Gene: ANO6

196527
BDPLT7|SCTS|TMEM16F
anoctamin 6
protein-coding
12q12
Ensembl:ENSG00000177119 MIM:608663 Vega:OTTHUMG00000169564 UniprotKB:Q4KMQ2
NG_028220.1
SNP Mapped
AD
0   
NA (AD)  3.831e-2 (ND)   (Frontal_Cortex)
7.641e-1 (AD)  1.974e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7965430chr12:45316447 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7138247chr12:45275970 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2052603chr12:45252483 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MSN0.896
MYD880.888
IL1R10.887
LIMS10.886
PLP20.881
OSMR0.878
WWTR10.874
ZNF2170.872
ANXA20.87
FNDC3B0.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.567
ABCC12-0.559
MARCH4-0.554
DLK2-0.551
SPEF1-0.534
ADRA1D-0.528
NEUROD6-0.524
PPEF1-0.523
HAS1-0.522
TMEM179-0.519

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ANO6 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ANO6 mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ANO6 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANO6 mRNA"27188386
C0581765-nitro-2-(3-phenylpropylamino)benzoic acid5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein24478309
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANO6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ANO6 gene27153756
D001151ArsenicArsenic affects the methylation of ANO6 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANO6 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANO6 mRNA"19150397
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ANO6 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ANO6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ANO6 mRNA26496021
C006780bisphenol Abisphenol A results in increased methylation of ANO6 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ANO6 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of ANO6 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO6 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of ANO6 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ANO6 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of ANO6 mRNA19167446
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ANO6 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ANO6 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ANO6 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ANO6 mRNA18042831
C067648digallic aciddigallic acid results in decreased activity of ANO6 protein24478309
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of ANO6 protein"24478309
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA24690739
C045651epigallocatechin gallateepigallocatechin gallate results in decreased activity of ANO6 protein24478309
D005485FlutamideFlutamide results in decreased expression of ANO6 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO6 mRNA20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ANO6 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ANO6 mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of ANO6 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ANO6 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ANO6 mRNA"20188158
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ANO6 mRNA25380136
D009544Niflumic AcidNiflumic Acid affects the activity of ANO6 protein24478309
C025589ochratoxin Aochratoxin A results in increased methylation of ANO6 gene26431795
D000073878Palm OilPalm Oil results in increased expression of ANO6 mRNA18042831
C046012pentanalpentanal results in decreased expression of ANO6 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANO6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ANO6 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of ANO6 mRNA18301758
D012999SomanSoman results in increased expression of ANO6 mRNA19281266
C578466T16AInh-A01T16AInh-A01 results in decreased activity of ANO6 protein24478309
D014050TolueneToluene results in increased expression of ANO6 mRNA22967744
D014212TretinoinTretinoin results in increased expression of ANO6 mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of ANO6 mRNA25979313
D014640VancomycinVancomycin results in decreased expression of ANO6 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005227calcium activated cation channel activity-IDA22946059  
GO:0005227calcium activated cation channel activity-IMP25651887  
GO:0005227calcium activated cation channel activity-ISS-  
GO:0005229intracellular calcium activated chloride channel activityNOTIDA21984732  
GO:0005229intracellular calcium activated chloride channel activity-IMP22946059  
GO:0005229intracellular calcium activated chloride channel activity-TAS-  
GO:0005244voltage-gated ion channel activity-ISS-  
GO:0005247voltage-gated chloride channel activity-IMP22006324  
GO:0005515protein binding-IPI25589784  25651887  
GO:0017128phospholipid scramblase activity-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002407dendritic cell chemotaxis-IEA-  
GO:0002543activation of blood coagulation via clotting cascade-IMP21107324  
GO:0006812cation transport-IDA22946059  
GO:0006821chloride transport-IMP22006324  22946059  
GO:0006869lipid transport-IEA-  
GO:0007596blood coagulation-ISS-  
GO:0017121phospholipid scrambling-IMP25651887  
GO:0017121phospholipid scrambling-ISS-  
GO:0030501positive regulation of bone mineralization-IMP25589784  
GO:0032060bleb assembly-IMP25651887  
GO:0034220ion transmembrane transport-TAS-  
GO:0034767positive regulation of ion transmembrane transport-IMP25651887  
GO:0035590purinergic nucleotide receptor signaling pathway-IMP25651887  
GO:0035630bone mineralization involved in bone maturation-IEA-  
GO:0035725sodium ion transmembrane transport-IGI25589784  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045794negative regulation of cell volume-IMP25651887  
GO:0046931pore complex assembly-IMP25651887  
GO:0060100positive regulation of phagocytosis, engulfment-ISS-  
GO:0061589calcium activated phosphatidylserine scrambling-IEA-  
GO:0061590calcium activated phosphatidylcholine scrambling-IEA-  
GO:0061591calcium activated galactosylceramide scrambling-IEA-  
GO:0070588calcium ion transmembrane transport-IGI25589784  
GO:0090026positive regulation of monocyte chemotaxis-IMP25651887  
GO:0097045phosphatidylserine exposure on blood platelet-IMP21107324  
GO:1902304positive regulation of potassium ion export-ISS-  
GO:1902476chloride transmembrane transport-IGI25589784  
GO:2000353positive regulation of endothelial cell apoptotic process-IMP22006324  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA22075693  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA21107324  22946059  25651887  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-HDA19581412  
GO:0016020membrane-HDA19946888  
GO:0034707chloride channel complex-IDA22006324  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  23533145  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal