Gene: FLCN

201163
BHD|FLCL
folliculin
protein-coding
17p11.2
Ensembl:ENSG00000154803 MIM:607273 Vega:OTTHUMG00000059275 UniprotKB:Q8NFG4
NG_008001.2
PubMed
ND
2   
6.288e-1 (AD)  8.011e-1 (ND)   (Frontal_Cortex)
9.871e-1 (AD)  7.829e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16696035chr17:17126176FLCN3.490e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HINFP0.919
PCID20.908
FBXO420.9
ABCC50.895
EYA30.895
KANSL10.894
PRR14L0.886
SMPD40.886
EDC30.882
DIDO10.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.527
OR4F29-0.483
KLRB1-0.369
KLRC2-0.346
TRDN-0.336
ASB4-0.333
TFPI2-0.328
LRRCC1-0.314
KLRF1-0.314
CD2-0.311

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of FLCN mRNA"22101062
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in increased expression of FLCN mRNA26821219
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of FLCN mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FLCN mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of FLCN mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FLCN mRNA"21346803
C0127962-butenal2-butenal results in increased expression of FLCN mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FLCN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FLCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLCN mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of FLCN mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of FLCN mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of FLCN mRNA17562736
D000447AldehydesAldehydes results in increased expression of FLCN mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of FLCN mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of FLCN mRNA25064622
D000638AmiodaroneAmiodarone results in increased expression of FLCN mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FLCN mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FLCN mRNA"18687144
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FLCN mRNA26377693
C006780bisphenol Abisphenol A affects the expression of FLCN mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FLCN mRNA25047013|2927551
C006780bisphenol Abisphenol A results in decreased expression of FLCN mRNA21932408
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of FLCN mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of FLCN mRNA25181051
D000069286BortezomibBortezomib results in increased expression of FLCN mRNA20977926
D002065BuspironeBuspirone results in increased expression of FLCN mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of FLCN mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of FLCN mRNA25979313
D002746ChlorpromazineChlorpromazine affects the expression of FLCN mRNA25064622
D002994ClofibrateClofibrate results in decreased expression of FLCN mRNA17585979
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of FLCN mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FLCN mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of FLCN mRNA19167446
D016572CyclosporineCyclosporine affects the expression of FLCN mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of FLCN mRNA25562108
D004041Dietary FatsDietary Fats results in decreased expression of FLCN mRNA18042831
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA24690739
D004237DiuronDiuron results in decreased expression of FLCN mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FLCN mRNA25064622
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FLCN mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of FLCN mRNA20655997|2364984
D005897GlafenineGlafenine results in decreased expression of FLCN mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FLCN mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FLCN mRNA25613284
D007657Ketone BodiesKetone Bodies results in increased expression of FLCN mRNA16807920
C045463leflunomideleflunomide results in increased expression of FLCN mRNA24136188
D008345ManganeseManganese results in increased expression of FLCN mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of FLCN mRNA17175027
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FLCN mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FLCN mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FLCN mRNA22776087
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FLCN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FLCN mRNA"25554681|2562005
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of FLCN mRNA26821219
C051752nefazodonenefazodone results in increased expression of FLCN mRNA24136188
D010100OxygenOxygen deficiency results in increased expression of FLCN mRNA17175027
D000073878Palm OilPalm Oil results in decreased expression of FLCN mRNA18042831
D010269ParaquatParaquat affects the expression of FLCN mRNA25064622
D052638Particulate MatterParticulate Matter results in increased expression of FLCN mRNA24769257
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA18593933
C046012pentanalpentanal results in increased expression of FLCN mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of FLCN mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of FLCN mRNA23091169
D010634PhenobarbitalPhenobarbital affects the methylation of FLCN gene19233941
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FLCN mRNA"27188386
C018637phoronephorone affects the expression of FLCN mRNA18198479
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FLCN mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of FLCN mRNA18445702
D010938Plant OilsPlant Oils results in increased expression of FLCN mRNA23370395
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FLCN mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of FLCN mRNA23018184
C005556propionaldehydepropionaldehyde results in increased expression of FLCN mRNA26079696
D011794QuercetinQuercetin results in increased expression of FLCN mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FLCN mRNA25895662
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of FLCN mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of FLCN mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FLCN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FLCN mRNA21215274
D013752TetracyclineTetracycline affects the expression of FLCN mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FLCN mRNA25613284
D013849Thimerosal"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLCN mRNA"27188386
D013853ThioacetamideThioacetamide affects the expression of FLCN mRNA25064622
C009495titanium dioxidetitanium dioxide affects the expression of FLCN mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FLCN mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FLCN mRNA28111298
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FLCN mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FLCN mRNA28973697
C406224valdecoxibvaldecoxib results in increased expression of FLCN mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of FLCN mRNA25064622
D014635Valproic AcidValproic Acid results in increased methylation of FLCN gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FLCN gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FLCN mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of FLCN mRNA22570695
D024483Vitamin K 3Vitamin K 3 affects the expression of FLCN mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IEA-  
GO:0005515protein binding-IPI17028174  18403135  18663353  22965878  25126726  27353360  
GO:0044877protein-containing complex binding-IDA17028174  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20573232  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP21209915  
GO:0001701in utero embryonic development-ISS-  
GO:0001932regulation of protein phosphorylation-IDA18663353  
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0007043cell-cell junction assembly-ISS-  
GO:0010508positive regulation of autophagy-IMP25126726  
GO:0010629negative regulation of gene expression-ISS-  
GO:0010823negative regulation of mitochondrion organization-ISS-  
GO:0030097hemopoiesis-ISS-  
GO:0030308negative regulation of cell growth-IDA20573232  
GO:0030336negative regulation of cell migration-IMP22965878  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IDA20573232  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-ISS-  
GO:0031929TOR signaling-IMP17028174  
GO:0032006regulation of TOR signaling-ISS-  
GO:0032007negative regulation of TOR signaling-ISS-  
GO:0032008positive regulation of TOR signaling-ISS-  
GO:0032465regulation of cytokinesis-IMP22965878  
GO:0035024negative regulation of Rho protein signal transduction-IMP22965878  
GO:0035065regulation of histone acetylation-ISS-  
GO:0043065positive regulation of apoptotic process-ISS-  
GO:0045785positive regulation of cell adhesion-IMP21209915  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA20573232  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP21209915  
GO:0051898negative regulation of protein kinase B signaling-ISS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO:0097009energy homeostasis-ISS-  
GO:1900181negative regulation of protein localization to nucleus-IDA21209915  
GO:1901723negative regulation of cell proliferation involved in kidney development-ISS-  
GO:2000973regulation of pro-B cell differentiation-ISS-  
GO:2001170negative regulation of ATP biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA17028174  18663353  
GO:0005737cytoplasm-IDA17028174  18663353  22965878  
GO:0005764lysosome-TAS25126726  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005929cilium-TAS25126726  
GO:0030496midbodycolocalizes_withIDA22965878  
GO:0044291cell-cell contact zonecolocalizes_withIDA22965878  
KEGG ID KEGG Term
hsa05211Renal cell carcinoma
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301695Birt-Hogg-Dube Syndrome (1993)Toro JR-
21482341[Multiple spontaneous pneumothoraces revealing Birt-Hogg-Dube syndrome]. (2011 Mar)Van Denhove ARev Mal Respir