Gene: TMEM17

200728
-
transmembrane protein 17
protein-coding
2p15
Ensembl:ENSG00000186889 MIM:614950 Vega:OTTHUMG00000129455 UniprotKB:Q86X19
NC_000002.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.301e-1 (AD)  2.143e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1997247chr2:62530420 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPA170.854
B3GALNT10.853
TMEM1770.849
TMX40.846
PRMT60.845
SCOC0.844
TCTEX1D20.843
PIGX0.84
NDUFAF60.837
CASD10.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.528
MTRNR2L9-0.486
TNFRSF10D-0.481
MTRNR2L6-0.468
MAGEA12-0.463
GPR4-0.457
MTRNR2L10-0.456
TBX15-0.455
MTRNR2L8-0.452
CNN2-0.447

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TMEM17 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of TMEM17 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM17 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM17 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TMEM17 mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of TMEM17 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TMEM17 gene28505145
C584509C646 compoundC646 compound results in increased expression of TMEM17 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of TMEM17 mRNA25979313
D016572CyclosporineCyclosporine affects the expression of TMEM17 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of TMEM17 mRNA27989131
D017313FenretinideFenretinide results in increased expression of TMEM17 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of TMEM17 mRNA26191083
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM17 mRNA28001369
D009532NickelNickel results in decreased expression of TMEM17 mRNA24768652|2558310
D012969Sodium FluorideSodium Fluoride results in decreased expression of TMEM17 mRNA27862939
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM17 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TMEM17 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMEM17 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of TMEM17 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMEM17 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26638075  
GO ID GO Term Qualifier Evidence PubMed
GO:0007224smoothened signaling pathway-ISS-  
GO:0060271cilium assembly-ISS-  
GO:1905515non-motile cilium assembly-IBA21873635  
GO:1905515non-motile cilium assembly-IMP26982032  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0035869ciliary transition zone-IBA21873635  
GO:0035869ciliary transition zone-ISS-  
GO:0036038MKS complex-ISS-  
GO:0060170ciliary membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal