Gene: FBXO15

201456
FBX15
F-box protein 15
protein-coding
18q22.3
Ensembl:ENSG00000141665 MIM:609093 Vega:OTTHUMG00000132842 UniprotKB:Q8NCQ5
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  4.124e-1 (ND)   (Frontal_Cortex)
5.811e-1 (AD)  5.489e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1430.761
RECQL50.753
PPP1R3E0.746
PLA2G60.734
ACBD40.734
SPAG80.733
PPOX0.727
ENDOV0.727
RABL2A0.725
COQ40.723

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.44
GSDMA-0.439
MTRNR2L9-0.423
FER1L6-0.421
MTRNR2L6-0.419
SIX1-0.418
SULT1E1-0.412
MTRNR2L10-0.411
FCER2-0.41
KIAA0040-0.403

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of FBXO15 mRNA16788091
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FBXO15 mRNA19191707
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FBXO15 mRNA22100608
C006780bisphenol Abisphenol A results in decreased expression of FBXO15 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of FBXO15 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FBXO15 gene28505145
D002737ChloropreneChloroprene results in increased expression of FBXO15 mRNA23125180
D003471CuprizoneCuprizone results in increased expression of FBXO15 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of FBXO15 mRNA20106945
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of FBXO15 mRNA22634610
D007213IndomethacinIndomethacin results in increased expression of FBXO15 mRNA28201806
C544151jinfukangjinfukang results in increased expression of FBXO15 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of FBXO15 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FBXO15 mRNA28001369
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of FBXO15 mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FBXO15 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FBXO15 mRNA"25554681
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of FBXO15 mRNA25658374
D011192Potassium DichromatePotassium Dichromate results in increased expression of FBXO15 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of FBXO15 mRNA19690047
C089730rosiglitazonerosiglitazone results in increased expression of FBXO15 mRNA16982809
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FBXO15 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of FBXO15 mRNA19073995
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of FBXO15 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FBXO15 mRNA22298810
D014635Valproic AcidValproic Acid results in decreased methylation of FBXO15 gene29154799
C025643vinclozolinvinclozolin results in increased expression of FBXO15 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26333835Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. (2015 Dec)Scheinfeldt LBAm J Med Genet B Neuropsychiatr Genet