increased expression of EIF2S1 protein19233273
D012402RotenoneRotenone results in increased phosphorylation of EIF2S1 protein19233273
D012402RotenoneRotenone results in decreased phosphorylation of EIF2S1 protein25428620
D012402Rotenonesalubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]25428620
C496827salubrinalEIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]]28986289
C496827salubrinalEIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]28986289
C496827salubrinal[salubrinal co-treated with EPO protein] results in increased phosphorylation of EIF2S1 protein23690448
C496827salubrinalsalubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]21809093
C496827salubrinalsalubrinal promotes the reaction [Paraquat results in increased expression of EIF2S1 protein modified form]28986289
C496827salubrinalsalubrinal promotes the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]25611565
C496827salubrinal[salubrinal results in decreased activity of EIF2S1 protein] which results in decreased susceptibility to decamethrin21555338
C496827salubrinalsalubrinal results in increased expression of EIF2S1 protein modified form25950987|2898628
C496827salubrinalsalubrinal results in increased phosphorylation of and results in decreased activity of EIF2S1 protein25170120
C496827salubrinalsalubrinal results in increased phosphorylation of EIF2S1 protein21809093|2369044
C496827salubrinalsalubrinal inhibits the reaction [Rotenone results in decreased phosphorylation of EIF2S1 protein]25428620
C496827salubrinalsalubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]28844859
C496827salubrinalsalubrinal inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 mRNA]28844859
C496827salubrinalsalubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein]24932542
C496827salubrinal[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK1 protein21147958
C496827salubrinal[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK3 protein21147958
C496827salubrinal[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK8 protein21147958
C496827salubrinal[salubrinal results in increased expression of EIF2S1 protein modified form] which results in increased phosphorylation of MAPK9 protein21147958
C496827salubrinalsalubrinal results in increased phosphorylation of EIF2S1 protein24932542
C496827salubrinalsalubrinal results in decreased activity of EIF2S1 protein21555338
C496827salubrinalsalubrinal results in increased expression of EIF2S1 protein modified form21147958
C093642SB 203580SB 203580 results in increased phosphorylation of EIF2S1 protein21090173
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of EIF2S1 mRNA12818353
D020280SertralineSertraline results in increased phosphorylation of EIF2S1 protein24865413
C009277sodium arsenatesodium arsenate results in decreased expression of EIF2S1 mRNA23922661
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]15788408
C017947sodium arsenitesodium arsenite results in increased phosphorylation of EIF2S1 protein15788408
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of EIF2S1 protein]21911445
C017947sodium arseniteEIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]16330322
C017947sodium arseniteEIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased expression of DDIT3 protein]16330322
C017947sodium arseniteEIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]16330322
C017947sodium arsenitesodium arsenite results in increased phosphorylation of EIF2S1 protein16330322|2191144
C016104sodium bichromatesodium bichromate results in increased expression of EIF2S1 mRNA22561333|2599309
C558809SR1001SR1001 results in decreased phosphorylation of EIF2S1 protein28698385
C559087SR 1078SR 1078 results in increased phosphorylation of EIF2S1 protein28698385
D019311StaurosporineStaurosporine results in increased phosphorylation of EIF2S1 protein21090173
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EIF2S1 mRNA21641980
C016766sulforafansulforafan promotes the reaction [arsenic trioxide results in increased expression of EIF2S1 protein modified form]22922937
C016766sulforafansulforafan results in increased expression of EIF2S1 protein modified form22922937
D013629TamoxifenTamoxifen affects the expression of EIF2S1 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]25611565
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]24802810
D000068698TenofovirTenofovir affects the phosphorylation of EIF2S1 protein27041070
C004648testosterone enanthatetestosterone enanthate affects the expression of EIF2S1 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of EIF2S1 mRNA18976794
C000591600tetrachlorobenzoquinone4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]27484784
C000591600tetrachlorobenzoquinoneAcetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]27484784
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form27484784
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased phosphorylation of EIF2S1 protein27484784
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of EIF2S1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EIF2S1 mRNA19684285
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF2S1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EIF2S1 mRNA17942748
D013749TetrachlorodibenzodioxinEIF2S1 mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPA5 protein]24932542
D013749TetrachlorodibenzodioxinEIF2S1 mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein]24932542
D013749TetrachlorodibenzodioxinEIF2S1 mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of DDIT3 protein]24932542
D013749Tetrachlorodibenzodioxinsalubrinal promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein]24932542
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of EIF2S1 protein24932542
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EIF2S1 mRNA25613284
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]23576437
D019284ThapsigarginEIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]20022965
D019284ThapsigarginThapsigargin results in increased expression of EIF2S1 protein modified form24224909
D019284ThapsigarginThapsigargin results in increased phosphorylation of EIF2S1 protein17553788|1923327
D019284Thapsigargin1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]23576437
D019284ThapsigarginEIF2S1 protein mutant form inhibits the reaction [Thapsigargin results in decreased expression of TIMM17A protein]24315374
D019284ThapsigarginEIF2S1 protein mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]24648495
D019284ThapsigarginEIF2S1 protein mutant form results in decreased susceptibility to Thapsigargin24315374
D019284ThapsigarginPTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]22509299
D019284ThapsigarginThapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 protein22509299
D019284ThapsigarginThapsigargin results in increased phosphorylation of EIF2S1 protein23576437|2431537
D019284ThapsigarginEIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]16324875
D019284Thapsigarginsalubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]28844859
D019284ThapsigarginThapsigargin results in increased expression of EIF2S1 mRNA28844859
D019284ThapsigarginThapsigargin results in increased phosphorylation of EIF2S1 protein16324875|2884485
D013853ThioacetamideThioacetamide results in increased expression of EIF2S1 mRNA23411599
D013883ThiostreptonThiostrepton results in increased expression of EIF2S1 protein modified form22321511
C423915TO-901317TO-901317 inhibits the reaction [Palmitates results in increased expression of EIF2S1 protein modified form]21209018
D014028Tobacco Smoke PollutionAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
D014028Tobacco Smoke PollutionDDIT3 mutant form inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
D014028Tobacco Smoke PollutionEIF2S1 mutant form inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA]21703327
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein21703327|2556832
D014028Tobacco Smoke Pollution[XBP1 mutant form co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]25568320
D014212TretinoinTretinoin results in decreased expression of EIF2S1 mRNA16054129
D014212TretinoinTretinoin results in increased phosphorylation of EIF2S1 protein22498432
D014212TretinoinTretinoin results in increased expression of EIF2S1 mRNA24977338
C011559tributyltinDantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]23743301
C011559tributyltintributyltin results in increased phosphorylation of EIF2S1 protein23743301
D014241TrichloroethyleneTrichloroethylene results in increased expression of EIF2S1 mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EIF2S1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of EIF2S1 protein]"27816613
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of EIF2S1 protein"27816613
C057693troglitazonetroglitazone results in decreased phosphorylation of EIF2S1 protein11834241
C080163trovafloxacintrovafloxacin results in decreased expression of EIF2S1 mRNA24136188
C005865troxerutin"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]]"25639565
C005865troxerutin"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]"25639565
D014415TunicamycinBortezomib inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]16357177
D014415TunicamycinNDRG1 protein inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]24532803
D014415TunicamycinSIRT7 protein inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]24210820
D014415TunicamycinTunicamycin results in increased expression of EIF2S1 protein modified form24224909
D014415TunicamycinTunicamycin results in increased phosphorylation of EIF2S1 protein16357177|1755378
D014415Tunicamycin[Tunicamycin results in increased phosphorylation of EIF2S1 protein] which results in decreased expression of MCL1 protein17553788
D014415TunicamycinEIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 protein]24648495
D014415TunicamycinEIF2S1 protein mutant form inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]16330322
D014415TunicamycinPTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]22509299
D014415TunicamycinTunicamycin results in increased activity of and results in increased phosphorylation of EIF2S1 protein22509299
D014415TunicamycinTunicamycin results in increased expression of EIF2S1 protein modified form25160872
D014415TunicamycinTunicamycin results in increased phosphorylation of EIF2S1 protein24648495
D014415TunicamycinGuanabenz promotes the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]24892553
D014415Tunicamycinsalubrinal inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 mRNA]28844859
D014415TunicamycinTunicamycin results in increased expression of EIF2S1 mRNA28844859
D014415TunicamycinTunicamycin results in increased phosphorylation of EIF2S1 protein24892553|2884485
C005466ursolic acidEIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]24802810
C005466ursolic acidtauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]24802810
C005466ursolic acidursolic acid results in increased phosphorylation of EIF2S1 protein24802810
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2S1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EIF2S1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EIF2S1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of EIF2S1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EIF2S1 gene25560391
D015215ZidovudineZidovudine results in increased phosphorylation of EIF2S1 protein27041070
D015034Zinc OxideZinc Oxide analog results in increased phosphorylation of EIF2S1 protein25680694

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003743translation initiation factor activity-IBA21873635  
GO:0003743translation initiation factor activity-IDA16289705  
GO:0005515protein binding-IPI9431994  11500362  16288713  16932749  17894550  18596238  
18971339  22323517  25393282  
GO:0043022ribosome binding-IBA21873635  
GO:0043022ribosome binding-IDA17894550  
GO ID GO Term Qualifier Evidence PubMed
GO:0006413translational initiation-TAS-  
GO:0007568aging-IEA-  
GO:0032057negative regulation of translational initiation in response to stress-ISS-  
GO:0034063stress granule assembly-ISS-  
GO:0034198cellular response to amino acid starvation-ISS-  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0034605cellular response to heat-IEA-  
GO:0034644cellular response to UV-ISS-  
GO:0034976response to endoplasmic reticulum stress-IMP18508033  
GO:0034976response to endoplasmic reticulum stress-ISS-  
GO:0036499PERK-mediated unfolded protein response-NAS22934019  
GO:0046777protein autophosphorylation-IEA-  
GO:0055085transmembrane transport-TAS-  
GO:1901216positive regulation of neuron death-IMP18508033  
GO:1905098negative regulation of guanyl-nucleotide exchange factor activity-IEA-  
GO:1990737response to manganese-induced endoplasmic reticulum stress-IEA-  
GO:2000676positive regulation of type B pancreatic cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005844polysome-TAS2948954  
GO:0005850eukaryotic translation initiation factor 2 complex-IBA21873635  
GO:0005850eukaryotic translation initiation factor 2 complex-IDA23063529  
GO:0005851eukaryotic translation initiation factor 2B complex-IBA21873635  
GO:0005851eukaryotic translation initiation factor 2B complexcolocalizes_withIDA11323413  
GO:0010494cytoplasmic stress granule-ISS-  
GO:0016020membrane-HDA19946888  
GO:0033290eukaryotic 48S preinitiation complex-IBA21873635  
GO:0043614multi-eIF complex-IBA21873635  
GO:0044207translation initiation ternary complex-IEA-  
GO:0070062extracellular exosome-HDA20458337  
GO:0097451glial limiting end-foot-IEA-  
KEGG ID KEGG Term
hsa03013RNA transport
hsa04141Protein processing in endoplasmic reticulum
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-381042PERK regulates gene expressionTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72649Translation initiation complex formationTAS
R-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43STAS
R-HSA-72695Formation of the ternary complex, and subsequently, the 43S complexTAS
R-HSA-72702Ribosomal scanning and start codon recognitionTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72731Recycling of eIF2:GDPTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26928076Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2alpha. (2016 Mar 1)Placzek ANElife
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy