Gene: PLD5

200150
PLDC
phospholipase D family member 5
protein-coding
1q43
Ensembl:ENSG00000180287 Vega:OTTHUMG00000039867 UniprotKB:Q8N7P1
NC_000001.11
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.383e-1 (AD)  7.696e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2809985chr1:242399419 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH10.85
GRIK10.799
TOX30.79
IGF10.785
KCNMB20.783
HAPLN10.78
ZNF385D0.772
KIT0.758
GAD10.755
SLC10A40.755

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLIN2-0.473
TMPRSS3-0.44
TEAD3-0.438
A4GALT-0.435
TRAF3IP2-0.435
TGIF1-0.434
FXYD3-0.428
NFATC1-0.426
GPR4-0.424
MT1A-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of PLD5 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PLD5 mRNA29067470
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLD5 mRNA26705709
C487081belinostatbelinostat results in decreased expression of PLD5 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PLD5 gene25435355
D004958EstradiolEstradiol results in increased expression of PLD5 mRNA20106945
C044887beta-methylcholinebeta-methylcholine affects the expression of PLD5 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PLD5 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PLD5 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PLD5 mRNA26272509
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PLD5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PLD5 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of PLD5 mRNA26033743
D004237DiuronDiuron metabolite results in increased expression of PLD5 mRNA24172598
C118739entinostatentinostat results in decreased expression of PLD5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLD5 mRNA"27188386
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PLD5 mRNA27392435
D007854LeadLead affects the expression of PLD5 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of PLD5 mRNA22613225
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLD5 mRNA28001369
D010936Plant ExtractsPlant Extracts results in decreased expression of PLD5 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLD5 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PLD5 mRNA25895662
D014284TriiodothyronineTriiodothyronine results in increased expression of PLD5 mRNA23397585
D014212TretinoinTretinoin results in decreased expression of PLD5 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of PLD5 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of PLD5 mRNA23179753
C111237vorinostatvorinostat results in increased expression of PLD5 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of PLD5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal