Gene: SLC39A11

201266
C17orf26|ZIP-11|ZIP11
solute carrier family 39 member 11
protein-coding
17q24.3-q25.1
Ensembl:ENSG00000133195 MIM:616508 Vega:OTTHUMG00000178306 UniprotKB:Q8N1S5
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.386e-1 (AD)  6.784e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08853318chr17:71089186SLC39A11Promoter4.466e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH200.8
PHLPP10.753
NEO10.752
GPRC5B0.746
BBS20.744
LIFR0.736
MEGF100.73
TPP10.729
TMEM1360.729
HTRA10.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.429
OR4F29-0.394
IBSP-0.344
FER1L6-0.334
LBH-0.317
CLEC6A-0.317
CETP-0.316
NMUR1-0.308
ANO1-0.301
GALR1-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC39A11 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SLC39A11 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A11 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of SLC39A11 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A11 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC39A11 mRNA29067470
D020106AcrylamideAcrylamide affects the expression of SLC39A11 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC39A11 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC39A11 mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC39A11 mRNA19770486
D001151ArsenicArsenic affects the methylation of SLC39A11 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC39A11 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC39A11 mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC39A11 mRNA"26238291
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC39A11 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SLC39A11 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC39A11 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC39A11 mRNA28628672
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of SLC39A11 mRNA19925653
C584509C646 compoundC646 compound results in increased expression of SLC39A11 mRNA26191083
D003042CocaineCocaine affects the expression of SLC39A11 mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC39A11 mRNA19549813|2059984
D019327Copper SulfateCopper Sulfate results in increased expression of SLC39A11 mRNA20599845
D003471CuprizoneCuprizone results in increased expression of SLC39A11 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of SLC39A11 mRNA27989131
C093628cyproconazolecyproconazole results in increased expression of SLC39A11 mRNA22334560
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC39A11 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC39A11 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of SLC39A11 mRNA27594783
D002945CisplatinCisplatin results in decreased expression of SLC39A11 mRNA25270620
D002117CalcitriolCalcitriol results in decreased expression of SLC39A11 mRNA20089671
D002117CalcitriolCalcitriol results in increased expression of SLC39A11 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SLC39A11 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of SLC39A11 mRNA27638505
D004298DopamineDopamine results in increased expression of SLC39A11 mRNA21983523
C109476epoxiconazoleepoxiconazole results in increased expression of SLC39A11 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC39A11 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC39A11 mRNA17942748
D018818FenoldopamFenoldopam results in increased expression of SLC39A11 mRNA21983523
D005557FormaldehydeFormaldehyde results in decreased expression of SLC39A11 mRNA23649840
C004312glycidolglycidol results in increased expression of SLC39A11 mRNA24915197
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in decreased expression of SLC39A11 mRNA20471814
C492448ICG 001ICG 001 results in increased expression of SLC39A11 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of SLC39A11 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC39A11 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC39A11 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC39A11 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC39A11 mRNA28628672
C544151jinfukangjinfukang results in increased expression of SLC39A11 mRNA27392435
D008727MethotrexateMethotrexate affects the expression of SLC39A11 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC39A11 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of SLC39A11 mRNA29191790
C028473N-acetyl-4-benzoquinoneimineSLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC39A11 mRNA"25554681
D010936Plant ExtractsPlant Extracts results in increased expression of SLC39A11 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of SLC39A11 mRNA21278054|2233456
D011794QuercetinQuercetin results in decreased expression of SLC39A11 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC39A11 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of SLC39A11 mRNA22714537
D013629TamoxifenTamoxifen affects the expression of SLC39A11 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SLC39A11 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SLC39A11 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC39A11 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SLC39A11 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC39A11 mRNA15034205
D019284ThapsigarginThapsigargin results in increased expression of SLC39A11 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC39A11 mRNA28065790
D014303TrinitrotolueneTrinitrotoluene affects the expression of SLC39A11 mRNA21346803
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A11 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC39A11 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC39A11 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC39A11 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SLC39A11 mRNA23034163
D015032ZincSLC39A11 protein results in increased transport of Zinc18326752
D015032ZincSLC39A11 protein results in increased uptake of Zinc17126599

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005385zinc ion transmembrane transporter activity-IBA21873635  
GO:0005385zinc ion transmembrane transporter activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0071577zinc ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000329fungal-type vacuole membrane-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005794Golgi apparatus-ISS-  
GO:0005886plasma membrane-ISS-  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24665060Genome-wide association study of smoking behaviours among Bangladeshi adults. (2014 May)Argos MJ Med Genet