Gene: DNAH12

201625
DHC3|DLP12|DLP3|DNAH12L|DNAH7L|DNAHC12|DNAHC3|DNHD2|HDHC3|HL-19|HL19
dynein axonemal heavy chain 12
protein-coding
3p14.3
Ensembl:ENSG00000174844 MIM:603340 Vega:OTTHUMG00000158598 UniprotKB:Q6ZR08
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.009e-1 (AD)  8.030e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10530169chr3:57529952DNAH12Promoter1.963e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAZ2B0.675
MEIS10.672
LRRC10.657
GTF2IRD2B0.654
THAP90.65
CECR20.65
CREB3L40.648
RNF320.646
DOCK50.643
USP400.638

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNOC-0.428
ELFN1-0.426
CHRNA2-0.394
CRH-0.385
KCNG1-0.356
SP8-0.355
VIP-0.35
SHISA8-0.348
TAC3-0.346
SSTR4-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000447AldehydesAldehydes results in increased expression of DNAH12 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of DNAH12 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DNAH12 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DNAH12 mRNA21871943
C006780bisphenol Abisphenol A results in decreased expression of DNAH12 mRNA29097150
C018475butyraldehydebutyraldehyde results in increased expression of DNAH12 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH12 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of DNAH12 mRNA26577399
C009160cyclonitecyclonite results in decreased expression of DNAH12 mRNA25559034
D004041Dietary FatsDietary Fats results in increased expression of DNAH12 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DNAH12 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH12 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNAH12 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DNAH12 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DNAH12 mRNA"25554681
C046012pentanalpentanal results in increased expression of DNAH12 mRNA26079696
D010656PhenylephrinePhenylephrine results in decreased expression of DNAH12 mRNA18158353
C005556propionaldehydepropionaldehyde results in increased expression of DNAH12 mRNA26079696
C502851quinocetonequinocetone results in increased expression of DNAH12 mRNA27046791
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAH12 protein28918527
D053260SootSoot results in decreased expression of DNAH12 mRNA26551751
C009495titanium dioxidetitanium dioxide results in decreased expression of DNAH12 mRNA23557971
D014635Valproic AcidValproic Acid results in decreased expression of DNAH12 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005874microtubule-IEA-  
GO:0005929cilium-IEA-  
GO:0030286dynein complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27144936Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins. (2016 Jun)Livshits GJ Clin Endocrinol Metab