Gene: SLFNL1

200172
-
schlafen like 1
protein-coding
1p34.2
Ensembl:ENSG00000171790 Vega:OTTHUMG00000005719 UniprotKB:Q499Z3
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.366e-1 (AD)  5.998e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17357905chr1:41018645 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR90.84
CCNA20.787
MIA0.765
KLK140.75
SLC7A90.748
CLDN90.741
QRICH20.721
TDRG10.709
CELSR10.703
CNTD20.7

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCT6B-0.497
RBM3-0.49
PRSS27-0.456
HSD17B8-0.44
CTSO-0.434
CDNF-0.403
HMGB3-0.403
HSF2BP-0.381
C9orf50-0.367
PBLD-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of SLFNL1 mRNA17562736
C006780bisphenol Abisphenol A results in decreased expression of SLFNL1 mRNA25181051
D003976DiazinonDiazinon results in decreased methylation of SLFNL1 gene22964155
D009532NickelNickel results in increased expression of SLFNL1 mRNA24768652
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLFNL1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of SLFNL1 mRNA23557933
C012526quercitrinquercitrin results in increased expression of SLFNL1 mRNA25193878
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLFNL1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLFNL1 mRNA21570461
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLFNL1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal