Gene: ELF5

2001
ESE2
E74 like ETS transcription factor 5
protein-coding
11p13
Ensembl:ENSG00000135374 MIM:605169 Vega:OTTHUMG00000166451 UniprotKB:Q9UKW6
NG_029477.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.344e-2 (AD)  3.297e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16930094chr11:34500102 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB20.769
MSLN0.765
GPR650.751
ANKRD220.726
LILRA10.721
MS4A4E0.72
TFPI0.716
EMILIN20.714
LILRB30.709
DAPP10.707

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM179-0.507
SLC7A4-0.476
OMG-0.473
SVOP-0.47
BDH1-0.466
PNMA3-0.461
EPHA10-0.46
KCNA2-0.459
RNFT2-0.458
THY1-0.457

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione promotes the reaction [PGR protein binds to ELF5 intron]"20519331
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of ELF5 mRNA"20519331
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of ELF5 protein"20519331
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"ELF5 protein results in increased susceptibility to 16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"20519331
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"Mifepristone inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of ELF5 protein]"20519331
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ELF5 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ELF5 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the expression of ELF5 mRNA"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with BMP4 protein] results in decreased methylation of ELF5 promoter"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased methylation of ELF5 promoter"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ELF5 mRNA21298039
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ELF5 mRNA"25351596
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ELF5 mRNA26377693
D004958EstradiolEGF protein promotes the reaction [Estradiol results in decreased expression of ELF5 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ELF5 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of ELF5 mRNA24758408
D004958EstradiolEstradiol results in increased expression of ELF5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ELF5 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ELF5 mRNA26496021
C006780bisphenol Abisphenol A affects the methylation of ELF5 promoter27334623
C006780bisphenol Abisphenol A results in increased methylation of ELF5 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ELF5 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ELF5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ELF5 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ELF5 mRNA15003993
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of ELF5 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of ELF5 mRNA16197558
C018021cobaltous chloridecobaltous chloride results in decreased expression of ELF5 mRNA24386269
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ELF5 mRNA"19167446
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ELF5 mRNA23640034
D003907Dexamethasone[Dexamethasone co-treated with Genistein] results in decreased expression of ELF5 mRNA25136773
D003907DexamethasoneDexamethasone results in decreased expression of ELF5 mRNA25136773
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ELF5 mRNA28085963
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ELF5 mRNA15171707
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ELF5 mRNA"27840820
D011397PromegestonePromegestone results in increased expression of ELF5 protein20519331
D004237DiuronDiuron results in decreased expression of ELF5 mRNA21551480
D004237DiuronDiuron results in increased expression of ELF5 mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of ELF5 mRNA"23811387
D019833Genistein[Dexamethasone co-treated with Genistein] results in decreased expression of ELF5 mRNA25136773
D019833Genistein[Genistein co-treated with vinclozolin] results in increased expression of ELF5 mRNA23160963
D019833GenisteinGenistein results in increased expression of ELF5 mRNA23160963
C412815GW 4064GW 4064 results in decreased expression of ELF5 mRNA26655953
C008261lead acetatelead acetate results in decreased expression of ELF5 mRNA22609695
D015122MercaptopurineMercaptopurine results in decreased expression of ELF5 mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of ELF5 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
D015735Mifepristone"Mifepristone inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of ELF5 protein]"20519331
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ELF5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ELF5 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of ELF5 mRNA23811387
D009532NickelNickel results in decreased expression of ELF5 mRNA24768652|2558310
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ELF5 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ELF5 mRNA26272509
D011372ProgestinsProgestins results in increased expression of ELF5 mRNA20519331
D053260SootSoot results in decreased expression of ELF5 mRNA26551751
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ELF5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ELF5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ELF5 mRNA17035482|2405805
C009495titanium dioxidetitanium dioxide results in increased expression of ELF5 mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ELF5 mRNA24935251|2627250
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ELF5 mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ELF5 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ELF5 mRNA23179753|2438349
C025643vinclozolin[Genistein co-treated with vinclozolin] results in increased expression of ELF5 mRNA23160963
C029297vinylidene chloridevinylidene chloride results in decreased expression of ELF5 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001712ectodermal cell fate commitment-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9840936  
GO:0008283cell proliferation-TAS9840936  
GO:0030154cell differentiation-IBA21873635  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0045596negative regulation of cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0060644mammary gland epithelial cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal