Gene: AHSG

197
A2HS|AHS|APMR1|FETUA|HSGA
alpha 2-HS glycoprotein
protein-coding
3q27.3
Ensembl:ENSG00000145192 MIM:138680 Vega:OTTHUMG00000156605 UniprotKB:P02765
NG_011436.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.366e-1 (AD)  9.484e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A450.538
CAPN140.526
ABCG50.517
DYRK1B0.506
TMC30.502
NOXA10.5
DHRS110.499
ABCB90.497
NUDT180.495
TRPM20.49

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH3-0.382
CD44-0.37
CHI3L2-0.364
APOL4-0.359
PIRT-0.355
TNFRSF11B-0.353
SERPINA3-0.351
GEM-0.35
WWTR1-0.347
EVC2-0.347

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of AHSG mRNA"20566314
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AHSG mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of AHSG mRNA"23962555
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AHSG mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of AHSG mRNA22230336|2906747
D000082AcetaminophenAcetaminophen results in increased expression of AHSG mRNA23358195
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of AHSG mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AHSG mRNA]17585979
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of AHSG mRNA"20566314
D020106AcrylamideAcrylamide results in decreased expression of AHSG mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AHSG protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AHSG mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AHSG gene27153756
C103303alitretinoinalitretinoin results in decreased expression of AHSG mRNA16648578
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AHSG mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AHSG mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AHSG mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AHSG mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AHSG mRNA22228805
C095105bexarotenebexarotene results in decreased expression of AHSG mRNA16648578
C452139BIRB 796BIRB 796 results in decreased expression of AHSG mRNA21328587
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of AHSG mRNA15912405
C006780bisphenol Abisphenol A results in increased expression of AHSG mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of AHSG protein24552547
D001761BleomycinBleomycin results in increased expression of AHSG protein25933445
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AHSG mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AHSG mRNA17961207
D019256Cadmium ChlorideCadmium Chloride affects the expression of AHSG mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AHSG mRNA17484886
C041167chromium nitratechromium nitrate results in decreased expression of AHSG protein23618972
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of AHSG mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AHSG mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of AHSG mRNA12851107
C018021cobaltous chloridecobaltous chloride results in decreased expression of AHSG mRNA24386269
D003300CopperAHSG protein binds to Copper23896426
D003300CopperCopper results in decreased expression of AHSG mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of AHSG mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of AHSG mRNA17211630
D016572CyclosporineCyclosporine results in decreased expression of AHSG mRNA20106945|2556210
C093628cyproconazolecyproconazole results in decreased expression of AHSG mRNA22334560
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of AHSG mRNA"20566314
D003907DexamethasoneAHSG gene polymorphism results in increased susceptibility to Dexamethasone20400291
D002945CisplatinCisplatin results in increased secretion of AHSG protein28885000
D004008Diclofenac"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein"25772430
C121718dicyclanildicyclanil results in increased expression of AHSG mRNA15664270
D004041Dietary FatsDietary Fats results in decreased expression of AHSG mRNA25016146
D004280DobutamineAHSG protein affects the susceptibility to Dobutamine16177000
D004317DoxorubicinDoxorubicin results in increased secretion of AHSG protein28885000
C070609EMD 53998EMD 53998 analog results in decreased expression of AHSG mRNA24977338
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AHSG mRNA26159488
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of AHSG protein20805001
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AHSG protein23301498
C109476epoxiconazoleepoxiconazole results in decreased expression of AHSG mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of AHSG mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AHSG mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AHSG mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of AHSG mRNA17108234
D005459FluoridesFluorides results in decreased expression of AHSG mRNA24561004
C056933fumonisin B1fumonisin B1 results in increased expression of AHSG mRNA16221962
D019833GenisteinGenistein results in decreased expression of AHSG mRNA12075121
C010974glyphosateglyphosate results in increased expression of AHSG mRNA16532367
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of AHSG mRNA"20566314
D007545IsoproterenolIsoproterenol results in increased expression of AHSG mRNA20003209|2133504
C052901lemongrass oillemongrass oil affects the expression of AHSG mRNA25976427
C052901lemongrass oillemongrass oil results in increased expression of AHSG mRNA25660481
C482199lipopolysaccharide, E coli O55-B5"[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein"25772430
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of AHSG mRNA"20566314
D008727MethotrexateMethotrexate results in increased expression of AHSG mRNA24449571
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of AHSG mRNA18804290
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of AHSG protein27384973
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AHSG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AHSG mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of AHSG mRNA18978301
D009525NiacinNiacin results in decreased expression of and results in decreased phosphorylation of AHSG protein19405044
D009532NickelAHSG protein binds to Nickel23896426
D009930Organic ChemicalsOrganic Chemicals results in increased expression of AHSG mRNA20526952
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of AHSG mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of AHSG protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AHSG protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AHSG mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AHSG mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of AHSG mRNA19159669
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of AHSG mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of AHSG mRNA16221962|1711813
D059808PolyphenolsPolyphenols results in decreased expression of AHSG mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AHSG protein23618972
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AHSG mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of AHSG mRNA22334560
D011794QuercetinQuercetin results in decreased expression of AHSG mRNA21632981
C059514resveratrolresveratrol results in decreased phosphorylation of AHSG protein25311616
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AHSG mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of AHSG mRNA22431001
C017947sodium arsenitesodium arsenite affects the expression of AHSG mRNA17450228
D012969Sodium FluorideSodium Fluoride results in decreased expression of AHSG mRNA27862939
D012969Sodium FluorideSodium Fluoride results in increased expression of AHSG protein28918527
D053260SootSoot results in increased expression of AHSG mRNA26551751
D013629TamoxifenTamoxifen affects the expression of AHSG mRNA17555576
D013726TerbutalineAHSG gene polymorphism results in increased susceptibility to Terbutaline16024912
D013726TerbutalineAHSG protein affects the susceptibility to Terbutaline16024912
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AHSG mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AHSG mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AHSG mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AHSG mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AHSG mRNA18796159|2403582
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AHSG mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AHSG mRNA15703262
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AHSG mRNA16267337
C009495titanium dioxidetitanium dioxide affects the expression of AHSG mRNA23557971
D014212TretinoinTretinoin results in decreased expression of AHSG mRNA23724009
D014635Valproic AcidValproic Acid results in decreased expression of AHSG mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AHSG gene25560391
C025643vinclozolinvinclozolin results in increased expression of AHSG mRNA23869203
C111237vorinostatvorinostat results in decreased expression of AHSG mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of AHSG mRNA"20526952
D015032ZincAHSG protein binds to Zinc23896426
C088658zoledronic acidzoledronic acid results in increased expression of AHSG protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-IBA21873635  
GO:0004869cysteine-type endopeptidase inhibitor activity-IEA-  
GO:0019210kinase inhibitor activity-NAS12203945  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-NAS12153747  
GO:0001503ossification-IEA-  
GO:0002576platelet degranulation-TAS-  
GO:0006907pinocytosis-NAS12773197  
GO:0006953acute-phase response-IDA12153747  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030500regulation of bone mineralization-NAS3474608  
GO:0030502negative regulation of bone mineralization-ISS-  
GO:0042326negative regulation of phosphorylation-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0046627negative regulation of insulin receptor signaling pathway-NAS12153747  
GO:0050727regulation of inflammatory response-IMP12642050  
GO:0050766positive regulation of phagocytosis-IDA12725640  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-NAS11922920  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IDA-  
GO:0031012extracellular matrix-IBA21873635  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21527649Serum fetuin-A levels are associated with vascular calcifications and predict cardiovascular events in renal transplant recipients. (2011 May)Marechal CClin J Am Soc Nephrol
15882283Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. (2005 Jun)Stenvinkel PKidney Int
28210079alpha2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease. (2017 Jan 21)Manolakis ACWorld J Gastroenterol
19345526[Origin of the mediacalcosis in kidney failure]. (2009 May)Torres PAJ Mal Vasc