Gene: ADGRE1

2015
EMR1|TM7LN3
adhesion G protein-coupled receptor E1
protein-coding
19p13.3-p13.2
Ensembl:ENSG00000174837 MIM:600493 Vega:OTTHUMG00000181966 UniprotKB:Q14246
NC_000019.10
SNP Mapped
2   ANCO-SNPs
CD|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.931e-1 (AD)  7.463e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs459998chr19:6914519 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs673320chr19:6909554 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]"19513120
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of ADGRE1 mRNA"19513120
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of ADGRE1 mRNA"21920950
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of ADGRE1 mRNA]"24162184
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acidstannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of ADGRE1 protein]]23611540
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of ADGRE1 protein]23611540
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ADGRE1 mRNA"25380136
C099958acanthoic acidacanthoic acid inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]28964808
D000082AcetaminophenAcetaminophen results in decreased expression of ADGRE1 protein22575169
D000082AcetaminophenAcetaminophen results in increased expression of ADGRE1 protein28435131
D000082Acetaminophencoomassie Brilliant Blue inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
D000082AcetaminophenMST1R protein affects the reaction [Acetaminophen results in decreased expression of ADGRE1 protein]22575169
D000082Acetaminophen[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
D000082Acetaminophentripterine inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ADGRE1 protein20106945
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of ADGRE1 mRNA"20224926
C031942argatrobanargatroban inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]22841818
D001151ArsenicADGRE1 mRNA results in decreased susceptibility to Arsenic17976673
C015001arsenitearsenite results in decreased expression of ADGRE1 mRNA18191166
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADGRE1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ADGRE1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADGRE1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of ADGRE1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of ADGRE1 mRNA27145005
C006780bisphenol Abisphenol A results in decreased expression of ADGRE1 mRNA25181051
D001786Blood Glucose[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of ADGRE1 mRNA27693381
C018475butyraldehydebutyraldehyde results in increased expression of ADGRE1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of ADGRE1 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADGRE1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADGRE1 mRNA22206755|2733941
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADGRE1 protein22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of ADGRE1 mRNA]22206755
D002251Carbon TetrachlorideTBXA2R protein affects the reaction [Carbon Tetrachloride results in increased expression of ADGRE1 protein]22206755
D002509CephaloridineCephaloridine results in increased expression of ADGRE1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ADGRE1 mRNA23650126
D002794Choline[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADGRE1 mRNA25178843
D002794CholineCholine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADGRE1 mRNA]25178843
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 mRNA20697377
D002794CholineMethionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADGRE1 mRNA]25178843
D002922CiguatoxinsCiguatoxins affects the expression of ADGRE1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of ADGRE1 mRNA22300585
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of ADGRE1 mRNA]23503329
D003042CocaineCocaine affects the expression of ADGRE1 mRNA20187946
C004692coomassie Brilliant Bluecoomassie Brilliant Blue inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
C004692coomassie Brilliant Blue[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
D003300Copper[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA25813056
D003471CuprizoneCuprizone results in increased expression of ADGRE1 mRNA27523638
D003474CurcuminCurcumin results in decreased expression of ADGRE1 mRNA18403477
D002945CisplatinCisplatin results in increased expression of ADGRE1 mRNA27594783
D004041Dietary FatsHMOX1 protein promotes the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]23390531
D004041Dietary Fats"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC promotes the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]"19513120
D004041Dietary Fatsargatroban inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]22841818
D004041Dietary FatsDietary Fats affects the expression of ADGRE1 mRNA23503329
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA28611668
D004041Dietary FatsDietary Fats results in decreased expression of ADGRE1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ADGRE1 mRNA19513120|2260994
D004041Dietary Fats[hexabromocyclododecane co-treated with Dietary Fats] results in increased expression of ADGRE1 mRNA24398136
D004041Dietary FatsINT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA]28611668
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]24465016|2561471
D004041Dietary Fatsrosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA]28611668
D004041Dietary Fats[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of ADGRE1 mRNA]23503329
D000073417Dietary Sugars[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA28611668
D000073417Dietary SugarsINT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA]28611668
D000073417Dietary Sugarsrosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA]28611668
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ADGRE1 mRNA25380136
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ADGRE1 protein]22101032
D000069347Erlotinib Hydrochloride[Interleukin 1 Receptor Antagonist Protein co-treated with Erlotinib Hydrochloride] results in decreased expression of ADGRE1 protein27738319
D000431Ethanolacanthoic acid inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]28964808
D000431EthanolEthanol affects the expression of ADGRE1 protein28843478
D000431EthanolEthanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]26858005
D000431EthanolEthanol results in increased expression of ADGRE1 mRNA26858005
D000431EthanolEthanol results in increased expression of ADGRE1 protein26858005|2888257
D000431EthanolFructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]26858005
D000431EthanolFructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein]26858005
D000431Ethanolgadolinium chloride inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]28882574
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADGRE1 mRNA12072388
C000499ferric oxideferric oxide analog results in increased expression of ADGRE1 mRNA24525745
D005632FructoseEthanol promotes the reaction [Fructose results in increased expression of ADGRE1 protein]26858005
D005632FructoseFructose promotes the reaction [Ethanol results in increased expression of ADGRE1 mRNA]26858005
D005632FructoseFructose promotes the reaction [Ethanol results in increased expression of ADGRE1 protein]26858005
D005632FructoseFructose results in increased expression of ADGRE1 protein26858005
D005632Fructose[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA25813056
C038958gadolinium chloridegadolinium chloride inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]28882574
C038958gadolinium chloride[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA25813056
C412815GW 4064GW 4064 results in decreased expression of ADGRE1 mRNA23371517
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with Dietary Fats] results in increased expression of ADGRE1 mRNA24398136
C541917INT 131INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA]28611668
D053590Interleukin 1 Receptor Antagonist Protein[Interleukin 1 Receptor Antagonist Protein co-treated with Erlotinib Hydrochloride] results in decreased expression of ADGRE1 protein27738319
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADGRE1 mRNA23086925
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in increased expression of ADGRE1 mRNA"17322064
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in increased expression of ADGRE1 protein"17322064
D008070Lipopolysaccharides"3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of ADGRE1 mRNA]"24162184
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ADGRE1 mRNA24162184|2733941
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of ADGRE1 mRNA24525745
D008345ManganeseManganese results in increased expression of ADGRE1 mRNA20224926
D008715Methionine[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADGRE1 mRNA25178843
D008715MethionineCholine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADGRE1 mRNA]25178843
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 mRNA20697377
D008715MethionineMethionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ADGRE1 mRNA]25178843
D008727MethotrexateMethotrexate affects the expression of ADGRE1 mRNA18502557
C523799MRK 003ADGRE1 results in increased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in decreased expression of ADGRE1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ADGRE1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ADGRE1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADGRE1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADGRE1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ADGRE1 mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ADGRE1 mRNA19812364
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of ADGRE1 mRNA]23503329
C434926N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride"N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]"18509044
D010098OxycodoneOxycodone results in decreased expression of ADGRE1 mRNA23439660
D010100OxygenOxygen deficiency results in decreased expression of ADGRE1 mRNA23539316
D010100Oxygen[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of ADGRE1 mRNA27693381
D000073878Palm OilPalm Oil results in decreased expression of ADGRE1 mRNA18042831
D052638Particulate MatterCCR2 gene mutant form inhibits the reaction [Particulate Matter results in increased expression of ADGRE1 mRNA]24149114
D052638Particulate MatterParticulate Matter results in increased expression of ADGRE1 mRNA24149114
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ADGRE1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ADGRE1 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of ADGRE1 mRNA18445702|2081375
C005556propionaldehydepropionaldehyde results in increased expression of ADGRE1 mRNA26079696
D011765Pyruvaldehydeepigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ADGRE1 protein]22101032
D011765PyruvaldehydePyruvaldehyde results in increased expression of ADGRE1 protein22101032
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA]24465016|2561471
C089730rosiglitazonerosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of ADGRE1 mRNA]28611668
C089730rosiglitazonerosiglitazone results in decreased expression of ADGRE1 mRNA21515302
D012999SomanSoman results in increased expression of ADGRE1 mRNA19281266
D053260SootSoot results in increased expression of ADGRE1 mRNA26551751
C559087SR 1078SR 1078 results in increased expression of ADGRE1 mRNA28698385
C518404stannous mesoporphyrinstannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of ADGRE1 protein]]23611540
D013311Streptozocinstannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of ADGRE1 protein]]23611540
D013311StreptozocinStreptozocin results in increased expression of ADGRE1 protein23611540
D013311Streptozocin4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of ADGRE1 protein]23611540
C061133tamibarotenetamibarotene results in increased expression of ADGRE1 mRNA15498508
C501413tesaglitazartesaglitazar results in decreased expression of ADGRE1 mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ADGRE1 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADGRE1 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADGRE1 mRNA17320037|2256453
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased expression of ADGRE1 protein20164154
C009495titanium dioxidetitanium dioxide results in increased expression of ADGRE1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADGRE1 mRNA20133372
D019772TopotecanTopotecan results in increased expression of ADGRE1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ADGRE1 mRNA15498508
C050414tripterine[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
C050414tripterinetripterine inhibits the reaction [Acetaminophen results in increased expression of ADGRE1 protein]28435131
C057693troglitazonetroglitazone results in decreased expression of ADGRE1 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased methylation of ADGRE1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of ADGRE1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of ADGRE1 mRNA26682919
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of ADGRE1 mRNA]23503329
C016837zinc chlorideNCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]18509044
C016837zinc chloride"N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]"18509044
C016837zinc chloridePARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of ADGRE1 protein]18509044
C016837zinc chloridezinc chloride results in increased expression of ADGRE1 protein18509044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IBA21873635  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0007155cell adhesion-TAS7601460  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS7601460  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal