Gene: EMD

2010
EDMD|LEMD5|STA
emerin
protein-coding
Xq28
Ensembl:ENSG00000102119 MIM:300384 Vega:OTTHUMG00000033186 UniprotKB:P50402
NG_008677.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC130.92
GNB20.916
EIF3I0.898
ALYREF0.898
DDOST0.897
LMAN20.896
ACTG10.892
ADRM10.892
TMED90.891
SMARCB10.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.764
OR4F29-0.724
MTRNR2L6-0.249
MTRNR2L9-0.244
OR6C74-0.218
P2RY14-0.202
MTRNR2L10-0.182
CTNNA3-0.181
HMHB1-0.168
XIRP2-0.163

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of EMD mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of EMD mRNA"18648102
D000171AcroleinAcrolein affects the expression of EMD mRNA19527780
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EMD mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of EMD mRNA25258189
D001280AtrazineAtrazine results in decreased expression of EMD mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of EMD mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of EMD mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of EMD protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of EMD mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EMD mRNA21297351
D004390ChlorpyrifosChlorpyrifos results in decreased expression of EMD mRNA18668222
D002994ClofibrateClofibrate results in decreased expression of EMD mRNA17585979
D003375CoumestrolCoumestrol results in increased expression of EMD mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of EMD mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EMD mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EMD mRNA21266533
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of EMD mRNA19527780
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EMD protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of EMD mRNA22079256
D000431EthanolEthanol results in increased expression of EMD mRNA28986285
C492448ICG 001ICG 001 results in increased expression of EMD mRNA26191083
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EMD mRNA26011545
C033069methyl salicylatemethyl salicylate affects the expression of EMD mRNA19527780
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EMD mRNA"25554681
D010416PentachlorophenolPentachlorophenol results in increased expression of EMD mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of EMD protein26178269
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EMD mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of EMD mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of EMD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EMD mRNA22714537
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of EMD mRNA22079256
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EMD mRNA25895662
D012834SilverSilver affects the expression of EMD mRNA27131904
D012999SomanSoman results in increased expression of EMD mRNA19281266
C004648testosterone enanthatetestosterone enanthate affects the expression of EMD mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EMD mRNA21570461|2468072
C009495titanium dioxidetitanium dioxide results in increased expression of EMD mRNA23409001
D014635Valproic AcidValproic Acid results in increased methylation of EMD gene29154799
C025643vinclozolinvinclozolin results in decreased expression of EMD mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0003779actin binding-IDA15328537  
GO:0005515protein binding-IPI12163176  15009215  15328537  15671068  16169070  16189514  
16858403  17462627  19323649  19933576  21610090  22399800  
25416956  25910212  27107012  
GO:0045296cadherin binding-HDA25468996  
GO:0045296cadherin binding-IBA21873635  
GO:0048487beta-tubulin binding-IBA21873635  
GO:0048487beta-tubulin binding-IDA17785515  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS7894480  
GO:0007084mitotic nuclear envelope reassembly-TAS-  
GO:0007517muscle organ development-TAS7894480  8589715  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:0046827positive regulation of protein export from nucleus-IMP16858403  
GO:0048147negative regulation of fibroblast proliferation-IMP16858403  
GO:0060828regulation of canonical Wnt signaling pathway-IMP16858403  
GO:0071363cellular response to growth factor stimulus-IMP16858403  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP16858403  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IBA21873635  
GO:0005635nuclear envelope-IDA16858403  27534416  
GO:0005635nuclear envelopecolocalizes_withIMP21610090  
GO:0005635nuclear envelope-TAS-  
GO:0005637nuclear inner membrane-IBA21873635  
GO:0005637nuclear inner membrane-IDA19167377  
GO:0005637nuclear inner membrane-NAS16858403  
GO:0005640nuclear outer membrane-IDA17785515  
GO:0005654nucleoplasm-IDA27534416  
GO:0005737cytoplasm-IDA27534416  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005819spindle-IBA21873635  
GO:0005874microtubule-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0031616spindle pole centrosomecolocalizes_withIDA19494128  
GO:0031965nuclear membrane-IBA21873635  
GO:0031965nuclear membrane-IDA-  
GO:0032541cortical endoplasmic reticulumcolocalizes_withIDA19494128  
KEGG ID KEGG Term
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-2993913Clearance of Nuclear Envelope Membranes from ChromatinTAS
R-HSA-2995383Initiation of Nuclear Envelope ReformationTAS
R-HSA-2995410Nuclear Envelope ReassemblyTAS
R-HSA-4419969Depolymerisation of the Nuclear LaminaTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24815103Five-year clinical results for treatment of intrabony defects with EMD, guided tissue regeneration and open-flap debridement: a case series. (2015 Feb)Mitani AJ Periodontal Res