Gene info: ID 196527

Gene: ANO6

GENE ID: 196527

Synonyms: BDPLT7|SCTS|TMEM16F

Description: anoctamin 6

Gene type: protein-coding

Location: 12q12

dbXrefs: Ensembl:ENSG00000177119 MIM:608663 Vega:OTTHUMG00000169564 UniprotKB:Q4KMQ2

RefSeq: NG_028220.1

Retrived from: SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) 3.831e-2 (ND) (Frontal_Cortex)

Pascal p-value : 7.641e-1 (AD) 1.974e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7965430	chr12:45316447 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs7138247	chr12:45275970 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs2052603	chr12:45252483 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MSN	0.896
MYD88	0.888
IL1R1	0.887
LIMS1	0.886
PLP2	0.881
OSMR	0.878
WWTR1	0.874
ZNF217	0.872
ANXA2	0.87
FNDC3B	0.867

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC7A4	-0.567
ABCC12	-0.559
MARCH4	-0.554
DLK2	-0.551
SPEF1	-0.534
ADRA1D	-0.528
NEUROD6	-0.524
PPEF1	-0.523
HAS1	-0.522
TMEM179	-0.519

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ANO6 mRNA"	19167446
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ANO6 mRNA"	19167446
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ANO6 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANO6 mRNA"	27188386
C058176	5-nitro-2-(3-phenylpropylamino)benzoic acid	5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein	24478309
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANO6 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of ANO6 gene	27153756
D001151	Arsenic	Arsenic affects the methylation of ANO6 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ANO6 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANO6 mRNA"	19150397
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of ANO6 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of ANO6 mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of ANO6 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased methylation of ANO6 gene	28505145
C018475	butyraldehyde	butyraldehyde results in decreased expression of ANO6 mRNA	26079696
D002220	Carbamazepine	Carbamazepine affects the expression of ANO6 mRNA	25979313
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO6 mRNA	20938992
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ANO6 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ANO6 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of ANO6 mRNA	19167446
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ANO6 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of ANO6 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of ANO6 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of ANO6 mRNA	18042831
C067648	digallic acid	digallic acid results in decreased activity of ANO6 protein	24478309
D017878	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of ANO6 protein"	24478309
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA	24690739
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased activity of ANO6 protein	24478309
D005485	Flutamide	Flutamide results in decreased expression of ANO6 mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO6 mRNA	20938992
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of ANO6 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of ANO6 mRNA	27392435
D008694	Methamphetamine	Methamphetamine results in increased expression of ANO6 mRNA	26307267
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO6 mRNA	20938992
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANO6 mRNA"	20188158
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of ANO6 mRNA	25380136
D009544	Niflumic Acid	Niflumic Acid affects the activity of ANO6 protein	24478309
C025589	ochratoxin A	ochratoxin A results in increased methylation of ANO6 gene	26431795
D000073878	Palm Oil	Palm Oil results in increased expression of ANO6 mRNA	18042831
C046012	pentanal	pentanal results in decreased expression of ANO6 mRNA	26079696
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANO6 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ANO6 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of ANO6 mRNA	18301758
D012999	Soman	Soman results in increased expression of ANO6 mRNA	19281266
C578466	T16AInh-A01	T16AInh-A01 results in decreased activity of ANO6 protein	24478309
D014050	Toluene	Toluene results in increased expression of ANO6 mRNA	22967744
D014212	Tretinoin	Tretinoin results in increased expression of ANO6 mRNA	21934132
D014635	Valproic Acid	Valproic Acid affects the expression of ANO6 mRNA	25979313
D014640	Vancomycin	Vancomycin results in decreased expression of ANO6 mRNA	18930951

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005227	calcium activated cation channel activity	-	IDA	22946059
GO:0005227	calcium activated cation channel activity	-	IMP	25651887
GO:0005227	calcium activated cation channel activity	-	ISS	-
GO:0005229	intracellular calcium activated chloride channel activity	NOT	IDA	21984732
GO:0005229	intracellular calcium activated chloride channel activity	-	IMP	22946059
GO:0005229	intracellular calcium activated chloride channel activity	-	TAS	-
GO:0005244	voltage-gated ion channel activity	-	ISS	-
GO:0005247	voltage-gated chloride channel activity	-	IMP	22006324
GO:0005515	protein binding	-	IPI	25589784 25651887
GO:0017128	phospholipid scramblase activity	-	IEA	-
GO:0042803	protein homodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002407	dendritic cell chemotaxis	-	IEA	-
GO:0002543	activation of blood coagulation via clotting cascade	-	IMP	21107324
GO:0006812	cation transport	-	IDA	22946059
GO:0006821	chloride transport	-	IMP	22006324 22946059
GO:0006869	lipid transport	-	IEA	-
GO:0007596	blood coagulation	-	ISS	-
GO:0017121	phospholipid scrambling	-	IMP	25651887
GO:0017121	phospholipid scrambling	-	ISS	-
GO:0030501	positive regulation of bone mineralization	-	IMP	25589784
GO:0032060	bleb assembly	-	IMP	25651887
GO:0034220	ion transmembrane transport	-	TAS	-
GO:0034767	positive regulation of ion transmembrane transport	-	IMP	25651887
GO:0035590	purinergic nucleotide receptor signaling pathway	-	IMP	25651887
GO:0035630	bone mineralization involved in bone maturation	-	IEA	-
GO:0035725	sodium ion transmembrane transport	-	IGI	25589784
GO:0043065	positive regulation of apoptotic process	-	ISS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045794	negative regulation of cell volume	-	IMP	25651887
GO:0046931	pore complex assembly	-	IMP	25651887
GO:0060100	positive regulation of phagocytosis, engulfment	-	ISS	-
GO:0061589	calcium activated phosphatidylserine scrambling	-	IEA	-
GO:0061590	calcium activated phosphatidylcholine scrambling	-	IEA	-
GO:0061591	calcium activated galactosylceramide scrambling	-	IEA	-
GO:0070588	calcium ion transmembrane transport	-	IGI	25589784
GO:0090026	positive regulation of monocyte chemotaxis	-	IMP	25651887
GO:0097045	phosphatidylserine exposure on blood platelet	-	IMP	21107324
GO:1902304	positive regulation of potassium ion export	-	ISS	-
GO:1902476	chloride transmembrane transport	-	IGI	25589784
GO:2000353	positive regulation of endothelial cell apoptotic process	-	IMP	22006324

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	IDA	22075693
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	21107324 22946059 25651887
GO:0005886	plasma membrane	-	TAS	-
GO:0009986	cell surface	-	HDA	19581412
GO:0016020	membrane	-	HDA	19946888
GO:0034707	chloride channel complex	-	IDA	22006324
GO:0035579	specific granule membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 20458337 23533145
GO:0070821	tertiary granule membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2672351	Stimuli-sensing channels	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-983712	Ion channel transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal