Gene: ZNF627

199692
-
zinc finger protein 627
protein-coding
19p13.2
Ensembl:ENSG00000198551 MIM:612248 Vega:OTTHUMG00000182035 UniprotKB:Q7L945
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.772e-1 (AD)  8.526e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POT10.814
RBM120.798
PEX130.798
STAM20.794
MARCH70.794
MYNN0.791
NMD30.791
CTDSPL20.787
THUMPD30.784
ABI10.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.467
PTGDR2-0.2
LCN1-0.174
MBD3L3-0.173
EPPIN-0.17
SPRR2A-0.168
WFIKKN1-0.163
HMHB1-0.159
CETP-0.154

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of ZNF627 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of ZNF627 mRNA22230336
D001151ArsenicArsenic affects the methylation of ZNF627 gene25304211
D004958EstradiolEstradiol results in decreased expression of ZNF627 mRNA23019147
D019327Copper SulfateCopper Sulfate results in decreased expression of ZNF627 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of ZNF627 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of ZNF627 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF627 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ZNF627 mRNA27594783
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ZNF627 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of ZNF627 mRNA20655997
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZNF627 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of ZNF627 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF627 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ZNF627 mRNA27392435
C045463leflunomideleflunomide results in increased expression of ZNF627 mRNA28988120
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ZNF627 mRNA18593933
C031389resorcinolresorcinol results in decreased expression of ZNF627 mRNA22623647
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZNF627 mRNA"26179874
D014520UrethaneUrethane results in increased expression of ZNF627 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ZNF627 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZNF627 mRNA23179753|2718838
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ZNF627 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24087953[Genetic predictors of myocardial infarction in subjects of young age]. (2013)Shesternia PAKardiologiia