Gene: ARID2

196528
BAF200|CSS6|p200
AT-rich interaction domain 2
protein-coding
12q12
Ensembl:ENSG00000189079 MIM:609539 Vega:OTTHUMG00000150487 UniprotKB:Q68CP9
NG_052800.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.332e-1 (AD)  8.528e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKN20.917
NIPBL0.894
LRRC580.887
BTBD70.886
MED130.884
PHIP0.876
LATS10.875
KAT6A0.868
MAP3K20.861
ZKSCAN80.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.488
OR4F29-0.441
CRH-0.278
TNFRSF18-0.258
NPW-0.25
GSG1-0.248
SHISA8-0.245
KCNG2-0.242
LCN1-0.238
PRTN3-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ARID2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ARID2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ARID2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARID2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARID2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARID2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARID2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ARID2 mRNA26690555
D000086AcetazolamideAcetazolamide results in increased expression of ARID2 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ARID2 gene27153756
D001280AtrazineAtrazine results in decreased expression of ARID2 mRNA22378314
D001554BenzeneBenzene results in increased expression of ARID2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ARID2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARID2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARID2 mRNA"19150397|2623829
C006780bisphenol Abisphenol A affects the expression of ARID2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ARID2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARID2 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of ARID2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ARID2 mRNA24982889
D002737ChloropreneChloroprene results in increased expression of ARID2 mRNA23125180
D003703DemecolcineDemecolcine results in increased expression of ARID2 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARID2 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of ARID2 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of ARID2 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ARID2 mRNA18042831
C012301domoic aciddomoic acid results in decreased expression of ARID2 mRNA18936300
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ARID2 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of ARID2 mRNA20655997|2364984
D005839GentamicinsGentamicins results in increased expression of ARID2 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ARID2 mRNA22634610
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARID2 protein18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARID2 mRNA28628672
C051890irinotecanirinotecan analog results in decreased expression of ARID2 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ARID2 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of ARID2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of ARID2 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ARID2 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARID2 mRNA25307878
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ARID2 mRNA]26733615
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARID2 mRNA26272509
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARID2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARID2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARID2 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ARID2 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of ARID2 mRNA18042831
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of ARID2 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of ARID2 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of ARID2 mRNA]26733615
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ARID2 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARID2 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ARID2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of ARID2 mRNA23012394
D011794QuercetinQuercetin results in decreased expression of ARID2 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ARID2 mRNA21427059
C009277sodium arsenatesodium arsenate results in increased expression of ARID2 mRNA21795629
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ARID2 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARID2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of ARID2 mRNA19465110
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ARID2 protein18951874
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ARID2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ARID2 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARID2 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of ARID2 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of ARID2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of ARID2 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARID2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARID2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ARID2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of ARID2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ARID2 mRNA26705709
D014635Valproic AcidValproic Acid results in decreased expression of ARID2 mRNA21427059
C025643vinclozolinvinclozolin affects the expression of ARID2 mRNA19015723
D014750VincristineVincristine results in increased expression of ARID2 mRNA23649840
C088658zoledronic acidzoledronic acid results in decreased expression of ARID2 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI15985610  22140357  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003007heart morphogenesis-IEA-  
GO:0006337nucleosome disassembly-IDA8895581  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0008285negative regulation of cell proliferation-IDA26169693  
GO:0030336negative regulation of cell migration-IDA26169693  
GO:0042592homeostatic process-IEA-  
GO:0048568embryonic organ development-IEA-  
GO:0060038cardiac muscle cell proliferation-IEA-  
GO:0060982coronary artery morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24585446Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population. (2015 Sep)Zhu BMol Carcinog
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res