Gene info: ID 201163

Gene: FLCN

GENE ID: 201163

Synonyms: BHD|FLCL

Description: folliculin

Gene type: protein-coding

Location: 17p11.2

dbXrefs: Ensembl:ENSG00000154803 MIM:607273 Vega:OTTHUMG00000059275 UniprotKB:Q8NFG4

RefSeq: NG_008001.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : 6.288e-1 (AD) 8.011e-1 (ND) (Frontal_Cortex)

Pascal p-value : 9.871e-1 (AD) 7.829e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16696035	chr17:17126176	FLCN		3.490e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HINFP	0.919
PCID2	0.908
FBXO42	0.9
ABCC5	0.895
EYA3	0.895
KANSL1	0.894
PRR14L	0.886
SMPD4	0.886
EDC3	0.882
DIDO1	0.882

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.527
OR4F29	-0.483
KLRB1	-0.369
KLRC2	-0.346
TRDN	-0.336
ASB4	-0.333
TFPI2	-0.328
LRRCC1	-0.314
KLRF1	-0.314
CD2	-0.311

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in increased expression of FLCN mRNA"	22101062
C490166	1-(4-methoxyphenyl)piperazine	1-(4-methoxyphenyl)piperazine results in increased expression of FLCN mRNA	26821219
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of FLCN mRNA"	20453058
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FLCN mRNA"	19167446
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of FLCN mRNA"	20406850
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of FLCN mRNA"	21346803
C012796	2-butenal	2-butenal results in increased expression of FLCN mRNA	20471460
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FLCN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLCN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FLCN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLCN mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of FLCN mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in increased expression of FLCN mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of FLCN mRNA	17562736
D000447	Aldehydes	Aldehydes results in increased expression of FLCN mRNA	25014914
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of FLCN mRNA	21298039
D000638	Amiodarone	Amiodarone affects the expression of FLCN mRNA	25064622
D000638	Amiodarone	Amiodarone results in increased expression of FLCN mRNA	19774075
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of FLCN mRNA	24449571
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of FLCN mRNA"	18687144
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of FLCN mRNA	26377693
C006780	bisphenol A	bisphenol A affects the expression of FLCN mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of FLCN mRNA	25047013\|2927551
C006780	bisphenol A	bisphenol A results in decreased expression of FLCN mRNA	21932408
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of FLCN mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of FLCN mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of FLCN mRNA	20977926
D002065	Buspirone	Buspirone results in increased expression of FLCN mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in increased expression of FLCN mRNA	26079696
D002220	Carbamazepine	Carbamazepine affects the expression of FLCN mRNA	25979313
D002746	Chlorpromazine	Chlorpromazine affects the expression of FLCN mRNA	25064622
D002994	Clofibrate	Clofibrate results in decreased expression of FLCN mRNA	17585979
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in increased expression of FLCN mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FLCN mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of FLCN mRNA	19167446
D016572	Cyclosporine	Cyclosporine affects the expression of FLCN mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in increased expression of FLCN mRNA	25562108
D004041	Dietary Fats	Dietary Fats results in decreased expression of FLCN mRNA	18042831
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of FLCN mRNA	21551480
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of FLCN mRNA	25064622
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of FLCN mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of FLCN mRNA	20655997\|2364984
D005897	Glafenine	Glafenine results in decreased expression of FLCN mRNA	24136188
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of FLCN mRNA	20044591
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FLCN mRNA	25613284
D007657	Ketone Bodies	Ketone Bodies results in increased expression of FLCN mRNA	16807920
C045463	leflunomide	leflunomide results in increased expression of FLCN mRNA	24136188
D008345	Manganese	Manganese results in increased expression of FLCN mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of FLCN mRNA	17175027
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of FLCN mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of FLCN mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of FLCN mRNA	22776087
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of FLCN mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of FLCN mRNA"	25554681\|2562005
C461488	N-benzylpiperazine	N-benzylpiperazine results in increased expression of FLCN mRNA	26821219
C051752	nefazodone	nefazodone results in increased expression of FLCN mRNA	24136188
D010100	Oxygen	Oxygen deficiency results in increased expression of FLCN mRNA	17175027
D000073878	Palm Oil	Palm Oil results in decreased expression of FLCN mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of FLCN mRNA	25064622
D052638	Particulate Matter	Particulate Matter results in increased expression of FLCN mRNA	24769257
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA	18593933
C046012	pentanal	pentanal results in increased expression of FLCN mRNA	26079696
D010634	Phenobarbital	Phenobarbital affects the expression of FLCN mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of FLCN mRNA	23091169
D010634	Phenobarbital	Phenobarbital affects the methylation of FLCN gene	19233941
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FLCN mRNA"	27188386
C018637	phorone	phorone affects the expression of FLCN mRNA	18198479
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FLCN mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of FLCN mRNA	18445702
D010938	Plant Oils	Plant Oils results in increased expression of FLCN mRNA	23370395
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of FLCN mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of FLCN mRNA	23018184
C005556	propionaldehyde	propionaldehyde results in increased expression of FLCN mRNA	26079696
D011794	Quercetin	Quercetin results in increased expression of FLCN mRNA	21632981
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of FLCN mRNA	25895662
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of FLCN mRNA	26496021
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of FLCN mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FLCN mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FLCN mRNA	21215274
D013752	Tetracycline	Tetracycline affects the expression of FLCN mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FLCN mRNA	25613284
D013849	Thimerosal	"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLCN mRNA"	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of FLCN mRNA	25064622
C009495	titanium dioxide	titanium dioxide affects the expression of FLCN mRNA	17656681
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of FLCN mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of FLCN mRNA	28111298
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FLCN mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of FLCN mRNA	28973697
C406224	valdecoxib	valdecoxib results in increased expression of FLCN mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of FLCN mRNA	25064622
D014635	Valproic Acid	Valproic Acid results in increased methylation of FLCN gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of FLCN gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of FLCN mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of FLCN mRNA	22570695
D024483	Vitamin K 3	Vitamin K 3 affects the expression of FLCN mRNA	20044591
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005085	guanyl-nucleotide exchange factor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	17028174 18403135 18663353 22965878 25126726 27353360
GO:0044877	protein-containing complex binding	-	IDA	17028174

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	20573232
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	21209915
GO:0001701	in utero embryonic development	-	ISS	-
GO:0001932	regulation of protein phosphorylation	-	IDA	18663353
GO:0001934	positive regulation of protein phosphorylation	-	ISS	-
GO:0007043	cell-cell junction assembly	-	ISS	-
GO:0010508	positive regulation of autophagy	-	IMP	25126726
GO:0010629	negative regulation of gene expression	-	ISS	-
GO:0010823	negative regulation of mitochondrion organization	-	ISS	-
GO:0030097	hemopoiesis	-	ISS	-
GO:0030308	negative regulation of cell growth	-	IDA	20573232
GO:0030336	negative regulation of cell migration	-	IMP	22965878
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	-	IDA	20573232
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	-	ISS	-
GO:0031929	TOR signaling	-	IMP	17028174
GO:0032006	regulation of TOR signaling	-	ISS	-
GO:0032007	negative regulation of TOR signaling	-	ISS	-
GO:0032008	positive regulation of TOR signaling	-	ISS	-
GO:0032465	regulation of cytokinesis	-	IMP	22965878
GO:0035024	negative regulation of Rho protein signal transduction	-	IMP	22965878
GO:0035065	regulation of histone acetylation	-	ISS	-
GO:0043065	positive regulation of apoptotic process	-	ISS	-
GO:0045785	positive regulation of cell adhesion	-	IMP	21209915
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	20573232
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	21209915
GO:0051898	negative regulation of protein kinase B signaling	-	ISS	-
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:0097009	energy homeostasis	-	ISS	-
GO:1900181	negative regulation of protein localization to nucleus	-	IDA	21209915
GO:1901723	negative regulation of cell proliferation involved in kidney development	-	ISS	-
GO:2000973	regulation of pro-B cell differentiation	-	ISS	-
GO:2001170	negative regulation of ATP biosynthetic process	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	17028174 18663353
GO:0005737	cytoplasm	-	IDA	17028174 18663353 22965878
GO:0005764	lysosome	-	TAS	25126726
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0005929	cilium	-	TAS	25126726
GO:0030496	midbody	colocalizes_with	IDA	22965878
GO:0044291	cell-cell contact zone	colocalizes_with	IDA	22965878

KEGG ID	KEGG Term
hsa05211	Renal cell carcinoma

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20301695	Birt-Hogg-Dube Syndrome (1993)	Toro JR	-
21482341	[Multiple spontaneous pneumothoraces revealing Birt-Hogg-Dube syndrome]. (2011 Mar)	Van Denhove A	Rev Mal Respir