Gene info: ID 1977

Gene: EIF4E

GENE ID: 1977

Description: eukaryotic translation initiation factor 4E

Gene type: protein-coding

Location: 4q23

dbXrefs: Ensembl:ENSG00000151247 MIM:133440 Vega:OTTHUMG00000161090 UniprotKB:P06730

RefSeq: NG_047048.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.684e-1 (AD) 9.611e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
UBE2V2	0.957
SCOC	0.941
PJA2	0.938
SRPK2	0.936
UCHL5	0.935
EIF4E3	0.934
PRKACB	0.933
ANKRD46	0.932
GDAP1	0.932
OLA1	0.931

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.523
OR4F5	-0.52
CSAG1	-0.501
RHOD	-0.451
EVC2	-0.443
MAGEA12	-0.442
RUNX3	-0.427
RNF135	-0.424
SIX5	-0.424
WDR38	-0.424

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01649	7-Methyl-Gpppa	Small Molecule		Experimental	Target
DB01960	7n-Methyl-8-Hydroguanosine-5'-Diphosphate	Small Molecule		Experimental	Target
DB02716	7-Methyl-Guanosine-5'-Triphosphate	Small Molecule		Experimental	Target
DB05165	LY2275796	Small Molecule	-	Investigational	Target
DB08217	S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of EIF4E mRNA"	19162173
C401932	15,16-dihydrotanshinone I	"15,16-dihydrotanshinone I results in decreased phosphorylation of EIF4E protein"	26282490
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4E protein	26282490
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EIF4E mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of EIF4E mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4E protein	26282490
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of EIF4E mRNA"	21346803
C495818	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	20053781
C528740	3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide	"3-(4-bromophenyl)-2-(ethylsulfonyl)-6-methylquinoxaline-1,4-dioxide promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]"	20524035
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of EIF4E mRNA"	18648102
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of EIF4E mRNA	19191707
C111106	7-methylguanosine 5'-diphosphate	7-methylguanosine 5'-diphosphate analog binds to EIF4E protein	27592390
C111106	7-methylguanosine 5'-diphosphate	7-methylguanosine-5'-monophosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C111106	7-methylguanosine 5'-diphosphate	7-methylguanosine triphosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C111106	7-methylguanosine 5'-diphosphate	Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C111106	7-methylguanosine 5'-diphosphate	Quinolones inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C111106	7-methylguanosine 5'-diphosphate	Sulfonamides inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C011925	7-methylguanosine-5'-monophosphate	7-methylguanosine-5'-monophosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C011925	7-methylguanosine-5'-monophosphate	7-methylguanosine-5'-monophosphate inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
C017516	7-methylguanosine triphosphate	7-methylguanosine triphosphate inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
C017516	7-methylguanosine triphosphate	7-methylguanosine triphosphate inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
C063261	acetylleucyl-leucyl-norleucinal	acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	15878868
D020106	Acrylamide	Acrylamide results in increased expression of EIF4E mRNA	28959563
C067527	aluminum maltolate	aluminum maltolate inhibits the reaction [BDNF protein results in increased phosphorylation of EIF4E protein]	21040763
D000638	Amiodarone	Amiodarone promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]	19771169
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EIF4E mRNA	16483693
D000841	Anisomycin	Anisomycin results in increased phosphorylation of EIF4E protein	9545260
D000841	Anisomycin	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	9545260
D000841	Anisomycin	Anisomycin results in increased phosphorylation of EIF4E protein	9545260
D000841	Anisomycin	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	9545260
D000841	Anisomycin	Anisomycin promotes the reaction [EIF4E protein binds to EIF4G protein]	10477262
D000841	Anisomycin	Anisomycin results in increased phosphorylation of EIF4E protein	10477262
D000841	Anisomycin	SB 203580 inhibits the reaction [Anisomycin promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
D000841	Anisomycin	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	10477262
D000841	Anisomycin	Sirolimus inhibits the reaction [Anisomycin promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
D000841	Anisomycin	Sirolimus inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	10477262
C006632	arsenic trioxide	arsenic trioxide affects the expression of EIF4E mRNA	20458559
C006632	arsenic trioxide	[arsenic trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein	18299328
C006632	arsenic trioxide	CGP 57380 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C006632	arsenic trioxide	CGP 57380 inhibits the reaction [[arsenic trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein]	18299328
C006632	arsenic trioxide	MAPK14 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C006632	arsenic trioxide	MKNK1 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C006632	arsenic trioxide	MKNK2 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C006632	arsenic trioxide	U 0126 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C015001	arsenite	arsenite affects the reaction [EIF4G protein binds to EIF4E protein]	12071973
C015001	arsenite	arsenite promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	12071973
C015001	arsenite	[arsenite results in decreased phosphorylation of EIF4EBP1 protein] promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	12071973
C015001	arsenite	arsenite results in increased phosphorylation of EIF4E protein	9545260
C015001	arsenite	SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	9545260
C015001	arsenite	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C015001	arsenite	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C015001	arsenite	arsenite promotes the reaction [EIF4E protein binds to EIF4G1 protein]	12781867
C015001	arsenite	arsenite results in increased phosphorylation of EIF4E protein	12781867\|9545260
C015001	arsenite	CGP 57380 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C015001	arsenite	MAPK14 protein affects the reaction [arsenite promotes the reaction [EIF4E protein binds to EIF4G1 protein]]	12781867
C015001	arsenite	MAPK14 protein mutant form inhibits the reaction [CGP 57380 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]]	12781867
C015001	arsenite	MAPK14 protein mutant form inhibits the reaction [SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]]	12781867
C015001	arsenite	SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867\|9545260
C015001	arsenite	U 0126 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C015001	arsenite	arsenite promotes the reaction [EIF4E protein binds to EIF4G protein]	10477262
C015001	arsenite	arsenite results in increased phosphorylation of EIF4E protein	10477262
C015001	arsenite	SB 203580 inhibits the reaction [arsenite promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
C015001	arsenite	SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	10477262
C015001	arsenite	Sirolimus inhibits the reaction [arsenite promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
C015001	arsenite	Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	10477262
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EIF4E mRNA	20127859\|2222880
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of EIF4E mRNA	22300585
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EIF4E mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	15878868
D004958	Estradiol	Estradiol affects the expression of EIF4E mRNA	21826169
D004958	Estradiol	Estradiol results in decreased phosphorylation of EIF4E protein	16033851
D004958	Estradiol	Everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]	16033851
C006780	bisphenol A	bisphenol A affects the expression of EIF4E mRNA	21826169
C006780	bisphenol A	bisphenol A results in increased expression of EIF4E mRNA	21890461
C006780	bisphenol A	bisphenol A results in increased expression of EIF4E mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EIF4E mRNA	28628672
D019256	Cadmium Chloride	acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	15878868
D019256	Cadmium Chloride	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	15878868
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of EIF4E protein	15878868
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EIF4E protein	24527689\|2622068
D019256	Cadmium Chloride	Cadmium Chloride results in increased ubiquitination of and results in decreased expression of EIF4E protein	15878868
D019256	Cadmium Chloride	EIF4E results in decreased susceptibility to Cadmium Chloride	15878868
D019256	Cadmium Chloride	lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	15878868
D002110	Caffeine	"Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]"	20230807
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA"	20230807
C466997	CGP 57380	CGP 57380 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C466997	CGP 57380	CGP 57380 inhibits the reaction [[arsenic trioxide results in increased phosphorylation of and results in increased activity of MKNK1 protein] which results in increased phosphorylation of EIF4E protein]	18299328
C466997	CGP 57380	CGP 57380 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C466997	CGP 57380	CGP 57380 inhibits the reaction [Cisplatin results in increased phosphorylation of EIF4E protein]	25923732
C466997	CGP 57380	CGP 57380 inhibits the reaction [sodium arsenite promotes the reaction [EIF4E protein modified form binds to EIF4ENIF1 protein]]	25923732
C466997	CGP 57380	CGP 57380 inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4E protein]	25923732
C466997	CGP 57380	CGP 57380 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
C466997	CGP 57380	CGP 57380 results in decreased phosphorylation of EIF4E protein	12781867\|2592373
C466997	CGP 57380	MAPK14 protein mutant form inhibits the reaction [CGP 57380 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]]	12781867
C466997	CGP 57380	CGP 57380 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]	16431125\|1803248
C466997	CGP 57380	CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]	15757502
D007464	Clioquinol	[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA	22415087
D007464	Clioquinol	[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein	22415087
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of EIF4E mRNA	19549813
D003513	Cycloheximide	Cycloheximide inhibits the reaction [EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of CCND1 protein]]	25923732
D003513	Cycloheximide	Cycloheximide inhibits the reaction [EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of ELAVL1 protein]]	25923732
D003513	Cycloheximide	Cycloheximide inhibits the reaction [EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of MCL1 protein]]	25923732
C007262	deoxynivalenol	deoxynivalenol results in decreased phosphorylation of EIF4E protein	16099139
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EIF4E mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of EIF4E mRNA	21266533
D002945	Cisplatin	CGP 57380 inhibits the reaction [Cisplatin results in increased phosphorylation of EIF4E protein]	25923732
D002945	Cisplatin	Cisplatin affects the reaction [Piroxicam results in decreased expression of EIF4E mRNA]	21858171
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of EIF4E mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of EIF4E mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased phosphorylation of EIF4E protein	25923732
C000944	dicrotophos	dicrotophos results in decreased expression of EIF4E mRNA	28302478
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of EIF4E mRNA	17490981
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of EIF4E mRNA	27638505
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of EIF4E mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of EIF4E mRNA	16174780\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4E mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of EIF4E mRNA	16174780
D005031	Ethylenethiourea	Ethylenethiourea results in increased expression of EIF4E mRNA	18801409
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of EIF4E mRNA	23649840
D000068338	Everolimus	Everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]	16033851
D000068338	Everolimus	Everolimus results in increased phosphorylation of EIF4E protein	16033851
C069346	fascaplysine	fascaplysine analog results in decreased phosphorylation of EIF4E protein	28756150
D005419	Flavonoids	Flavonoids results in increased expression of EIF4E mRNA	18035473
D005472	Fluorouracil	Fluorouracil inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]	15611226
D005472	Fluorouracil	Fluorouracil results in increased expression of EIF4E mRNA	16584549
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of EIF4E mRNA]	15016801
D005473	Fluoxetine	Fluoxetine results in increased phosphorylation of EIF4E protein	16817885
D005480	Flurbiprofen	Flurbiprofen results in increased phosphorylation of EIF4E protein	18056468
D005480	Flurbiprofen	MAPK14 protein promotes the reaction [Flurbiprofen results in increased phosphorylation of EIF4E protein]	18056468
D005485	Flutamide	Flutamide results in increased expression of EIF4E mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of EIF4E mRNA	23649840
D019833	Genistein	Genistein results in decreased expression of EIF4E mRNA	22228119
D005947	Glucose	Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]	19765649
D005947	Glucose	Glucose results in increased phosphorylation of EIF4E protein	19765649
D005947	Glucose	resveratrol inhibits the reaction [Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]]	19765649
D005947	Glucose	resveratrol inhibits the reaction [Glucose results in increased phosphorylation of EIF4E protein]	19765649
D006046	Gold	[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein	27470402
D006151	Guanosine	Guanosine analog binds to EIF4E protein	27592390
D006151	Guanosine	Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
D006151	Guanosine	Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
D006820	Hyaluronic Acid	Hyaluronic Acid results in increased phosphorylation of EIF4E protein	16864594
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [EIF4G protein binds to EIF4E protein]	12071973
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	12071973
D006861	Hydrogen Peroxide	[Hydrogen Peroxide results in decreased phosphorylation of EIF4EBP1 protein] promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	12071973
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased phosphorylation of EIF4E protein	9545260
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]	9545260
D007052	Ibuprofen	Ibuprofen results in increased phosphorylation of EIF4E protein	18056468
D007052	Ibuprofen	MAPK14 protein promotes the reaction [Ibuprofen results in increased phosphorylation of EIF4E protein]	18056468
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of EIF4E mRNA	19208803
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of EIF4E protein	19208803
C020758	indium trichloride	indium trichloride results in decreased expression of EIF4E protein	19539025
C020758	indium trichloride	indium trichloride results in increased expression of EIF4E protein	19539025
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EIF4E mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EIF4E mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of EIF4E mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in decreased expression of EIF4E mRNA	20003209
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]	20388789
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of EIF4E mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of EIF4E mRNA	27392435
C011890	kojic acid	kojic acid results in decreased expression of EIF4E mRNA	16595896
C067713	lactacystin	lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein]	15878868
D008044	Linuron	Linuron results in decreased expression of EIF4E mRNA	28705778
D008070	Lipopolysaccharides	CGP 57380 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]	16431125\|1803248
D008070	Lipopolysaccharides	IRAK2 protein promotes the reaction [Lipopolysaccharides results in increased activity of EIF4E protein]	21291324
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of EIF4E protein	21291324
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of EIF4E protein	16431125
D008070	Lipopolysaccharides	[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]	16431125
D008731	Methoxychlor	Methoxychlor results in increased methylation of EIF4E gene	23303685
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of EIF4E mRNA	23649840
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA"	20230807
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of EIF4E mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of EIF4E mRNA"	25554681\|2562005
C031721	naphthalene	[naphthalene co-treated with AKT1] results in increased expression of EIF4E protein	22122896
C031721	naphthalene	[naphthalene co-treated with AKT1] results in increased phosphorylation of EIF4E protein	22122896
C546012	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide results in decreased expression of EIF4E protein	27470402
C051752	nefazodone	nefazodone results in increased expression of EIF4E mRNA	24136188
D009534	Niclosamide	Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]	19771169
D009538	Nicotine	"Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]"	20230807
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA"	20230807
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of EIF4E mRNA	17616710
C507134	ON 01910	ON 01910 results in decreased activity of EIF4E protein	19198627
C055122	orlistat	orlistat results in increased phosphorylation of EIF4E protein	18796435
C421324	pateamine A	pateamine A affects the localization of EIF4E protein	16951406
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of EIF4E mRNA	23948077
C494474	perchlorate	perchlorate results in increased expression of EIF4E mRNA	18801409
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of EIF4E mRNA	19162173
D010480	Perhexiline	Perhexiline promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]	19771169
D010634	Phenobarbital	Phenobarbital results in increased expression of EIF4E mRNA	19363144
D010656	Phenylephrine	CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]	15757502
D010656	Phenylephrine	Phenylephrine results in increased phosphorylation of EIF4E protein	15757502
D010656	Phenylephrine	Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]	15757502
D010656	Phenylephrine	U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]	15757502
D010894	Piroxicam	Cisplatin affects the reaction [Piroxicam results in decreased expression of EIF4E mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of EIF4E mRNA	21858171
D011374	Progesterone	Progesterone results in increased expression of EIF4E mRNA	19690047
C045950	propiconazole	propiconazole results in increased expression of EIF4E mRNA	19363144\|2127805
D011794	Quercetin	[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein	27470402
D011794	Quercetin	Quercetin inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]	15611226
D015363	Quinolones	Quinolones inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
D015363	Quinolones	Quinolones inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
C059514	resveratrol	resveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4E protein]	15297429
C059514	resveratrol	resveratrol inhibits the reaction [Glucose promotes the reaction [EIF4E protein binds to EIF4G1 protein]]	19765649
C059514	resveratrol	resveratrol inhibits the reaction [Glucose results in increased phosphorylation of EIF4E protein]	19765649
D015474	Isotretinoin	Isotretinoin results in decreased expression of EIF4E mRNA	20436886
D012314	RNA Cap Analogs	RNA Cap Analogs binds to EIF4E protein	16248001
D012315	RNA Caps	7-methylguanosine-5'-monophosphate inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
D012315	RNA Caps	7-methylguanosine triphosphate inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
D012315	RNA Caps	Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
D012315	RNA Caps	Quinolones inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
D012315	RNA Caps	RNA Caps binds to EIF4E protein	27592390
D012315	RNA Caps	Sulfonamides inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
C085746	rottlerin	rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]	19771169
C049705	S-1,2-dichlorovinyl-N-acetylcysteine	"S-1,2-dichlorovinyl-N-acetylcysteine affects the expression of EIF4E mRNA"	16844155
C093642	SB 203580	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093642	SB 203580	SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 inhibits the reaction [IL1B protein results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093642	SB 203580	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
C093642	SB 203580	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093642	SB 203580	MAPK14 protein mutant form inhibits the reaction [SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]]	12781867
C093642	SB 203580	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867\|9545260
C093642	SB 203580	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 inhibits the reaction [TNF protein results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
C093642	SB 203580	[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]	16431125
C093642	SB 203580	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	9545260
C093642	SB 203580	SB 203580 inhibits the reaction [Anisomycin promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
C093642	SB 203580	SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	10477262
C093642	SB 203580	SB 203580 inhibits the reaction [arsenite promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
C093642	SB 203580	SB 203580 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	10477262
C093642	SB 203580	SB 203580 results in decreased phosphorylation of EIF4E protein	10477262
D020123	Sirolimus	EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein]	19560264
D020123	Sirolimus	Sirolimus results in decreased activity of EIF4E protein	19560264
D020123	Sirolimus	Sirolimus results in increased phosphorylation of EIF4E protein	26282490
D020123	Sirolimus	Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]	15757502
D020123	Sirolimus	Sirolimus inhibits the reaction [Anisomycin promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
D020123	Sirolimus	Sirolimus inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]	10477262
D020123	Sirolimus	Sirolimus inhibits the reaction [arsenite promotes the reaction [EIF4E protein binds to EIF4G protein]]	10477262
D020123	Sirolimus	Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	10477262
C017947	sodium arsenite	CGP 57380 inhibits the reaction [sodium arsenite promotes the reaction [EIF4E protein modified form binds to EIF4ENIF1 protein]]	25923732
C017947	sodium arsenite	CGP 57380 inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4E protein]	25923732
C017947	sodium arsenite	Cycloheximide inhibits the reaction [EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of CCND1 protein]]	25923732
C017947	sodium arsenite	Cycloheximide inhibits the reaction [EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of ELAVL1 protein]]	25923732
C017947	sodium arsenite	Cycloheximide inhibits the reaction [EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of MCL1 protein]]	25923732
C017947	sodium arsenite	EIF4E mutant form results in increased susceptibility to sodium arsenite	25923732
C017947	sodium arsenite	EIF4ENIF1 mutant form inhibits the reaction [EIF4E protein modified form results in decreased susceptibility to sodium arsenite]	25923732
C017947	sodium arsenite	EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of CCND1 protein]	25923732
C017947	sodium arsenite	EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of ELAVL1 protein]	25923732
C017947	sodium arsenite	EIF4E protein modified form inhibits the reaction [sodium arsenite results in decreased expression of MCL1 protein]	25923732
C017947	sodium arsenite	EIF4E protein modified form inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]	25923732
C017947	sodium arsenite	EIF4E protein modified form inhibits the reaction [sodium arsenite results in increased activity of CASP7 protein]	25923732
C017947	sodium arsenite	EIF4E protein modified form results in decreased susceptibility to sodium arsenite	25923732
C017947	sodium arsenite	EIF4E protein results in decreased susceptibility to sodium arsenite	16283521
C017947	sodium arsenite	sodium arsenite affects the localization of EIF4E protein	16951406
C017947	sodium arsenite	sodium arsenite affects the methylation of EIF4E gene	28589171
C017947	sodium arsenite	sodium arsenite inhibits the reaction [RBM4 protein binds to EIF4E protein]	17284590
C017947	sodium arsenite	sodium arsenite promotes the reaction [EIF4E protein modified form binds to EIF4ENIF1 protein]	25923732
C017947	sodium arsenite	sodium arsenite results in increased expression of EIF4E mRNA	12016162\|2859598
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of EIF4E protein	25923732
C017947	sodium arsenite	sodium arsenite results in increased ubiquitination of and results in decreased expression of EIF4E protein	16283521
C471405	sorafenib	sorafenib inhibits the reaction [MKNK1 protein results in increased phosphorylation of EIF4E protein]	16109713
C471405	sorafenib	sorafenib results in decreased phosphorylation of EIF4E protein	16109713\|2175055
C471405	sorafenib	[sorafenib results in decreased phosphorylation of EIF4E protein] which results in decreased expression of MCL1	21750559
D013012	Sorbitol	Sorbitol inhibits the reaction [EIF4G protein binds to EIF4E protein]	12071973
D013012	Sorbitol	Sorbitol promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	12071973
D013012	Sorbitol	[Sorbitol results in decreased phosphorylation of EIF4EBP1 protein] promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]	12071973
D013012	Sorbitol	Sorbitol results in decreased phosphorylation of EIF4E protein	9545260
D013012	Sorbitol	Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]	9545260
C000609819	squaramide	squaramide analog binds to EIF4E protein	27592390
D013449	Sulfonamides	Sulfonamides binds to EIF4E protein	27592390
D013449	Sulfonamides	Sulfonamides inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]	27592390
D013449	Sulfonamides	Sulfonamides inhibits the reaction [RNA Caps binds to EIF4E protein]	27592390
D013629	Tamoxifen	Tamoxifen affects the expression of EIF4E mRNA	17555576
D013739	Testosterone	Testosterone results in increased expression of EIF4E mRNA	20843997
C534735	tetraarsenic tetrasulfide	tetraarsenic tetrasulfide results in decreased expression of EIF4E protein	19208803
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EIF4E mRNA	15056799
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EIF4E mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EIF4E mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of EIF4E mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
D013755	Tetradecanoylphorbol Acetate	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
D013755	Tetradecanoylphorbol Acetate	SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein	9545260
D013755	Tetradecanoylphorbol Acetate	[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
D013755	Tetradecanoylphorbol Acetate	CGP 57380 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
D013755	Tetradecanoylphorbol Acetate	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	9545260
D013755	Tetradecanoylphorbol Acetate	SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]]	9545260
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [EIF4EBP1 protein binds to EIF4E protein]	12781867
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein	12781867\|9545260
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EIF4E mRNA	25613284
D013792	Thalidomide	Thalidomide results in decreased expression of EIF4E protein	18291259
D019284	Thapsigargin	Thapsigargin results in decreased expression of EIF4E mRNA	24648495
D019284	Thapsigargin	Thapsigargin results in decreased expression of EIF4E protein	24648495
D013876	Thiophenes	Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF4E mRNA]	16140955
D014212	Tretinoin	Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of EIF4E mRNA]	16140955
D014212	Tretinoin	Tretinoin results in decreased expression of EIF4E mRNA	16140955
D014212	Tretinoin	Tretinoin results in increased expression of EIF4E mRNA	24977338
C032910	triadimefon	triadimefon results in increased expression of EIF4E mRNA	19363144
C012589	trichostatin A	trichostatin A affects the expression of EIF4E mRNA	28542535
D014415	Tunicamycin	Tunicamycin results in increased expression of EIF4E mRNA	17127020
C113580	U 0126	U 0126 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of EIF4E protein]	18299328
C113580	U 0126	U 0126 inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]	12781867
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4E protein]	12781867
C113580	U 0126	[SB 203580 co-treated with U 0126] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF4E protein]	16431125
C113580	U 0126	U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]	15757502
D014635	Valproic Acid	Valproic Acid results in decreased expression of EIF4E mRNA	20546886
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of EIF4E gene	25560391
C016837	zinc chloride	[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA	22415087
C016837	zinc chloride	[Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein	22415087

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000339	RNA cap binding	-	TAS	3469651
GO:0000340	RNA 7-methylguanosine cap binding	-	IDA	19750007
GO:0003723	RNA binding	-	HDA	22681889
GO:0003743	translation initiation factor activity	-	IDA	22578813
GO:0003743	translation initiation factor activity	-	ISS	-
GO:0005515	protein binding	-	IPI	7651417 7935836 9593750 9878069 10772338 10856257 15153109 15247416 15361857 16189514 16271312 16467844 16504179 16699599 16739988 17353931 18955708 19060904 19262567 19834456 20212144 20224576 20430826 20616046 20880835 20927323 21191102 22678294 23665581 23788676 24207126 24211447 25416956 27065194 29358667
GO:0019899	enzyme binding	-	IDA	23814182
GO:0031370	eukaryotic initiation factor 4G binding	-	IDA	18337562 23814182
GO:0070491	repressing transcription factor binding	-	IDA	23814182

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	IMP	14673156
GO:0006405	RNA export from nucleus	-	TAS	-
GO:0006406	mRNA export from nucleus	-	TAS	-
GO:0006413	translational initiation	-	TAS	-
GO:0006417	regulation of translation	-	IDA	22578813
GO:0010507	negative regulation of autophagy	NOT	IMP	18426977
GO:0016032	viral process	-	IEA	-
GO:0045931	positive regulation of mitotic cell cycle	-	IMP	14673156

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000932	P-body	-	IDA	20616046
GO:0005737	cytoplasm	-	IDA	19393246 23814182
GO:0005829	cytosol	-	IDA	19750007
GO:0005829	cytosol	-	TAS	-
GO:0005845	mRNA cap binding complex	-	IDA	16271312
GO:0010494	cytoplasmic stress granule	-	IDA	21883093
GO:0016281	eukaryotic translation initiation factor 4F complex	-	IDA	22578813
GO:0016442	RISC complex	-	IDA	20616046
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	23814182
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa03013	RNA transport
hsa04150	mTOR signaling pathway
hsa04910	Insulin signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1169408	ISG15 antiviral mechanism	TAS
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	TAS
R-HSA-159227	Transport of the SLBP independent Mature mRNA	TAS
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	TAS
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	TAS
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-165159	mTOR signalling	TAS
R-HSA-166208	mTORC1-mediated signalling	TAS
R-HSA-168256	Immune System	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-429914	Deadenylation-dependent mRNA decay	TAS
R-HSA-429947	Deadenylation of mRNA	TAS
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	TAS
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	TAS
R-HSA-72613	Eukaryotic Translation Initiation	TAS
R-HSA-72649	Translation initiation complex formation	TAS
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	TAS
R-HSA-72702	Ribosomal scanning and start codon recognition	TAS
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	TAS
R-HSA-72737	Cap-dependent Translation Initiation	TAS
R-HSA-72766	Translation	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-913531	Interferon Signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21159249	[Expression and its clinical significance of eIF4E in non-small cell lung cancer]. (2010 Dec)	ZHANG B	Zhongguo Fei Ai Za Zhi
28789440	TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. (2017 Aug)	Hao L	Oncol Lett
19289374	Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. (2009 Jan)	Khoury T	Clin Lung Cancer
25936472	Immunohistochemical characterization of the mTOR pathway in stage-I non-small-cell lung carcinoma. (2015 Jul)	Shin E	Lung Cancer