Gene: ELAVL2

1993
HEL-N1|HELN1|HUB
ELAV like RNA binding protein 2
protein-coding
9p21.3
Ensembl:ENSG00000107105 MIM:601673 Vega:OTTHUMG00000019700 UniprotKB:Q12926
NG_016425.2
PubMed|SNP Mapped
1   ANCO-SNPs
OD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.558e-1 (AD)  5.683e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2195731chr9:23785969 (GRCh38.p7)C>Aopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELAVL40.974
CDK140.966
SNAP910.963
CADPS0.962
PRKCE0.962
GABRA10.961
GLRB0.957
NELL20.956
SYT10.956
SNX100.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.562
ARHGEF5-0.55
SYDE1-0.529
RHOD-0.528
HEY2-0.528
REST-0.528
RNF135-0.528
CMTM3-0.523
CHST14-0.522
CNN2-0.519

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ELAVL2 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ELAVL2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ELAVL2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ELAVL2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ELAVL2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ELAVL2 mRNA"25510870
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ELAVL2 mRNA20829426
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ELAVL2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ELAVL2 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ELAVL2 mRNA16483693
D000068180AripiprazoleAripiprazole results in increased expression of ELAVL2 mRNA17868501
C015001arsenitearsenite results in increased methylation of ELAVL2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ELAVL2 mRNA21964900|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ELAVL2 mRNA21839799
C006780bisphenol Abisphenol A affects the expression of ELAVL2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ELAVL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ELAVL2 mRNA25181051
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ELAVL2 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of ELAVL2 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ELAVL2 mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ELAVL2 mRNA21266533
C118739entinostatentinostat results in decreased expression of ELAVL2 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ELAVL2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ELAVL2 mRNA29097150
C540355fenamidonefenamidone results in decreased expression of ELAVL2 mRNA27029645
C551027GANT 61GANT 61 results in increased expression of ELAVL2 mRNA22265815
C029310lardlard results in increased expression of ELAVL2 mRNA26115784
D007854LeadLead affects the splicing of ELAVL2 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ELAVL2 mRNA"24972896
D008731MethoxychlorMethoxychlor affects the expression of ELAVL2 mRNA20829426
C028007nickel monoxidenickel monoxide results in decreased expression of ELAVL2 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ELAVL2 mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of ELAVL2 mRNA24236059
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ELAVL2 mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of ELAVL2 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ELAVL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ELAVL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ELAVL2 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of ELAVL2 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ELAVL2 mRNA21427059
D012906SmokeSmoke results in decreased expression of ELAVL2 mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ELAVL2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of ELAVL2 mRNA19465110
C012589trichostatin Atrichostatin A results in decreased expression of ELAVL2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of ELAVL2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ELAVL2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of ELAVL2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ELAVL2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of ELAVL2 mRNA21427059
C025643vinclozolinvinclozolin affects the expression of ELAVL2 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of ELAVL2 mRNA18042343
D024483Vitamin K 3Vitamin K 3 affects the expression of ELAVL2 mRNA20829426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003730mRNA 3'-UTR binding-TAS8158249  
GO:0005515protein binding-IPI17289661  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006355regulation of transcription, DNA-templated-TAS8158249  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet