Gene: HTR3D

200909
5HT3D
5-hydroxytryptamine receptor 3D
protein-coding
3q27.1
Ensembl:ENSG00000186090 MIM:610122 Vega:OTTHUMG00000156858 UniprotKB:Q70Z44
NG_012750.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.624e-1 (AD)  3.181e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOR0.79
MUC170.728
TAS2R600.712
FGF210.696
CPN20.685
TMPRSS130.678
GCM10.678
CNGA20.673
GJA80.673
TAAR10.669

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.239
NDP-0.185
SLITRK4-0.173
ZNF540-0.172
KRT13-0.171
GSTM1-0.17
CHAD-0.168
RFTN2-0.167
PDE11A-0.162
ZBTB44-0.161

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HTR3D gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of HTR3D mRNA21757418
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HTR3D mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased methylation of HTR3D gene24570342
C017947sodium arsenitesodium arsenite results in increased expression of HTR3D mRNA24570342

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI17392525  
GO:0022850serotonin-gated cation-selective channel activity-IDA17392525  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007210serotonin receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil
20021265Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010)Goecke TWActa Obstet Gynecol Scand