Gene: EPHA2

1969
ARCC2|CTPA|CTPP1|CTRCT6|ECK
EPH receptor A2
protein-coding
1p36.13
Ensembl:ENSG00000142627 MIM:176946 Vega:OTTHUMG00000009527 UniprotKB:P29317
NG_021396.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.760e-1 (AD)  9.712e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR40.843
NFKB20.838
ITPRIP0.825
TUBB60.824
CDH50.813
BCL30.813
LRRC320.813
TNFRSF10B0.81
ICAM20.809
VASP0.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.56
SLC7A4-0.544
PPEF1-0.529
FSTL5-0.521
PTPRR-0.513
MARCH4-0.512
CALHM1-0.507
MYADML2-0.502
SLC1A6-0.502
KCNB2-0.501

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01254DasatinibSmall Molecule302962-49-8Approved|InvestigationalTarget
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeExperimentalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EPHA2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of EPHA2 mRNA19933214
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of EPHA2 mRNA"20702594
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of EPHA2 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C496492abrineabrine results in increased expression of EPHA2 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of EPHA2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of EPHA2 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of EPHA2 mRNA18544908
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EPHA2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EPHA2 mRNA21632981|2715375
D000393Air PollutantsAir Pollutants analog results in increased expression of EPHA2 mRNA21757418
D000447AldehydesAldehydes results in increased expression of EPHA2 mRNA25014914
D001151ArsenicArsenic affects the methylation of EPHA2 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EPHA2 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of EPHA2 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of EPHA2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHA2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EPHA2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EPHA2 mRNA21569818|2261060
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EPHA2 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of EPHA2 mRNA25210133
C095105bexarotenebexarotene results in decreased expression of EPHA2 mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of EPHA2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of EPHA2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of EPHA2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of EPHA2 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of EPHA2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EPHA2 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of EPHA2 mRNA19010381
D002220CarbamazepineCarbamazepine affects the expression of EPHA2 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C007036cholanic acidcholanic acid binds to and results in decreased activity of EPHA2 protein22529030
C007036cholanic acidcholanic acid inhibits the reaction [EFNA1 protein binds to and results in increased phosphorylation of and results in increased activity of EPHA2 protein]22529030
D003042CocaineCocaine affects the expression of EPHA2 mRNA15691709
D019327Copper SulfateCopper Sulfate results in increased expression of EPHA2 mRNA19549813
C402665CP 31398CP 31398 results in increased expression of EPHA2 mRNA15155752
D003471CuprizoneCuprizone results in increased expression of EPHA2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of EPHA2 mRNA20106945|2556210
C093628cyproconazolecyproconazole results in decreased expression of EPHA2 mRNA22045034
D000069439DasatinibDasatinib results in decreased activity of EPHA2 protein21128601
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EPHA2 mRNA23640034
C014347decitabinedecitabine affects the methylation of EPHA2 gene17630775
C016366dibenzothiophenedibenzothiophene results in increased expression of EPHA2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EPHA2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EPHA2 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of EPHA2 mRNA20438755|2304172
D017292DoxazosinDoxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein22845314
D017292Doxazosin[Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] which results in increased phosphorylation of and results in increased activity of PTPN11 protein22845314
D017292DoxazosinLithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein]22845314
D004317DoxorubicinDoxorubicin results in increased expression of EPHA2 mRNA16900372
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EPHA2 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EPHA2 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPHA2 mRNA17942748
C540355fenamidonefenamidone results in increased expression of EPHA2 mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of EPHA2 mRNA28329830
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of EPHA2 mRNA]15016801
D017313FenretinideFenretinide results in increased expression of EPHA2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EPHA2 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of EPHA2 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of EPHA2 mRNA21396975
C544151jinfukangjinfukang results in decreased expression of EPHA2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EPHA2 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EPHA2 mRNA24796395
C410337K 7174K 7174 results in increased expression of EPHA2 mRNA24086573
C008261lead acetatelead acetate results in increased expression of EPHA2 mRNA11578147
C045463leflunomideleflunomide results in increased expression of EPHA2 mRNA28988120
D008095Lithocholic AcidLithocholic Acid analog binds to and results in decreased phosphorylation of and results in decreased activity of EPHA2 protein23489211
D008095Lithocholic AcidLithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]23489211
D008095Lithocholic AcidLithocholic Acid binds to and results in decreased activity of EPHA2 protein23489211
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]22529030
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein]21479221
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]21479221
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein]22845314
D008095Lithocholic AcidLithocholic Acid results in increased expression of EPHA2 protein22845314
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
D008727MethotrexateMethotrexate affects the expression of EPHA2 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of EPHA2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride affects the expression of EPHA2 mRNA21613230
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of EPHA2 mRNA24810058
D016685MitomycinMitomycin results in decreased expression of EPHA2 mRNA12760830
D009151Mustard GasMustard Gas affects the expression of EPHA2 mRNA15651846
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of EPHA2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of EPHA2 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EPHA2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EPHA2 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of EPHA2 mRNA20551477
D009532NickelNickel results in increased expression of EPHA2 mRNA25583101
C017557nickel subsulfidenickel subsulfide results in decreased expression of EPHA2 mRNA12760830
D009966OrphenadrineOrphenadrine affects the expression of EPHA2 mRNA23665939
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of EPHA2 mRNA18593933
C046012pentanalpentanal results in increased expression of EPHA2 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of EPHA2 protein26879310
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of EPHA2 mRNA17097637
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EPHA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of EPHA2 mRNA26272509
D010705PhosgenePhosgene affects the expression of EPHA2 mRNA16300373
C006253pirinixic acidpirinixic acid results in increased expression of EPHA2 mRNA18445702|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of EPHA2 mRNA]20059764
C545373ponatinibponatinib analog results in decreased activity of EPHA2 protein21561767
C545373ponatinibponatinib results in decreased activity of EPHA2 protein19878872
C005556propionaldehydepropionaldehyde results in increased expression of EPHA2 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EPHA2 mRNA27029645
D011794QuercetinQuercetin results in increased expression of EPHA2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EPHA2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of EPHA2 mRNA19073995
D012834SilverSilver results in increased expression of EPHA2 mRNA26014281|2655175
C017947sodium arsenitesodium arsenite results in increased expression of EPHA2 mRNA12760830
C016104sodium bichromatesodium bichromate results in decreased expression of EPHA2 mRNA12760830
D012999SomanSoman results in increased expression of EPHA2 mRNA19281266
D053260SootSoot results in increased expression of EPHA2 mRNA26551751
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of EPHA2 mRNA15601916
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of EPHA2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHA2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EPHA2 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EPHA2 mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EPHA2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EPHA2 mRNA19933214|2188995
C009495titanium dioxidetitanium dioxide results in increased expression of EPHA2 mRNA27760801
D014118Toxins, Biological"Toxins, Biological affects the expression of EPHA2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of EPHA2 mRNA16604517
C032910triadimefontriadimefon results in decreased activity of EPHA2 protein21251949
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EPHA2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of EPHA2 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of EPHA2 mRNA25979313|2607246
D014635Valproic AcidValproic Acid affects the expression of EPHA2 mRNA26072468
D014635Valproic AcidValproic Acid results in decreased expression of EPHA2 mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of EPHA2 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of EPHA2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of EPHA2 mRNA23034163
D014800VitalliumVitallium analog results in decreased expression of EPHA2 mRNA23825117
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of EPHA2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IDA10655584  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005003ephrin receptor activity-IEA-  
GO:0005005transmembrane-ephrin receptor activity-IBA21873635  
GO:0005515protein binding-IPI10655584  15777695  18948590  19525919  19573808  20228801  
20505120  20679435  22036564  22244754  22939624  23358419  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001649osteoblast differentiation-ISS-  
GO:0007155cell adhesion-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007275multicellular organism development-TAS7918100  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IDA18339848  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010591regulation of lamellipodium assembly-IMP19573808  
GO:0016477cell migration-IMP23358419  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030216keratinocyte differentiation-IMP20861311  
GO:0030316osteoclast differentiation-ISS-  
GO:0033598mammary gland epithelial cell proliferation-ISS-  
GO:0033628regulation of cell adhesion mediated by integrin-IDA10655584  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043491protein kinase B signaling-IDA19573808  
GO:0043535regulation of blood vessel endothelial cell migration-ISS-  
GO:0045765regulation of angiogenesis-ISS-  
GO:0046058cAMP metabolic process-IMP27385333  
GO:0046718viral entry into host cell-IEA-  
GO:0046849bone remodeling-ISS-  
GO:0048013ephrin receptor signaling pathway-IDA10655584  20861311  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048870cell motility-IMP26158630  
GO:0051898negative regulation of protein kinase B signaling-IDA19573808  
GO:0060326cell chemotaxis-IMP19573808  20679435  
GO:0060444branching involved in mammary gland duct morphogenesis-ISS-  
GO:0070309lens fiber cell morphogenesis-ISS-  
GO:0070372regulation of ERK1 and ERK2 cascade-IMP20861311  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070848response to growth factor-IMP19573808  
GO:0090630activation of GTPase activity-IMP20679435  
GO:1903078positive regulation of protein localization to plasma membrane-IMP20679435  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IDA18794797  20861311  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA10655584  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA10655584  
GO:0009986cell surface-HDA19581412  
GO:0009986cell surface-IDA25063885  
GO:0030027lamellipodium-IDA26158630  
GO:0031256leading edge membrane-IDA19573808  20679435  
GO:0031258lamellipodium membrane-IEA-  
GO:0032587ruffle membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseTAS
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19934338EphA2 in the early pathogenesis and progression of non-small cell lung cancer. (2009 Dec)Brannan JMCancer Prev Res (Phila)
26158630Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. (2015 Jul 9)Zhou YNat Commun
19531623Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer. (2009 Jul 1)Brannan JMClin Cancer Res
24673449EPHA2 Polymorphisms in Estonian Patients with Age-Related Cataract. (2016)Celojevic DOphthalmic Genet
22236865Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma. (2012 Jun)Ishikawa MLung Cancer