Gene: APOBEC3A

200315
A3A|ARP3|PHRBN|bK150C2.1
apolipoprotein B mRNA editing enzyme catalytic subunit 3A
protein-coding
22q13.1
Ensembl:ENSG00000128383 MIM:607109 Vega:OTTHUMG00000151004 UniprotKB:P31941
NC_000022.11
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21345826chr22:39353650APOBEC3A7.300e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEACAM10.777
LILRA50.775
FFAR20.759
PLAC80.758
DDX60L0.754
CD300E0.739
HSH2D0.736
IL1R20.735
GBP50.724
SAMD90.718

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.441
GABRA5-0.419
CHRNA4-0.412
NEUROD6-0.395
ATOH7-0.393
NNAT-0.392
SEZ6-0.391
MARCH4-0.391
SLC1A6-0.39
RCOR2-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of APOBEC3A mRNA"23146750
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of APOBEC3A protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of APOBEC3A mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of APOBEC3A mRNA26690555
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of APOBEC3A mRNA"23195993
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of APOBEC3A mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of APOBEC3A mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APOBEC3A mRNA20064835
D019327Copper SulfateCopper Sulfate results in increased expression of APOBEC3A mRNA19549813
C064925gadodiamidegadodiamide results in increased expression of APOBEC3A mRNA20959327
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of APOBEC3A mRNA23086925
D009532NickelNickel results in decreased expression of APOBEC3A mRNA23195993
D009532NickelNickel results in increased expression of APOBEC3A mRNA25583101
D012822Silicon DioxideSilicon Dioxide results in increased expression of APOBEC3A mRNA25351596
D014520UrethaneUrethane results in decreased expression of APOBEC3A mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of APOBEC3A gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IBA21873635  
GO:0004126cytidine deaminase activity-IBA21873635  
GO:0004126cytidine deaminase activity-IDA16527742  21123384  
GO:0004126cytidine deaminase activity-IMP20062055  
GO:0005515protein binding-IPI22915799  24557838  
GO:0008270zinc ion binding-IEA-  
GO:0047844deoxycytidine deaminase activity-IMP22457529  
GO ID GO Term Qualifier Evidence PubMed
GO:0009972cytidine deamination-IEA-  
GO:0010529negative regulation of transposition-IDA16527742  20062055  21123384  
GO:0016554cytidine to uridine editing-IBA21873635  
GO:0044356clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine-IDA20062055  
GO:0045071negative regulation of viral genome replication-IDA16527742  
GO:0045087innate immune response-IDA21123384  
GO:0051607defense response to virus-IDA21123384  22457529  
GO:0070383DNA cytosine deamination-IDA16527742  21123384  
GO:0070383DNA cytosine deamination-IMP20062055  
GO:0071466cellular response to xenobiotic stimulus-IDA20062055  
GO:0080111DNA demethylation-IBA21873635  
GO:0080111DNA demethylation-IDA21496894  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16527742  21123384  21835787  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA16527742  21123384  21835787  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72200mRNA Editing: C to U ConversionTAS
R-HSA-75072mRNA EditingTAS
R-HSA-75094Formation of the EditosomeTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18437100Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue. (2008 Aug)Hussain NPediatr Res
23284801Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers. (2012)Schwender HPLoS One
29028944Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer. (2017 Dec 7)Selinski SCarcinogenesis
21995620Effect of homozygous deletions at 22q13.1 on alcohol dependence severity and cue-elicited BOLD response in the precuneus. (2013 May)Liu JAddict Biol