Gene: A2M

2
A2MD|CPAMD5|FWP007|S863-7
alpha-2-macroglobulin
protein-coding
12p13.31
Ensembl:ENSG00000175899 MIM:103950 Vega:OTTHUMG00000150267 UniprotKB:P01023
NG_011717.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.768e-1 (AD)  6.617e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCB10.905
SLCO2B10.864
CYYR10.857
ABCG20.853
TGFBR20.853
EMCN0.849
FLI10.847
PTPRB0.839
LEF10.825
CLEC14A0.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.399
OR4F5-0.364
TEPP-0.288
C1orf53-0.286
HAS1-0.283
TMEM121-0.281
CHST8-0.281
MESP1-0.277
DRD5-0.265
NEUROG2-0.263

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00102BecaplerminBiotechDrug165101-51-9Approved|InvestigationalTarget
DB00515CisplatinSmall Molecule15663-27-1ApprovedTarget
DB00626BacitracinSmall Molecule1405-87-4ApprovedTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB08888OcriplasminBiotechDrug1048016-09-6ApprovedTarget
DB06796MangafodipirSmall Molecule155319-91-8Approved|Investigational|WithdrawnCarrier
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of A2M mRNA"17690111
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of A2M mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of A2M mRNA"27413110
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of A2M mRNA"20566314
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of A2M mRNA20566314
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of A2M mRNA17690111
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of A2M mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of A2M mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of A2M mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of A2M mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of A2M mRNA"15059925
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of A2M mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of A2M mRNA"19692669
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of A2M mRNA"17292976
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of A2M mRNA"18289764
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of A2M mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of A2M mRNA"27188386
C0801227-nitroindazole7-nitroindazole results in increased activity of A2M19240864
D000082AcetaminophenAcetaminophen results in increased expression of A2M mRNA12883083|8878780
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of A2M mRNA"20566314
C096064acteinactein results in increased expression of A2M mRNA19527300
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of A2M mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of A2M gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of A2M mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of A2M mRNA28522335
D015119Aminocaproic AcidAminocaproic Acid results in decreased expression of A2M protein11304663
D000643Ammonium ChlorideAmmonium Chloride affects the expression of A2M mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of A2M mRNA16715494
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of A2M mRNA"22863853
D000965AntimonyAntimony results in decreased expression of A2M mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of A2M mRNA17547211
D047310ApigeninApigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]15618353
D001280AtrazineAtrazine results in increased expression of A2M mRNA25929836|2741310
C547126AZM551248AZM551248 results in decreased expression of A2M mRNA22323515
D001414BacitracinBacitracin results in increased expression of A2M mRNA18289764
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of A2M mRNA12883083
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of A2M mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of A2M mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of A2M mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of A2M mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of A2M mRNA22316170
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of A2M mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of A2M mRNA28628672
C006780bisphenol Abisphenol A results in increased methylation of A2M promoter27312807
C006780bisphenol Abisphenol A results in increased expression of A2M mRNA24534842
C006780bisphenol Abisphenol A results in increased expression of A2M mRNA27104808
C006780bisphenol Abisphenol A affects the expression of A2M mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of A2M mRNA26794494
D002104CadmiumA2M protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in increased expression of A2M mRNA23741332
D019256Cadmium ChlorideApigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]15618353
D019256Cadmium ChlorideCadmium Chloride results in increased expression of A2M mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased expression of A2M protein15618353
D019256Cadmium Chloride"N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]"15618353
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA]20360939
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of A2M mRNA19395590
D020355Cholates"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of A2M mRNA"25814186
D020355Cholates"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of A2M protein"25814186
D002791Cholesterol, Dietary"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of A2M mRNA"25814186
D002791Cholesterol, Dietary"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of A2M protein"25814186
D002994ClofibrateClofibrate results in increased expression of A2M mRNA12883083
D002995Clofibric AcidClofibric Acid affects the expression of A2M mRNA17602206
C052387cocoa butter"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of A2M mRNA"25814186
C052387cocoa butter"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of A2M protein"25814186
D003300CopperA2M protein binds to Copper23896426
D003300CopperCopper results in increased expression of A2M mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of A2M mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of A2M mRNA15755911
D003471CuprizoneCuprizone results in increased expression of A2M mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of A2M mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of A2M mRNA19770486
D016572CyclosporineCyclosporine results in increased expression of A2M mRNA21865292
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of A2M mRNA"20566314
C515055darinaparsindarinaparsin results in increased expression of A2M mRNA22535156
D000069439DasatinibDasatinib results in increased expression of A2M mRNA20579391
D003907DexamethasoneDexamethasone results in increased expression of A2M mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of A2M mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of A2M mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of A2M mRNA12971794
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of A2M mRNA"17690111
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of A2M mRNA28962523
D002945CisplatinCisplatin binds to A2M protein16773208
D002945CisplatinCisplatin results in increased expression of A2M mRNA18289764
D004008DiclofenacDiclofenac results in increased expression of A2M mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of A2M mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of A2M mRNA21852083
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of A2M mRNA]20360939
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M protein20935162
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of A2M promoter25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of A2M mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of A2M mRNA20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of A2M protein27565560
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of A2M mRNA17547211
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of A2M mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of A2M mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of A2M mRNA12883083
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of A2M promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of A2M mRNA17557909
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of A2M protein10928463
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of A2M mRNA17690111
D005485FlutamideFlutamide results in decreased expression of A2M mRNA24136188
D005485FlutamideFlutamide results in increased expression of A2M mRNA24793618
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of A2M mRNA21149847
C039281furanfuran results in decreased expression of A2M mRNA15120968
C039281furanfuran results in increased expression of A2M mRNA26194646
C056507gemcitabinegemcitabine results in increased expression of A2M protein20531411
D005897GlafenineGlafenine results in increased expression of A2M mRNA24136188
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of A2M mRNA16206274
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in increased expression of A2M mRNA20471814
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of A2M mRNA"20566314
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in increased expression of A2M mRNA20566314
C113661imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) binds to A2M protein16773208
C016517indole-3-carbinolindole-3-carbinol affects the expression of A2M mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of A2M mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of A2M mRNA28628672
C051890irinotecanirinotecan results in increased expression of A2M mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of A2M mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of A2M mRNA28628672
D007538IsoniazidIsoniazid results in increased expression of A2M mRNA12883083
D007545IsoproterenolIsoproterenol results in increased expression of A2M mRNA21335049
D007654KetoconazoleKetoconazole results in decreased expression of A2M mRNA18289764
D007854LeadA2M protein binds to Lead23896426
C008261lead acetatelead acetate affects the expression of A2M mRNA21864555
C008261lead acetatelead acetate results in decreased expression of A2M mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of A2M mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of A2M mRNA11779202
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of A2M mRNA"20566314
C011907melaminemelamine results in increased expression of A2M23052191
D008627Mercuric ChlorideMercuric Chloride results in increased expression of A2M mRNA27188386
D008628MercuryMercury results in decreased expression of A2M mRNA17547211
D008701MethapyrileneMethapyrilene results in decreased expression of A2M mRNA15120968
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of A2M mRNA26924002
C001020N(6),N(6)-dimethyladenine"N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]"15618353
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of A2M"21654424
C031721naphthalenenaphthalene metabolite binds to A2M protein15892573
C031721naphthalenenaphthalene analog results in increased expression of A2M mRNA24976557
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate affects the expression of A2M mRNA18289764
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of A2M mRNA12883083|2538013
D009532NickelA2M protein binds to Nickel23896426
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of A2M mRNA17616710
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of A2M mRNA27935865
C464660obeticholic acidobeticholic acid results in decreased expression of A2M mRNA27939613
C025589ochratoxin Aochratoxin A results in increased expression of A2M mRNA12700408
C076029olanzapineolanzapine affects the phosphorylation of A2M protein25821032
D009966OrphenadrineOrphenadrine affects the expression of A2M mRNA23665939
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of A2M mRNA23567314
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of A2M mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of A2M mRNA21984479
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of A2M mRNA23602845
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of A2M mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of A2M mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of A2M mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of A2M mRNA21984479
D010634PhenobarbitalPhenobarbital affects the expression of A2M mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of A2M protein20935162
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of A2M promoter25374375
D010634PhenobarbitalPhenobarbital results in decreased expression of A2M mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of A2M mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of A2M mRNA26272509
D010862PilocarpinePilocarpine results in increased expression of A2M mRNA17971868
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of A2M mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of A2M mRNA16940010
D028321Plant PreparationsA2M protein results in decreased uptake of Plant Preparations27262837
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of A2M mRNA27989595
C009007potassium persulfatepotassium persulfate results in increased expression of A2M protein20815409
D011241PrednisonePrednisone results in decreased expression of A2M protein11304663
D011374ProgesteroneProgesterone affects the expression of A2M mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of A2M mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of A2M mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of A2M mRNA24780913
D011748PyrogallolPyrogallol results in increased expression of A2M mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in increased expression of A2M mRNA]20362636
D015474IsotretinoinIsotretinoin results in increased expression of A2M mRNA20436886
D012643SeleniumSelenium inhibits the reaction [T-2 Toxin results in decreased expression of A2M mRNA]21144892
D012643SeleniumSelenium promotes the reaction [T-2 Toxin results in decreased expression of A2M protein]21144892
D012643SeleniumSelenium results in increased expression of A2M mRNA18997278
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of A2M mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of A2M mRNA23221170
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in increased expression of A2M mRNA]20362636
D019821SimvastatinSimvastatin results in decreased expression of A2M mRNA16414398
D020123SirolimusSirolimus results in increased expression of A2M mRNA21865292
C017947sodium arsenitesodium arsenite affects the expression of A2M mRNA19590694
C017947sodium arsenitesodium arsenite results in increased expression of A2M mRNA16014739
C016104sodium bichromatesodium bichromate affects the expression of A2M mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of A2M mRNA25993096
D012999SomanSoman results in increased expression of A2M mRNA19281266
D013141Spiro CompoundsSpiro Compounds analog results in decreased expression of A2M mRNA25320076
D010042OuabainOuabain affects the expression of A2M protein17268060
D013605T-2 ToxinSelenium inhibits the reaction [T-2 Toxin results in decreased expression of A2M mRNA]21144892
D013605T-2 ToxinSelenium promotes the reaction [T-2 Toxin results in decreased expression of A2M protein]21144892
D013605T-2 ToxinT-2 Toxin results in decreased expression of A2M mRNA21144892
D013605T-2 ToxinT-2 Toxin results in decreased expression of A2M protein21144892
D016559TacrolimusTacrolimus results in increased expression of A2M mRNA21865292
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of A2M mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of A2M mRNA19770486
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of A2M mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of A2M mRNA21215274
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of A2M mRNA2440878
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of A2M mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of A2M mRNA16297948|2341159
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of A2M protein19478969
D014204Trenbolone AcetateTrenbolone Acetate affects the expression of A2M protein24072461
D014236TrichlorfonTrichlorfon results in decreased expression of A2M mRNA23340335
D014241TrichloroethyleneTrichloroethylene results in increased methylation of A2M gene27618143
C012589trichostatin Atrichostatin A results in increased expression of A2M mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of A2M mRNA29024780
D014425TurpentineTurpentine results in increased expression of A2M mRNA11779202
D014635Valproic AcidValproic Acid affects the expression of A2M mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of A2M mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of A2M gene29154799
D014635Valproic AcidValproic Acid results in increased expression of A2M mRNA28001369
D014640VancomycinVancomycin results in increased expression of A2M mRNA18289764
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of A2M gene25560391
C025643vinclozolinvinclozolin results in increased expression of A2M mRNA22570695
D014800VitalliumVitallium analog results in increased expression of A2M mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of A2M mRNA20044591
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of A2M mRNA27935865
D015032ZincA2M protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI18485748  
GO:0004867serine-type endopeptidase inhibitor activity-IDA12538697  
GO:0005096GTPase activator activity-TAS-  
GO:0005102signaling receptor binding-IMP15226301  
GO:0005515protein binding-IPI6698368  14687906  15226301  
GO:0019838growth factor binding-IDA9398211  
GO:0019899enzyme binding-IPI11435418  
GO:0019959interleukin-8 binding-IPI10880251  
GO:0019966interleukin-1 binding-IDA9714181  
GO:0043120tumor necrosis factor binding-IDA9714181  
GO:0048306calcium-dependent protein binding-IPI15226301  
GO ID GO Term Qualifier Evidence PubMed
GO:0001869negative regulation of complement activation, lectin pathway-IDA12538697  
GO:0002576platelet degranulation-TAS-  
GO:0007597blood coagulation, intrinsic pathway-TAS-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0048863stem cell differentiation-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0070062extracellular exosome-HDA20458337  21362503  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8963896HDL assemblyTAS
R-HSA-8963898Plasma lipoprotein assemblyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
1721608IgM in the airways of asthma patients. (1991)Hol BEInt Arch Allergy Appl Immunol
28138311Specific networks of plasma acute phase reactants are associated with the severity of chronic obstructive pulmonary disease: a case-control study. (2017)Arellano-Orden EInt J Med Sci
2443322Humoral defending mechanisms in children of smoking parents. (1987)Wagner VCzech Med
2476329Local increase of antiprotease and neutrophil elastase-alpha 1-proteinase inhibitor complexes in lung cancer. (1989 Jul)Marchandise FXEur Respir J
3102187Humoral factors of resistance in the cohort of workers exposed to vinylchloride in the span of six years, concerning the influence of smoking. (1986)Wagnerova MCzech Med
2461983Factors of humoral resistance in workers exposed to vinyl chloride with a view to smoking habits. (1988)Wagnerova MJ Hyg Epidemiol Microbiol Immunol
28627459Peripheral blood gene expression of acute phase proteins in people with first episode psychosis. (2017 Oct)Yee JYBrain Behav Immun