Gene: GGN

199720
-
gametogenetin
protein-coding
19q13.2
Ensembl:ENSG00000179168 MIM:609966 Vega:OTTHUMG00000182080 UniprotKB:Q86UU5
NC_000019.10
PubMed
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.838e-1 (AD)  8.131e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPATA2L0.767
BEGAIN0.706
VGF0.705
KCNIP30.691
SBK10.685
B4GALT20.68
FLRT10.678
ST3GAL20.675
FMNL10.672
ELFN10.67

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CP-0.489
VNN2-0.467
CLEC2B-0.461
SLC19A3-0.458
CFH-0.451
CFI-0.451
RNASE4-0.45
CWF19L2-0.448
SELL-0.439
ST6GALNAC3-0.436

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of GGN mRNA29067470
C006780bisphenol Abisphenol A results in decreased expression of GGN mRNA17706920
C006780bisphenol ALHB protein affects the reaction [bisphenol A results in decreased expression of GGN mRNA]17706920
C006780bisphenol Abisphenol A results in decreased expression of GGN mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGN gene20938992
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GGN mRNA23914054
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GGN mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GGN mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of GGN mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGN gene20938992
D005839GentamicinsGentamicins results in decreased expression of GGN mRNA22061828
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GGN mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GGN mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GGN mRNA27432991
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGN gene20938992
D010936Plant ExtractsPlant Extracts results in decreased expression of GGN mRNA23557933
D014635Valproic AcidValproic Acid affects the expression of GGN mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006302double-strand break repair-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007276gamete generation-ISS-  
GO:0007283spermatogenesis-IEA-  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17922225Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. (2008 Mar)Liu CHJ Biomed Sci
24083798Natural history of ground-glass nodules detected on the chest computed tomography scan after major lung resection. (2013 Dec)Kim HSAnn Thorac Surg
16868150Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men. (2006 Aug)Lundin KBEur J Endocrinol
9610786The androgen receptor gene GGN microsatellite and prostate cancer risk. (1998 May)Platz EACancer Epidemiol Biomarkers Prev
25361983Genetic features of pulmonary adenocarcinoma presenting with ground-glass nodules: the differences between nodules with and without growth. (2015 Jan)Kobayashi YAnn Oncol
28158988Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. (2017 Feb 3)Bagshaw ATBMC Med Genet
19159685The GGN and CAG repeat polymorphisms in the exon-1 of the androgen receptor gene are, respectively, associated with insulin resistance in men and with dyslipidemia in women. (2009 Feb)Rodriguez-Gonzalez GJ Steroid Biochem Mol Biol
24417917[Value of low-dose spiral computed tomography in lung cancer screening]. (2013 Oct 15)Zhang YZhonghua Yi Xue Za Zhi