Gene info: ID 1991

Gene: ELANE

GENE ID: 1991

Synonyms: ELA2|GE|HLE|HNE|NE|PMN-E|SCN1

Description: elastase, neutrophil expressed

Gene type: protein-coding

Location: 19p13.3

dbXrefs: Ensembl:ENSG00000197561 MIM:130130 Vega:OTTHUMG00000181839 UniprotKB:P08246

RefSeq: NG_009627.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.890e-1 (AD) 2.604e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DEFA4	0.74
CTSG	0.718
BPI	0.688
DEFA3	0.682
CEACAM8	0.678
MS4A3	0.677
SERPINB10	0.611
CEACAM3	0.597
PRG2	0.595
AZU1	0.593

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GVQW1	-0.28
FAM19A4	-0.259
HS3ST5	-0.258
TCEANC	-0.257
HNF1A	-0.246
DNAJC28	-0.241
CLCN4	-0.241
HSD17B1	-0.238
ZNF835	-0.232
PCDH9	-0.226

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00019	Pegfilgrastim	BiotechDrug	208265-92-3	Approved	Target
DB00058	Alpha-1-proteinase inhibitor	BiotechDrug	9041-92-3	Approved	Target
DB00099	Filgrastim	BiotechDrug	121181-53-1	Approved	Target
DB02341	Mdl 101,146	Small Molecule	149859-17-6	Experimental	Target
DB03925	Freselestat	Small Molecule	208848-19-5	Experimental\|Investigational	Target
DB05161	Elafin	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Lipids results in increased secretion of ELANE protein]"	25920576
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [ELANE protein results in increased expression of MUC5AC mRNA]"	10843967\|1191908
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [ELANE protein results in increased expression of MUC5AC protein]"	17456367
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [ELANE protein results in increased expression of TGFA protein]"	17456367
C560790	2-(2-fluorobenzamido)benzoate ethyl ester	2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of ELANE protein]	21457779
D000814	Aniline Compounds	ELANE protein results in increased hydrolysis of Aniline Compounds analog	6566611
D000814	Aniline Compounds	ELANE protein results in increased hydrolysis of Aniline Compounds analog	6566611
D019268	Antibodies, Antineutrophil Cytoplasmic	"Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]"	18438818
D019268	Antibodies, Antineutrophil Cytoplasmic	"[Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]] which results in decreased activity of ELANE protein"	18438818
D001104	Arbutin	Arbutin results in decreased expression of ELANE mRNA	17103032
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ELANE protein	21467743
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ELANE mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of ELANE mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride affects the reaction [COL2A1 protein results in increased secretion of ELANE protein]	26070417
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of ELANE promoter	22457795
D002994	Clofibrate	Clofibrate results in decreased expression of ELANE mRNA	17585979
D003042	Cocaine	"Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]"	18438818
D003042	Cocaine	"[Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]] which results in decreased activity of ELANE protein"	18438818
D003300	Copper	[Copper binds to Tobramycin] which results in decreased activity of ELANE protein	23072509
D003300	Copper	Copper deficiency results in increased expression of ELANE mRNA	26033743
D003571	Cytochalasin B	[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein	19686721
D003571	Cytochalasin B	pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein]	19686721
D003676	Deferoxamine	Deferoxamine inhibits the reaction [ELANE protein results in increased expression of MUC5AC mRNA]	11919081
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ELANE mRNA	28628672
D002945	Cisplatin	Cisplatin results in decreased expression of ELANE mRNA	27594783
D004041	Dietary Fats	Dietary Fats results in increased expression of ELANE mRNA	25016146
D009240	N-Formylmethionine Leucyl-Phenylalanine	2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of ELANE protein]	21457779
D009240	N-Formylmethionine Leucyl-Phenylalanine	[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein	19686721
D009240	N-Formylmethionine Leucyl-Phenylalanine	N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of ELANE protein	21457779
D009240	N-Formylmethionine Leucyl-Phenylalanine	pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein]	19686721
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ELANE mRNA	28628672
D007501	Iron	Iron deficiency results in decreased expression of ELANE mRNA	20368581
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ELANE mRNA	28628672
C011890	kojic acid	kojic acid results in decreased expression of ELANE mRNA	16595896
D008055	Lipids	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Lipids results in increased secretion of ELANE protein]"	25920576
D008055	Lipids	Lipids results in increased secretion of ELANE protein	25920576
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of ELANE protein	11302825
D008070	Lipopolysaccharides	Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]	11302825
C009900	lipoteichoic acid	lipoteichoic acid results in increased secretion of ELANE protein	11302825
C009900	lipoteichoic acid	Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein]	11302825
C092152	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased expression of MUC5AC mRNA]"	17456367
C092152	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased expression of MUC5AC protein]"	17456367
C092152	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased expression of TGFA protein]"	17456367
C092152	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased phosphorylation of EGFR protein]"	17456367
D005996	Nitroglycerin	Nitroglycerin results in increased expression of ELANE protein	10884648
C006253	pirinixic acid	pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein]	19686721
C009007	potassium persulfate	potassium persulfate results in increased expression of ELANE protein	20815409
C428725	pyridaben	pyridaben results in increased expression of ELANE mRNA	22563483
D017382	Reactive Oxygen Species	ELANE protein results in increased abundance of Reactive Oxygen Species	10843967\|1191908
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the reaction [ELANE protein results in increased expression of MUC5AC mRNA]	10843967
D017382	Reactive Oxygen Species	Reactive Oxygen Species promotes the reaction [ELANE protein results in increased expression of MUC5AC mRNA]	11919081
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ELANE mRNA	25895662
C069195	sivelestat	sivelestat results in decreased activity of ELANE protein	19088179
C017947	sodium arsenite	sodium arsenite results in decreased expression of and affects the splicing of ELANE mRNA	25879800
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ELANE mRNA	28922406
D013792	Thalidomide	Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]	11302825
D013792	Thalidomide	Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein]	11302825
D014031	Tobramycin	[Copper binds to Tobramycin] which results in decreased activity of ELANE protein	23072509
D000515	alpha 1-Antitrypsin	alpha 1-Antitrypsin results in decreased activity of ELANE protein	6566611
D000515	alpha 1-Antitrypsin	alpha 1-Antitrypsin results in decreased activity of ELANE protein	6566611
D014635	Valproic Acid	Valproic Acid results in increased methylation of ELANE gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ELANE mRNA	17292431
D014800	Vitallium	Vitallium analog results in increased expression of ELANE mRNA	23825117
D015054	Zymosan	MMP9 protein affects the reaction [Zymosan affects the activity of ELANE protein]	19088179
D015054	Zymosan	MMP9 protein affects the reaction [Zymosan affects the expression of ELANE mRNA]	19088179
D015054	Zymosan	Zymosan affects the expression of and affects the activity of ELANE protein	19088179
D015054	Zymosan	Zymosan affects the expression of ELANE mRNA	19088179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	6980881
GO:0003714	transcription corepressor activity	-	IMP	19506020
GO:0004175	endopeptidase activity	-	IDA	6980881 12887060
GO:0004252	serine-type endopeptidase activity	-	IBA	21873635
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	12114510 12223522 14688365 19506020 21979170
GO:0008201	heparin binding	-	IDA	11907569
GO:0008233	peptidase activity	-	IDA	11907569 20421939
GO:0019955	cytokine binding	-	IPI	12393522

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	19506020
GO:0001878	response to yeast	-	IEA	-
GO:0002438	acute inflammatory response to antigenic stimulus	-	IBA	21873635
GO:0002523	leukocyte migration involved in inflammatory response	-	IEA	-
GO:0002812	biosynthetic process of antibacterial peptides active against Gram-negative bacteria	-	IDA	20421939
GO:0006508	proteolysis	-	IBA	21873635
GO:0006508	proteolysis	-	IDA	11907569 20421939
GO:0006874	cellular calcium ion homeostasis	-	NAS	15140022
GO:0006909	phagocytosis	-	IBA	21873635
GO:0009411	response to UV	-	IDA	11928814
GO:0019730	antimicrobial humoral response	-	TAS	-
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0030163	protein catabolic process	-	NAS	12887060
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0042742	defense response to bacterium	-	IDA	14705961
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043406	positive regulation of MAP kinase activity	-	NAS	14730209
GO:0044130	negative regulation of growth of symbiont in host	-	IEA	-
GO:0045079	negative regulation of chemokine biosynthetic process	-	IDA	12223522
GO:0045415	negative regulation of interleukin-8 biosynthetic process	-	IDA	12223522
GO:0045416	positive regulation of interleukin-8 biosynthetic process	-	IDA	14730209
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IDA	15010259
GO:0050728	negative regulation of inflammatory response	-	NAS	15140022
GO:0050778	positive regulation of immune response	-	IEA	-
GO:0050922	negative regulation of chemotaxis	-	NAS	15140022
GO:0070945	neutrophil mediated killing of gram-negative bacterium	-	IDA	20421939
GO:0070947	neutrophil mediated killing of fungus	-	IEA	-
GO:1903238	positive regulation of leukocyte tethering or rolling	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	12114510
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	20421939 25645918
GO:0005737	cytoplasm	-	IDA	19506020
GO:0009986	cell surface	-	IDA	12114510
GO:0017053	transcriptional repressor complex	-	IDA	19506020
GO:0030141	secretory granule	-	IDA	11907569
GO:0035578	azurophil granule lumen	-	TAS	-
GO:0035580	specific granule lumen	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa05322	Systemic lupus erythematosus

Reactome ID	Reactome Term	Evidence
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-166658	Complement cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6803157	Antimicrobial peptides	TAS
R-HSA-977606	Regulation of Complement cascade	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res