Gene: ELAVL4

1996
HUD|PNEM
ELAV like RNA binding protein 4
protein-coding
1p33-p32.3
Ensembl:ENSG00000162374 MIM:168360 Vega:OTTHUMG00000007877 UniprotKB:P26378
NC_000001.11
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.552e-1 (AD)  4.068e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9436447chr1:50125060 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs9436444chr1:50124126 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELAVL20.974
GABBR20.951
GABRA10.949
OPCML0.948
SYT10.946
SNAP910.945
PRKCE0.944
LRFN50.944
NELL20.944
CDK140.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAP1-0.543
LRAT-0.543
ARHGEF5-0.538
RHOD-0.519
HEY2-0.518
GJA3-0.509
REST-0.505
CSAG1-0.498
RAI14-0.496
CHST14-0.49

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of ELAVL4 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ELAVL4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ELAVL4 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of ELAVL4 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of ELAVL4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ELAVL4 mRNA18974090
D004390ChlorpyrifosChlorpyrifos results in decreased expression of ELAVL4 mRNA20691718
D004041Dietary FatsDietary Fats results in increased expression of ELAVL4 mRNA25016146
C016517indole-3-carbinolindole-3-carbinol affects the expression of ELAVL4 mRNA21396975
C008261lead acetatelead acetate results in increased expression of ELAVL4 mRNA24260418
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ELAVL4 protein26558463
C020771methylmercury hydroxidemethylmercury hydroxide results in increased expression of ELAVL4 mRNA20493249
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ELAVL4 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ELAVL4 mRNA24810058
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ELAVL4 mRNA]12710931
D008942MitoxantroneELAVL4 mRNA affects the susceptibility to Mitoxantrone16044152
C523799MRK 003MRK 003 results in increased expression of ELAVL4 mRNA21169257
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ELAVL4 protein19474218
C017947sodium arsenitesodium arsenite affects the expression of ELAVL4 mRNA19590694
C017947sodium arsenitesodium arsenite affects the methylation of ELAVL4 gene28589171
D013853ThioacetamideThioacetamide results in decreased expression of ELAVL4 mRNA23411599
D014212TretinoinTretinoin results in increased expression of ELAVL4 mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ELAVL4 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of ELAVL4 mRNA15901671
C012589trichostatin Atrichostatin A results in decreased expression of ELAVL4 mRNA15901671
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ELAVL4 mRNA]12710931
D014635Valproic AcidValproic Acid results in decreased expression of ELAVL4 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of ELAVL4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ELAVL4 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased expression of ELAVL4 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of ELAVL4 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ELAVL4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-TAS1655278  
GO:0003730mRNA 3'-UTR binding-TAS10848602  
GO:0017091AU-rich element binding-IDA10710437  
GO ID GO Term Qualifier Evidence PubMed
GO:0006396RNA processing-TAS1655278  
GO:0006397mRNA processing-TAS10348344  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28957450Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium. (2017)Wang TPLoS One